Conserved Protein Domain Family
DUF4501

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pfam14946: DUF4501 
Domain of unknown function (DUF4501)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 167 and 308 amino acids in length. The exact function of this protein remains unknown, but it is thought to be a single-pass membrane protein. This family contains many highly conserved cysteine residues.
Statistics
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PSSM-Id: 464393
Aligned: 14 rows
Threshold Bit Score: 224.621
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019648572  69 SVGQQPECCVDVVDANTTCGGTSLCGPGCYRHRNEDGSVSCIRCGNGTYssecggrpaapptrpTWPASHRGATSPVTGW 148
XP_016277751  23 GAVPQPECCMDVLYVNVSCPDTDQCASGCYWHWNVDGSRSCLQCRNESF---------------PVAGAYATECRSIGNK 87 
XP_003228493  23 SLESELECCMDAMEANTTCLASNQCSPGCYRRWNEDGSSSCIKCENETIa--------------ATPVDNLTDCRNNAAR 88 
XP_003212292  23 SSVSETECCVDMLESNSSCPIANQCSPGCYRRWNEDGSSSCIKCKNETLp--------------VATVYNLSDCRNTGIR 88 
XP_014342957  23 SSVSQEDCCVGVKDVNGTCPVNNQCRTGCYRHWYENGTTTCTRCRNETF---------------ADNLNNVTECHNLNST 87 
AAI54855      21 ILSMVYDCCSE-RDLNGSCSISHRCSPGCYRLWSEDGSSTCVKCKNETSl-------------gSEVIPNVTECRNFGSS 86 
XP_023209233  26 LHHNSVECCGEKQKVNNSCSNDTHCEPGCFYRLLENSNVVCIFCDSAA-----------------VDLENVTVC------ 82 
XP_018865054  23 NMAQLPECCVDVVGVNASCPGTSLCGPGCYRRWNADGSASCVRCGNGT-----------------LPAYNGSECRSFAGR 85 
XP_004999739  23 NKAQQPECCVDVLDINATCPGTNLCGPGCYRRGSADGSISCVRCQNGT-----------------FPAYNASECRSLSGW 85 
Q58D09        36 TQGQQPECCVDAGNINATCPGTSLCGPGCYGRPAEDGSVSCVQCRNGT--------------------HNSSECRGLAGR 95  cattle
XP_019648572 149 GAQFPV---NRSTGTPGQPNLGSPQVAASLFLGTLFISSGLILSVAGFFYLKRTSKLPKVFYGRHKAPALQPGEAAAMIP 225
XP_016277751  88 EINYTS---YRTTVTPFLQTLGGPQVAISLFLGTFFISSCLILSIALFFYFKRSSKLPHFFYRRNKASVLQPGETAAMIP 164
XP_003228493  89 GMNSQT---NFSTITPVTLGVGGPEVAASLIFGTFVISLFLILCVASFFYLKRANKLPNLFYRRSKGSVVQSAESASMLS 165
XP_003212292  89 GMNFQM---NISTVTPFIQNIGGPEVAASLILGTFFISLFLILSVASFFYLKRANKLPNVFYRRNKASVLQPSETASMIP 165
XP_014342957  88 EIDPGT---STSTILPTLQKVGGPAVAASLLLGTLFISLFLILSVASFFYLKRSNKLPNIFYRRNKASVLQPSEPATVTY 164
AAI54855      87 TLDISL---NSSSTPYVPHNLGSPGIAASLLLGILFISLFLILSVASFFYLKRSQKLPEIFYRRNKASIFQPSEMASMIP 163
XP_023209233  83 TYNYTLerkNHTTVTTVIPKIGGPGVAASVLLGTLLISMFLILTVASFFYLKRSNRLPGFFYRRNKAFIFQPSETAVMI- 161
XP_018865054  86 GAPFPM---NRSSGTPGRPHPGAPRVAASLFLGTFFISSGLILSVAGFFYLKRSSKLPRVCYRRNKAPALQPGEAAAMIP 162
XP_004999739  86 GAQFPM---NRSTGTPGQPHFGAPRVAVSLFLGTFFISMGLILSVAGFFYLKRSSKLPKIFYRSDKALALQPSEAAAMIP 162
Q58D09        96 GAQFPV---NKSAGMPGWQSVGGPQVAASLFLGTFLISSGLILSVAAFFYLKRASKLPKVFYGRNRAPALQPGEAAVMIP 172 cattle
XP_019648572 226 PPQPSVRKPRYVRRERPLDRDAGSTAVSSVEARVSNV 262
XP_016277751 165 PPNSSVRKPRYVRRDRSLTRPSTPTMIASVQTRVSNV 201
XP_003228493 166 PP-SSVRKPRYVRRERSLMTSSTSTTL-SAETRVSNV 200
XP_003212292 166 PPATSVRKPRYVRRERSLVTSASAAMISSSETRVSNV 202
XP_014342957 165 TPPSSVRKPRYVRRERPSVMSPTATLMSSIETRVSNV 201
AAI54855     164 NPKSSVRKPRYVRRERSRTTAAPDS---SAETRVSNV 197
XP_023209233 162 ---PSGRKQRYVRRERPSTRNI-TTIPTSAATQVHNL 194
XP_018865054 163 PPQSSVRKPRYVRRERPLDRATDPAAFPG-EARISNV 198
XP_004999739 163 APQSSVRKPRYVRRERPPDRAVD-TTFPAVDARISNV 198
Q58D09       173 PPQSSVRKPRYVRRERPLDRDVGPTTVSSVEARVSNV 209 cattle
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