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Poxvirus Bcl-2-like proteins This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB). These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic alpha-helix that is surrounded by an additional layer of 6-7 amphipathic alpha-helices. Included in this family are proteins B14, A52, A46, C6, K7, N1, and N2. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",