Conserved Protein Domain Family
mit_SMPDase

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pfam14724: mit_SMPDase (this model, PSSM-Id:405423 is obsolete and has been replaced by 464282)
Mitochondrial-associated sphingomyelin phosphodiesterase
The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyze the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.
Statistics
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PSSM-Id: 405423
Aligned: 8 rows
Threshold Bit Score: 1257.8
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NXE4        47 QPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNpvEYSIVMEFL 126 human
XP_005463022   8 QPSFLLANLKADATTKPLLQRCQDLVKIIDEYPAKELHLIFPWLVESVFGSLDGVIAGWNLRFLHSRSN--EYNIVMDFL 85  Nile tilapia
XP_015221715   8 QPSFLLANLKADCMNKSLLQQCQELVKIIDEYPAKELHFIFPWLVETVFGSLDGVLVGWNLRYLQAKAN--EYNIVLEFL 85  spotted gar
XP_415236     29 QPSFLLATLKADCVNKPFAQRCHDLETVIEEFPAKELHGIFPWLVESIFGSLDGTIVGWNLRCLQGRTNptEYSVALDFL 108 chicken
XP_008121782  16 QHSYLLASLRADCLNKPFAQRCLDLQTVIQDFPAKELHAIFPWLVESIFGSLDGVLVGWSLRTLQGRTNptEYNLALEFL 95  green anole
KAE8634566     9 QPSFLLGSLKADCVTKPFLQRCQDLVRVIEDFPAKELHAIFPWLIETVFGSLDGSILGWNLRGLHERINplEFHTALEFL 88  tropical clawed...
XP_016288249 111 pPSFLLASLKADCVNKPFTQRCHDLVKVIDDFPAKELHYIFPWLVESIFGSLDGILVGWNLRCLQGRMNpiEYSIAMEFL 190 gray short-tail...
XP_014344765   9 QANFLLASLKADFENKSLSQRCHDLAKVIEDYPVKELSSIFPWLIESAFGSLDGSIIGWNLRGLQSRMNpiEYSTVVEFL 88  coelacanth
Q9NXE4       127 DPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGG-LGLNLALNPFEYYIFFFALSLI 205 human
XP_005463022  86 NPSGPMMKLVYKLQAEEYKYEIPINYLPGPVKACIQEGVLPDCPLFHNKLQFPLSGL-LTLNIAFNPFEFFMFNFAYCLI 164 Nile tilapia
XP_015221715  86 NPSGPMMKLVYKLQAEEYKYEFSVSYLPGPVRASIQGGVLPDCPLFHNKLQSPLSGL-LSLSLSLNPFEYYMFCFASSLI 164 spotted gar
XP_415236    109 DPSGPMMKLVYKLQAEEYRYDFPVSYLPGPVKASIQEQVLPECSLYHNKVQFPSSGG-LGLNLALNPFEYYMFYFAISLI 187 chicken
XP_008121782  96 DPGGPMMELVYKLQAEEYRYDFPVSYLPAPVKASIQERILPECSLYHNKVQFPPSGGvLGLSLALNPYEYYMFYFAISLI 175 green anole
KAE8634566    89 DPSGAMMKLVYKLQAEEYKYDFPVSFLPSPVRASIQERVLPECPLYHNKIQFPASGG-ISFNLALNSFEYFMFHFAFCLL 167 tropical clawed...
XP_016288249 191 DPSGPMMKLVYKLQAEDYKYDFPVSYLPEPVRACIQERVLPECPLYHNKIQFPPAGG-QGLHLALNPFEYYMFFFALSLV 269 gray short-tail...
XP_014344765  89 DPSGPMMKLVYKLQAEEYKYEFPVSFLPDPVRASILEGVLPDCPLYHSKIQIPSLGG-LSLSISLNPFECFLFYFAANLL 167 coelacanth
Q9NXE4       206 TQK------------PLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSS-SPGGTSPSPPPRTPAIPFASYGLHH 272 human
XP_005463022 165 TPK------------NYPPGQYGSSTDSAYFVLVDTYLKYFLPTEGSVPPSPFS-DSRGSVSAPSPRSSSVSFASYGIHS 231 Nile tilapia
XP_015221715 165 TPK------------NYPVGQHVNASDSAYFVLVDNYLKYFLPTEGNVPPSPFS-DVRGTVSPPAPRSPTVPFAGYGVHY 231 spotted gar
XP_415236    188 TQK------------NSPITHHISPSNSAYFILVDTYLKCFLPTEGSVLPPPSS-NPGGAIPSPTPRSPAVPFTSYGMHH 254 chicken
XP_008121782 176 TQK------------NVHPTYHVSMSNSAYFVLVDRYLKWFLPTEGNVIPPRSS-DPGGPAPSPAPRSPVMPFTSYGMHP 242 green anole
KAE8634566   168 KQR------------SFPQGHYFSTADSAYYILVDKYLKWFLPAEGNVPPPHSP-NTGGTVPLPAPRSPSISFASYGSH- 233 tropical clawed...
XP_016288249 270 TQR------------P------------------------------------------------TPRTPAVPFSSYGLHH 289 gray short-tail...
XP_014344765 168 TQRartflserqhpkSYLVGQPVSTSDSAYFVLVDRYLKYFLPTEGNLPPPPMSlNPGGTVSPPVPRSPAIQFASYGIHH 247 coelacanth
Q9NXE4       273 TSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAK----------LEVLHYRLS---VSS 339 human
XP_005463022 232 PSLLKHHIFHQPSVNADPAAQEIWRSETLLQMFVEIWLHHYSLEMYQKLQSPQVK----------LALLQYRLS---MSS 298 Nile tilapia
XP_015221715 232 SSLLKRHISHQPSVNADPAAQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPQVK----------LEVLQYRLG---ISS 298 spotted gar
XP_415236    255 TSLLKRHIAHQPSVNADPASQEIWRSETLLQIFVEMWLHHYSLEMYQKMQSPHIK----------LEVLHYRLS---ISS 321 chicken
XP_008121782 243 TSLLKRHIAHQTSANADPASQEIWRSETMLQVFVEMWLHHYPLDIYQKIQSPHIK----------LETFHYHLPsiySPS 312 green anole
KAE8634566   234 PSLLKRHISHQHLVNADPAAQEIWRTETLLQVFVEIWLHHYSLEMYQKMQSPNAK----------LEALHNRLS---VSS 300 tropical clawed...
XP_016288249 290 TSLLKRHISHQPSVNADPASQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAK----------LEVLHYRLS---VSS 356 gray short-tail...
XP_014344765 248 SSLLKRHISHQPSVNADPAAQEIWRSETVLQVFVEMWLHHYSLDLYQKLQSPHMKavcdhkgsikLEILQYRLG---VSN 324 coelacanth
Q9NXE4       340 ALY-SPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFAN-SLKPE-QA--SPSAHSHA-TSPLEEFKRAAVPRFVQ 413 human
XP_005463022 299 MPCqPHAPPGSGTLHTYQEPFSPTEEHVLVVRLLVKHLHAFSN-SLKPE-QLssSPSAHSHThTSPLEEFKRVVVQRFVQ 376 Nile tilapia
XP_015221715 299 LHCsTPTPPGYGTLHTYQEPFSPTEEHVLVVRLLVKHLHAFSN-SLKPE-QIssSPSTHS-H-TSPLEEFKRVVIPRFVQ 374 spotted gar
XP_415236    322 KHHgSPAQSSYQALHAYQESFKPTEEHVLVVRLLVKHLHAFSN-SLKPE-PL--SPSAHSHT-ASPLEEFKRVVIPRFVQ 396 chicken
XP_008121782 313 SSFaFPIQSSYRSYYTYQESFKPSEEQVLVIRLLVKHLHAFSNsSLRAEaPAspSPSGHSHS-PGPLEEFKRIVIPRFLQ 391 green anole
KAE8634566   301 ATHvYPALPG--SLHSYQELFQPTEEHVLVVRLLVKHLHTFSN-SLRPE-QV--SPSTHSHT-ASPLEELKRVVVPRFIQ 373 tropical clawed...
XP_016288249 357 SLHsSPAQPSYQALHAYQESFKPTEEHVLVVRLLLKHLHAFSN-SLKPE-QL--SPSTHSHT-ASPLEEFKRVVIPRFVQ 431 gray short-tail...
XP_014344765 325 VHYgTSLQPGYGTLRAYQEPFNPSEEHVLVVRLLIKHLHAFSN-SLRPE-QI--SPLAHSHT-ASPLEEFKRVVIPRFVQ 399 coelacanth
Q9NXE4       414 QKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPDKQAP-GSDsQPRCVSEKW------APFVQENLLMYTKLF 484 human
XP_005463022 377 QKLYLFLQHCFGHWPLDASFRAVLETWLSYIQPWR--YTGEKANP-QPD-QNRTVPEKW------ESFVHENLLMYTKLF 446 Nile tilapia
XP_015221715 375 QKLYVFLQHCFGHWPLDASFRAVLETWLSYIQPWR--YTTDKQSP-QADnQNRSVPDKW------ASFVQENLLMYTKLF 445 spotted gar
XP_415236    397 QKLYIFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPEKPPQ-TAElLPRSVSEKW------AAFIQENLLMYTKLF 467 chicken
XP_008121782 392 QKLYVFLHHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPERATL-GAEqAPRIMSEKW------APFVQENLLMFTELF 462 green anole
KAE8634566   374 QKLYIFLQHCFGHWPLDASFRAVLEMWLSYVQPWR--YVLERSSPvSGEmQNRNVPEKW------STFVQENLLFYTKLF 445 tropical clawed...
XP_016288249 432 QKLYIFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPEKPFL-ATDpQPRSIPEKW------APFVQENLLLYTRLF 502 gray short-tail...
XP_014344765 400 QKLYVFLQHCFGHWPLDASFRVV-------LETWLsyLQPWRYPP-EKWlHAFQENQERsvpdkwAAFVQENLLLYTKLF 471 coelacanth
Q9NXE4       485 VGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIP----------------HRQHRLFTAPTF 548 human
XP_005463022 447 QVFLNRAVRTDLVNAKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPEHVLH----------------HRQPRGYLTPGQ 510 Nile tilapia
XP_015221715 446 QGFLNRAVRTDLVNAKNALMLFRVSKVFAQPNLSEMIQKGEQLFLEPEHVLH----------------HRQHRLFMTPGH 509 spotted gar
XP_415236    468 VGFLNRTLRTDLVSPKNALMVFRVAKVFAQPNLAEMILKGEQLFLEPELVIP----------------HRQHRLFMTPTL 531 chicken
XP_008121782 463 VAFLTRALRTDLVSPKNALMLFRATKVFAQPSLAPVIQKAEQLFLEMDLAINaasspaslgagsspllRSQPRLLLSLR- 541 green anole
KAE8634566   446 LRFLNRALRSDLVNPKNALMVFRAAKVFSQQNLPEMIQNGEQLFLKPEHVIP----------------HRQHRLLLTPNL 509 tropical clawed...
XP_016288249 503 IGFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVMP----------------HRQHRVFMTPNF 566 gray short-tail...
XP_014344765 472 QGFLNRALRTDLVSPKNALMVFRVAKVFTQPNLAEMIQKGEQLFLEPEHVLH----------------HRQQRIFMTPSL 535 coelacanth
Q9NXE4       549 TGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAES-------PAGH 621 human
XP_005463022 511 GGSYLSSRQRVVTDMVFKVKSHVYGLEGQDCQYKQMFGTELRGAVMKLIQIIAQARQTAKRISDHSSEV-------AANK 583 Nile tilapia
XP_015221715 510 GGSFLSSRQPVITDSVFKVKSHVYSLEGQDCQYKQMFGAEVRNSVLKLVQLIAQARQTAKSISAHTAEA-------AANQ 582 spotted gar
XP_415236    532 GGSFLSSWPPAITDASFKVKSHVYSLEGQDFQYKQMFGTEVRNLVLKLAQLICQAQQTAKSISDHSAET-------TASH 604 chicken
XP_008121782 542 GASSLSD-----SASAFKIKSRLYGLQGQEAQYRPLFGPEVRGMVLRLVQLIVQAQQRLKSLDPSSWDAsptgplpSSSP 616 green anole
KAE8634566   510 GGSFLSSWQPPITDTSLKVKSHVFSLEGQDCHYMQMFGTEARNLVLRLAQMISQAKQTAKSISNHSPDS-------SANQ 582 tropical clawed...
XP_016288249 567 PGNLLSSWPPTITDASFKVKSHVYSLEGQEGQYKQMFGPEVRALVLRLAQMIAQAKQTANSLSDYSNEM-------SANR 639 gray short-tail...
XP_014344765 536 GGSFLSLRQPAITDASFKVKNHVYSLEGQECQYRPMFGTEVRNMVLKLAQQIAQAKQTAKSISDHSVEA-------ASSR 608 coelacanth
Q9NXE4       622 SFLSWLGFSSMDTNGSYT----ANDLDEMGq-DSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLP 696 human
XP_005463022 584 SFLSWFGLGASDLNNSFP----GAEPEETG--EYLKKTHEFLDRALENLCQIFKLNQGQLNQLISNLGSLEDDGNSKQLP 657 Nile tilapia
XP_015221715 583 SFLSWLGFGSSDPNASYT----GSDVDDMGl-ESIKKTDEYLDRVLDYLRQIFRLNTGQLSQIMVNYVSTQDDFGSKQLP 657 spotted gar
XP_415236    605 SFFSWFKFTPSEMNGSYT----GNDLDEIGq-DSIKKTDEYLEKALEYLCQIFKLNEAQLTQMMMKCGTAQDENGKKQLP 679 chicken
XP_008121782 617 SFLSWLRFGISDPNGSSSssaaGSDLDEAGhlDGGRRTEEYLEKALEFLCLIFRLNEAQLSRVMLTLGAAPDESGVKQRP 696 green anole
KAE8634566   583 SFLSWFGLGSPDFNGSYN----GGDLDEAGy-DTIRKTDEHLEKALDYICQIFRLNPTQLGQLTANCDSSQDENGKNKLP 657 tropical clawed...
XP_016288249 640 SFFSWLGFRHVDVNGTFS----ANDLDELGq-DSIKKTDEYLEKALEYLGQIFRISEAQLTQVMVNVGATPDENGKKQLP 714 gray short-tail...
XP_014344765 609 SFLSWFKFDSPDFSSSYM----GNDLDELGp-SNIKKTDEYLDKALENLCHVFRLNALQLSQMAANFTTAQNDGGKKQLP 683 coelacanth
Q9NXE4       697 DCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINH-------------------- 756 human
XP_005463022 658 DCVQSENGLILTDLGRRQIINGLRRFDIHYQGDPELQPIRSYENALLVRLFYRISSLINE-------------------- 717 Nile tilapia
XP_015221715 658 DCIRGENGLILTDLGRMQIINGLRRFEIDYQGDPELQPIRSYESAVLVRLLFRLSSLINE-------------------- 717 spotted gar
XP_415236    680 DCIESENGLILTPLGRYQMINGLRRFDVQYQGDTELQPIRSYENATLVRLLYRLSSALNE-------------------- 739 chicken
XP_008121782 697 DCAETDAGLVLTPLGRYQIINGLRRFEISYQGDPELQPIRSYENPTLVRSLFRLSSTINEwglsfslslsllfsalwpca 776 green anole
KAE8634566   658 DCIQSEDGLVLTSLGRYQIINGLRKFEVEYRGDPELQPIRSYENAMLVRYLFRLSSVLNE-------------------- 717 tropical clawed...
XP_016288249 715 DCIMSDEGLVLTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEAAPLVRLLFRVSSALNR-------------------- 774 gray short-tail...
XP_014344765 684 DCIEGETGLILTPLGRYQIINGLRRFDIVYQGDPELQPIRSYESAVLVRLLFRLSSAVNE-------------------- 743 coelacanth
Q9NXE4       757 RFAG-QMAALCSRDDFLGSFCRYHLT-EPGLASRHLLSPV------GRRQVAgHTRGPRLSLR 811 human
XP_005463022 718 RFGR-HMNALCSRPDFLGRLSRHYLT-NLDSTTKLKHSPM------SRRMLE-RSQRPRLSLR 771 Nile tilapia
XP_015221715 718 RFAG-EMASLCSRRDFLGRLSRYYLT-RPPVPGKSTRSPA------TRHSPE-WQTRPRLSLR 771 spotted gar
XP_415236    740 RLAD-QMDVLCSREDFVGRFCRYHLT-NPHLVHKIRYSPV------LKDRTS-QNWGPRISLR 793 chicken
XP_008121782 777 QWVGaDVRGPAPGGDFLGSLARFHLL-----------EPAwsgglgGRQSWE-WAERPRLSLr 827 green anole
KAE8634566   718 RFAE-SMGTLCAREDFLGKVCRCHLT---SCSRKGKKSPI------TSICPS-EPTTPRIRLR 769 tropical clawed frog
XP_016288249 775 RFAG-QMAALCSREDFLGAFCRYHLM-DLVQAQRTRLSPV------APHRAG-RPHGPRISLR 828 gray short-tailed opossum
XP_014344765 744 RFAG-DMEALCARDNFLGRLSCYYLMpPPPLVERFRHSPV------TRRDLA-PMQHPRVSLR 798 coelacanth
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