4BQ4


Conserved Protein Domain Family
Agarase_CBM
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pfam17992: Agarase_CBM (this model, PSSM-Id:407835 is obsolete and has been replaced by 436194)
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Agarase CBM like domain
This is the N-terminal CBM-like domain in exo-beta-agarase proteins (EC:3.2.1.81) found in the marine microbe Saccharophagus degradans. This enzyme catalyzes a critical step in the metabolism of agarose by S. degradans through cleaving agarose oligomers into neoagarobiose products that can be further processed into monomers. The CBM-like domain is structurally very similar to some CBM families. A loop in the CBM-like domain is involved in forming the roof of the active site channel. The contribution of the CBM-like domain to formation of the active site of the enzyme supports a role in substrate recognition explaining the exo-mode of beta-agarase action.
Links
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Statistics
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PSSM-Id: 407835
Aligned: 12 rows
Threshold Bit Score: 257.246
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4BQ4_B                     7 DFENDQVPSNIHFLNARASIETYTgi--nGEPskGLKLAMQSKQHSYTGLAIVPEQP-WDWS--EFTSASLYFDIVSVGD 81   Sa...
Q15SI3                    54 DFAGVTDMQDVTLTAADMHVVDVD-----GEQ--KLAIDLHAKEHKSAGFSFIPDSP-WDWS--HEGQFAFAIEIENPSQ 123  Ps...
EWH09658                  36 DFEQAEHLKHIQTENAKLTSVKQG-----DNS--AVKISFDSKNNHVSGFEFKSDNG-WDWS--NDSSFAFALDIQNPKN 105  Ca...
WP_067157817               5 DFENGKQPKELKLQNATAEVIQRG-----SGK--ALSIRLLSEDNHTSAFSFEPEGT-WDWS--AMGNFAFALDISNAES 74   Mi...
WP_048688993              36 DFEDETDKHIILLENADAKMIQSS-----QGN--ALEIKLESKNNHDASFTVQPKTP-WNFS--QYQNAAIALDIKNPSA 105  Ca...
EWH10187                  30 DFEDQGHKNMVVLENATAQLVDGN-----VGK--ALNISLNSENHHDASFSIVPQKP-WDLS--QYPNVGISIDIKNPAA 99   Ca...
Q9RKF0                    59 DFQDGLVPAEVGPYQAKTTIVGR------GDK--KLRVDFQARKNYYSSFSVRPEPV-WNWSaeESESLGIAMELTNPSD 129  St...
WP_016403205              24 DFAE-QIPKAFSFSNVDAELVSEGngittGSQ--ALKVTTHSKENFYTSIFIEPEQP-FDWS--ALPNFSFAFDVTNLGR 97   Ag...
AYW35330                  51 DFENTSIPLQVKTANAKTELTDQN-----GSK--ALNVKFNSAKHEWTSVDFVPENGvWDWS--KYKSFSIAFDISNQGQ 121  Ca...
EWH08638                  41 DFENSAVPVEVKVANATASIVKQGat--sGDQ--ALNVKFNSKAHEWTSIEFTPAQP-WDWS--EYESFSIAFDISNVGQ 113  Ca...
PRJNA315367:A3224_10080   57 DFDKTAIPATVKVNNGAVSLVDSAr----GDK--ALLVKLDLKENNSAALVIAPEEP-WDWS--EFSGFNLAFDVANKGT 127  Mi...
AYW35322                  46 DFEKGQVPDGFEFWNAASSVTDKTsa-idGNH--SLLVKVNTLDNNSAGMRIKPEKA-FDWS--EYQDFNLAFDLTNAGT 119  Ca...

4BQ4_B                    82 HSTQFYLDVTDQNGAVFTRSIDIPVG-KMQSYYAKLSGHDlevpds--gdvndLNLASGLRSNPPTWT--SDDRQFVWMW 156  Sa...
Q15SI3                   124 SSTHLYVSVKDATGQSHNRSFAVPGH-SQDTYFMALNDPD-------------LSIETGIRSNPNNWQ--SEFTPMIWRY 187  Ps...
EWH09658                 106 TSVHMYVTAKDKAGKTHNRSFVVPAN-SAETYFIELKGLD-------------LNQETGIRSNPPSWQ--SDYVPIIWRH 169  Ca...
WP_067157817              75 SSVHLYVKATDNEGRTHSRSFVVPEQ-SSATYFFEMKGPD-------------LAVDTGIRSNPPSWM--SEYQDMIYRW 138  Mi...
WP_048688993             106 TSTHVYIYTYDANNAFQLRNVVIPAN-SNNSYLIELKSLG-------------LQVNSGIRNNPPSWQ--HDYVQTIWRG 169  Ca...
EWH10187                 100 SSTHLYIYTYDANNAFQLRNVVVPAN-SNNSYLIELKSLG-------------LQVNSGIRNNPPSWQ--HDYVHTIWRG 163  Ca...
Q9RKF0                   130 RSVQLTIDLESSTG-VATRSVNVPAG-GGGTYYFDVDSPA-------------LHRDTGLRADP-SWLadKDVTSAVWMW 193  St...
WP_016403205              98 RSTQIFINIFDKQGQMHSRSINVAGG-SCKTYLNELKGEFlk---------ggLNYESGFRSNPAAWD--TPFHYATWMW 165  Ag...
AYW35330                 122 YSTQLFLNVYDKNGQVYTRSVNVPVG-DAKTYYSKMAGHDlgspnnahsekveLNLSSGLRSNPETWD--TDDVQFIWMW 198  Ca...
EWH08638                 114 YSTQLFLNVFDKNGQVYTRSVNVPVGeDAKTYYSKMAGHDlvspknkhgenveLNLSSGLRSNPPTWNegDDQVQFIWMW 193  Ca...
PRJNA315367:A3224_10080  128 ESVQIDVTMTDKNGDSYTRGMVVPADgVWRTYYAKLHGHDqqdpds--aakneFNFSSGLRSNPPTWQ--SDDVMLHSFW 203  Mi...
AYW35322                 120 ESLQIDLTISDENGGFYTRGLVVPVG-KTQTFYAKMDGHDqqdppw--atqteFNFASGLRSNPVTWQ--SDDKQVYSFW 194  Ca...

4BQ4_B                   157 GVKNLDLSGIAKISLSVQSAMHDKTVIIDNIRIQPNPPQDENFL 200  Saccharophagus degradans 2-40
Q15SI3                   188 GTKKIDLSQVKSIEFDVRGVPEDKHLIVDNPRLIKPQKIDQNYL 231  Pseudoalteromonas atlantica T6c
EWH09658                 170 GSKNIDISQITSIKFNIRGVLEDKQLVIDNARLIYPKALDKNYL 213  Catenovulum agarivorans DS-2
WP_067157817             139 GDKSLNVSEIDSIEFSVAGVLENKYVVVDNVRLIQPESLDEMYL 182  Microbulbifer thermotolerans
WP_048688993             170 GVKQPDTSAISKIRFLISGVLEDKTLEIDNIKVVEPKQYDENFL 213  Catenovulum maritimum
EWH10187                 164 GIKQPDSSAISKIRFLVSGVLEDKQLEIDNIKVVEPKQFDNNFL 207  Catenovulum agarivorans DS-2
Q9RKF0                   194 GSKETDTSRISQLNFYVAGLLHDRSVIVDDIRVVRDAPADPDYL 237  Streptomyces coelicolor
WP_016403205             166 GEMNIDLSAVAKIELSIHGTLIDHQLVLDNFRVIFTPECNPDFL 209  Agarivorans albus
AYW35330                 199 GNKNLDTSGIKRISLSVQYNLHDKEVTIDNVRLMPHPKMNPDYL 242  Catenovulum maritimum
EWH08638                 194 GNKNLDTSGITKISLSVQYNLHNKEVTIDNVRVMPNPKMDPDYL 237  Catenovulum agarivorans DS-2
PRJNA315367:A3224_10080  204 GKKLLDLSGITKISFGSDGSLSNRQYTIDNIRLRANPEMDKNFL 247  Microbulbifer thermotolerans
AYW35322                 195 GKKRLDISAITAINFSANGLLSDRQFTVDNIRLRANPKMDENFL 238  Catenovulum maritimum
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