1QD1


Conserved Protein Domain Family
FTCD_N
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pfam07837: FTCD_N (this model, PSSM-Id:400269 is obsolete and has been replaced by 462283)
Formiminotransferase domain, N-terminal subdomain
The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains.
Links
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Statistics
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PSSM-Id: 400269
Aligned: 159 rows
Threshold Bit Score: 109.096
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1QD1_A         6 CVPNFSEGKNQEVIDAISRAVAQT----PGCVLLDVDSGPSTNRTVYTF------------VGRPED---VVEGALNAAR 66 
XP_015573974   5 CKLFISESRNRTALDSIERAARLN----PETVIVNKFEDRAYNRIRYTLvsyv-----vldSIGTAIyspLQQTVLVMVE 75  castor bean
EMS48877      21 CKLYISESQNAAVVDAISRIGQKD----PEVVLLNKFEDEYYNRVRYTLvsyi----nsesATGEAVfspIRKVLLAMIE 92  Triticum urartu
Q75ID2         9 CKLYISESQNAKVVDAITRIGQKD----PEVVLLSKFEDDHYNRVRYTLasyi----inenSTGEVKfspMRRVLLEMIE 80  Japanese rice
XP_004982519  32 CKLYISESRNPTAIDAIDLAAKTD----PQVAVLSKFEDCLYNRVRYTLvsyi-----iddSSTEVIyspIRKVLLAMME 102 foxtail millet
EER93876      23 CKLYISETRNTMAMDTIEHASKSD----AQVVVVSQLGDHHYNRFRYTLvsyi----vddsSTGEVIyspIRKVLLAMIE 94  sorghum
EFN58522       1 --VYVSEARDGDILRQLESVARQA----PGACLANLFTDEPYNRTNFTL--------------VGRSvpaLAAAASTLAR 60  Chlorella varia...
XP_001419526  14 AVVYVSEGRRTAVLDVIERVAREAtaprRPVALVNVFRDAEYNRTGFTL--------------AGRDvddVRRAALDVAQ 79  Ostreococcus lu...
XP_002501051  19 AVVYVSEGKDADAVNVLQTVAEKAcq-qHGTRVLNVFRDDEYNRTGFTLgvgv----asvaGHATPSvepLKQSALALTE 93  Micromonas commoda
XP_003057262  17 AVVYVSEGKNEGVVANLERTAEETce-kHGAKVVNVFRDVEYNRTGFTLgmgiasaaslepAALSGAvepLRQSALALTE 95  Micromonas pusi...

1QD1_A        67 AAYQLIDMSRHHGEHPRMGALDVCPFIPVRg---VTMDECV-------------------RCAQAFGQRLAEEL-GVPVY 123
XP_015573974  76 AAYGAINLESHCGAHPRLGVVDDIVFHPLs---wASLDEAS-------------------WLAKAVAAEIGSRF-QVPVF 132 castor bean
EMS48877      93 AAFSAINLEVHCGTHPRIGVVDDISFHPLtq--aATMEDAA-------------------QLAKLVASDIGNGL-QVPVF 150 Triticum urartu
Q75ID2        81 KAFSTINLETHTGTHPRIGVIDDMSFHPLn---qATMEDAA-------------------QLAKTVASDIGNFL-QVPVF 137 Japanese rice
XP_004982519 103 AAFSAINLELHSGAHPRMGVNDDLSFHPLg---qATMEDAA-------------------SLAKQVASDIGNGF-QVPVF 159 foxtail millet
EER93876      95 AAFATINLESQSGTHPRIGVVDDLSFHPVg---qATIEDAA-------------------SLAKQVASDIGNGL-QVPVF 151 sorghum
EFN58522      61 AALALLDLRQHAATHPRLGCVDHISCHPLPtseaGSAAAAAaaadagelrqrqqdeagaaALAVAIASELGSGPqAVPVY 140 Chlorella varia...
XP_001419526  80 VSLREVDMRAHDATHPRVGVVDHVSCHALA----GERAGAA-------------------KLAKSIGEGLGTL--GVPVK 134 Ostreococcus lu...
XP_002501051  94 QALKTIDLRNHSATHPRCGAVDHISCHAVGd---APDDLAA-------------------QLAKCLGEGIGDRL-KVPVL 150 Micromonas commoda
XP_003057262  96 KALSLIDLRTHTATHPRCGVVDHISCHAIGd---ADDAAAA-------------------CLAKTLGERIGVES-RVPVL 152 Micromonas pusi...

1QD1_A       124 LYGEAARtaGRQSLPALRAG--EYEALPEKL-KqaeWA-----------------------PDFGPSAFVPSWGATVAGA 177
XP_015573974 133 LYAAAHS--TGKALDTIRRElgYYRPN-F-MgNq--WAgwtmpd------------illekPDEGPQQVSRARGITMIGA 194 castor bean
EMS48877     151 LYAAAHP--TGKSVSAVRRElgYFRPN-H-KgVq--WAgpvlpd------------tlpmkPDVGPVHVPHERGATMVGA 212 Triticum urartu
Q75ID2       138 LYGAAHP--TGKPVTAVRRElgYFQPN-Y-MgIq--WMgqvlpd------------ilpvkPDEGPDHVSRERGAIMIGA 199 Japanese rice
XP_004982519 160 LYAAAHP--TGKSVGAIRRElgYYRPN-H-MgNq--WSgtmlpd------------vlpisPDEGPTNVSSERGATTVGA 221 foxtail millet
EER93876     152 LYAAAHP--TGKSVGAIRRElgYYRPN-Y-KeNq--WLgsvlpd------------vlpvkPDVGPTHVSHKRGATTVGV 213 sorghum
EFN58522     141 TYGWAHQ--QRQPLDAVRRQlgYFQGSS--------WHgglqapaaeaagaadaelqlplaPCFGPAVVPARSGVCCVGA 210 Chlorella varia...
XP_001419526 135 LYGDAAS--DGIGLDEIRRRsgYFSGAAGGR-----WTgefav-------------ergfaFDYGPSDVPEREGFGMVGA 194 Ostreococcus lu...
XP_002501051 151 LYGLASS--TGTQLADLRRKygYFRRTSQDVg----WSgahrvg------------dgqveADYGPSTIPPESGILMLGA 212 Micromonas commoda
XP_003057262 153 LYGNASG--VGTQLAALRRRygYFKETAARTgG---WAgehvvd------------ggevlSDYGPSIVPPEAGVVMLGA 215 Micromonas pusi...

1QD1_A       178 R 178
XP_015573974 195 R 195 castor bean
EMS48877     213 Q 213 Triticum urartu
Q75ID2       200 A 200 Japanese rice
XP_004982519 222 T 222 foxtail millet
EER93876     214 T 214 sorghum
EFN58522     211 g 211 Chlorella variabilis
XP_001419526 195 v 195 Ostreococcus lucimarinus CCE9901
XP_002501051 213 T 213 Micromonas commoda
XP_003057262 216 T 216 Micromonas pusilla CCMP1545
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