pfam04834: Adeno_E3_14_5 (this model, PSSM-Id:309809 is obsolete and has been replaced by 461451)
Early E3 14.5 kDa protein
The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C-terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumor necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.
Jiyao W et al.(2023). "The conserved domain database in 2023.",