1QD1


Conserved Protein Domain Family
FTCD_N
?
pfam07837: FTCD_N 
Formiminotransferase domain, N-terminal subdomain
The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains.
Links
?
Statistics
?
PSSM-Id: 462283
Aligned: 154 rows
Threshold Bit Score: 107.557
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1QD1_A         3 LVECVPNFSEGKNQEVIDAISRAVAQTp----GCVLLDVDSGPSTNRTVYTF------------VGRPED---VVEGALN 63 
XP_015573974   2 LLCCKLFISESRNRTALDSIERAARLNp----ETVIVNKFEDRAYNRIRYTLvsyv-----vldSIGTAIyspLQQTVLV 72 
EMS48877      18 VICCKLYISESQNAAVVDAISRIGQKDp----EVVLLNKFEDEYYNRVRYTLvsyi----nsesATGEAVfspIRKVLLA 89 
Q75ID2         6 VICCKLYISESQNAKVVDAITRIGQKDp----EVVLLSKFEDDHYNRVRYTLasyi----inenSTGEVKfspMRRVLLE 77  Japanese rice
XP_004982519  29 FICCKLYISESRNPTAIDAIDLAAKTDp----QVAVLSKFEDCLYNRVRYTLvsyi-----iddSSTEVIyspIRKVLLA 99 
EER93876      20 FIFCKLYISETRNTMAMDTIEHASKSDa----QVVVVSQLGDHHYNRFRYTLvsyi----vddsSTGEVIyspIRKVLLA 91 
EFN58522       1 -----VYVSEARDGDILRQLESVARQAp----GACLANLFTDEPYNRTNFTL--------------VGRSvpaLAAAAST 57 
XP_001419526  11 AFAAVVYVSEGRRTAVLDVIERVAREAtaprrPVALVNVFRDAEYNRTGFTL--------------AGRDvddVRRAALD 76 
XP_002501051  16 GLVAVVYVSEGKDADAVNVLQTVAEKAcq-qhGTRVLNVFRDDEYNRTGFTLgvgv----asvaGHATPSvepLKQSALA 90 
XP_003057262  14 GLVAVVYVSEGKNEGVVANLERTAEETce-khGAKVVNVFRDVEYNRTGFTLgmgiasaaslepAALSGAvepLRQSALA 92 

1QD1_A        64 AARAAYQLIDMSRHHGEHPRMGALDVCPFIPVRg---VTMDECV-------------------RCAQAFGQRLAEEL-GV 120
XP_015573974  73 MVEAAYGAINLESHCGAHPRLGVVDDIVFHPLs---wASLDEAS-------------------WLAKAVAAEIGSRF-QV 129
EMS48877      90 MIEAAFSAINLEVHCGTHPRIGVVDDISFHPLtq--aATMEDAA-------------------QLAKLVASDIGNGL-QV 147
Q75ID2        78 MIEKAFSTINLETHTGTHPRIGVIDDMSFHPLn---qATMEDAA-------------------QLAKTVASDIGNFL-QV 134 Japanese rice
XP_004982519 100 MMEAAFSAINLELHSGAHPRMGVNDDLSFHPLg---qATMEDAA-------------------SLAKQVASDIGNGF-QV 156
EER93876      92 MIEAAFATINLESQSGTHPRIGVVDDLSFHPVg---qATIEDAA-------------------SLAKQVASDIGNGL-QV 148
EFN58522      58 LARAALALLDLRQHAATHPRLGCVDHISCHPLPtseaGSAAAAAaaadagelrqrqqdeagaaALAVAIASELGSGPqAV 137
XP_001419526  77 VAQVSLREVDMRAHDATHPRVGVVDHVSCHALA----GERAGAA-------------------KLAKSIGEGLGTL--GV 131
XP_002501051  91 LTEQALKTIDLRNHSATHPRCGAVDHISCHAVGd---APDDLAA-------------------QLAKCLGEGIGDRL-KV 147
XP_003057262  93 LTEKALSLIDLRTHTATHPRCGVVDHISCHAIGd---ADDAAAA-------------------CLAKTLGERIGVES-RV 149

1QD1_A       121 PVYLYGEAARtaGRQSLPALRAG--EYEALPEKLkqaeWA-----------------------PDFGPSAFVPSWGATVA 175
XP_015573974 130 PVFLYAAAHS--TGKALDTIRRElgYYRPN-F-Mgn-qWAgwtmpd------------illekPDEGPQQVSRARGITMI 192
EMS48877     148 PVFLYAAAHP--TGKSVSAVRRElgYFRPN-H-Kgv-qWAgpvlpd------------tlpmkPDVGPVHVPHERGATMV 210
Q75ID2       135 PVFLYGAAHP--TGKPVTAVRRElgYFQPN-Y-Mgi-qWMgqvlpd------------ilpvkPDEGPDHVSRERGAIMI 197 Japanese rice
XP_004982519 157 PVFLYAAAHP--TGKSVGAIRRElgYYRPN-H-Mgn-qWSgtmlpd------------vlpisPDEGPTNVSSERGATTV 219
EER93876     149 PVFLYAAAHP--TGKSVGAIRRElgYYRPN-Y-Ken-qWLgsvlpd------------vlpvkPDVGPTHVSHKRGATTV 211
EFN58522     138 PVYTYGWAHQ--QRQPLDAVRRQlgYFQGSS-------WHgglqapaaeaagaadaelqlplaPCFGPAVVPARSGVCCV 208
XP_001419526 132 PVKLYGDAAS--DGIGLDEIRRRsgYFSGAAGGR----WTgefav-------------ergfaFDYGPSDVPEREGFGMV 192
XP_002501051 148 PVLLYGLASS--TGTQLADLRRKygYFRRTSQDVg---WSgahrvg------------dgqveADYGPSTIPPESGILML 210
XP_003057262 150 PVLLYGNASG--VGTQLAALRRRygYFKETAARTg--gWAgehvvd------------ggevlSDYGPSIVPPEAGVVML 213

1QD1_A       176 GAR 178
XP_015573974 193 GAR 195
EMS48877     211 GAQ 213
Q75ID2       198 GAA 200 Japanese rice
XP_004982519 220 GAT 222
EER93876     212 GVT 214
EFN58522     209 GAG 211
XP_001419526 193 GAV 195
XP_002501051 211 GAT 213
XP_003057262 214 GAT 216
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap