1Z5V,3CB2


Conserved Protein Domain Family
gamma_tubulin

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cd02188: gamma_tubulin 
Click on image for an interactive view with Cn3D
The gamma-tubulin family
Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.
Statistics
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PSSM-Id: 276957
Aligned: 69 rows
Threshold Bit Score: 441.981
Created: 5-Feb-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
nucleotideoligomer
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:1Z5V; Human gamma tubulin with bound GTP; defined by using 4.0 A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ###  #                                                                  
1Z5V_A      3 REIITLQLGQCGNQIGFEFWKQLCAEHGISPEAiveef-----------------------------ategtDRKDVFFY 53  human
AFP65465    3 RETYTIQIGRCGIHSGHELWKQLCSEHKLNPEGksyknq----------------------------kkfsnENKDIFFK 54  Chroomonas mesosti...
ABW97925    3 KEIFTIQLGKCGIQTGHEFWKIISGEHFINPEGkiffkk----------------------------kknliENKEIFFS 54  Hemiselmis andersenii
AEA38970    3 REHYTIQIGKFGLQVGHEYWKEIFSELNSNFKRsh------------------------------------cQDKFSFFK 46  Cryptomonas parame...
O93807      3 GETITLQVGQCGNQVGLQYWQQLATEHGIQSDGsstpypkdindlqlqelnnsgsspqsypqqtkpngkyrnDHPELFFT 82  Candida albicans
CCH61254    3 GEYITIQIGQCGNKVGQQFWSQLLIEHGLANDGsvqfd------------------------------kdlyDHKRPFFK 52  Tetrapisispora bla...
CDR37884   10 TLLHPYLPRQCGNQVGQKFWSQLCKEHAIGADGlstat------------------------------ekrtDEPSVFFN 59  Cyberlindnera fabi...
CDK26334    3 GEILTIQAGQCGNQVGEEFWGQLLKEHGLDNSGqkiqs-----------------------------nvkseDKTRPFFL 53  Kuraishia capsulat...
P53378      3 GEIITLQAGQCGNHVGKFLWSQLAKEHAIGTDGlsqlpd---------------------------ssterdDDTKPFFR 55  Saccharomyces cere...
KCV72127    3 KEIVSIQLGQCGNQVGLSYWSALCREHGLSPDGvvqstp---------------------------lgqhtsDMKDIFFS 55  Fonticula alba
Feature 1                                                     #                               
1Z5V_A     54 QADDEHYIPRAVLLDLEPRVIHSilnspyaklyNPENIYLSehggGAGNNWASGFSQGEKi------------HEDIFDI 121 human
AFP65465   55 ETSNGKFLPRALLFDLEPRVLHNlnrsaykslyDKKNIIFSt--qSAGNNWAKGYYQSIDy------------QVQLEEN 120 Chroomonas mesosti...
ABW97925   55 ETSKGTFLPRTFLFDLEPRILFGiingnyqnfyEKKNILFSk--qSAGNNWAIGYYKSIEf------------QSEIEEI 120 Hemiselmis andersenii
AEA38970   47 ESSCGKIVPRAILFDLEPRTLNKlqnstfskfyPSLNIVSDn--rSTGGNWANGYIGADKn------------KENIENV 112 Cryptomonas parame...
O93807     83 LSDSNTYTPRSILIDMEPSVIAKstsa--lpmfNPRNVHLSnqgnGAANNWINGYKYGTEe------------EETLLNL 148 Candida albicans
CCH61254   53 DHQNNNYTPRAILLDTEPSVIQNiknsy-hdlfNDRNIWVSpgetGAGNSWAKGYTLGESy------------IDDFFNI 119 Tetrapisispora bla...
CDR37884   60 THDEKRYTPRAILVDMEPGVINDirntt-dhlfNDRNIHVSseglGAGNIWSKGYDYAESe------------KEAFIDI 126 Cyberlindnera fabi...
CDK26334   54 EVGSDRYTPRAILLDLEPRVIGSiqtkf-pdlfDPRLTYMDaafgGAGNNWARGFNYGKQh------------EEDLLEI 120 Kuraishia capsulat...
P53378     56 ENSRNKFTPRAIMMDSEPSVIADventf-rgffDPRNTWVAsdgaSAGNSWANGYDIGTRn------------QDDILNK 122 Saccharomyces cere...
KCV72127   56 QVSDHKWVPRLVMADLEPRVIDQvlvgphadlfRRDRVFKGsdggGAGNVWTKGYWESATsgagtdapsdlafEFLLGDM 135 Fonticula alba
Feature 1                       # #####                         # #                           
1Z5V_A    122 IDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYp-KKLVQTYSVFPNQdem-sdVVVQPYNSLLTLKRLTQNA 199 human
AFP65465  121 FRKNSEKCENLGIFNIIHSISGGTGAGAGSLVIEILRDEFp-GKFINCYSIVPSQmea-seTVVQPYNSILSYRWLTLYA 198 Chroomonas mesosti...
ABW97925  121 LRKNLENCDNLGCFNIFHSIAGGTGSGTGSYLMEIIREEFs-KKIINCYSIIPNRiga-sdTVIQPYNSILSFRWLTLFA 198 Hemiselmis andersenii
AEA38970  113 IRKNIEESDQMPFFDIFHSLEGGTGSGSGSYILEMIKDEFl-GKFVTSYPLIPNQkki-snTVIQPYNSILSIRWLTLYA 190 Cryptomonas parame...
O93807    149 IDREVDKCDNLSNFQLFHSVAGGTGSGVGSKMLEVISDRYghKKLLNTFSIFPSNedt-sdVVVQPYNTILTLKRLIDYS 227 Candida albicans
CCH61254  120 IDREVEDTNNLEGFQIIHSIAGGTGSGIGSLLLEKLQERYp-SKLIITYSVFPAKta---eVVVQPYNSILTLRRLAEYS 195 Tetrapisispora bla...
CDR37884  127 IDHELDSCDNLEAFQMLHSVAGGTGSGVGSLFLEVLSDRYn-KKLVTTCSVFPESgqs-sdVVVQPYNTMLTLRRLIEQS 204 Cyberlindnera fabi...
CDK26334  121 VDRSLDQCDSPEGFQLVHSVAGGTGSGMGSFMLELLSDRYp-KLFAKSYSVFPDMgnfaseVVVQPYNTLLTLRRLVENC 199 Kuraishia capsulat...
P53378    123 IDKEIDSTDNFEGFQLLHSVAGGTGSGLGSNLLEALCDRYp-KKILTTYSVFPARss---eVVVQSYNTILALRRLIEDS 198 Saccharomyces cere...
KCV72127  136 INREAEACDRLEGFMLTHSIGGGTGAGVGSRTLEWLVDNFp-SKHIQTSSIFPQIrgs-sdVVLAPYNVLLSLRRLAECA 213 Fonticula alba
Feature 1            #                        #  ##                                           
1Z5V_A    200 DCLVVLDNTALNRIATDRLhiq-------npSFSQINQLVSTIMSASTTTLRYPgym---------nnDLIGLIASLIPT 263 human
AFP65465  199 DCVTFFDNSSLEKIISSDTeig-------niNFKHINFLISKIINSSTENIRFPins---------nqSLESSLMSIIPM 262 Chroomonas mesosti...
ABW97925  199 DCVTFFENSALEKIISSLNpni-------kpDSKEINYLISKIISISSENIRFSenf---------knSWENQFSSLIPT 262 Hemiselmis andersenii
AEA38970  191 DSVVFFENSSIEKIISSHNknv-------klHMYQINSLIAKIITTIKMSEIYPels---------knNIETLFNTLTPV 254 Cryptomonas parame...
O93807    228 DATFVFHNDSLNRIENILFnnnsniqhddndLFLGANKLIALVSASVSNPLRFPgym---------ysSMESIVSNLIPT 298 Candida albicans
CCH61254  196 NAAIVFDNDSLSHITNQVFttm-------enGYTQSNQLISATMSSITNSVRFPsym---------ysSLTSIFSTLIPT 259 Tetrapisispora bla...
CDR37884  205 DANMVFENSALLNNAIRSFqns-------spTTHQSNELIATCLSASTNTLRYPgym---------hnSLTSILSTLVLT 268 Cyberlindnera fabi...
CDK26334  200 DVVIPFDNAALSQVASQSLnvs-------spSYSDTNKLISTVMASITNSIRFPtsf---------gtSLQGIFAPLIPS 263 Kuraishia capsulat...
P53378    199 DATVVFDNASLLNISGKVFrnp-------niDLQHTNQLISTIISSVTNSIRFPsym---------ysSMSSIYSTLIPS 262 Saccharomyces cere...
KCV72127  214 DAVFVFDNSAFANSSHFRQsqlag--lapkeSFGVNNRFIARALALATAPMRLPstpggpgsasggsaGLGGIIASLVPD 291 Fonticula alba
Feature 1                                                                                     
1Z5V_A    264 PRLHFLMTGYTPlttdqs----------------------------vasvrKTTVLDVMRRLLQPKNVMVStgrdrqtnh 315 human
AFP65465  263 PNLHFISAGISNwaffq-----------------------------kkkstILTKIDSVKSFFDNNSVSCPfd-----eg 308 Chroomonas mesosti...
ABW97925  263 PKLHFFSAGISNlkff-------------------------------nkkkKNSPMDLLHQVFDNKTTSFSfs-----eg 306 Hemiselmis andersenii
AEA38970  255 NGLHFFTAAVSNfstk--------------------------------gkkDPLLTDQRGSSFSISNCTIPisf---edg 299 Cryptomonas parame...
O93807    299 PDLKFLTSSIAPfs-----------------------------------tqKHNYLNEYDMLLELSNDRYKtnrv-ggdt 342 Candida albicans
CCH61254  260 PDLNFLVPSISPftsdyitnnysn----------------nnsnsllrntkSLNVSDILLDLTDPVNSLIThsnksssri 323 Tetrapisispora bla...
CDR37884  269 PDLHFLIPSYTPytsdflt--------------------------npkpvrKSSAYDVILELLDRRIRMVDtnd---thn 319 Cyberlindnera fabi...
CDK26334  264 PELSFIIPSFTPytsnyvs--------------------------fakkqrRSTGYDVILDLVNKKNRLVTpsd---ehd 314 Kuraishia capsulat...
P53378    263 PELHFLSPSFTPftsdyih--------------------------ddiahkGHSSYDVMLDLLDPSNSLVStam---nnp 313 Saccharomyces cere...
KCV72127  292 SRLQFLTPSLSAwpravgdlplagagggdfdpalgggmyplsgrgagpgtgGQTLRDMLPNLLRPDHRLAGapgg--ppg 369 Fonticula alba
Feature 1                                                                                     
1Z5V_A    316 CYIAILNIIQG----------EVDPTQVHKSLQRIRERklanf------------------------------------- 348 human
AFP65465  309 KLISSIYFLNN----------SSNSLNFSNLLKKIHQEkkiky------------------------------------- 341 Chroomonas mesosti...
ABW97925  307 KLISSLLFSQN----------QSKYFNEPNILKKLHEEkkiay------------------------------------- 339 Hemiselmis andersenii
AEA38970  300 KLISSFHILNR----------NPLQNNIYEHLKKSYKKsemkf------------------------------------- 332 Cryptomonas parame...
O93807    343 SYISMLNYLIGy---------NLDQREIRKGILKSQQRisfv-------------------------------------- 375 Candida albicans
CCH61254  324 TYFNCFTTLIGk---------FNSNDDILRYVVKANKKlnft-------------------------------------- 356 Tetrapisispora bla...
CDR37884  320 SYISIFNILQG----------SYNHSDVQKAIIKAQQRanfv-------------------------------------- 351 Cyberlindnera fabi...
CDK26334  315 SHIAALDVLIGgs------fsEQDLFADHKATIIAKKRltqp-------------------------------------- 350 Kuraishia capsulat...
P53378    314 TYFNVYNTIIG----------NVEPRQISRAMTKLQQRikfp-------------------------------------- 345 Saccharomyces cere...
KCV72127  370 RLIAAWASISSgsaggpgaapSLEAHDVHHALARLRHRgllvstshapsslpttaqflalgqqaataaaamshdhlpagg 449 Fonticula alba
Feature 1                                                                                     
1Z5V_A    349 -------------ipwgPASIQVALSRKspyl--------psahRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQ 407 human
AFP65465  342 -------------tqwnPITINITNLNLvkkt---------kttVPGDICLVNHTIVKNFFISTLNQYDVLRKRNAFLNN 399 Chroomonas mesosti...
ABW97925  340 -------------tswgSVPVNIFNLPSstl----------ndsTKKELCFYNHTNIKKFFSKNKEQYDIFRKKNAFLNN 396 Hemiselmis andersenii
AEA38970  333 -------------iewaPPSIHYTNLFDfsk-----------rkNFIEMCLYNHSSLKKIFEKVLSEYDCLKKRNAFLND 388 Cryptomonas parame...
O93807    376 --------------pwvARSVLVVHGKKspyl---------kntNLEGIQVTNNTSMIDVFTKILKQFDLLIKRKAYLNR 432 Candida albicans
CCH61254  357 --------------swtSKSMNINIGRRspifsanqtesadnfsNINGMMLSNSSTIIPILDRISSQFDKIYHKQAFINS 422 Tetrapisispora bla...
CDR37884  352 --------------pwsAASVHVARGKKsphhi------tpdsdYVSGLMLSNSSSIVTLLDKTCKQYDKIMRRQAFVGG 411 Cyberlindnera fabi...
CDK26334  351 --------------kwtSQLLQVSHSPRspyalqq---spelenVVNGLMLSNNSSIVSLLDKVLRQYDRLYSKKAFLNT 413 Kuraishia capsulat...
P53378    346 --------------swsSSAMHVNIGRRspylpl-----qpnenEVSGMMLSNMSTVVNVFENACNTFDKVFAKGAFLNN 406 Saccharomyces cere...
KCV72127  450 gfrrqafsspppfapwvPASLQIAVSGQpaampaa--tepapnqAPDGLLLSNWTGIAATFHEYCTAFSRMNTRRAYYRQ 527 Fonticula alba
Feature 1                                    
1Z5V_A    408 FRKEDMfk---dnFDEMDTSREIVQQLIDEY 435 human
AFP65465  400 YLKNFSsg---dgIELFADAKETVQSLVEEY 427 Chroomonas mesostigmatica CCMP1168
ABW97925  397 YLKNFPsn---dgIELFTDAKESVENLIEEY 424 Hemiselmis andersenii
AEA38970  389 YLKEFNse---ntFNLFQDARETVYSLIKNY 416 Cryptomonas paramecium
O93807    433 YYSSVEeen--evMEMFNESRESVKSIIDEY 461 Candida albicans
CCH61254  423 FNDPSRtd---sdFPDFEESSRVVKDLINNY 450 Tetrapisispora blattae CBS 6284
CDR37884  412 YRVGSVfq---dgLEEFKESREAVQAVMDEY 439 Cyberlindnera fabianii
CDK26334  414 FTAHDVnge--diETELEQAREVVEAFRDGY 442 Kuraishia capsulata CBS 1993
P53378    407 YNVGDLfqsmqnvQDEFAESREVVQSLMEDY 437 Saccharomyces cerevisiae S288c
KCV72127  528 YTAYLPsqsdadfHEELMQCYDAVRDLISEY 558 Fonticula alba

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