2OCC


Conserved Protein Domain Family
Cyt_c_Oxidase_VIIc
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cd00929: Cyt_c_Oxidase_VIIc 
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Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIc subunit is found only in eukaryotes and its specific function remains unclear. Peroxide inactivation of bovine CcO coincides with the direct oxidation of tryptophan (W19) within subunit VIIc, along with other structural changes in other subunits.
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Statistics
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PSSM-Id: 238469
Aligned: 16 rows
Threshold Bit Score: 60.7832
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Subunit VIIc/ISubunitSubunit
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:Subunit VIIc/I interface [polypeptide binding site]
Evidence:
  • Structure:2OCC_L: Interface with 2OCC_A (subunit I), defined using 3.5A contacts
  • Citation:PMID 8638158
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ### #         ##            #  ## #          #  ###  ## #  ##  #
2OCC_L        1 SHYEEGP--------GKN-----------IPFSVENKWRLLAMMTL-FFGSGFAAPFFIVRHQLLK 46  cow
NP_492596    17 GHSSHSPsavtytgqGPNtfvndgwasarLPFHVTNKWGFAAKAVT-FLAIGFWAPFIVVEYQLRK 81  Caenorhabditis elegans
AAF58857     20 SGHGGVP--------GEN-----------LPFGLTNKYRITALFTI-GCVLGFGSPFLIVRHQLLK 65  fruit fly
P04039       28 VHFKDGV--------YEN-----------IPFKVKGRKTPYALSHFgFFAIGFAVPFVACYVQLKK 74  baker's yeast
EAL41744     21 HSHGGIP--------GEN-----------LPFSLTNRYKLTAMFIV-FFGSGLGAPFFILRHQLLK 66  Anopheles gambiae str. PEST
AAT92215     27 HDEGGIP--------GSN-----------LPFKINNRFGLTIKFAL-FFGTGFGLPFFAVRHQLLK 72  western blacklegged tick
AAS52746     22 AHYEEGV--------YSN-----------IPMKIHNRRIPYAVLHFgFFALGFSLPFVAVYVQFKK 68  Ashbya gossypii ATCC 10895
ABD98739     20 SQPGGIP--------GVN-----------LPFSLDNKFKLTALFVV-YFGSGMSVPFLMLRHSLTK 65  Graphocephala atropunctata
XP_001177355 22 AGYGEGP--------GTN-----------MPFPTRNKWLLLGIMAA-FFGSGFAAPFVLVRHQLLK 67  purple urchin
XP_001120568 26 HGPEGYP--------GAN-----------LPINIQNRYVLTATFIL-FFGSGLSLPFLVLRYHLLK 71  honey bee

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