4FMW


Conserved Protein Domain Family
Trm10euk_A
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cd18101: Trm10euk_A 
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eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A
Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A (TM10A) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349974
Aligned: 24 rows
Threshold Bit Score: 252.908
Created: 29-Aug-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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SAM binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:4FMW; Homo sapiens TRM10 with bound SAM, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4FMW_A        21 LRLIIDCSFDhlXVLKDIKKLHKQIQRCYAENRRalhPVQFYLTshggqlkknxdendkgwvNWKDIHIKPehyse---- 96  human
ERG83862     133 QRIAIDLSYEklMNEKQILGTITQLSFCYAANRRaanPTQLAFAnfgqsirtl-flsnksrtNWDVILEERplyea---- 207 pig roundworm
BAN21172     106 IRVALDFSFDhlMKEKDLHKCINQFNHCYSINRKcenPLQFYVTnfngkakel-mskhngyrNWDVNIHEEsylgl---- 180 Riptortus pedes...
XP_015784266  93 VNIAIDLSFNsmMNEKELRKLMKQIQRCYSLNRRsdaPCQLYLTslkdeiakglmskqpgfdYWDIHRKEEhfldafk-- 170 two-spotted spi...
CEF64261      93 IRVAIDMSFDeyMSDVNIKATVNQLQFCYGYNRRaenPMQLYIVglngrgnee-flkqsdnnSWDVHTTSKtltem---- 167 Strongyloides r...
EFX83275      58 VAIVVDLSFDtfMDEKSIAKCVKQICRCYSINRRaanPVQYHITsldgaslte-msknsgyqNWDVNLHGKhftdl---- 132 common water flea
KPM10486       8 ANIIIDCDYQnyMNEDELKKLCNQLNRCYSLNRHsdaPVNLYFTsikgklqnfmkslhpgyaRWDVFLSEKhwse----- 82  Sarcoptes scabiei
NP_501789     87 QRIALDMSFDdlMIEKDQKRTVQQIGWCYTANRHspdPFQFHVVgfdgpsrk---iydgnehNLNQDIHLHqeklen--- 160 Caenorhabditis ...
KFM72672      82 LKICFDLSLAdvMTAPEFSKTFKQLHRCYSINRRakaPLQLYVTgftdstket-mskmsgcfNWDVNFSRElyskv---- 156 Stegodyphus mim...
XP_017489452 106 VALVIDCDFAeyMTEMELKKLCKQINRCYAVNKRstkPVQLFFTsvtgevrkmmdryqtgykSWDAVVTERhweevfnfq 185 snowberry fruit...

Feature 1                                     ###                      ## # #                    
4FMW_A        97 --------------------likkeDLIYLTSDSPNILKELd------eSKAYVIGGLVDHNhHKGLTYKQASdyg-inH 149 human
ERG83862     208 ---------------------ykreEIVYLTADSDNVLETLd------aSKVYVIGGLLDHNsLKGLCLDVAVkek-vaH 259 pig roundworm
BAN21172     181 ---------------------fnkdELIYLTSDSDNVVTTLe------eSKVYIIGALVDHNsQKGLTLKIAKeqn-igH 232 Riptortus pedes...
XP_015784266 171 -------------------dfkekgTLIFLSSDSPNLLPDVaeiqkrggDYAYIIGGLVDHNvHKGLTLGLAQksg-iqT 230 two-spotted spi...
CEF64261     168 ---------------------fskdELVYLTADSENDLDDIe------dDKVYVIGGLLDHNsCPKLTLELAKkng-irH 219 Strongyloides r...
EFX83275     133 ---------------------fskeKIVYLTAESDHLIDKIe------dDHVYIIGGLVDHNsHKGLCHRLAVekg-lrH 184 common water flea
KPM10486      83 ---------------------ifssKIIYLTGDSSNILPDCkei--qdsNDIFVIGGLIDHNrHKGLSLKRAIeeykvqH 139 Sarcoptes scabiei
NP_501789    161 --------------------lfkpeEIVYLTSESENVLSDLd------dTKVYVIGGIVDHNsQKGLCYRIAQekg-fgH 213 Caenorhabditis ...
KFM72672     157 ---------------------fpkeDIVYLTSDSPNVLDELd------yNKAYIIGALVDHNrLKNICYERAEkeg-vgH 208 Stegodyphus mim...
XP_017489452 186 akaangpeeakveskaestenpskrRIVYLTGDSPNSLEDCaalq-aanEGVFIIGGLIDHNrHKGLTLERATtlvgleH 264 snowberry fruit...

Feature 1         ## #          ## #  #                              
4FMW_A       150 AQLPLGnfvkxnsRKVLAVNHVFEIILEYLet-----rDWQEAFFTILPQRK 196 human
ERG83862     260 ARLPIDdyvkmrtRKVLTINQVFEILLRYTet-----hSWKDAFFHVIPKRR 306 pig roundworm
BAN21172     233 ARLPIDefiemktRRVLTIDHVFGIIVNVAcc----gmCWRESFLKVIPQRK 280 Riptortus pedestris
XP_015784266 231 ARLPIDqcmelcvSKVLAVNHVFEIMLNATng-----iAWSQSFMNVIPARK 277 two-spotted spider mite
CEF64261     220 AKLPIGnymrlktRSVLTINQVYDIILKYTet-----kSWEDAFFKVIPIRK 266 Strongyloides ratti
EFX83275     185 GRLPIGenidmktRKVLTIDHVFNIMVNVCng-----qKWKEALLEVLPARK 231 common water flea
KPM10486     140 SRLPLDlhikltqSRILSIPHVFEIMLNAVnks---mdDWSMIFKKVIPIRK 188 Sarcoptes scabiei
NP_501789    214 AKLPLDehllmksRRVLTINQVYEILVHYSvh-----kNWKDALLSIIPERK 260 Caenorhabditis elegans
KFM72672     209 ARLPLDihfkfktRKVLTIDQVYLIFLRLTeg-----kSWIDAILETVPKRK 255 Stegodyphus mimosarum
XP_017489452 265 ARLPIGeyismkqHLILAIPHVFEIMLYAAngtlgdgvGWAEIFHRVIPQRK 316 snowberry fruit fly

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