6QWL,6QNW,6XZG


Conserved Protein Domain Family
Flu_PB2

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pfam00604: Flu_PB2 
Influenza RNA-dependent RNA polymerase subunit PB2
PB2 can bind 5' end cap structure of RNA.
Statistics
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PSSM-Id: 395481
Aligned: 6 rows
Threshold Bit Score: 1201.66
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6QWL_Q     3 LAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMKWAMCSNFPLALTKgDMAN--RIP-LEYKGIQL 79  
P03428     1 MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADK-RITE--MIPeRNEQGQTL 77   Influenza A virus ...
Q6I7C4     5 LTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTTSRKEKNPSLRMRWAMSSKFPIIANK-RMLEeaQIP-KEHNNVAL 82   Influenza C virus ...
Q9QLL6     3 LAKIELLKQLLRDNEAKTVLRQTTVDQYNIIRKFNTSRIEKNPSLRMKWAMCSNFPLALTKgDMAN--RIP-LEYKGIQL 79   Influenza B virus ...
6QNW_C     1 MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADK-RITE--MVPeRNEQGQTL 77  
6XZG_CP1   5 LTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTTSRKEKNPSLRMRWAMSSKFPIIANK-RMLEeaQIP-KEHNNVAL 82  
6QWL_Q    80 KTNAEDIGT-KGQMCSIAAVTWWNTYGP-IGDTEGFEKVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEMP 157 
P03428    78 WSKMNDAGS-DRVMVSPLAVTWWNRNGP-ITNTVHYPKIYKTYFERVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLS 155  Influenza A virus ...
Q6I7C4    83 WEDTEDVSKrDHVLASASCINYWNFCGPcVNNSEVIKEVYKSRFGRLERRKEIMWKELRFTLVDRQRRRVDTQPVEQRLR 162  Influenza C virus ...
Q9QLL6    80 KTNAEDIGT-KGQMCSIAAVTWWNTYGP-IGDTEGFEKVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEMP 157  Influenza B virus ...
6QNW_C    78 WSKMSDAGS-DRVMVSPLAVTWWNRNGP-MTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLS 155 
6XZG_CP1  83 WEDTEDVSKrDHVLASASCINYWNFCGPcVNNSEVIKEVYKSRFGRLERRKEIMWKELRFTLVDRQRRRVDTQPVEQRLR 162 
6QWL_Q   158 PDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCL 237 
P03428   156 AKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLT 235  Influenza A virus ...
Q6I7C4   163 TGEIKDLQMWTLFEDEAPLASKFILDNYGLVKEMRSKFANKPLNKEVVAHMLEKQFNPESRFLPVFGAIRPERMELIHAL 242  Influenza C virus ...
Q9QLL6   158 PDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCL 237  Influenza B virus ...
6QNW_C   156 AKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLT 235 
6XZG_CP1 163 TGEIKDLQMWTLFEDEAPLASKFILDNYGLVKEMRSKFANKPLNKEVVAHMLEKQFNPESRFLPVFGAIRPERMELIHAL 242 
6QWL_Q   238 QGENWRQIYHPGGNKLTESRSQSMIVACRKIIRRSIVA-SNPLELAVEIANKTVI----DTEPLKSCLTAIDGGDVACDI 312 
P03428   236 QGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVS-ADPLASLLEMCHSTQI----GGIRMVDILRQNPTEEQAVDI 310  Influenza A virus ...
Q6I7C4   243 GGETWIQEANTAGISNVDQRKNDMRAVCRKVCLAANASiMNAKSKLVEYIKSTSMrigeTERKLEELILETDDVSPEVTL 322  Influenza C virus ...
Q9QLL6   238 QGENWRQIYHPGGNKLTESRSQSMIVACRKIIRRSIVA-SNPLELAVEIANKTVI----DTEPLKSCLAALDGGDVACDI 312  Influenza B virus ...
6QNW_C   236 QGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVS-ADPLASLLEMCHSTQI----GGTRMVDILRQNPTEEQAVDI 310 
6XZG_CP1 243 GGETWIQEANTAGISNVDQRKNDIRAVCRKVCLAANASiMNAKSKLVEYIKSTSMrigeTERKLEELILETDDVSPEVTL 322 
6QWL_Q   313 IRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKIGIWDGEEEFHVRCGECRGILKKSKMRMEKLLINSAK 392 
P03428   311 CKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRD 390  Influenza A virus ...
Q6I7C4   323 CKSALGGPLGKTLSFGPMLLKKISGSGVKVKDTVYIQGVRAVQFEYWSEQEEFYGEYKSATALFSRKERSLEWITIGGGI 402  Influenza C virus ...
Q9QLL6   313 IRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKIGIWDGEEEFHVRCGECRGILKKSQMRMEKLLINSAK 392  Influenza B virus ...
6QNW_C   311 CKAAMGLRISSSFSFGGFTFKRTSGSSIKREEELLTGNLQTLKIRVHDGYEEFTMVGKRATAILRKATRRLVQLIVSGRD 390 
6XZG_CP1 323 CKSALGGQLGKTLSFGPMLLKKISGSGVKVKDTVYIQGVRAVQFEYWSEQEEFYGEYKSATALFSRKERSLEWITIGGGI 402 
6QWL_Q   393 KEDMKDLIILCMVFSQDTRMFQGVRGEINFLNRAGQLLS--PMYQLQRYFLNRSND-----LFDQWGYEESPKASE-LHG 464 
P03428   391 EQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLN--PMHQLLRHFQKDAKV-----LFQNWGVEPIDNVMG-MIG 462  Influenza A virus ...
Q6I7C4   403 NEDRKRLLAMCMIFCRDGDYFKDAPATITMADLSTKLGReiPYQYVMMNWIQKSEDnlealLYSRGIVETNPGKMGsSMG 482  Influenza C virus ...
Q9QLL6   393 KEDMKDLIILCMVFSQDTRMFQGVRGEINFLNRAGQLLS--PMYQLQRYFLNRSND-----LFDQWGYEESPKASE-LHG 464  Influenza B virus ...
6QNW_C   391 EQSVAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLN--PMHQLLRHFQKDAKV-----LFQNWGIEHIDNVMG-MIG 462 
6XZG_CP1 403 NEDRKRLLAMCMIFCRDGDYFKDAPATITMADLSTKLGReiPYQYVMMNWIQKSEDnlealLYSRGIVETNPGKMGsSMG 482 
6QWL_Q   465 INELMNAS-DYTLKGVVVTKNVIDDFSSTETEKVSITKNLSLIKRTGEVIMGANDVSELESQAQLMITYDTPKMWEMGTT 543 
P03428   463 ILPDMTPSiEMSMRGVRISKMGVDEYSSTERVVVSIDRFLRIRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGP 542  Influenza A virus ...
Q6I7C4   483 IDGSKRAI--KSLRAVTIQSGKIDMPESKEKIHLELSDNLEAFDSSGRIVATILDLPSDKKVTFQDVSFQHPDLAVLRDE 560  Influenza C virus ...
Q9QLL6   465 INELMNAS-DYTLKGVVVTKNVIDDFSSTETEKVSITKNLSLIKRTGEVIMGANDVSELESQAQLMITYDTPKMWEMGTT 543  Influenza B virus ...
6QNW_C   463 VLPDMTPStEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGP 542 
6XZG_CP1 483 IDGSKRAI--KSLRAVTIQSGKIDMPESKEKIHLELSDNLEAFDSSGRIVATILDLPSDKKVTFQDVSFQHPDLAVLRDE 560 
6QWL_Q   544 KELVQNTYQWVLKNLVT---------LKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRD-QEVMKTD 613 
P03428   543 ESVLVNTYQWIIRNWET---------VKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDvLGTFDTA 613  Influenza A virus ...
Q6I7C4   561 KTAITKGYEALIKRLGTgdndipsliAKKDYL----SLYNLPEVKLMAPLIRPNRKGVYSRVARKLVSTQVT-TGHYSLH 635  Influenza C virus ...
Q9QLL6   544 KELVQNTYQWVLKNLVT---------LKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRD-QEVMKTD 613  Influenza B virus ...
6QNW_C   543 ESVLVNTYQWIIRNWET---------VKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDvLGTFDTT 613 
6XZG_CP1 561 KTAITKGYEALIKRLGTgdndipsliAKKDYL----SLYNLPEVKLMAPLIRPNRKGVYSRVARKLVSTQVT-TGHYSLH 635 
6QWL_Q   614 QFIKLLPFCFSPPKLRSngepYQF--LRLVLKGGGENfIEVRKGSPLFSYNPQ-TEVLTICGRmmSLKGKIED-EERNRS 689 
P03428   614 QIIKLLPFAAAPPKQSR----MQFssFTVNVRGSGMR-ILVRGNSPVFNYNKA-TKRLTVLGK--DAGTLTEDpDEGTAG 685  Influenza A virus ...
Q6I7C4   636 ELIKVLPFTYFAPKQGM---------FEGRLFFSNDSfVEPGVNNNVFSWSKAdSSKIYCHGIaiRVPLVVGD-EHMDTS 705  Influenza C virus ...
Q9QLL6   614 QFIKLLPFCFSPPKLRSngepYQF--LRLMLKGGGENfIEVRKGSPLFSYNPQ-TEILTICGRmmSLKGKIED-EERNRS 689  Influenza B virus ...
6QNW_C   614 QIIKLLPFAAAPPKQSR----MQFssLTVNVRGSGMR-ILVRGNSPAFNYNKT-TKRLTILGK--DAGTLIEDpDEGTSG 685 
6XZG_CP1 636 ELIKVLPFTYFAPKQGM---------FEGRLFFSNDSfVEPGVNNNVFSWSKAdSSKIYCHGIaiRVPLVVGD-EHMDTS 705 
6QWL_Q   690 MGNAVLAGFLVSGKYDPDLGDFKTIEELEKLKPGEKANILLYQGKPVKVVKRKRYSALSNDISQGIKRQRMT 761 
P03428   686 VESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA 757  Influenza A virus (A/Puert...
Q6I7C4   706 L--ALLEGFSVC-ENDPR-APMVTRQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMS 773  Influenza C virus (C/Ann A...
Q9QLL6   690 MGNAVLAGFLVSGKYDPDLGDFKTIEELERLKPGEKANILLYQGKPVKVVKRKRYSALSNDISQGIKRQRMT 761  Influenza B virus (B/Lee/1...
6QNW_C   686 VESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMA 757 
6XZG_CP1 706 L--ALLEGFSVC-ENDPR-APMVTRQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMS 773 
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