Conserved Protein Domain Family
GEMIN8
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pfam15348: GEMIN8 (this model, PSSM-Id:405933 is obsolete and has been replaced by 464664)
Gemini of Cajal bodies-associated protein 8
GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.
Links
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Statistics
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PSSM-Id: 405933
Aligned: 32 rows
Threshold Bit Score: 162.092
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6AY77        10 SWYSHPVYARYWQHYYHAMLWMQSHQNAYRKFRDSYFTs---pWFFPHGVQPWSSFAYETGHPWNSEGQHMEWQESPYSV 86  Norway rat
XP_416829     13 PWYSQKMYARYWKHYDLAMRWMHRHQEAYRKAMESFYHv---pWPPYAA-SPSRRYSDWDGDDPPCTHNRF------SNY 82  chicken
XP_016154390   6 PWYSQKVYARYWRHYDLAMRWMRRHQKAYRKAVECCYHlprhpWHPAAA-SPSSHYPHWGGNDLSHSQNCSPSYRPSVRV 84  Collared flycat...
OCA45776      11 PWYAGRVYARYWKHYSQAMYWLYRHKRAYSVAMASLSYp---sWYPAGN-VQNRRYSDWEGGKSSQSDIYL---RPHRQV 83  tropical clawed...
XP_003218936  84 PWHSQKIYARYWKHYNQAMEWMYRHRNAYNKAMEFLYNq---sFCPPAD-HPSSRYADWDEGE-----------HLHEQA 148 green anole
XP_015217242  10 PWYSHPLYARYWSHYQQAAHWQHKHWQAYRKALEAAYCv---pYRAEGA-AVARRH----------------SSGSERES 69  spotted gar
XP_005463147  10 SWFSSPVYSRYWQHYQQAMAWHQRHRRAYRKALEAAYGp---cCYQEEGRSDRARYADWSSAE----------------- 69  Nile tilapia
XP_007228750   9 AWYSHPVYARYWLHYQQAMTWHQRHRQAYSKAVQAAYGp---aLYHMFP-TTSPRYTDWHSEE----------------- 67  Mexican tetra
XP_005168438  11 LWFAHDVYSRYWQHYQQAMNWNQKHKRAYRSALEAGYFq---tLYSMNPSATMQCYSDWHGNE----------------- 70  zebrafish
XP_005996189  14 PWYAHQMYSRYWRHYHQAMHWLHRHKEAYRKAVESFYYl---lWHSRMT-AEGHRYADWSDDERPVRRSHCPSELGRVNQ 89  coelacanth

Q6AY77        87 SHPRSFEQPLYNSRRSQASAREd-eEALCEEEE----LESDSDDEVECDLSNMEITEELRQYFAQTERHREERRRQQQLD 161 Norway rat
XP_416829     83 SPRGRAQQYMDAQPGKEDDDREe--EEEDSEVE----EDSESEGEFEYDLSNMEITEELRQFFAQTERHREELRRQQQLE 156 chicken
XP_016154390  85 PYHGGAQQYAGAYQEREDADEDsemEEDAERDTem-eEDSESEGEIEYDLSNMEITEELRQFFAETERHREELRRQQQLE 163 Collared flycat...
OCA45776      84 IHPQRTRPCLKVSESKEIESEMecdKEVTSDSE---------EEGIECDTTNMEITEELRQYFAETERHREELRKQQQLE 154 tropical clawed...
XP_003218936 149 FTQNRPTRYYPRSRQAPYNTKRrqtVEMVLETD----SESESEGDVEYDLSNMEITEELRQYFEQTERHREELRKQQQLE 224 green anole
XP_015217242  70 AGPEACPRFPSGGKRGPSASRRaagTKRVRCSRdg-eENSSSDGEVECDVSNMEITEELRQYFAETERHREERRKQQQLE 148 spotted gar
XP_005463147  70 ---------------------------SNSEDEeggvEESSSESEIECDVSNMEISEELRQYFAQTERHKEELKKQQQME 122 Nile tilapia
XP_007228750  68 RKDRTRGRMKRRGRGYAVEEDEevpEST---EE----SESSEESEIECNVSKMEISAELRQFFAQTEQHREELKKQQQME 140 Mexican tetra
XP_005168438  71 ----------CLKNSHRDRLKEkreNEITGSDSei-eEESSDESQLECDVSNMDISEELRQYFAQTERHRQELKKQQQME 139 zebrafish
XP_005996189  90 RESQSQRWQYPTPSSKHQASEEkesTSEDEEDD----DDSGSGDEIECDVSNMEITEELRQYFAQTERHREELRRQQQLE 165 coelacanth

Q6AY77       162 EERLNDYVNADHGLYFNHH-RSVEPPSEKPWERRQAEMKRLYGNSAPKILAMEAAVQLSFDKHCDRKQPKYWPVIPLKF 239 Norway rat
XP_416829    157 AEQQEMYVEADQDLYRNMK-RSVEPPAERPGERRVAEMEKLYGDEAAKILAMETAMQLIFDRNCDKKQPKYWPIIPLKL 234 chicken
XP_016154390 164 AE--DPYVEADQDLHRRVE-RSVEPPTERPGERRMAEMKKLYGAEAAKIQAMEAAMQLIFDRNCDKKQPKYWPIIPLKL 239 Collared flycatcher
OCA45776     155 AENHEQYIAADHDLHVATR-TSKEPPSERPGERRRAEMKKLYGEDAPKILGMETAMQLNFDRHCDKKQPKYWPIIPLKL 232 tropical clawed ...
XP_003218936 225 AEHHDMYVEADHDLHLSTG-RSTQPPAEKAGERRTAEMRKLYGVGANKIQAMETTMQLSFDRNCDKKQPKYWPIIPLKL 302 green anole
XP_015217242 149 EEQQSAYVPADHDLYRVAR-RSAQPPRDQPGVRRGIEMKMLYGEDAAKIQGMETAMQLTFDRNCDLKQPKYWPVIPLKL 226 spotted gar
XP_005463147 123 AEQQGSYVPADQDLHSFSLqSSVAPPLERPGERRTAEMKKLYGGDAAKIMAMEAAMQLNFERNCDLKQPKYWPVIPLKL 201 Nile tilapia
XP_007228750 141 AERQEDYVLADQDLHRVSW-RSAQAPVERPGERRSAEMKKLYGKDAAKIQGMETAMQLTFDRNCDRKQPkywpviplnl 218 Mexican tetra
XP_005168438 140 AEQQDSYILADQDLHRVSW-RSTLPPSERPGERRTAEMKKLYGKDAAKIQGMETAMQLTFERNCDKKQPKYWPVIPLNL 217 zebrafish
XP_005996189 166 AECQDSYVAADHDLHVSAG-RTVQPPTERPGERRVAEMKRLYGEDAAKIQGMETAMQLTFDRNCDKKQPKYWPIIPLKL 243 coelacanth
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