1QZ0,1YGR,2NLK,2SHP,2QEP,2NZ6,1BZC,1YGR,2FH7,2NLK,2A8B,2JJD,2B3O,2FH7,2BZL,1WCH,2B49,3M4U,2OOQ,2JJD,4GFU,4ICZ,3D42


Conserved Protein Domain Family
PTPc
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cd00047: PTPc 
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catalytic domain of protein tyrosine phosphatases
Protein tyrosine phosphatases (PTP, EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG, and are characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane proteins, only one copy may be active.
Links
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Statistics
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PSSM-Id: 350343
Aligned: 147 rows
Threshold Bit Score: 100.052
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 10 residue positions
Conserved feature residue pattern:x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of PTPs with bound phosphorylated peptide substrates
  • Structure:3D42: Human HePTP binds monophosphorylated Erk2 peptide; contacts at 4A
    - View structure with Cn3D
  • Structure:4ICZ: Human PTPN9 binds Her2 phosphopeptide; contacts at 4A
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  • Structure:4GFU: human PTPN18 binds Her2-pY1248 phosphopeptide; contacts at 4A
    - View structure with Cn3D
  • Structure:1QZ0: Yersinia pestis phosphatase YopH binds two phosphotyrosyl mimetic-containing hexapeptides; contacts at 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                          
1QZ0_A          81 DLNANYIQVgn--tRTIACQYPlqs------------------------------qleSHFRMLAENr------------ 116   Yersinia pe...
XP_001749210   533 YYNASFIPTyspqmPIIVAEGPqrp------------------------------tltLFWQMMWQQe------------ 570   Monosiga br...
XP_001750851  9696 YINANWVAGyqdeeQYICAQTPmpa------------------------------tirSFWCAVLRHr------------ 9733  Monosiga br...
NP_505965      114 YLNSSWIDGyretrKFIVAPSPmse------------------------------svaQFWRCVFDRn------------ 151   nematode
NP_499709      905 FINANVMKFge--iSWIMAQGPmdgtehlekisk-------------vppkpkkstleKHWAVIDQYd------------ 957   Caenorhabdi...
NP_497652      826 FINANVMMFgk--iEWIMAQGPmdgtekkkde----------------tdkpkrstceKHWALIEQHn------------ 875   Caenorhabdi...
NP_490945      988 FINANLMEIdg--vKWIMTQGPmdgtehvqeekknaekrksgekvskkpivpkkdtreKFWGMIEEYr------------ 1053  Caenorhabdi...
EFO26186        97 YINANYVDGfreekKFILTQSPmes------------------------------tveSFWAMIYQEn------------ 134   Loa loa
XP_568329       68 YLNANVVTDgk-ggRWIAAQAPppq------------------------------afnTFFKALYSGaaigr-------- 108   Cryptococcu...
XP_001829367   109 YLNASWVLEkhggkWWIATQAPlph------------------------------tshSFLSVLLQPvtrpppallaptt 158   Coprinopsis...

Feature 1                                                                                          
1QZ0_A         117 -------------tPVLAVLASsseianqrfGMPDYFRqsgt------------ygsITVESKMTQQVglgd--gimADM 169   Yersinia pe...
XP_001749210   571 -------------vSLVAMTTTisdg--sqvVGERYWPsegdi---------leigpLQITLEHEHTNl-------aICE 619   Monosiga br...
XP_001750851  9734 -------------vAVVATMMEd--------ARNQYWPerlhkp-------mllgegYTVTLLSQDIKep-----daWCT 9780  Monosiga br...
NP_505965      152 -------------sLIVVTLCEll-----deKGKPFVPvkigep--------lviddMTIELDNIRKVrp------aTYS 199   nematode
NP_499709      958 -------------vGIVAQLASvies--ddrKFAPYYSekvgekmtf-grytvttksINTKLENFTDKk-------sFVM 1014  Caenorhabdi...
NP_497652      876 -------------vAICVQLCGfveg--edkKCASYYSdkvggvlrf-rnyslktidIKTDLAEFTDKk-------dFTL 932   Caenorhabdi...
NP_490945     1054 -------------tGVVAQLCQfked--genKCAEYYStevkge--------mkfgrYTVKTVSVEENldqftdkqtAKV 1110  Caenorhabdi...
EFO26186       135 -------------vVEIVAMTSly-----saATFLYVPikraat--------aifgpYSIKFCGSQLIrd------aYEA 182   Loa loa
XP_568329      109 ----------lpnnVILVQLTGwees--gipKADPYMEhkm--------------pdMGVHLSRREIIdr-----isSTL 157   Cryptococcu...
XP_001829367   159 satpstsphpttrvRTVVQLTQnves--grrKAHAYFPskvgksmivpaeegsealgVKATLLHQETIqe-----ahCLR 231   Coprinopsis...

Feature 1                                                               ##                         
1QZ0_A         170 YTLTIReag-----------------------------qktISVPVVHVGNWPDQTAVs----sEVTKALASLVDQTaet 216   Yersinia pe...
XP_001749210   620 RSLRVKhidl----------------------------gitRDVKLLQMLFWVAGEACed---sHRFLAFAERVRDArsk 668   Monosiga br...
XP_001750851  9781 RAFRVAhad-----------------------------grnHVVHQLQLLNCEPAKVLap---tLARFALSCELQRDasg 9828  Monosiga br...
NP_505965      200 SVLKISekgv----------------------------eshKTVILLTYSGWGKLGYPqkpsdiLDLLADMNHMRTIlrk 251   nematode
NP_499709     1015 YNLEYKndqwq-------------------------dkklkKTVSVLHFTAWPDHGAPk-----NPDYALDIIRFCEsy- 1063  Caenorhabdi...
NP_497652      933 YTVEITnyrkn-------------------------kgeqkKTVDILLYSAWPEHGAPq-----EAYPALEILKFCEty- 981   Caenorhabdi...
NP_490945     1111 YTIEFHnnkvl--------------------------mkvpFPVKILAFSGWPDHGAPae---pHTALDIIKYCESFk-- 1159  Caenorhabdi...
EFO26186       183 SVLKLKkgd-----------------------------gqeRKILHICFYTWHDKGTPer---pTEMLYLVSDINYNrkl 230   Loa loa
XP_568329      158 TEVALQgd-------------------------------rrVNLFHYQFDAWPDHGVPt----gAAVQALRELVKEVdek 202   Cryptococcu...
XP_001829367   232 STIAVVpvknpppvntstyesvefddeggkedkfgevhdqrVIFTHLLYTSWPDHGVPe----eEDRASLVEFIRLAdrl 307   Coprinopsis...

Feature 1                                           #######                                        
1QZ0_A         217 krnmyesk---------gssavaddsklRPVIHCRAGVGRTAQLIGAMCMNDSRns--------------qlSVEDMVSQ 273   Yersinia pe...
XP_001749210   669 l-----------------------kpdqPLLVHGITAVGRAGAFCALLNLLDRFdne------------rrlNVVDELTR 713   Monosiga br...
XP_001750851  9829 --------------------------agPLLVHDDVGAGLSGILLHTLVCVSMGldt------------grvDPARVLIR 9870  Monosiga br...
NP_505965      252 qglekk--------------ifddsqrtPMTLVCFDGFSRSCTLVALDILCQRLtashei-------gtpfvDILDTIAR 310   nematode
NP_499709     1064 --------------------------ktSVLVHCSAGVGRTGTLVAIKYGIQLCtte------------rttNLLSIVCP 1105  Caenorhabdi...
NP_497652      982 --------------------------kkNVLVHCSEGVGRTGTLVAIKYGIDLClkk------------kvtQIIDIILP 1023  Caenorhabdi...
NP_490945     1160 ---------------------------tNVLVHCSVGVGRTGTLVAIKYGIQLCskq------------evsDMALVVDP 1200  Caenorhabdi...
EFO26186       231 fteeaek------------sgwfkggrsPIVVHCSTGASRSGTLAVLDICCRKMdyteklp-----hgnvlvDVRDTVLR 293   Loa loa
XP_568329      203 rr----------------------eldcEVWVHCSAGVGRTGTFIALSSLLSPDep--------------nvSSPIGPLP 246   Cryptococcu...
XP_001829367   308 nrdvslasypptssstsasnegdldpdpPIIVGCSAGVGRTGSFIALSSLMRHLgdlppansptpssvlppsPLGPLPEQ 387   Coprinopsis...

Feature 1                               #          
1QZ0_A         274 MRVQrng-----------imvQKDEQLDVLIK 294   Yersinia pestis
XP_001749210   714 LRQArsh------------fiSDVVYLETILA 733   Monosiga brevicollis MX1
XP_001750851  9871 LLEQrra------------mlQAPVQLRLSCE 9890  Monosiga brevicollis MX1
NP_505965      311 LRMLrga------------acMKAEQFVFLSM 330   nematode
NP_499709     1106 VRNCrfg------------avQSAQQLMYLIV 1125  Caenorhabditis elegans
NP_497652     1024 VRQCrhg------------avQDDTQVTYILL 1043  Caenorhabditis elegans
NP_490945     1201 VRACryg------------avQTEQQLIYMLL 1220  Caenorhabditis elegans
EFO26186       294 VRTQrdk------------avMKPEQYLLLHL 313   Loa loa
XP_568329      247 RETPfanae--------gclcRLSVNLSFCTK 270   Cryptococcus neoformans var. neoformans JEC21
XP_001829367   388 MSEDcvaqeidglreqrqrmvDRPEQVVLIYE 419   Coprinopsis cinerea okayama7#130

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