Conserved Protein Domain Family
HORMA
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pfam02301: HORMA (this model, PSSM-Id:396743 is obsolete and has been replaced by 460526)
HORMA domain
The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognize chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.
Links
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Statistics
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PSSM-Id: 396743
Aligned: 120 rows
Threshold Bit Score: 60.3765
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFJ00812           18 SLEAVKTLVAAGLGCIAFLRDLLP--EDNFTKTSFsafddsfgmstdgrtptpassqkpggFKVMTITRNST-------- 87  Schizophyl...
EGS20224           23 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML------------- 61  Chaetomium...
jgi:THITE_2039922  21 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML------------- 59  Thielavia ...
EPE04486           22 SAKLVSEFFQYSIHSILFQRGVYP--AEDFTSVKK--------------------------YGLNMLGRSTEhhgttgsg 73  Ophiostoma...
EJT72915           32 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAIKK--------------------------YGLNML------------- 70  Gaeumannom...
EGY15545           22 SAKLVAEFFQYSIHTILFQRGVYP--AEDFSVVKK--------------------------YGLNMLa------------ 61  Verticilli...
XP_011107312       89 SAKMVSEFFEYSIHSILFQRGVYP--PDDFAPVKK--------------------------YGLNML------------- 127 Dactylelli...
CCX07047           37 SAKRVTEFFEYSINTILYQRGVYP--AEEFTTVKK--------------------------YGLNML------------- 75  Pyronema o...
EME46196           35 SSKLVTEFFEFACNAILFQRGVYP--PEDFAPVKK--------------------------YGLNMM------------- 73  Dothistrom...
XP_003668671        5 ITKWLKIYLKSYINLILYYRNVYPstTFDFTTYQT--------------------------FNLPQF------------- 45  Naumovozym...

EFJ00812           88 --EEADR---LLNYVeNGIFDALQ----KQYLESFIFGIY-LDKDKpndVVEAYTFNFEYHQVPGT-DVVIPImatirkt 156 Schizophyl...
EGS20224           62 ----VSSddqVRAYIkK-IMLQLDkwmlAGKVQKLVIVITdKDTGE---HVERWQFDVQILQKTSKrSKPSSKssatpsa 133 Chaetomium...
jgi:THITE_2039922  60 ----VSSddqVRAYIkK-IMTQLDkwmvGGKVSKLVIVITdKDTGE---HVERWQFDVQILAKPKSkSSSKSKpsttsgg 131 Thielavia ...
EPE04486           74 anKAVSAddqVRAYIkK-IMGQLDrwmaGGQISKLVLVITdKDTGD---HVERWQFDVQITASKKKsKTKGSSaaattad 149 Ophiostoma...
EJT72915           71 ----VSAddqVKAYIkK-IMGQLDrwmvKGKISKLVIVITdKDTGE---HVERWQFDVQIFGGKSKsSSKSKTaaaaaaa 142 Gaeumannom...
EGY15545           62 --AAVSSddqVRAYIkK-IMGQLDrwmkYGKISKLVIVITsKDTGE---HVERWQFDVQIFNQHKSaKSKAAKadqen-- 133 Verticilli...
XP_011107312      128 ----VNTddqVKAYIkK-IMSQLSkwmlGGKISKFILVISdKDSGE---KLERWQFDVQILAKSKKkKGDAEAdtvmggt 199 Dactylelli...
CCX07047           76 ----VTIddnVKDYIkK-IMGQLGrwmlHGKISKLVIVISsKDDGE---VVERWVFDVQVLGGGNKdKAGATGaagaagg 147 Pyronema o...
EME46196           74 ----VSIddqVKAYVkK-IMSQLSkwmqKSKISKLVIVVTnKETGE---HVERWQFDVNMFLGESKkKRATSSgnkense 145 Dothistrom...
XP_003668671       46 --TPINRhpqLQSYIeELILDLLSk---LNHIYHISLCIInKSNEI---CVEKYVLDFGEFKHITTtTNNARDdgd---- 113 Naumovozym...

EFJ00812          157 lgnlslgagddslqrarstgddplqqalNQGKAPTFGDVKARVKVRVVSIYARDIDLTVT---Pgsseashllydadgas 233 Schizophyl...
EGS20224          134 den---------------eagssstaaaSSPPEKTEAEIQAEIAALFRQITASVTFLPQL---Q---------------- 179 Chaetomium...
jgi:THITE_2039922 132 adqenaps------hadsensraaaappAPAADKTEAEIQAEIAAIFRQITASVTFLPQLpggH---------------- 189 Thielavia ...
EPE04486          150 ke-----------------nndggsaaaPPAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A---------------- 193 Ophiostoma...
EJT72915          143 vagaggqe-----naeaagagaaaaaaaATAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A---------------- 198 Gaeumannom...
EGY15545          134 -----------------------aapvtEDAPDKTEKEIQDEIAAIFRQITASVTFLPQL---D---------------- 171 Verticilli...
XP_011107312      200 dk-----------------enagagtstEATMEKTEKEIQEEIQSIFRQITASVTFLPML---Dn--------------- 244 Dactylelli...
CCX07047          148 tvekde----------ngkvlavgkdapGKEPFKTEKEIQQEIAGLFRQITATVTFLPML---E---------------- 198 Pyronema o...
EME46196          146 ---------------------paadeapAAAVEKSESDVQAEIQALFRQITASVSFLPML---D---------------- 185 Dothistrom...
XP_003668671      114 --------------------------ddEDNQILSESEVFDEFRSSLNSLISHLEKLPKI---K---------------- 148 Naumovozym...

EFJ00812          234 aqyvdvallssqssrgtEkRYANFKVFYNAS------TPIDYeapgfkpgdvdkdrwyimtHAIDEIPERYTMGKLDTGH 307 Schizophyl...
EGS20224          180 -------------------GDCTFNVLVYADas--seVPVEWgd---------------sdPKEIENGERVQLRSFSTSN 223 Chaetomium...
jgi:THITE_2039922 190 -------------------GGCTFNVLVYVDdaetveVPVEWgd---------------sdAKEIANGERVQLRGFSTHC 235 Thielavia ...
EPE04486          194 -------------------GDCTFNVLVYADad--seVPVEWgd---------------sdAKEIVNGERVQLRGFSTSS 237 Ophiostoma...
EJT72915          199 -------------------GDCTFNVLVYADad--seVPVEWgd---------------sdAKEIENGERVQLRGFSTAS 242 Gaeumannom...
EGY15545          172 -------------------GDCTFNVLVYADad--seVPVEWgd---------------sdAKEIENAERVQLRGFSTSN 215 Verticilli...
XP_011107312      245 -------------------NHCTFNVLVYADgd--aeVPMEWgd---------------geDLGIQDAEQVQLRSWSSSS 288 Dactylelli...
CCX07047          199 -------------------GNCTFNVLVYADgd--aeVPMEWgd---------------sdAREIQNGEKVTLRSWGTSS 242 Pyronema o...
EME46196          186 -------------------GNCTFNVLVYADad--seVPLEWgd---------------sdAKEVKNAEKVMLRSFSTNS 229 Dothistrom...
XP_003668671      149 -----------------D-NMVTFQIVINAV-------------------------------------------ELQLGH 167 Naumovozym...

EFJ00812          308 H 308 Schizophyllum commune H4-8
EGS20224          224 H 224 Chaetomium thermophilum var. thermophilum DSM 1495
jgi:THITE_2039922 236 H 236 Thielavia terrestris NRRL 8126
EPE04486          238 H 238 Ophiostoma piceae UAMH 11346
EJT72915          243 H 243 Gaeumannomyces tritici R3-111a-1
EGY15545          216 H 216 Verticillium dahliae VdLs.17
XP_011107312      289 H 289 Dactylellina haptotyla CBS 200.50
CCX07047          243 H 243 Pyronema omphalodes CBS 100304
EME46196          230 H 230 Dothistroma septosporum NZE10
XP_003668671      168 H 168 Naumovozyma dairenensis CBS 421
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