2CRJ


Conserved Protein Domain Family
HMG-box_HMG20B

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cd22018: HMG-box_HMG20B 
Click on image for an interactive view with Cn3D
high mobility group (HMG)-box found in high mobility group protein 20B (HMG20B) and similar proteins
HMG20B, also called SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, SMARCE1-related protein (SMARCE1R), BRCA2-associated factor 35 (BRAF35), HMG box-containing protein 20B, HMG domain-containing protein 2 (HMGXB2), HMG domain-containing protein HMGX2, Sox-like transcriptional factor, or structural DNA-binding protein BRAF35, is a DNA binding factor that acts as a repressor of erythroid differentiation. It is required for correct progression through the G2 phase of the cell cycle and entry into mitosis. It is also required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. HMG20B is a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex.
Statistics
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PSSM-Id: 438834
Aligned: 6 rows
Threshold Bit Score: 163.222
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
putative DNA
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ## #####  ##      #           ##  #  ##      #   #  #   #  #                  
2CRJ_A         7 GPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPAEKQRYLDEAEKEKQQYLKELWAYQQSEAYKVCTE 86  house mouse
RLV88843      88 GPKAPVTGYVRFLNERREQIRTQHPDLPFPEITKMLGAEWSKLQLSEKQRYLDEAEREKQQYMKELREYQQSEAYKMCTE 167 Gouldian finch
Q9P0W2        69 GPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTE 148 human
OCT97433      67 GPKAPVTGYVRFLNERREQIRAQHPDLPFPEITKMLGAEWSTLPPHEKQRYLDEAERDKQQYMKELREYQQSESYKMCAE 146 African clawed ...
NP_001018387  52 GPKAPVTGYVRFLNERREHIRALHPDLPFPEITKRLGAEWSRLAPHDKQRYLDEAERDKMQYARELREYQKSEAYQITCA 131 zebrafish
XP_007908366  83 GPKAPVTGYVRFLNERREQIRMQHPDLPFPEITRMLGNEWSKLPPLEKQRYLDEAEKDKQQYIKELKEFQQTEAYKLSTQ 162 elephant shark
Feature 1             
2CRJ_A        87 SGPSS 91  house mouse
RLV88843     168 KIQEK 172 Gouldian finch
Q9P0W2       149 KIQEK 153 human
OCT97433     147 KIQEK 151 African clawed frog
NP_001018387 132 KVQDK 136 zebrafish
XP_007908366 163 KIQEK 167 elephant shark

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