2C63


Conserved Protein Domain Family
14-3-3_eta

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cd10025: 14-3-3_eta 
Click on image for an interactive view with Cn3D
14-3-3 eta, an isoform of 14-3-3 protein
14-3-3 eta isoform (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide) is expressed mainly in brain, and is involved in hypothalamic-pituitary-adrenocortical (HPA) axis regulation. In humans, it is encoded by the YWHAH gene, and is a positional and functional candidate for schizophrenia as well as bipolar disorder (BP). This gene contains a 7 bp repeat sequence in its 5' Untranslated Region (UTR), and early-onset schizophrenia has been associated with changes in the number of this repeat. 14-3-3 eta and gamma are found in the serum and synovial fluid of patients with joint inflammation. Specifically, 14-3-3 eta, which plays a regulatory role in chondrogenic differentiation, is significantly overexpressed in juvenile rheumatoid arthritis (JRA), a chronic inflammatory disease often associated with growth impairment. Overexpression of Gremlin 1, the bone morphogenetic protein antagonist, may play an oncogenic role in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma, since it functions by interaction with the 14-3-3 eta domain. Therefore, Gremlin 1 and its binding protein 14-3-3 eta could be appropriate targets for developing diagnostic and therapeutic strategies against human cancers. 14-3-3 domain is an essential part of 14-3-3 proteins, a ubiquitous class of regulatory, phosphoserine/threonine-binding proteins found in all eukaryotic cells, including yeast, protozoa and mammalian cells.
Statistics
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PSSM-Id: 206761
Aligned: 3 rows
Threshold Bit Score: 408.348
Created: 12-Jul-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide bindingdimer interface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:2C63: Human 14-3-3 protein eta isoform bound to peptide; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                       #      #                         
2C63_A         4 DREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTmADGNEKKLEKV 83  human
CAG31751       3 DREQLLQRARLAEQAERYDDMASAMKSVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTmADGNEKKLEKV 82  chicken
NP_001086403   3 DREQLLQRARLAEQAERYEDMAAAMKSVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTlADGNEKKLEKV 82  African clawed ...
Feature 1                                                         ##                             
2C63_A        84 KAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVAsGEKKNSVVEASEAAYKEAFEISK 163 human
CAG31751      83 KAYREKIEKELETVCNDVLALLDKYLIKNCNDFQYESKVFYLKMKGDYYRYLAEVAaGEKKNSVVEASEAAYKEAFEISK 162 chicken
NP_001086403  83 KSYREKIEAELEAVCSEVLALLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLSEVGsGERKKSVTDASEASYKEAFEISK 162 African clawed ...
Feature 1                      ##  #                                        #  #   #            
2C63_A       164 EQMqPTHPIRLGLALNFSVFYYEIqNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEE 242 human
CAG31751     163 EHMqPTHPIRLGLALNFSVFYYEIqNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEE 241 chicken
NP_001086403 163 EHMqPTHPIRLGLALNFSVFYYEIqGNPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEE 241 African clawed frog

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