Conserved Protein Domain Family
Mesothelin

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pfam06060: Mesothelin 
Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known.
Statistics
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PSSM-Id: 368727
Aligned: 4 rows
Threshold Bit Score: 1021.32
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q13421         1 MALPTARPLLGSCGTPALG-SLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLST 79  human
2_pfamImport   1 MALLTALSPRRSCRTAPHC-SLLLLLLTLGWVQPLRTQAGESRQQAAPLDPVLANLSSFTSLSPDRLLGFTCADVSGLSP 79 
1_pfamImport   1 MAWSTARLPLKSCMILTHS-SLL-LLLNLGWVQALRDQTVMTQKAAILLNPVLANKSNLASLDPSFLCDFTCTEVSGMSI 78 
Q61468         1 MALPTARPLLGSCGSPICSrSFLLLLLSLGWIPRLQTQTTKTSQEATLLHAV-NGAADFASLPTGLFLGLTCEEVSDLSM 79  house mouse
Q13421        80 ERVRELAVALAQKNVKLSTEQLRCLAHRLSE--PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAP 157 human
2_pfamImport  80 EHVKELAVAMGQKNATLQADQLRCLAHGLPThlAPEDLDAFLPDLLLFLNPAEFSGPQACAHFFSHISKANVDVLPRRSP 159
1_pfamImport  79 EHAQELAMAIKQKNITLRVDQLHCLARHLSKhlVPKNLNIFPVDMLPFFNPDLFTGPQACTQFFSGIAKANVDVLPRGAP 158
Q61468        80 EQAKGLAMAVRQKNITLRGHQLRCLARRLPRhlTDEELNALPLDLLLFLNPAMFPGQQACAHFFSLISKANVDVLPRRSL 159 house mouse
Q13421       158 ERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPP 237 human
2_pfamImport 160 ERQRLLPAALVCRGVQGSQVSEEDVLALGGLACDLPGCFVANSAAALLPRLAGCPGSLDQDQQEAVRAVLQGRGPPYGSP 239
1_pfamImport 159 ERRQLLLAALACQGVQGSLVSEDNVQALGGLACDLPGHIIATSAAVVLPRLATCPGPLDQNQQEAARAALQGGGTPYGPP 238
Q61468       160 ERQRLLMEALKCQGVYGFQVSEADVRALGGLACDLPGKFVARSSEVLLPWLAGCQGPLDQSQEKAVREVLRSGRTQYGPP 239 house mouse
Q13421       238 STWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIF 317 human
2_pfamImport 240 SKWSVSTLDTLQGLLPILDQDFIQDIPKGVMTAWLQRFYRNPSGPRPELTVVLPRLRRDTEKEACPPGREAHVVEEKLVF 319
1_pfamImport 239 SRWSVSTLDALQSLLAVLDQSIIRTIPKGVTNAWLHHTSQEPSGRWPDLTTILVRLKRSTEEKVCPPGRKPQVVDEDLFF 318
Q61468       240 SKWSVSTLDALQSLVAVLDESIVQSIPKDVKAEWLQHISRDPSRLGSKLTVIHPRFRRDAEQKACPPGKEPYKVDEDLIF 319 house mouse
Q13421       318 YKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKA 397 human
2_pfamImport 320 YSDRELEACVDGALLVAEIDHVNALPFTYQQLNIFKRKLDKIYPKGYPESLIQHLGYFFLTMTPEDIHKWNVTSLQVVKD 399
1_pfamImport 319 YDNWELEACVDGALLATQMDRVNAIPFTYQQLNIFKHKLDETYPQGYPESLILSLGHFFYFMNPEDIQKWNVTSLDTLKA 398
Q61468       320 YQNWELEACVDGTMLARQMDLVNEIPFTYEQLSIFKHKLDKTYPQGYPESLIQQLGHFFRYVSPEDIHQWNVTSPDTVKT 399 house mouse
Q13421       398 LLEVNKGHEMSPQAprrp---lpqvATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLD 474 human
2_pfamImport 400 LLRVSKGRDMDAQAtrhlsgllpqvAALIAQYVKGNGWLDKDSLDALATFHPTYLCFFSSRQLGSVPPSIIWVVRPHDLD 479
1_pfamImport 399 LLKVSKKPNMDTKE-----------VTLIARYLQGSGQLDKDTLDALAGFHPTYLCALSPEQLGSVPDSLLWAARPQDLD 467
Q61468       400 LLKVSKGQKMNAQA-----------IALVACYLRGGGQLDEDMVKALGDIPLSYLCDFSPQDLHSVPSSVMWLVGPQDLD 468 house mouse
Q13421       475 TCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPH 554 human
2_pfamImport 480 TCNQTQMDILYAKAHLTFQNVSGAEYFVKIQPFLGGASTEDLRALSQQNVSMDMVTFKTLKKEAVVGLTVQEVQNLLGPH 559
1_pfamImport 468 SCSSKQLVVLYPKAHLAFQNVSKPEYLEKISPFLGGVSIEDLHALSHQNVSMDMSTFKKLPVKVVERLTVAEVQNLLGPH 547
Q61468       469 KCSQRHLGLLYQKACSAFQNVSGLEYFEKIKTFLGGASVKDLRALSQHNVSMDIATFKRLQVDSLVGLSVAEVQKLLGPN 548 house mouse
Q13421       555 VEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVL-TVLALLLASTL 629 human
2_pfamImport 560 VVGLKAEQKNSPVWDWILRQRQDDLDAMGLGLQGGIPNGYQVLDRSHPAALSDGHHLLGSRPMLsTMLALLLALAL 635
1_pfamImport 548 MAGLKAEERNSPVKEWIFQQRQEDLDMLGLGLRGGIPNGYMILDFNSREAFSRGTLLLASGFLLaLILVLLVAGTL 623
Q61468       549 IVDLKTEEDKSPVRDWLFRQHQKDLDRLGLGLQGGIPNGYLVLDFNVREAFSSRASLLGPGFVLiWIPALLPALRL 624 house mouse
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