Conserved Protein Domain Family
Paramyxo_P

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pfam01806: Paramyxo_P (this model, PSSM-Id:280054 is obsolete and has been replaced by 460340)
Paramyxovirinae P phosphoprotein C-terminal region
The subfamily Paramyxovirinae of the family Paramyxoviridae now contains as main genera the Rubulaviruses, avulaviruses, respiroviruses, Henipavirus-es and morbilliviruses. Protein P is the best characterized, structurally of the replicative complex of N, P and L proteins and consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P protein is an essential part of the viral RNA polymerase complex formed from the P and L proteins. P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional.The C-terminal part of P (PCT) is only functional as an oligomer and forms with L the polymerase complex. PNT is poorly conserved and unstructured in solution while PCT contains the oligomerization domain (PMD) that folds as a homotetrameric coiled coil (40) containing the L binding region and a C-terminal partially folded domain, PX (residues 474 to 568), identified as the nucleocapsid binding site. Interestingly, PX is also expressed as an independent polypeptide in infected cells. PX has a C-subdomain (residues 516 to 568) that consists of three {alpha}-helices arranged in an antiparallel triple-helical bundle linked to an unfolded flexible N-subdomain (residues 474 to 515).
Statistics
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PSSM-Id: 280054
Aligned: 2 rows
Threshold Bit Score: 484.75
Created: 19-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O57285 319 EENTSSMKEMATLLTSLGVIQSAQEFESSRDASYVFAKRALKSANYAEMAFNVCGLILSAEKSFANRVDENKQLLKQIQE 398 Sendai virus (strain ...
O57285 319 EENTSSMKEMATLLTSLGVIQSAQEFESSRDASYVFAKRALKSANYAEMAFNVCGLILSAEKSFANRVDENKQLLKQIQE 398 Sendai virus (strain ...
O57285 399 SVESFRDIYKRFSEYQKEQNSLLMSNLSTLHIITDRGGKTDNPDSPTRSPSVFAKTKENKTKATRFDPSMETMGDMRYKP 478 Sendai virus (strain ...
O57285 399 SVESFRDIYKRFSEYQKEQNSLLMSNLSTLHIITDRGGKTDNPDSPTRSPSVFAKTKENKTKATRFDPSMETMGDMRYKP 478 Sendai virus (strain ...
O57285 479 DLLREDEFREEIRNPVYQERDTEPRASNASRLLPSREKPTIHSLKLVIESSPLSRAEKAAYVKSLSKCKTDQEVKAVMEL 558 Sendai virus (strain ...
O57285 479 DLLREDEFREEIRNPVYQERDTEPRASNASRLLPSREKPTIHSLKLVIESSPLSRAEKAAYVKSLSKCKTDQEVKAVMEL 558 Sendai virus (strain ...
O57285 559 VEEDIESL 566 Sendai virus (strain Ohita)
O57285 559 VEEDIESL 566 Sendai virus (strain Ohita)
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