3BS7,3BS5


Conserved Protein Domain Family
SAM_aveugle-like

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cd09510: SAM_aveugle-like 
Click on image for an interactive view with Cn3D
SAM domain of aveugle-like subfamily
SAM (sterile alpha motif) domain of SAM_aveugle-like subfamily is a protein-protein interaction domain. In Drosophila, the aveugle (AVE) protein (also known as HYP (Hyphen)) is involved in normal photoreceptor differentiation, and required for epidermal growth factor receptor (EGFR) signaling between ras and raf genes during eye development and wing vein formation. SAM domain of the HYP(AVE) protein interacts with SAM domain of CNK, the multidomain scaffold protein connector enhancer of kinase suppressor of ras. CNK/HYP(AVE) complex interacts with KSR (kinase suppressor of Ras) protein. This interaction leads to stimulation of Ras-dependent Raf activation. This subfamily also includes vertebrate AVE homologs - Samd10 and Samd12 proteins. Their exact function is unknown, but they may play a role in signal transduction during embryogenesis.
Statistics
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PSSM-Id: 188909
Aligned: 16 rows
Threshold Bit Score: 110.856
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface ML [polypeptide binding site]
Evidence:
  • Structure:3BS5; Drosophila/Human, SAM_HYP /SAM_CNK2 dimer, contacts at 4A.
  • Comment:The mid-loop (ML) surface of the SAM domain of HYP (or aveugle) Drosophila protein interacts with the end-helix (EH) surface of the SAM domain of human CNK2 protein.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #####  ##  #    #  ##                        
3BS7_A         1 KAVYLWTVSDVLKWYRRHCGE-YTQYEQLFAQHDITGRALLRITDSSLQRMGVTDNRDREAIWREIVKQRLKTDI 74  fruit fly
3BS5_A        21 KAVYLWTVSDVLKWYRRHCGE-YTQYEQLFAQHDITGRALLRITDSSLQRXGVTDNRDREAIWREIVKQRLKTDI 94  fruit fly
XP_002123543  92 KPVHVWTQTEVCKWLKRHLPEdQAHYTELFAYHDITGKTLLGLNEIKLTRMGVCDTGHRNNILHEILKLQMKDYM 166 Ciona intestinalis
XP_002596793  31 KPAYIWSHEEVMRWFKKHCADyYRKYAEAFTFHEITGQSLMRLTDEKLERMGITDEQHRADLMGHLYRLKLRHEG 105 Florida lancelet
XP_001944433  21 KVVYQWTVQDVQKWFRRHCYDyYVLYGEKFLQHEIIGRALIRINENQLYRMGIINPDHSQDICREILKLRLKTYI 95  pea aphid
XP_002735492  35 RPVFLWSVSDVSKWLRRHCPLyYGLYGNLFEEHEISGRALVHLNSRKLDQMGINNADHRSELMNQFLRLRLKHEQ 109 Saccoglossus kowalev...
Q9BYL1       113 RPVVLWSQQDVCKWLKKHCPHnYLVYVEAFSQHAITGRALLRLNAEKLQRMGLAQEAQRQEVLQQVLRLQVREEG 187 human
NP_001103868  86 RPVVLWSQQDVCRWLKKHCPHnYLTYVEAFSHHAITGRALLRLNGEKLERMGLVQETLRQELLQQVLQLQVQEEG 160 zebrafish
XP_002194002 109 KPVVLWTQQDVCKWLKKHCPHnYLIYVEAFSHHAITGRALLRLNGEKLQRMGIVLETQRQEVLQQVLQLQVREEV 183 Taeniopygia guttata
Q8N8I0        72 KPVALWTQQDVCKWLKKHCPNqYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQHILQQVLQLKVREEV 146 human

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