4Z34,4Z35,4Z36


Conserved Protein Domain Family
7tmA_LPAR1_Edg2
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cd15344: 7tmA_LPAR1_Edg2 
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lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
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Statistics
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PSSM-Id: 341348
Aligned: 7 rows
Threshold Bit Score: 425.594
Created: 25-Dec-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4Z34: Human lysophosphatidic acid receptor 1 (LPAR1) binds an antagonist (Ono-9780307), contacts at 4A
  • Structure:4Z35: Human lysophosphatidic acid receptor 1 (LPAR1) binds an antagonist (Ono-9910539), contacts at 4A
  • Structure:4Z36: Human lysophosphatidic acid receptor 1 (LPAR1) binds an antagonist (Ono-3080573), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                                                 #      #   #          ##  ##
4Z34_A        68 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 147
P46628        50 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 129 sheep
Q9PU17        52 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 131 African clawed ...
NP_001108554  55 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 134 chicken
NP_001004502  32 KLVMGLGITVCIFIMLANLLVMVAIYINRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 111 zebrafish
4Z35_A        68 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 147
4Z36_A        68 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 147

Feature 1          #                                                                 #        #  
4Z34_A       148 TSLTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 227
P46628       130 TTVTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 209 sheep
Q9PU17       132 TSLTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVVIWTVAIVMGAIPSVGWNCICDLEQCSNMAPLYSDSYLIF 211 African clawed ...
NP_001108554 135 TSLTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDITHCSNMAPLYSDSYLVF 214 chicken
NP_001004502 112 TSLTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVIIWTMSIVMGAIPSVGWNCICAIDTCSNMAPLYSNSYLGF 191 zebrafish
4Z35_A       148 TSLTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 227
4Z36_A       148 TSLTASVANLLAIAIERHITVFRMQLHTRMsNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSCSYLVF 227

Feature 1        #                                                                               
4Z34_A       228 WAIFNLVTFVVMVVLYAHIFGYVADlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatppkledkspdspe 307
P46628       210 WAIFNLVTFVVMVVLYAHIFGYVRQrtmrmsr------------------------------------------------ 241 sheep
Q9PU17       212 WTIFNLVTFVVMVVLYAHIFVYVRQktmrmsr------------------------------------------------ 243 African clawed ...
NP_001108554 215 WAIFNLVTFVVMVVLYAHIFGYVRQrtmrmsr------------------------------------------------ 246 chicken
NP_001004502 192 WAIFNLVTFVVMVVLYAHIFMYVRQrtmrmsr------------------------------------------------ 223 zebrafish
4Z35_A       228 WAIFNLVTFVVMVVLYAHIFGYVADlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatppkledkspdspe 307
4Z36_A       228 WAIFNLVTFVVMVVLYAHIFGYVADlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkggsggsdspe----- 302

Feature 1                                                                                #  #  ##
4Z34_A       308 mkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylrNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 387
P46628       242 -------------------------------------------hssgprrNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 278 sheep
Q9PU17       244 -------------------------------------------hssgprrNRDTMMSLLKTVVIVLGAFIVCWTPGLVLL 280 African clawed ...
NP_001108554 247 -------------------------------------------hssgprrNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 283 chicken
NP_001004502 224 -------------------------------------------hssgqrrNRDTMMSLLKTVVIVLGAFIVCWTPGLVIL 260 zebrafish
4Z35_A       308 mkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylrNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 387
4Z36_A       303 mkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylrNRDTMMSLLKTVVIVLGAFIICWTPGLVLL 382

Feature 1                      ## ##                         
4Z34_A       388 LLDVcCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 431
P46628       279 LLDVcCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 322 sheep
Q9PU17       281 LLDIcCPQCNILAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 324 African clawed frog
NP_001108554 284 LLDVcCPQCNVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 327 chicken
NP_001004502 261 LLDVvCANCNVLTYEKFFLLLAEFNSAMNPIIYSYRDKEMSITF 304 zebrafish
4Z35_A       388 LLDVcCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 431
4Z36_A       383 LLDCcCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 426

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