P09303 17 NpetpngfdDSVYLNFTSMHSIQPILSRIRELAAitiPKERVPR-LCWFKQLLELQAPPEMqRn---------------- 79 Human herpesvirus 3 ... Q2HR89 14 S--------PGFILNMTSDAKVRSVVEQIDRLSN---ITTSPPE-MGWYDLEFDPLEDEGP-F----------------- 63 Human herpesvirus 8 ... O36393 5 P--------KSFILNMTSEAKVRMIVQKIKALSEe--TTSDSPD-ISWFDAEFDPDDLGPR------------------- 54 Alcelaphine herpesvi... Q777D7 12 S--------STFMLNMTSDASVRRIVRRIGTLARr--RVQQLPD-METFSPEFDPELSEPP-F----------------- 62 Epstein-Barr virus P10189 32 R--------AEAFLNFTSMHGVQPILKRIRELSQqqlDGAQVPH-LQWFRDVAALESPAGLpLr---------------- 86 Human alphaherpesvir... P52356 12 D--------NKFLLNMSSAPKIELIVDKVASLSe---RRLEGRLpEDWFRHIMDPETEFNSeFadalcigid-------- 72 Human herpesvirus 6 ... F5HEN8 17 D--------DALILNLSSAAKIERIVDKVKSLSRe--RFAPEDFsFQWFRSISRVERTTDNnPsaattaaatatvhssvs 86 Human herpesvirus 5 ... Q01014 5 S--------PEFILNMTSDAKVRIIVEKIRKLSN---ITTRPPE-MTLYNDQFDPEQCPGT-L----------------- 54 Herpesvirus saimiri ... Q66647 5 G--------AGFILNMTSDSKVRAIVGRIRGLAA---KTVPPPE-MSWFDSQFDPEDAEGP-F----------------- 54 Equid herpesvirus ty...
P09303 80 -----------------------eLPFSVYLISGNAGSGKSTCIQTLNEAIDCIITGSTRVAAQNVHAKLStayasRPIN 136 Human herpesvirus 3 ... Q2HR89 64 ------------------------LPFSAYVITGTAGAGKSTSVSALHQNLNCLITGATVVAAQNLSRALK-----SYCP 114 Human herpesvirus 8 ... O36393 55 ------------------------LPFSTYCITGTAGAGKSTSIAALHQNLNCLITGATVVAAQNLSKTLH-----SFCP 105 Alcelaphine herpesvi... Q777D7 63 ------------------------LPFSAYVITGTAGAGKSTSVSCLHHTMDCLVTGATTVAAQNLSQTLR-----AYCP 113 Epstein-Barr virus P10189 87 -----------------------eFPFAVYLITGNAGSGKSTCVQTINEVLDCVVTGATRIAAQNMYAKLSgaflsRPIN 143 Human alphaherpesvir... P52356 73 ----------------efaqplpfLPFKALLVTGTAGAGKTNSIQTLAANLDCIVTATTSIAAQNLSVVLNrs-ksAQVK 135 Human herpesvirus 6 ... F5HEN8 87 ssaaaaasseaggtrvpcvdrwpfFPFRALLVTGTAGAGKTSSIQVLAANLDCVITGTTVIAAQNLSAILNrt-rsAQVK 165 Human herpesvirus 5 ... Q01014 55 ------------------------LPFTCYVITGTAGAGKSTSISALYQNLNCLITGATTVASQNLSRCLK-----TYCP 105 Herpesvirus saimiri ... Q66647 55 ------------------------LPFSTFLITGTAGAGKSTSISALYQSLNCLITGATAVAAQNLSNGLK-----TYCP 105 Equid herpesvirus ty...
P09303 137 TIFHEFGFRGNHIQAQLg--------RyaYNWTTTPPSIEDLQKRDIVYYWEVLIDITKRVFQMgddgrggtstfktlwa 208 Human herpesvirus 3 ... Q2HR89 115 TIYHAFGFKSRHINICQ---------R--KVPKVTQSSIEQLQRYELARYWPTVTDIIREFMRK---------------- 167 Human herpesvirus 8 ... O36393 106 TIYTAFGFKSRHINLLN---------RkpQIKLCGDSDITAVQYYELSKYWPVIKDIIGEFCKK---------------- 160 Alcelaphine herpesvi... Q777D7 114 TVYSAFGFKSRHINMTQ---------RvsSHGRSTDAALEELQRRDLAKYWPVLSDIAAEFRRT---------------- 168 Epstein-Barr virus P10189 144 TIFHEFGFRGNHVQAQLg--------QypYTLTSNPASLEDLQRRDLTYYWEVILDLTKRALAAsggeelrn-efralaa 214 Human alphaherpesvir... P52356 136 TIFKTFGFNSSHVSMSe---------Rq-SYIANDERSIQIQQKQDLSIYWNVISDIADRALG----------------- 188 Human herpesvirus 6 ... F5HEN8 166 TIYRVFGFVSKHVPLADsavshetleRyrVCEPHEETTIQRLQINDLLAYWPVIADIVDKCLNM---------------- 229 Human herpesvirus 5 ... Q01014 106 TIFNAFGFKSKHINILP---------R--SVPRRTLDTIEQIQNFELCKYWPILTSIIQEFSKK---------------- 158 Herpesvirus saimiri ... Q66647 106 TIYSAFGFKSRHINILP---------R--HGRNAPARDMEGIQRNELCKYWPVISDILGEFTKK---------------- 158 Equid herpesvirus ty...
P09303 209 iERLLNKPTGSMSGTAFIACGSLPAFTRSNVIVIDEAGLLGRHILTAVVYCWWLLNAIYQSPQYINGRKPVIVCVGSPTQ 288 Human herpesvirus 3 ... Q2HR89 168 -KQKGQYSSLSQSAFRLLCRMGGANLWTSNIIVIDEAGTLSSHILTAVVFFYWFYNSWLDTPLYRNGAVPCIVCVGSPTQ 246 Human herpesvirus 8 ... O36393 161 -KKFGLYASMSEEAYRVFGCLGSPQLWTTNIIIIDEAGTLSSHVLMAVVFLWWFFNGWLNTRQYLNGKIPCIVCVGSPTQ 239 Alcelaphine herpesvi... Q777D7 169 -KPRGLYSGVSGPAFEVLRDMHQGQLWTTNVIVVDEAGTLSVHILTAVVFCYWFFNAWLRTPLYRRGRIPCIVCVGSPTQ 247 Epstein-Barr virus P10189 215 lERTLGLAEGALTRLAPATHGALPAFTRSNVIVIDEAGLLGRHLLTAVVYCWWMINALYHTPQYAARLRPVLVCVGSPTQ 294 Human alphaherpesvir... P52356 189 -------------AVACKTKELP-DLCESSVIVIDEAGVILRHILHTVVFFYWFYNALYKTPLYEDGIVPCIVCVGSPTQ 254 Human herpesvirus 6 ... F5HEN8 230 -WER-KAASASAAAAAAACEDLS-ELCESNIIVIDECGLMLRYMLQVVVFFYYFYNALGDTRLYRERRVPCIICVGSPTQ 306 Human herpesvirus 5 ... Q01014 159 -KNLGQYSSISLAAFNMLAKMTT-TLWTTNVIVIDEAGTLSSHILTAVVFCYWFYNSWLNTPLYRSGAVPCIVCVGSPTQ 236 Herpesvirus saimiri ... Q66647 159 -KQRGQYEHLTGAAFGALAKMGTPTLWTTNIIVIDEAGTLSSHILTAVVFLYWFYNSWLQTPLYKSGAVPCVVCVGSPTQ 237 Equid herpesvirus ty...
P09303 289 TDSLESHFQHDMQRSHVTPSENILTYIICNQTLRQYTNISHNWAIFINNKRCQEDDFGNLLKTLEYGLPITEAHARLVDT 368 Human herpesvirus 3 ... Q2HR89 247 TDAFQSVFNHTQQRNEISACDNVLTFLLGKREVADYIRLDENWALFINNKRCTDPQFGHLLKTLEYNLDISPELMDYIDR 326 Human herpesvirus 8 ... O36393 240 TDAYHSQFDHSKQQQHVRECDNVLSLIIGNKTVSDYVKISENWALFINNKRCTDPEFGHMLKVLEYGLEISDDVMEYINR 319 Alcelaphine herpesvi... Q777D7 248 TDAFQSSFSHETQVNKIRECDNILTFLVGNPRAATYVDVARNWALFINNKRCTDVQFGHLMKTLEYGLELSPDILAYVDR 327 Epstein-Barr virus P10189 295 TASLESTFEHQKLRCSVRQSENVLTYLICNRTLREYARLSYSWAIFINNKRCVEHEFGNLMKVLEYGLPITEEHMQFVDR 374 Human alphaherpesvir... P52356 255 SNALVTSFNPLTQNKDVKRGIDVLSALICDDVLSKYCEVDNNWIIFVNNKRCADHAFGDFLKHIEFGLPLKPELIEYVDQ 334 Human herpesvirus 6 ... F5HEN8 307 TEALESRYDHYTQNKSVRKGVDVLSALIQNEVLINYCDIADNWVMFIHNKRCTDLDFGDLLKYMEFGIPLKEEHVAYVDR 386 Human herpesvirus 5 ... Q01014 237 TDAFNSTYNHIQQKYNIMECDNILSFIIGNKVVSEYISLTNNWALFINNKRCTDPEFGHLLKTLEYSLKISPKTMEYIDR 316 Herpesvirus saimiri ... Q66647 238 TDAIQSTYNHSMQKHHIQECDNILTFLMKHEAVSRYVDLNHNWALFINNKRCTDPEFGHLLKTLEYNLDISPRMVDYIDR 317 Equid herpesvirus ty...
P09303 369 FVVPASYINNPANLPGWTRLYSSHKEVSAYMSKLHAHLKLS-----------KNDHFSVFALPTYTFIRLTAFDEY---R 434 Human herpesvirus 3 ... Q2HR89 327 FVVPKSKILDPLEYAGWTRLFISHQEVKSFLATLHTCLSSNk----------DAVSTKLFTCPVVCEVFTEPFEEY---K 393 Human herpesvirus 8 ... O36393 320 LVVPRSKIMDPMQYVGWTRLFLSHSEVKQYLGSLHSALSSNq----------SSTTCTLFTCPIVCEVFHDAVEEY---K 386 Alcelaphine herpesvi... Q777D7 328 FVVPRAAIMDPAQYVGWTRLFLSHAEVKTFLTTLHATLKTAgqgraargtggDGGGVTMFTCPVECEVFLDPLAQY---K 404 Epstein-Barr virus P10189 375 FVVPENYITNPANLPGWTRLFSSHKEVSAYMAKLHAYLKVT-----------REGEFVVFTLPVLTFVSVKEFDEY---R 440 Human alphaherpesvir... P52356 335 FVKPASYIRNPMNEIETTRLFLSHNEVKNYFRSLHEQVEVT------------NR-NNLFVFPVYFLIKNKTFEDY---K 398 Human herpesvirus 6 ... F5HEN8 387 FVRPPSSIRNPSYAAEMTRLFLSHVEVQAYFKRLHEQIRLS-------------ERHRLFDLPVYCVVNNRAYQELcelA 453 Human herpesvirus 5 ... Q01014 317 FVVPKAQILNPLEFLGWTRLFLSHAEVKSYLSSLHTALVTg----------tNVSGAKLFTCPIVCEVFTKAFNEY---K 383 Herpesvirus saimiri ... Q66647 318 FVVPKSKILSPLEYVGWTRLFVSHREVKAYLTALHETLSLNqgg------atAEADARLFTCPVVCEVFTDTFNEY---R 388 Equid herpesvirus ty...
P09303 435 KLTGQPGLSVEHWIRANSGRLHNYSQSRDHDMGTVKYETh----SNRDl------------------------------- 479 Human herpesvirus 3 ... Q2HR89 394 RAVGLTHMTPIEWVTKNLFRLSNYSQFADQDMAVVGTYI-----TDASt------------------------------- 437 Human herpesvirus 8 ... O36393 387 EAVNVPSLTPLEWLARNTYRLSNYSQFIDQDMTTVSTDV-----GEASt------------------------------- 430 Alcelaphine herpesvi... Q777D7 405 TLVGLPGLTAHTWLQKNYARLGNYSQFADQDMVPVGTEQ-----DEERv------------------------------- 448 Epstein-Barr virus P10189 441 RLTHQPGLTIEKWLTANASRITNYSQSQDQDAGHMRCEVh----SKQQl------------------------------- 485 Human alphaherpesvir... P52356 399 SEIGNFSLEIEPWFKSNIHRLNTYSQFADQDLSKTVQLEei-vlEDGSve------------------------------ 447 Human herpesvirus 6 ... F5HEN8 454 DPLGDSPQPVELWFRQNLARIINYSQFVDHNLSSEITKEalrpaA--Dvvatnnpsvqahggggsvigstggndetaffq 531 Human herpesvirus 5 ... Q01014 384 SHVNLPSLTATEWLSKNLHRLSNYSQFIDQDMTAIHTET-----TDTSt------------------------------- 427 Herpesvirus saimiri ... Q66647 389 EAVNLPGLTVTEWLQKNLCRLSNYSQFIDQDLSAVHIET-----GEESt------------------------------- 432 Equid herpesvirus ty...
P09303 480 ------------iVARTDITYVLNSLVVVTTRLRKLVIGFSGTFQSFAKVLRDDSFVKARGETSIEYAYRFLSNLIFGGL 547 Human herpesvirus 3 ... Q2HR89 438 -------------QITFATKFVKNSYATLTGKTKKCICGFHGSYQRFKSILDGELFIESHSHDNPAYVYSFLSTLLYNAM 504 Human herpesvirus 8 ... O36393 431 -------------KVTYATKFVKGSYVSVNGKTKKCFMGFMGTYAQFKRVLDSESFLDTHGHEQPEHAYAFLCQLLYNSM 497 Alcelaphine herpesvi... Q777D7 449 -------------KVTYNVTYVKHSSVSVNCKTKKSICGYTGTFGDFMDTLEADSFVEAHGHEQPEYVYSFLARLIYGGI 515 Epstein-Barr virus P10189 486 ------------vVARNDVTYVLNSQIAVTARLRKLVFGFSGTFRAFEAVLRDDSFVKTQGETSVEFAYRFLSRLIFSGL 553 Human alphaherpesvir... P52356 448 -----------etLITCHLKHIRNSSIGVTSKIKASTVGFSGTYEKFVELLQSDLFIEKTSCDQTIHAYSFLSGLMFGGM 516 Human herpesvirus 6 ... F5HEN8 532 dddtttapdsretLLTLRITYIKGSSVGVNSKVRACVIGYQGTVERFVDILQKDTFIERTPCEQAAYAYSLVSGLLFSAM 611 Human herpesvirus 5 ... Q01014 428 -------------KVTYLTKYVKNTYISLNGKTKKCVCGYVGTYKNFKKILESESFIDSHANDQPEFVYSFLCTILYNSL 494 Herpesvirus saimiri ... Q66647 433 -------------KVTYLVKYVKNSYVSLNGKTKKCICGFMGTFEKFKTILDNETFIDAHSHDQPEYVYSFLNTLLYNGM 499 Equid herpesvirus ty...
P09303 548 INFYNFLLNKNlHPdkvsLAYKRLAALTLEllsgtnkaPLHEAAVNgagagidcdgaatsa-------dkafcftkapes 620 Human herpesvirus 3 ... Q2HR89 505 YSFYAHGVKQG-HE----EFLRDLRELPVS--------QELISEMS---------------------------------- 537 Human herpesvirus 8 ... O36393 498 YNFYQAAVQSD-CA----SYISALNNIPIP--------EVLCAPAHs--------------------------------- 531 Alcelaphine herpesvi... Q777D7 516 YAFSHGGHSLCeNG----EYVAELGAVPLPgrt---wdPEVTAGMEl--------------------------------- 555 Epstein-Barr virus P10189 554 ISFYNFLQRPGlDAtqrtLAYARMGELTAEil----slRPKSSGVPtqasvmadagapge--------rafdfkqlgprd 621 Human alphaherpesvir... P52356 517 YSFCCSKFTTP-------EVLMEIKNIKMPsie---flESEMSRMSpdvq-----------------------------t 557 Human herpesvirus 6 ... F5HEN8 612 YYFYVSPYTTE-------EMLRELARVELPdvs---slCAAAAATAaapawsggenpinnhvdadssqggqsvpvsqrme 681 Human herpesvirus 5 ... Q01014 495 YNFHNYGVTEK-NE----SYLNDLANLKLP--------ENLTHLYTq--------------------------------- 528 Herpesvirus saimiri ... Q66647 500 YAFHKHGLDAG-DE----GYLDALRRLPIP--------PNITHLSTf--------------------------------- 533 Equid herpesvirus ty...
P09303 621 kvTASIPEDpddvi----------ftalnDEV--IDLVYCQYEFSYPKSS---NEVHAQFLLMKAIYDGRYAILAELFES 685 Human herpesvirus 3 ... Q2HR89 538 --SEDVLGQ--------------------EGD--TDAFYLTASLPPSPTHaalPTLVAYYSGAKELFCNRLALARRHFGD 593 Human herpesvirus 8 ... O36393 532 ---ELACSEpln--------------------egeDLFYHKTLPPPTARStslANIIAIYQGLKDIFIARMEAATRYQMP 588 Alcelaphine herpesvi... Q777D7 556 ---GELPLEvawd-------------gerSPA---AVFYARVLAPPAANSaplCSLLNIYNDLRAYFRQCLDVAVRYGGR 616 Epstein-Barr virus P10189 622 ggPDDFPDDdldvi----------fagldEQQ--LDVFYCHYTPGEPETT---AAVHTQFALLKRAFLGRFRILQELFGE 686 Human alphaherpesvir... P52356 558 veTDERYDFglvndgl------sdvdlleIDPc-GDPFFTRYSKLPLTNSlsfEEISLLYTTFKDIFISRFAILQKHTKG 630 Human herpesvirus 6 ... F5HEN8 682 hgQEETHDIpclsnhhddsdaitdaelmdHTSlyADPFFLKYVKPPSLALlsfEETVHMYTTFRDIFLKRYQLMQRLTGG 761 Human herpesvirus 5 ... Q01014 529 ---TDLDIErea---------------lmlED---DVFYHMVSPPPTASSaslPCLISWYTALKDIFISRLKLATTWFSN 587 Herpesvirus saimiri ... Q66647 534 ---QDALDQteaa-------------llnPES---DIFYHMTCAPPSASSaslSTLISFYMSLKSVFLQRLALAVSRFGR 594 Equid herpesvirus ty...
P09303 686 SFTTAPFSAYV-DNVNFNGSELLIGNVR--GGLLSLALQTDTYTLLGYTFAPVPVFVEELTRkklyretTEMLYALHVPL 762 Human herpesvirus 3 ... Q2HR89 594 EFLHSDFSTFT-VNIVVRDGVDFVSTSPglHGLVAYASTIDTYIIQGYTFLPVRFGRPGGQR-------LSEDLRRKMPS 665 Human herpesvirus 8 ... O36393 589 NFGYSSFNTFL-SNTIVKNNVDFVSAEPi-SGLLDYASTVESYMLQGYTFSPIYFGKLPLQSt------LSKDLRDKLPN 660 Alcelaphine herpesvi... Q777D7 617 EFRDLPFCTFT-NNMLIRDNIEFTSDEPllHGLLDYASTTENYTLLGYTHLNVFFGIRGKQQ-------PQDAGSSRMPR 688 Epstein-Barr virus P10189 687 AFEVAPFSTYV-DNVIFRGCEMLTGSPR--GGLMSVALQTDNYTLMGYTYARVFAFADELRRrhatanvAELLEEAPLPY 763 Human alphaherpesvir... P52356 631 KFGKTLLVTYNrNNVSRKQCGEIYSHLKsfYGMLTYAIPANNYTLEGYTNDNVVHLGTDKQl-------PQILYKKGLPR 703 Human herpesvirus 6 ... F5HEN8 762 RFATLPLVTYNrRNVVFKANCQISSQTGsfVGMLSHVSPAQTYTLEGYTSDNVLSLPSDRHRi------HPEVVQRGLSR 835 Human herpesvirus 5 ... Q01014 588 KFLDREFTSFT-INMLVRDNIEFTSTNGrlHGLLEYASTVESYKLQGYTFLPVNFGRSQTTV-------ISKDLQDKMPS 659 Herpesvirus saimiri ... Q66647 595 DFAERTFQTFT-INMMIQNGVDFTSASErlFGLLGYASNVDTYKLKGYTFIPVGFGRFNQAE-------LSRDLRDKMPV 666 Equid herpesvirus ty...
P09303 763 MVLQDQHGFVSIVNANVCEFTESIED-AELAMATTVDYGLSSKLAMTIARSQGLSLEKVAICFTAD--KLRLNSVYVAMS 839 Human herpesvirus 3 ... Q2HR89 666 IVVQDSSGFIACLENNVTKMTETLEGgDVFNICCAGDYGISSNLAMTIVKAQGVSLSRVAISFGNHr-NIRASLVYVGVS 744 Human herpesvirus 8 ... O36393 661 LVVRDADGFICCLDNNLTKMTENLESgAQIHMCSVGDYGISSKLAMTIAKAQGLSLDKVAVCFGNHq-KIKRSHVYVALS 739 Alcelaphine herpesvi... Q777D7 689 LMVKDEAGFVCCLEHNTNKLYETIED-KSLNLCSIRDYGISSKLAMTIAKAQGLSLNKVAICFGSHr-NIKPGHVYVALS 766 Epstein-Barr virus P10189 764 VVLRDQHGFMSVVNTNISEFVESIDS-TELAMAINADYGISSKLAMTITRSQGLSLDKVAICFTPG--NLRLNSAYVAMS 840 Human alphaherpesvir... P52356 704 LVIKDEMGFISVLDNNVSKFIDVVNG-QSFHLCTTVDYATVSKVSMTITKSQGLSIQKVAIDFGSDpkNLKLSSIYVGMS 782 Human herpesvirus 6 ... F5HEN8 836 LVLRDALGFLFVLDVNVSRFVESAQG-KSLHVCTTVDYGLTSRTAMTIAKSQGLSLEKVAVDFGDHpkNLKMSHIYVAMS 914 Human herpesvirus 5 ... Q01014 660 IVVQDSSGFIACLEKNVNKMLETLDDgKSFHLCSAGDYGISSKLAMTIVKAQGTSLDKVAICFSNHk-KIKVSHIYVAIS 738 Herpesvirus saimiri ... Q66647 667 VVVEDPHGFIACLENNVNKMTEVMENgDLIHICTAGDYGISSKLAMTIAKAQGMSLSRVAVCFGNSk-FVRKSHVYVAIS 745 Equid herpesvirus ty...
P09303 840 RTVSSRFLKMNLNPLRERYE--KSAEISDHILAALRDPNVHVVY 881 Human herpesvirus 3 strain Dumas Q2HR89 745 RAIDARYLVMDSNPLKLMDRgdAQSPSSKYIIKALCNPKTTLIY 788 Human herpesvirus 8 strain GK18 O36393 740 RATDANNLVIDSNPLSNRECemDICKSSKHIVAALCNPQTLLIY 783 Alcelaphine herpesvirus 1 strain C500 Q777D7 767 RARHSNCVVMDRNPLSEMITg-EGNPASGYIVDALKNSRALLVY 809 Epstein-Barr virus P10189 841 RTTSSEFLRMNLNPLRERHE--RDDVISEHILSALRDPNVVIVY 882 Human alphaherpesvirus 1 strain 17 P52356 783 RVTDPNNLIMNVNPLRLNYE--NDNFIAPHIVKALKNENTMLIF 824 Human herpesvirus 6 (strain Uganda-1102) F5HEN8 915 RVTDPEHLMMNVNPLRLPYE--KNTAITPYICRALKDKRTTLIF 956 Human herpesvirus 5 strain Merlin Q01014 739 RATNPNHIVMDCNPLKLLVNdtQS-ISSQHIIKALNNPNTLLVY 781 Herpesvirus saimiri (strain 11) Q66647 746 RATDPRHMVIDCNPLKNLEEdrEDNKTSKYIVQALNNPDTILVY 789 Equid herpesvirus type 2 strain 86/87
Jiyao W et al.(2023). "The conserved domain database in 2023.",