Conserved Protein Domain Family
3Beta_HSD
?
pfam01073: 3Beta_HSD 
3-beta hydroxysteroid dehydrogenase/isomerase family
The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyzes the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.
Links
?
Statistics
?
PSSM-Id: 366449
Aligned: 8 rows
Threshold Bit Score: 362.07
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q67477   7 VVTGGCGFLGRHIINNLILFESsLKEVRVYD------IRIDQWLldLVEKCNIIki-vPVIGDVRNKSTLDEALRSADVV 79  Fowlpox virus strain ...
Q98318   5 AVTGGGGFIGSYIVRALLQCERtLIELRVID------VRWGTKV--SSRNVNVV----YIYCDVCDTARLCAALEGVDVL 72  Molluscum contagiosum...
P26670   5 AVTGGAGFLGRYIVKLLISADD-VQEIRVID------IVEDPQP--ITSKVKVIn---YIQCDINDFDKVREALDGVNLI 72  Vaccinia virus WR
P14060   7 LVTGAGGFLGQRIIRLLVKEKE-LKEIRVLD------KAFGPELreEFSKLQNKtkltVLEGDILDEPFLKRACQDVSVI 79  human
P24815   7 LVTGAGGFVGQRIIKMLVQEKE-LQEVRALD------KVFRPETkeEFSKLQTKtkvtVLEGDILDAQCLRRACQGISVV 79  house mouse
O22813  15 VVTGGLGFVGAALCLELVRRG--ARQVRSFD------LRHSSPWsdDLKNSGVR----CIQGDVTKKQDVDNALDGADCV 82  thale cress
A9X4U2  16 VVLGGRGFIGRSLVSRLLRLGN--WTVRVADsghtlhLDESDSLleDALSSGRAs---YHCVDVRDKPQIVKVTEGSYVV 90  thale cress
P53199   8 LIIGGSGFLGLHLIQQFFDINP-KPDIHIFD------VRDLPEKlsKQFTFNVDdi-kFHKGDLTSPDDMENAINESKAN 79  Saccharomyces cerevis...

Q67477  80 IHIASINDVAG-KFTNDSIMDVNINGTKNVVDSCLYNGVRVLVYTSSYSAVGPNFLGDAMIrGNENTYYQSN--HKEAYP 156 Fowlpox virus strain ...
Q98318  73 IHTAGLVDVMG-EYSEDEIYRANVHGTHSALSACVCAGVRFVVYTSSMEVVGPNMRAEPFV-GDEKTEYESC--HQHCYP 148 Molluscum contagiosum...
P26670  73 IHTAALVDVFG-KYTDNEIMKVNYYGTQTILAACVDLGIKYLIYTSSMEAIGPNKHGDPFI-GHEHTLYDIS--PGHVYA 148 Vaccinia virus WR
P14060  80 IHTACIIDVFG-VTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQnGHEEEPLENT--WPAPYP 156 human
P24815  80 IHTAAVIDVTG-VIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLnGHEEQNHEST--WSDPYP 156 house mouse
O22813  83 LHLASYGMSGKeMLRFGRCDEVNINGTCNVLEAAFKHEITRIVYVSTYNVVFG---GKEILnGNEGLPYFPLddHVDAYS 159 thale cress
A9X4U2  91 FYM-GATDLRS-HDYFD-CYKVIVQGTRNVISACRESGVRKLIYNSTADVVFD--GSQPIRdGDESLRRPLK--FQSMLT 163 thale cress
P53199  80 VVVHCASPMHG--QNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFN---GQDVHnADETWPIPEV--PMDAYN 152 Saccharomyces cerevis...

Q67477 157 LSKQLSEKYILEANG-TMSNIGlRLCTCALRPLGVFGEYCPVLETLYRRSYKSR-KMYKYADDKVFHSRVYAGNVAWMHI 234 Fowlpox virus strain ...
Q98318 149 RSKAEAEELVLSSNGrRVRGGQ-RMLTCALRPPGVYGEGNQLLLRLAKNYVRMGlHVPRTVCENALQSRVYVGNVAWMHV 227 Molluscum contagiosum...
P26670 149 KSKRMAEQLVMKANNsVIMNGA-KLYTCCLRPTGIYGEGDKLTKVFYEQCKQHGnIMYRTVDDDAVHSRVYVGNVAWMHV 227 Vaccinia virus WR
P14060 157 HSKKLAEKAVLAANGwNLKNGG-TLYTCALRPMYIYGEGSRFLSASINEALNNN-GILSSVGKFSTVNPVYVGNVAWAHI 234 human
P24815 157 YSKKMAEKAVLAANGsMLKNGG-TLNTCALRPMYIYGERSPFIFNAIIRALKNKgILCVTGKFSI-ANPVYVENVAWAHI 234 house mouse
O22813 160 RTKSIAEQLVLKSNGrPFKNGGkRMYTCAIRPAAIYGPGEDRHLPRIVTLTKLGlALFKIGEPSVKSDWIYVENLVLAII 239 thale cress
A9X4U2 164 DFKAQAEALIKLANN---RDG---LLTCALRSSIVFGPGDTEFVPFLVNLAKSGyAKFILGSGENISDFTYSENVSHAHI 237 thale cress
P53199 153 ETKAIAEDMVLKAND-----PSsDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGqSKFQIGDNNNLFDWTYAGNVADAHV 227 Saccharomyces cerevis...

Q67477 235 LAARNMIENg----qHSPLCNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRNt----CLPL 287 Fowlpox virus strain NVSL
Q98318 228 LAARALQEP------DSRLPGNAYFCYDHSPCMDYEAFNVMLLRSFGVELGGp----RLPR 278 Molluscum contagiosum virus subtype 1
P26670 228 LAAKYIQYP------GSEIKGNAYFCYDYSPSCSYDMFNLLLMKPLGIEQGSriprwmlkm 282 Vaccinia virus WR
P14060 235 LALRALQDPk----kAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSr---wSFPL 288 human
P24815 235 LAARGLRDPk----kSTSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNAs---wSLPL 288 house mouse
O22813 240 LASMGLLDDipgregQPVAAGQPYFVSDGYPVN-TFEFLRPLLKSLDYDLPKctisvPFAL 299 thale cress
A9X4U2 238 CAVKALDSQ------MEFVAGKEFFITNLKPVR-FWDFVSHIVEGLGYPRPSi----KLPV 287 thale cress
P53199 228 LAAQKLLDPk----tRTAVSGETFFITNDTPTY-FWALARTVWKADGHIDKHv---iVLKR 280 Saccharomyces cerevisiae S288C
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap