pfam15338: TPIP1 (this model, PSSM-Id:373764 is obsolete and has been replaced by 464658)
p53-regulated apoptosis-inducing protein 1
TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localized within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.
Jiyao W et al.(2023). "The conserved domain database in 2023.",