6PPB


Conserved Protein Domain Family
Herpes_UL17
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pfam04559: Herpes_UL17 (this model, PSSM-Id:398316 is obsolete and has been replaced by 461354)
Herpesvirus UL17 protein
UL17 protein is required for DNA cleavage and packaging in herpes viruses. It has been shown to associate with immature B-type capsids, and is required for the the localization of capsids and capsid proteins to the intranuclear sites where viral DNA is cleaved and packaged. In the virion, UL17 is a component of the tegument, which is a protein layer surrounding the viral capsid.
Links
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Statistics
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PSSM-Id: 398316
Aligned: 37 rows
Threshold Bit Score: 246.569
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6PPB_KK    1 MDAHAINERYV------GPRCHRLAHVVLPRTFLLHHAIPLEPEIIFSTYTRFSRSPGSSR------------------- 55 
Q18LD4     1 MEIHLFNEIGK------VTDGPFMVHVALSTYRFDLGQIDM---LFIRSVFLHNKHISC--------------------- 50  Elephantid herpesvi...
Q9QJ20     1 METHLYYDTLYq-----YQGGVYPAHICLPTDAYLPMRVDCIESLYFRCVFFKNGMHYTE-------------------- 55  Human herpesvirus 6...
AUI40782   1 METHLFSDLAFeq--vfEEDPQLPLHVVLDPVDLSFAEAETVRYVYYRSDPDPVGR------------------------ 54  Rhesus cytomegalovirus
P16799     1 METHLYSDLAFea--rfADDEQLPLHLVLDQEVLSNEEAETLRYVYYRNVDSAGRSTGRAPggdeddapasddaedavgg 78  Human herpesvirus 5...
Q8QS07     1 METHLYSDLAFea--rfAADWQLPLHLVLDHSALSCEEAETLRYVYYRNAVRPAPPPQSTEqggpeq------------- 65  Chimpanzee cytomega...
Q997C6     1 METHLCSELNRda---tGDRERLPVHLFLTERTLPYAVFRGLRALHVRVAGAADAE------------------------ 53  Tupaiid betaherpesv...
CAJ86575   1 METHLRFEQAAse---dDRDRLVPVHVVFAEDALSYREFEGLHTLCFKIISRPDAR------------------------ 53  Murine cytomegalovi...
Q9DWA9     1 METHLRFEPDDgdrgspAAARLVPVHVVFNQDTLSYGDFRALSSVTYRVVSPEGAGP----------------------- 57  Rat cytomegalovirus...
Q9WI09     1 MDVHINNWRFL------SHRCDLLVHVVLPTQLLEKFNIGMFDNVVFYVKTRFHDGKMPTP------------------- 55  Bovine gammaherpesv...

6PPB_KK   56 ----------RLVV-CGKRV-LPGEENQLAsSP------------------------SGLALSLPLFShd---gNFHPFD 96 
Q18LD4    51 ----------WIRIpFNIRN-VDVDLHRYFsfkpkrkn-----------ertiilarPVVFFSLPLLSpgidnnKLAVEA 108 Elephantid herpesvi...
Q9QJ20    56 ----------WSKLkFTVIS-REIKFKDVLkNAdfde-----------------lftGLVVMTIPIPIvdfhfdI----D 103 Human herpesvirus 6...
AUI40782  55 ----------WRRAtFRVFL-RPFELLTYLrDAgltvapt-----------frvvchHALFTTLGIRCae---qrLSGAQ 109 Rhesus cytomegalovirus
P16799    79 drafdrerrtWQRAcFRVLP-RPLELLDYLrQSgltvtlek---------eqrvrmfYAVFTTLGLRCpd---nrLSGAQ 145 Human herpesvirus 5...
Q8QS07    66 -----daaedWQRAaFRVLP-RPLELLAYLrDSgltvtlpa--------ddpgvrmyYAVFTTLGLRCpd---krISGSQ 128 Chimpanzee cytomega...
Q997C6    54 ----------WRRLaYQTWP-RELLLARLVpnrlrgd--------------ervraaYGLATTVWLDCpg---rvVVPTR 105 Tupaiid betaherpesv...
CAJ86575  54 ----------WEHIpYFERLdREFVLKSLFhDKcrhlsaspgdgpwtlhgggdencrYGLAFSVVLHLrd---veWWK-D 119 Murine cytomegalovi...
Q9DWA9    58 ----------WRRVpYVQRVdRDFSVGSLFrRErarlsadpgpgvpafygderercnFGLVFTALVRVre---gaWWH-D 123 Rat cytomegalovirus...
Q9WI09    56 ----------YLKV-WGLFF-NHSYDFPNIdS--------------------------GLALSLPIFVer---dmYNPLN 94  Bovine gammaherpesv...

6PPB_KK   97 ISVLRISC---------------------PGS------NlSLTVRFLYLSLVVAM------------------------G 125
Q18LD4   109 MCICRFVN---------------------TNGa-----E-FFDLEFMYEDILRE-------------------------- 135 Elephantid herpesvi...
Q9QJ20   104 SVILKLVY---------------------PQL------V-HREIVLRLYDLIC--------------------------- 128 Human herpesvirus 6...
AUI40782 110 MLYLRLVW---------------------NEE------R-FRDWEFLVRDLLREEmsvcqstep---------------- 145 Rhesus cytomegalovirus
P16799   146 TLHLRLVW---------------------PDG------S-YRDWEFLARDLLREEmeankrdrqhqlatttnhrrrgglR 197 Human herpesvirus 5...
Q8QS07   129 MLYLRLMW---------------------DQG------R-QRDWEFLARDLLREEieanridrhqrelaearavnnrrlT 180 Chimpanzee cytomega...
Q997C6   106 LVRLRFAYrsardsptvrgageappapavADRdrdpvdR-SFVLDFWVKDLLAARepmypasddgdevdrpaaaghggaT 184 Tupaiid betaherpesv...
CAJ86575 120 VIKFRLFI---------------------GDD------E-TVDIDCTFVRLLREGlrffgevrrtrqprsgprsassrlL 171 Murine cytomegalovi...
Q9DWA9   124 LLRIRLLV---------------------RDE------E-VVEIDCTLARLLWEGfrffervrrnrpaavggrpggrggG 175 Rat cytomegalovirus...
Q9WI09    95 MVWLKVYY---------------------PVSk-----Q-TKFLSFFYMQLVQGQregal-------------------- 127 Bovine gammaherpesv...

6PPB_KK  126 AGRNNAR--------------------------------SPTVDGVSPPEGAVA--HPLEELQRLARATPDPAPTRgpLQ 171
Q18LD4   136 ---------------------------------------FPDVGDECIKEDDHV--DDFFTLGAC-------------SS 161 Elephantid herpesvi...
Q9QJ20   129 ---------------------------------------IRPSSDRPSEVSAKNigIDFYQLTSQ-------------GN 156 Human herpesvirus 6...
AUI40782 146 ------------------------------adrpdpsllMTDAMLELAKSSSTT--APFFEMPSSGTGNNNASSAS--AA 191 Rhesus cytomegalovirus
P16799   198 NNLDNGSd------------------------------rRLPEAAVASLETAVS--TPFFEIPNGAGTSSAN------GD 239 Human herpesvirus 5...
Q8QS07   181 SGTARPLlssattssapshpllgsepafgrsdspamaaaAAAAAELPPLESAAG--TPFFQIPRAPAGADGGSG----QS 254 Chimpanzee cytomega...
Q997C6   185 ATT------------------------------------APDAVTAAAAAAAVAdgGGLARFFHIDG-----------DR 217 Tupaiid betaherpesv...
CAJ86575 172 HHHPHHHragaagd------------------ddgdvddDEGLPEGLLGAAADG--PGFFDLGD--------------NR 217 Murine cytomegalovi...
Q9DWA9   176 AAIAAEAeaea-------------------------grdEEELPEDVAAQCGLD----FFELDD--------------RR 212 Rat cytomegalovirus...
Q9WI09   128 ----------------------------------rvqkkDNSTKNILPPISSCPftQIYNSILESHTGIITAKNT---VD 170 Bovine gammaherpesv...

6PPB_KK  172 VLTGLLR----------AGSDGDRATHHMALEAPGTVRGESLDPPVSQKGPARTRHRPPPVRLSFNPVNADV-----PAT 236
Q18LD4   162 ATVGTVQnstgqdhrspVNDNNEHTVTPGPLEPPSVVRGVD------SNSGNGLNNMTPGKCNGYPTGKHVWk----AID 231 Elephantid herpesvi...
Q9QJ20   157 KQTPDEEkr-------------cLFFQQGPLEPPSTVRGLK----AAGNAKPMQFPAHVNEKMTESFLSDSWfe--qKVR 217 Human herpesvirus 6...
AUI40782 192 DESSQVErrv----iqfLRGDSELTYHAGPLEPPSKIRGHEIV-QPRIEVNPDVIYASGPHEDDRTSKTDEWqk-ggVLR 265 Rhesus cytomegalovirus
P16799   240 GRFSNLEqrv----arlLRGDEEFIYHAGPLEPPSKIRGHELV-QLRLDVNPDLMYATDPHDRDEVARTDEWkg-agVSR 313 Human herpesvirus 5...
Q8QS07   255 GGPSDLElrv----arlLRGDPEFTYHAGPLEPPSRIRGRELV-QTRVDINPDLMYATSAQEPVEVSRTDEWkg-agVSR 328 Chimpanzee cytomega...
Q997C6   218 KLSPSLKeyl----drfAGVRDGEAAAPGPLERPSWVRGRPSTALLAARRLEFLDAGDEKAVG-SASRTARWfrvdnDLR 292 Tupaiid betaherpesv...
CAJ86575 218 KMSEEMEdrl-----arFALKRVSAADFGPLEPPSKVRGRE---IKARRGEFFRDGDAPAAPDPVRSRSDRWfgcdnAIR 289 Murine cytomegalovi...
Q9DWA9   213 RMSEDMErrl-----arFAKKRVSAVDFGPLEPPSKVRGRE---IVNPRGEFFSDGEAVEVPPPVRSRTDRWfgsdnAVC 284 Rat cytomegalovirus...
Q9WI09   171 VLHDMLEtr-----------pERQIKHHLALETPGKVRGTVK--VEPREAAPSNPCTGELVKLQVSFRETSKq----ITH 233 Bovine gammaherpesv...

6PPB_KK  237 WRDATNVYSGA-PYYVCVYE----RGGRQED------DWLPIPLSFPEEPVPPPPSLVFMDDLFINTKQCDFVDTLEAAC 305
Q18LD4   232 IYRLQPLHTPSdNVYRVLYDkssfLKPRISQpp---yDGLASCFF-----------LRHEVYRFMRVIGTEIIDKFFDVM 297 Elephantid herpesvi...
Q9QJ20   218 CKKILDFTQTY-RVVVCWYElsfsREMQIEN------NLLSASQLKrvn----aadFWDRTDRYLRDIGSRVLTHIVKTL 286 Human herpesvirus 6...
AUI40782 266 LGSVWDVRQRL-RLHVLWYAqsfwRSRGLKYed--reEDLRLTLD-----------SYFDRLSVEYQLLREVYREIKAVL 331 Rhesus cytomegalovirus
P16799   314 LREVWDVQHRV-RLRVLWYVnsfwRSRELSYdd--heVELYRALD-----------AYRARIAVEYVLIRAVRDEIYAVL 379 Human herpesvirus 5...
Q8QS07   329 RREVWDVQRRV-RFHVLWYVnsfwRTCGLTYdd--neADLYRALD-----------AYRSRIAVEYVLIRAVRDEIRLVL 394 Chimpanzee cytomega...
Q997C6   293 PVPVQDAERRR-DGYVFWYResccAPWTLTTapddaaAAAARESFEr---------GLEAWPRCLLAVCEEVAERLALAL 362 Tupaiid betaherpesv...
CAJ86575 290 ISYAQEVTGSR-RFAVIWYSesigSTVDVDVgraddgEAAVTSFE-----------HTRRWETAVTRVYGATSRQLAAAV 357 Murine cytomegalovi...
Q9DWA9   285 VSRVQGVLGPR-SFLVVWYSesagADVEGESdglddgPAVVLCFQ-----------HVRRWDLTLTRVYNAAAAGLGEAV 352 Rat cytomegalovirus...
Q9WI09   234 IARVKHIISGL-QYYVCFYDslisGDFFTFQsv---lDILPQ----KDLAAIDPLAIILSDRQFLQTKQDGFINSLELKC 305 Bovine gammaherpesv...

6PPB_KK  306 RTQ-GYTLRQRVPVAIPRDAEIADAVKSHFLEACLVLRGLASEASAWIRAATSPPLGRHACWMD---------------- 368
Q18LD4   298 NSEdG-ILFQKFLCHV-PMNALDISIPEMVYLSQNVWTSHVDPRSCIIKGVVAHLFKNPRRp------------------ 357 Elephantid herpesvi...
Q9QJ20   287 QIHnR-QFKQKFNCNF-PVNFSFEHLLSFMQLGKDFWILNLTLDSCIIKAIICFLGFRNGR------------------- 345 Human herpesvirus 6...
AUI40782 332 RSDr--MVAQKFSCHL-SIETSWLLIWELFDRALELWRDQADVNSCIIKALAHKLRSKAQSshg---------------- 392 Rhesus cytomegalovirus
P16799   380 RRDgG-ALPQRFACHV-SRNMSWRVVWELCRHALALWMDWADVRSCIIKALTPRLSRGAAA-AAqrarrqrersapkpqe 456 Human herpesvirus 5...
Q8QS07   395 QHRr--ALRQLFACHV-VRKMSWIHVWELFRHALELWIDRADERSCIIKALTPRLGRPARA--Ptperldrdasa-lkpy 468 Chimpanzee cytomega...
Q997C6   363 RSGp--ELRQTLACHL-AADGDYRALPDLLVLSRNVWLIRMDEDSCIIKALVEYVAQTDRSt------------------ 421 Tupaiid betaherpesv...
CAJ86575 358 TRVg--GLAQRFYVNL-YAGLRAGDLVELLLLSRDAWLVNGTGGGCIIKALSSDLHRRRRS------------------- 415 Murine cytomegalovi...
Q9DWA9   353 RRGg--ALAQRFRVDL-CSDLRGRDLAELLGLSRDVWLVNATGDGCIIKALSHDLRPRRRD------------------- 410 Rat cytomegalovirus...
Q9WI09   306 IKQ-GFTVHQKLPILIEKDDECVELIQDHFTEACFVIRQIINPESAWIQCAISTFHGKGGCWMD---------------- 368 Bovine gammaherpesv...

6PPB_KK  369 ------VLGLWESRPHTlGLELR-GVNCG---GTDGDWL-------------EILKQPDVQKTVSGSLVA-------CVI 418
Q18LD4   358 ------CFVGSLTENEYwVDVID-IRQNRiyyGQKIKLA---------------VDQETNLLTCNDKSRRyeqraglSVL 415 Elephantid herpesvi...
Q9QJ20   346 --------KSFLAQDEVwGDLID-CSKGSviyGEKIQWI-------------LDSTNNLYSTRREKQNKSwelyvdcCAL 403 Human herpesvirus 6...
AUI40782 393 ---nsvSAGKTNPSETWyADVVR-CVRAEvnlGVEVHVEt------------CSQSGLWLVRGRDGHLRKwitqpqtYVL 456 Rhesus cytomegalovirus
P16799   457 llfgprNESGPPAEQTWyADVVR-CVRAQvdlGVEVRAAr------------CPRTGLWIVRDRRGRLRRwlsqpevCVL 523 Human herpesvirus 5...
Q8QS07   469 pwlagrGSLPEEPERVWyADVVR-CVRAQvdlGVEVRVRr------------CRRTGLWVARDRRGQLRRwpsqaevCVL 535 Chimpanzee cytomega...
Q997C6   422 -----rYCGRSDPRTEYwADVID-YSRCRvssGLSLRRLagpdgrsaseadaDGDAPLLRLAHLDGRPAEwsadpslCVL 495 Tupaiid betaherpesv...
CAJ86575 416 -------GDLVDGCRVGwADVIW-YAQARvasGIPIKLMr------------VGGDGLWRSFLDSGKLTDwelntdvCVL 475 Murine cytomegalovi...
Q9DWA9   411 --------YERSDGLLGwADVIR-YSSGKvdgGLAVRLVp------------AGPSGLWRSVYDDGEPTGwetdpraCVL 469 Rat cytomegalovirus...
Q9WI09   369 ------TVKLWECGSHDlGQDIShLIKPGigeQGMWEIL--------------LRDPKFKTVVCKSSHv--------CLV 420 Bovine gammaherpesv...

6PPB_KK  419 V-TPALEAWLVLPGGFAIKGRYRA 441
Q18LD4   416 YiNTDLCCIWSFTGGFAVEFRLTL 439 Elephantid herpesvirus 1 (isolate Kiba)
Q9QJ20   404 YvSEKLELDFVLPGGFAITGKFAL 427 Human herpesvirus 6 strain Z29
AUI40782 457 YaTPGLVFHWVLPGGFAISSRVCL 480 Rhesus cytomegalovirus
P16799   524 YvTPDLDFYWVLPGGFAVSSRVTL 547 Human herpesvirus 5 strain AD169
Q8QS07   536 YvTPELHFHWVLPGGFAVSSRLCL 559 Chimpanzee cytomegalovirus
Q997C6   496 YvDRALNVSWALPGGFALTWRLCP 519 Tupaiid betaherpesvirus 1
CAJ86575 476 YaFEDRSLFWVLPGGFCATFQLQV 499 Murine cytomegalovirus (strain K181)
Q9DWA9   470 YaLIDGTLVWALPGGFSAVFALAV 493 Rat cytomegalovirus Maastricht
Q9WI09   421 I-KSLIEAWLILPGGFAIKGSYFI 443 Bovine gammaherpesvirus 4
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