Conserved Protein Domain Family
DUF2464

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pfam10240: DUF2464 
Multivesicular body subunit 12
MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.
Statistics
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PSSM-Id: 463017
Aligned: 35 rows
Threshold Bit Score: 241.438
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001266326  16 RPVLSLQIVETVAKCPAGYWPVSRTYDEDSDAGLQRQNg-LFGKKSSHYICLSKS-----EGVPGYVMDGMAVIGDGELI 89 
XP_001966153  59 RPITSLHIVEDFERCPKNFSAINRTYDQDSDADLWRDYs-LFGRQNTRYLCLSKS-----EGLPEYVVETLQVIAEKTQP 132
KRF80832      60 RPITSLHIVEDFDRCPKNFNAIHRTYDQDADADLWRENniLFGRQTTRYLCLSKS-----EGLPEYVVETLKVIAEKVPP 134
XP_001995775  68 RPITSLHIVEDFERCPKNFSAIHRTYDQDADADLWRENnlLFGRQTTRYLCLSKS-----EGLPEYVVETLKVIAEKVPP 142
PDM64612      17 LPITAICIVADRNKAPIGFTPILKTHDESVDADLWRESafSIWSRPVRYIAVSREik-taIPSSRSVITDLTVTKESEPV 95 
4_pfamImport   1 LPITAICIVGDKNKSPRGFVPVVKCHDDQSDADLWRDGffAI-NRQVRYICTSTEip-dtIKTAVQVVTNLIIVRESDPI 78 
Q17687        15 IPITAICIVADKNKAPRGFLPIIKCQDDQTEADLWRDGffTI-NRQVRYICTSTEipdsnIKTPVQVITNLIIVRESDPI 93  Caenorhabditis ...
EKC22387      29 RPITQVAIVADSTRCPPGFTLIDRTYDRRDDADLWRDG--LFGRKVVRFLCVEKMpp----spGRDVLVDVAVIGERDAI 102
ESN95197       5 LPITNLGIVADLSKCPPSYIVLVKSTDKREDCDLWKDS--VFKSKCTRYLCFTRAiekhqDHL-QDVLVNIFLINDRDPV 81 
XP_002121685   5 QPITNVCIVAERNACPPRYNILDRTIEN-EDADFWKDG--LFKSKIRRYLCFTREpsqnqLNE---VITDMALIGVKDPV 78 
NP_001266326  90 PAGYSVAGRAG--------------KRRLCTRVSRhTASATSLVTDVIVCSKM-RTAPQGFILAGAISGKMVCYKVSGGS 154
XP_001966153 133 PKEFSLLSRTAdsdq------kawrKRQIAYKLSK-RGTVTQAVTDIILCSKL-KVAPDGFKLAGDINGVLICYKTGAI- 203
KRF80832     135 PKEFSLLSRTAdtdq------kawrKRQIAYKLSK-RGTVVQAVTDIILCSKL-KIAPDGFKLAGDINGVLICYKTGAI- 205
XP_001995775 143 PKEFSLLSRTAdsdq------kawrKRQIAYKLSK-RGTVTQAVTDVILCSKL-KIAPDGFKLAGDINGVLICYKTSAI- 213
PDM64612      96 PHGYIAIDYTAdske------kalrKRFLCVKTEP-LESCVDAVTDVIVLSKT-KKPPRDHSLAGEVDGILICFKTGVI- 166
4_pfamImport  79 PHGYVAIDYTAdsre------kslrKKWLCIRTEP-RDRVVDAIGEIIIMGKS-KKVPRDYTSAGEIDSLLVCYKVVAI- 149
Q17687        94 PHGYVAIDYTAdsre------kslrKKYVCIRTEP-RDRVVDAIGEIIILGKT-KKVPRDYTSAGDIDSLLICYKVISI- 164 Caenorhabditis ...
EKC22387     103 PAGFTCVDFTSdtre------kavkKKMLCVRYMS-SDLTNDAICELILLTKGvRRPPNGYTLVGELNYMGLCYKMAGFR 175
ESN95197      82 PEGCRIVHKTMdtcvfiiyfkkalqKKLLCIRMLP-RNSTCEAVSDMIILSRN-KKPPNNYTAIGEINGLVLCYQMCNLA 159
XP_002121685  79 PVGYTALKETAdtre------qalkKHNLCIRYIP-KTSTSSAISDILLCRDN-SYKERMYTLMGELNGINVAFKLSTIH 150
NP_001266326 155 AdtSPThahneyenvvtnltpeanrrlravpeRPPK-----LPtLITdlnnlnitqspasypki---------------- 213
XP_001966153 204 ----------------------------------PVrmpppLPaGNGagatceveqalnrlnmqgqrns----------- 238
KRF80832     206 ----------------------------------PVrlpppVPgNGCevelalnrlnlhgqrnsrgpl------------ 239
XP_001995775 214 ----------------------------------ATrlpppIPgIPSsnsnananansnssceveqalnrlnlhgqqqqr 259
PDM64612     167 ----------------------------------PPhygmkQShSDTnigfn---------------------------- 184
4_pfamImport 150 ----------------------------------PQtygipTSn------------------------------------ 159
Q17687       165 ----------------------------------PQtygiqTSn------------------------------------ 174 Caenorhabditis ...
EKC22387     176 K------------------------------------------------------------------------------- 176
ESN95197     160 NlqQGCv------------------------gGG---------------------------------------------- 169
XP_002121685 151 Ip------------------------------------------------------------------------------ 152
NP_001266326 214 ------------nglvtdhdyealnpsyNIKPSRPA-------------------PRPPSSKSPvpeakspqpvarKKGP 262
XP_001966153 239 ------rgplpqpptehhdyeeikanyqINSPQRPA-------------------PPRPATAAAs-------------aS 280
KRF80832     240 --------pqvpattehhdyeeiqahyqINSPQRPA-------------------PPRPASTTGaa---------tGTET 283
XP_001995775 260 aggargplpqlpaggehhdyeeiqahyqINSPQRPA-------------------PPRPA-------------------T 301
PDM64612     185 -----------------------lggpsRLGPSSAY-------------------PQLDMPHPSsh--------stSDLN 214
4_pfamImport 160 --------------------------------SSSAletkpts------gglypgLPNPNIYNSt----------pSNLN 191
Q17687       175 --------------------------------STSNiesqaa-------gglypgL--PNLSNSt----------pANLD 203 Caenorhabditis ...
EKC22387     177 -------------------------------PGVQMdshqghandstfhtqgyttQSTPMNMSSlasn-----lpyNPTP 220
ESN95197     170 -------------------------------------------------------DDDPMLHTInn---------vDNSN 185
XP_002121685 153 -------------------------------tNRPA-------------------PPPPVQRVNt-----------TAVN 171
NP_001266326 263 APlpg---prnTIYQTLG-------GYNGMEGVPFVLNSK----------------LRGLPSDSlT--QFPVIKKRT-RF 313
XP_001966153 281 GGkgty-----ggtGTLG-------TYTELEGVPFVMDVR----------------LQRNQTGT----EIPTLPEI---S 325
KRF80832     284 AGragh-----fgiGTLG-------TYTELEGVPFAMHAM----------------LQRSQLMT----ELPTLPEI---S 328
XP_001995775 302 SGrsgy-----ggtGTLG-------TYTELEGVPFILNPL----------------LQRSQPIT----ELPTLPDI---S 346
PDM64612     215 HVrndahnaftIKGAVPS-------RINPIEGVNFIVNPR----------------IVNTQKKSs---SLPPIPSYD--T 266
4_pfamImport 192 VTggsnssaftLKNVGIP-------RVKAIDGIDFKLNPS----------------FV-SNDSD-RdsQLPDLSQFAhLE 246
Q17687       204 VTgsssnsaftMKNAGAP-------RVKAIDGIDFKVNPM----------------FVNSSGSN-NssQLPDLSQFNdLD 259 Caenorhabditis ...
EKC22387     221 YKkngplergtSFTDSAH-------TLQALQGLPFELNRK----------------VFSDDLDI----SIPQIPYKS-IM 272
ESN95197     186 NNscsdvnnttTSNALVYyndigslVVNAMYDIPFCLNASigiddltrnellhlngYKNRYDED---------------M 250
XP_002121685 172 TPapmndtiqrNHTQQQQh-----nVMSGIEGVEWKLHDR----------------FTQTKAGM-NskTALNIEIRT-RS 228
NP_001266326 314 ELDRDYSYNFAIE 326
XP_001966153 326 TILKNLDYDFQLE 338
KRF80832     329 SLLKTLDYDFQLE 341
XP_001995775 347 TLLKTLDYDFQLE 359
PDM64612     267 YFQDEFNYGFQLE 279
4_pfamImport 247 MNSDRYNYNFATE 259
Q17687       260 RLDDKYNYSYATE 272 Caenorhabditis elegans
EKC22387     273 DIENQYSYDFSVE 285
ESN95197     251 DIETEFSYDFTVE 263
XP_002121685 229 ELIDLCAYDFTKE 241
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