Conserved Protein Domain Family
LYRIC
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pfam15686: LYRIC (this model, PSSM-Id:406178 is obsolete and has been replaced by 434858)
Lysine-rich CEACAM1 co-isolated protein family
LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumor cell migration and invasion by activating the transcription factor NF-kappaB.
Links
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Statistics
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PSSM-Id: 406178
Aligned: 12 rows
Threshold Bit Score: 327.242
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003444226   6 RGLALEKAELLSSHLKELLSSGQGYVRARFGVDL--GLKPELYPTWVILS-TVAAGLLLLLSL--SWAAVC--GGLLAGk 78  Nile tilapia
8_pfamImport   2 QVFTLEKAEQLSGRLREVLSGGQAYILARFGVDM--GLEPDLYSAWIVLS-ATALVLLLLLAV--SWAAVR--GGPLLGk 74 
1_pfamImport   1 RGAALEKAELLSGHLKELVSTGQQYVRDRFGVDL--GLNPDVYPTWVILS-TATVGLLLLLRL--SWAAAC--GGRFAGk 73 
XP_017207032   6 QEIASQHVEQITGYVRESLSTGLVYLKSELGIDL--GLNPDLCAPWLLLL-TAWAGLVLLLVL---WVSVC--RG-FSKr 76  zebrafish
7_pfamImport   2 QEAASEQFNLLTKRLNELLSKGLGLLRSELGVDL--GLKPELIPPWVILL-AACTGLVLMVAL---WASTC--RSLFKKr 73 
9_pfamImport   2 QDAASQQVKLLTNRLNELLSKSLGLLRSELGVDL--GLKPELIPPWVILL-AACTGLVLMVVL---WASVC--RAIFKKr 73 
Q9Z1W6         7 QDELAQQAEEGSARLRELLSVGLGFLRTELGLDL--GLEPKRYPSWVILVgTGALGLLLLFLLgyGWAAAC--AGARKKr 82  Norway rat
XP_012427396   7 QEAAARWAEEAAARVRDALSGGLGLLRAELGLEL--GLDPQALPAWLALAvPAALGFVLLGLL---LAAAC--GGGLRKk 79  zebra finch
XP_008106595   8 PESVARQAEEVSARLREVLSAGAGLLRTELGLELppALEPQRLPGWLLLLaTSLLPLLLLLVL--LWGLRCgrGGSARPr 85  green anole
XP_005464971   5 QDAAARQVILLTDRVNELLSRGLELLRSELGVDF--GLKPELIPPWMILL-LAGTGLLLMVAL---WASVC--RGLFKKr 76  Nile tilapia
XP_007488206  10 QDVLAQQAEEGSAPLRELLSAGLYLLRTELGLDL--GLEPHSYPAWVILLgTAAVGLLLLLLLglGWAAAC--AGARQRr 85  gray short-tail...
XP_006001076   6 QDAAAQQAEVVSARLRELMSSGLGLLRTELGLDL--GLDPERYPSWAILL-VAVLGLLVVGLV---WAATC--AGr---- 73  coelacanth

XP_003444226  79 krgSPVTHGSSRS-------------SSsggggepLK-----------------------------AGFAKTA-KPEEQK 115 Nile tilapia
8_pfamImport  75 ---TPTTRVDPRS-------------CVp------DK-----------------------------AGPAKPV-GAEEPK 102
1_pfamImport  74 krgSPDPRGAGE------------------------------------------------------PGKAQTP-KPEEQK 98 
XP_017207032  77 lagTETGDSAEN------------------------------------------------------TGPAQPVkKADEPK 102 zebrafish
7_pfamImport  74 paeNAADDGIAEK-----------------------------------------------------RDSGKPV-KSEEPK 99 
9_pfamImport  74 gavRPEDDGIEIK-----------------------------------------------------RTVSKPI-KSEEPK 99 
Q9Z1W6        83 ---RSPPRKREEV-------------TPptp--apED-----------------------------PAQLKNL-RSEEQK 114 Norway rat
XP_012427396  80 parSAAVRKGDEAvgagltagggpgkAA-------GP-----------------------------GPGQLNL-KGDEQK 122 zebra finch
XP_008106595  86 rlrRTTAEEEEED-------------EDe-----eEDddeeeeaaatpkaglarggggphkgppltGPAGLLL-KADEQK 146 green anole
XP_005464971  77 pvmSHADDGIELK-----------------------------------------------------RTVGKPV-KSEEPK 102 Nile tilapia
XP_007488206  86 ---RSPPRRREEA-------------STpvpvpapED-----------------------------GALLKNL-KSEDSR 119 gray short-tail...
XP_006001076  74 ---KGAGREKEPL-------------SSsvaavssSR-----------------------------APAGKNQ-KIDDQK 107 coelacanth

XP_003444226 116 KKNKKKTVEKk--Sqsngq-pvtvAQ-EEVKVAEAVSK------------------------------------------ 149 Nile tilapia
8_pfamImport 103 KRNKKKTAEKvqtA----------SAsYDVTVAQSKQTpnasisilslglhaqtmaaaavpltvgssatlsaaisakqpv 172
1_pfamImport  99 KRNKKKPLDKn--Tqsngq-pvaaAQ-DAVKVKATVVVp----------------------------------------- 133
XP_017207032 103 RRNRKKNAEKk--Aqrng--lavePQ-EEVKTADDQEL------------------------------------------ 135 zebrafish
7_pfamImport 100 KK-KKKSTEKk--Aqpngr-aaaePQ-EEAIAAEETVPhqq--------------------------------------- 135
9_pfamImport 100 KK-KKKVFVWnqkTqsngr-avaePQ-EEAIVSEELVPhh---------------------------------------- 136
Q9Z1W6       115 KKNRKKLPEK---Pkpng--rtveIPeDEVVRTPRSITak---------------------------------------- 149 Norway rat
XP_012427396 123 KRNRKKLPERa--Arpngr-sfidVSeDEVIQTVRKDNik---------------------------------------- 159 zebra finch
XP_008106595 147 KRNKKKAPEK---AgrlngqpaheISeEEITPTVRRENlk---------------------------------------- 183 green anole
XP_005464971 103 KK-KKKA-EKk--Sqpngr-aiaePQ-EEAIASEEIVPhh---------------------------------------- 136 Nile tilapia
XP_007488206 120 KKNRKRLTEK---Pkpngr-tvleVPeEEVVTTPRREAqq---------------------------------------- 155 gray short-tail...
XP_006001076 108 KKAKKKSAEK---Gkpngr-taveLPeEEAVPVLLKETlk---------------------------------------- 143 coelacanth

XP_003444226 150 --LPAQIKTEKKqevqa--------------------------pvqvKKNKKKNKT----DVKPVQLLSSNDGKEPDD-- 195 Nile tilapia
8_pfamImport 173 nlTPPVLKPKKDkteqq--------------------------pvqaKKTKKKVKI----DVKPAQPVTTNDWKEPDEgq 222
1_pfamImport 134 -kPAPQVKTQKVpevqa--------------------------avqvMKNKKKTKTivkpAVKPAQLVSTNDGKETDDa- 185
XP_017207032 136 ----AEVRADKG-----------------------------------KKNKKKTKA----SAKEKKSSTSVDGKEPDEav 172 zebrafish
7_pfamImport 136 qqPAAEGKAEKAseitisrvhsdvnpllksplsprcpctmepeqlplKKSKKKAKQ----PVKETKTGTA-TGKEPEE-- 208
9_pfamImport 137 qpPPSEVKLEKIpe--------------------------------aKKSKKKAKQ----AAKETKPAAG-DGKEPEEei 179
Q9Z1W6       150 qpPETDKKNEKS-----------------------------------KKNKKKSKS----DAKAVQNSSRHDGKEVDE-- 188 Norway rat
XP_012427396 160 qpVDTEKKNEKS------------------------------------KKKKKSKG----DSKTVQDSSRLDGKEVDE-- 197 zebra finch
XP_008106595 184 qpSDVEKKTEKS-----------------------------------KKNKKKQRG----DAKTVQDQSRADGKEADE-- 222 green anole
XP_005464971 137 qpPPPEVKPEKVae--------------------------------vKKSKKKAKQ----AVKETKTVTT-DGKEPEEg- 178 Nile tilapia
XP_007488206 156 qqLDAEKKNEKL-----------------------------------KKNKKKSKS----EVKAVQNSTRHDRKEVDE-- 194 gray short-tail...
XP_006001076 144 qpLETEKKTEKS-----------------------------------KGKKKKPKA----EAKQVHDVSALEGKEFEE-- 182 coelacanth

XP_003444226 196 ----------GVWETKVSNREKRqQRRKEKGPEDsg-gPGS--------VEASKTHVEATVpAAV----NKRNRGNhesf 252 Nile tilapia
8_pfamImport 223 ---------aGTWETKVSNREKK-KRRKDKISEDsc-gPGG--------PEAPKAQVETPVvTAT----AKKNRGN---- 275
1_pfamImport 186 ----------GNWETKVSNREKKqQRRKDRGPEDsg-sPGG--------LQAPKGNVETp--AATarvnTKKNRGNtgik 244
XP_017207032 173 gnmsvmvnlaGTWETKVSNREKRqQRRKDKAPDDesgsPVPsaa--sgaTEQLQTTLEEAEtTITsavsTPPVQrvv--- 247 zebrafish
7_pfamImport 209 ----------GTWETKVSNKEKReQRKKEKGSSDgsasPGGgdar-aspPEQPKASVAPTP--AS----QKKKKGE---- 267
9_pfamImport 180 phsa-qwsfsGTWETKVSNKEKReQRKKDKSSSDgsasPGGgdtpvstpPEQPKTTAAPAP--TN----QKKKK------ 246
Q9Z1W6       189 ----------GAWETKISHREKRqQRKRDKVLTD----SGSldstipgiENTITVTTEQLT-TASfpvgSKKNKGDshln 253 Norway rat
XP_012427396 198 ----------GAWETKISNREKRqQRKRDKVLND----GGSgesnlqgiENTVTVPIEQLMpTPSlpvgLRKNKGDalln 263 zebra finch
XP_008106595 223 ----------GAWETKISNREKRqQRKRDKVLTD----TGPesni-samENSVSLSTEPLTsSASfsvgPRKNKGDtvln 287 green anole
XP_005464971 179 -----------TWETKVSNKEKReQRKKDKSSSDgsasPGGggtpvsvpTEQPKASTAPAS--TN----QKKKKGE---- 237 Nile tilapia
XP_007488206 195 ----------GAWETKVSNREKRqQRKRDKVQPD----TGPldpavsgiESGYTVTTEQLI-TASfpvgSRKNKGDslln 259 gray short-tail...
XP_006001076 183 ----------GAWETKVSNREKR-QRKRDKVLND----VGSgdanlhgtDATTVASAEQPTaMATvsivPRKTKGEpvht 247 coelacanth

XP_003444226 253 ----hsrTTGKGDA-A-SEAVKDKV----SSSWRKEPSV----NGGGWNDMSLKIPGQMSTMEGnKWSaISAATHYRAPP 318 Nile tilapia
8_pfamImport 276 -------NVLSQNQ-G-PQLSAPSA----SPSRRGEPSVvdddDGGGWTSVSAKKTEQKGSGRKpVHA-APQPSVPQKQQ 341
1_pfamImport 245 askfnsrT-----------LCTCTV----SSARREEPSV----NGGGWTDASRQTG-----------SgVPAATHYRAAP 294
XP_017207032 248 ----evdPPEIEATfV-QDPVIPQV----TPCWEEVLTV----NGSGWSDLGLQLPSHMTSVQTeSWTsMTVPTE-RQTS 313 zebrafish
7_pfamImport 268 -------TAKVKSE-K-IEVVAPQV------TSREVV-------AATVTEKALKAP----APKAgPWT--------TASE 313
9_pfamImport 247 -------------E-C-YITIVPQPpqatSLKDLKVAAV-----SACITEVPVKVPTHKISGKSePWK--------ANRE 298
Q9Z1W6       254 vqvsnfkSGKGDST-L-Q------V----SSGLNENITV----NGGGWSEKSVKLSSQLSAGEE-KWNsVPPASAGKRKT 316 Norway rat
XP_012427396 264 aqinsskPAKGESS-I-P-----QV----SPGLSESHTV----NGGSWNEKSVKISSQIGVGEE-KWTsVPSTAAGKRKT 327 zebra finch
XP_008106595 288 vqvnnskSGKGDTT-LqQ------V----PSGLNEGPTV----NGGNWNEKPVKISPQINTSEE-KWTpV-SSAGGKRKN 350 green anole
XP_005464971 238 -------STKVKPE-K-VEAVVSK------VNSNNAVEV-----SSAVPDVPVKIPAQTVAPKTaSCT--------TSRE 289 Nile tilapia
XP_007488206 260 vqgsnfkSGKGDLT-L-Q-------------GLNENPTV----NGGGWNEKSIKIPSQISAGEE-KWTsVSSASAGKRKI 319 gray short-tail...
XP_006001076 248 nqltgvkSGTGDSV-S-Q-------------GWIEAPDV----NGGAWTDVPMKIPSQISGGEEkKWTpMQATSAANRNQ 308 coelacanth

XP_003444226 319 EpqpWAQESQA--------------TAWSGID-GRIKADLSPvsFS-------ML------------------------- 351 Nile tilapia
8_pfamImport 342 S---WTQETQAa------------aAGRSSTD-ARGKTGPKTvsFS-------VL------------------------- 373
1_pfamImport 295 RpqtWGQETPGttsgqnqpvtqrnrRTWSGID-GRKKADINPvtFS-------ML------------------------- 341
XP_017207032 314 EpsvWPQDMEG---------------SWTIVDrPNI-----PvtFS-------GL------------------------- 341 zebrafish
7_pfamImport 314 PallWRPDVDE---------------SWTVIErGMATT--SPvsLS-------GL------------------------- 344
9_pfamImport 299 es-lWGGDIDE---------------SWTVIEaGMPTAERKLvsLA-------GL------------------------- 330
Q9Z1W6       317 EqsaWTQDPGDtna---------ngKDW-----GRNWSDRSI--FS-------GI------------------------- 348 Norway rat
XP_012427396 328 EtlaWGQDTGDang---------ngKDWgvslvGRPWKERSL--FT-------PIaawnvdarintseqn---sasfssf 386 zebra finch
XP_008106595 351 EtsaWGKDTGDng----------ngKDWGVSLvGRTWGERTL--FP-------GI------------------------- 386 green anole
XP_005464971 290 pp-lWKTGINE---------------AWTVSKrGMPTTQVNLmsLPslgigtaEP------------------------- 328 Nile tilapia
XP_007488206 320 EpsiWGQDTGDtsa---------ngKDWGVSLvGRTWGERSL--FP-------GIaswsgnvdrrvnnsteqnsapfssl 381 gray short-tail...
XP_006001076 309 EtttWRPDTGDtng---------paKDWSAPLvRKTWGEHTL--FP-------SI------------------------- 345 coelacanth

XP_003444226 352 -------GL------------------------------N-----------TTdp----iS------------------- 360 Nile tilapia
8_pfamImport 374 -------GC------------------------------N-----------ATet----pS------------------- 382
1_pfamImport 342 -------GP------------------------------N-----------ATavsletiS------------------- 354
XP_017207032 342 ------------------------------------------------------------P------------------- 342 zebrafish
7_pfamImport 345 -------GV------------------------------G-----------TTe-------------------------- 350
9_pfamImport 331 -------NA------------------------------E---------------------------------------- 333
Q9Z1W6       349 -------GS------------------------------T-----------AEpv---sqS------------------- 358 Norway rat
XP_012427396 387 gltpgvsGS------------------------------N-----------SEsv---sqA------------------- 403 zebra finch
XP_008106595 387 -------AW------------------------------SgvdgrintpeqSSps---fsSlglnpkvsgsssepvsqpg 426 green anole
XP_005464971 329 -------K------------------------------------------------------------------------ 329 Nile tilapia
XP_007488206 382 alnttvsGS------------------------------T-----------TEvs----qS------------------- 397 gray short-tail...
XP_006001076 346 -------GTwpgvdgrvkttgqntasfstlglnssvsgsS-----------SEpv---pqS------------------- 385 coelacanth

XP_003444226 361 -NSVDLQWASRPKV---DDEWSG--FNGMAAADPSSDWNAPVEHWGNYe-ePPvlvtPAPVQKEQPV 420 Nile tilapia
8_pfamImport 383 -NSAELQWASQKEAngaNDDWSG--FARAAPADPSSDWYAPVEHWGNY---EGvaamAAPPRKAEPA 443
1_pfamImport 355 -NSM--EWAKPPDV---DNEWSG--YNGKAAADHSCDWNAPEEHWGNYe-ePPvlvtPAPPLKEPPV 412
XP_017207032 343 -AVPDLSWSAPPAVp-vDDEWSG--IKS-SSADPSCDWNAPSEEWGNYieqQPv---SAAPL-EQPG 400 zebrafish
7_pfamImport 351 -PASSLPWLSPPRV---DDEWSGpsFTGGTSVDPSSDWNAPSEAWGNYe-ePAa---EPPPAAEPPA 409
9_pfamImport 334 -PVRDLPWIGQPRV---DDEWSG--LNG-SSVDPSSDWNAPAEVWGNYe-dPTs---AAPPLPQKLL 389
Q9Z1W6       359 -TTSDYQWDGSRNQphiDDEWSG--LNGLSSADPSSDWNAPAEEWGNWvdeDR----ASLLKSQEPI 418 Norway rat
XP_012427396 404 -GTSDFQWDLSHAQtpvDDEWSG--LNGLSSADPSSDWNAPAEEWGNWvdeEKv---ASVPQREERs 464 zebra finch
XP_008106595 427 tTDFQWDLNRNQAHvd--dEWSG--LNGLSSADPTSDWNAPAEEWGNWveeEKs---PSIPQLEEGL 486 green anole
XP_005464971 330 -PVNDLPWISQPRL---DDEWSG--LNG-GSVDTSSDWNAPSEAWGNYe-ePTl---EPPPAQEQPL 385 Nile tilapia
XP_007488206 398 -TASDFQWDVSRNQphiDDEWSG--LNGLSSTDPSSDWNAPAEEWGNWvdeEK----ASFLKSQELA 457 gray short-tailed opossum
XP_006001076 386 -STTDLQWDS--VLtpiDDEWSG--ANGLPPADPSSDWNAPAEEWGNWveeEA----AQPPQPEEPV 443 coelacanth
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