4LVM,4LVI,5N2Q


Conserved Protein Domain Family
MobM_relaxase
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cd17242: MobM_relaxase 
relaxase domain of MobM and similar proteins
With some plasmids, recombination can occur in a site-specific manner that is independent of RecA. In such cases, the recombination event requires another protein called Pre (plasmid recombination enzyme), also known as Mob (conjugative mobilization). The best characterized member of this family is encoded by the streptococcal plasmid pMV158 that recognizes the plasmid origin of transfer. MobM converts supercoiled plasmid DNA into relaxed DNA by cleaving a phosphodiester bond of a specific dinucleotide and remains bound to the 5'-end of the nick site.
Links
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Statistics
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PSSM-Id: 410988
Aligned: 715 rows
Threshold Bit Score: 62.2807
Created: 7-Jul-2015
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Mn binding siteDNA binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Mn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:[EH] [DQH] H [QNH]Click to see conserved feature residue pattern help
Evidence:
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #                                                           
4LVM_A         4 VARMQKMKa---gNLGGAFKHNERVfethsnkdINPSRSHlNYELTDrdr---svsYEKQIKDYVNENkv-----snRAI 72  Streptococcus a...
WP_132782590   8 IIHARRIKng--gHARLLERHCRREvpgverwqTAPERAReNVTMGSm-------kNRERIMTHITELkl-----waRKP 73  Treponema sp. J25
WP_071859332   2 KLEKTDYRf---yELEQVQRHNQREive--ssiVQPDKTSlNYDVLNkkf----idYKKIIRKYLTHLss------tKSI 66  Enterococcus hirae
WP_128186591  13 QVRIQPRKa---gAYAGQRKHDMRRgpq--psyVDSTKTAnNEVLIEppt---pgdLRKVNEERRAQRdt------kRAM 78  Sinirhodobacter...
WP_073038204   2 TANSKAVSarlepSRSGQRAHDLRLgpq--peyVDETRSHlNRTIIEpltsaalrdEWHKVKDRIGKK---------GKI 70  Roseovarius pac...
WP_012607413   6 SVRLEHLNs---vTYGGQQQHDMRDakri-pkyVDKDRSDkNSILIAgpsa--dhlQQEIIRHRKKAKq--------RGF 71  Acidithiobacillus
EES53778       3 SVRVKGLRs---pQSHGAFGHDSRTgyi--pknVDRSRIHlNTVLIGd-------mTLESLSRSREEQevrirnytkKAP 70  Leptospirillum ...
WP_035747364  15 RAAQTRIKgrnatAAGGQRAHDMRMgpq--payVDQSRSHlNRVLMEpkt----gaQLRAISEKRRALrd-----taRGM 83  Haematobacter m...
WP_071675876  17 SVRIAADTm---sGYSGQRRHDLRVgtl--pkyVDEKRVHlNRVLITppt---paeMREIAKARRARRet------qRAM 82  Marivita sp. SS...
EFT38000       5 VARMQKVKs---gNLVGVGNHNQRNtdnhsnkdIDVERSHlNYDLVNrt-----enYKRDIEQFINDNks-----ssRAV 71  Enterococcus fa...

Feature 1                                                                 #       # #            
4LVM_A        73 RKDavlCDEWIITSDkdff---ekldEEQTRTFFETAKNYFAENYGe--sNIAYASVHLDE-STPHMHMG-------VVP 139 Streptococcus a...
WP_132782590  74 QKNaayCVEFVITASr----------EIGEMGEYFKAAVEWLQKKA----ELFFLAAHYDE-KTPHVHAY-------VLP 131 Treponema sp. J25
WP_071859332  67 HSNwtiLIEWRIIFKesal---kklsVRETKLFFLQIVQTFQKLYGl--sNIIYAHVHFDE-EKPHLHIG-------LIP 133 Enterococcus hirae
WP_128186591  79 RSDaavAFIGILTFGaeaqgffdalsIEEQNAAFEEAAQAVAMHLNt---TVAGLVVHRDE-SAPHAHFV-------LPA 147 Sinirhodobacter...
WP_073038204  71 RSNqnlSYAGIITFGhaaqrifeglpKERQDAAFLEVGQKIAERFNt---RLTGMVFHGDE-TAPHAHFQ-------LRG 139 Roseovarius pac...
WP_012607413  72 RKDgrlALSGIVTFGteaqsiindmtPEKQNAVFRKIAERTAKLADr---ELISLVVHRDE-SAPHAHFM-------LRS 140 Acidithiobacillus
EES53778      71 RKDanyYISGIITFSkea------rdDVNSRPPDEQAKKFVEDMARslnlKILYLIRHSDE-STNHFHFMl-----eNVD 138 Leptospirillum ...
WP_035747364  84 KSNasvAIVGIITFGheaqiifekltPEQQDAAYWETAEAIATRLNs---PLTGLVAHADE-SAPHAHFQ-------LPA 152 Haematobacter m...
WP_071675876  83 KSNaaiATAGILTFGseaaqmfealsQEDQDRAFRDLAEAVAAHLNt---SVHALVVHLDE-ATIHAHCM-------LCA 151 Marivita sp. SS...
EFT38000      72 RKDavlINEWIITSD-----------NPFFKDKDDKEIDDLSDYYAmt-dKAVKKTIFYGRnGKPETKYFgvrdsnrFIR 139 Enterococcus fa...

Feature 1                                                                                        
4LVM_A       140 Fen----------gKLSSKAMf--------dREELKHIQE--DLPRYMSDHg----fELERGKlnsea------------ 183 Streptococcus a...
WP_132782590 132 I-------------QLEGQKYrystdallgdRKDLERLQE--EFWREVGKIf-----SLDRGEkterrservrhtglsty 191 Treponema sp. J25
WP_071859332 134 Mke----------gRLNSAYIm--------sKYKNCEIET--ELLKKLEAVlqqnktSIYRKKstndhmk---------- 183 Enterococcus hirae
WP_128186591 148 Y-------------DLDGQPLtvt-----vkRQTLKELQD--VTAKAFQRYa----pDIERGRsvaermlagatraetln 203 Sinirhodobacter...
WP_073038204 140 Iae---------dgTMLSQVVk---------RAALREIQT--ITAKVMASHa----dGIERGKekwvrieege------- 188 Roseovarius pac...
WP_012607413 141 Ykh----------dQETGHEIpmn-----laAVDLRMLQD--VAGNEVSDL------GITRGKskkkriadge------- 190 Acidithiobacillus
EES53778     139 Ie-----------gQAKARTLn---------KKALSGIQD--KAGEFFSQI------GIKRGVkk--------------- 175 Leptospirillum ...
WP_035747364 153 Y-------------DLTGHPIset-----akRGVLREIQT--LTGEIMGRHa----pGIERGNskasrlqagaspadvvn 208 Haematobacter m...
WP_071675876 152 Ydnd--------gvPLSRATT----------PAILSELQD--LTAEVLQRYc----pEIERGTrygdrlaagaewpdvih 207 Marivita sp. SS...
EFT38000     140 IynkkqerkdnadvEVMSEHLw---------RVEIELKRDmvDYWNDCFNDl-----HILKPDwt--------------- 190 Enterococcus fa...

Feature 1                                  
4LVM_A       184 ----------------khktvAEFKR 193 Streptococcus agalactiae
WP_132782590 192 a--srqsraavaagqvpqqepERLQR 215 Treponema sp. J25
WP_071859332 184 --------------eqlnaeyQEYKE 195 Enterococcus hirae
WP_128186591 204 r---svrelhadlpqelaakrKEVEE 226 Sinirhodobacter populi
WP_073038204 189 -----------dfastvnrsvQQLHE 203 Roseovarius pacificus
WP_012607413 191 -----------epanwihrsvKQLHE 205 Acidithiobacillus
EES53778     176 --------------------kERLEK 181 Leptospirillum ferrodiazotrophum
WP_035747364 209 -----rqvnqlhaelpaeiaaKEAER 229 Haematobacter missouriensis
WP_071675876 208 ksvkqlhrelpadlaakraelEALEQ 233 Marivita sp. SSW136
EFT38000     191 -------------------spEKLNE 197 Enterococcus faecalis TX2137

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