1723953 108 GeKVREAFEqfLEdFSVQStdt-------------gevEKVYRAQ-------IEFMKIYDl--NTIYIDYQHLSMREn-- 163 baker's yeast 19074471 1 ----------------------------------------------------------MAlekEEEVDLIDLCERNP--- 19 Encephalitozoon c... 19074880 1 --------------------------------mhietwGMYFPEEeltafneLVQVILETkkkLQSILLGDRLGRVL--- 45 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 8 ReIIGMLKRmpNKqADWDNdllptlkamfnpksvsnakSQLISEGvisqeivDGKKIITLikdPYELQAPNVFDEEMfla 87 Methanocaldococcu... 2497830 2 vnFDEEVFRa-YYeHKIKSf------------------IKEELSN-------NLIKGNIFef---dIEKFLMHFPDAc-- 50 Methanocaldococcu... 2497831 6 GdVDMELRDedLIlEEVRDy------------------LTAYLRN-------IHQEDIILdneRVVVDLNQLYNYGLm-- 58 Methanocaldococcu... 2497832 1 --------------------------------------MINMCYNfenvkkaYEDQLKNYiknSLIPNLSSHANNEVvki 42 Methanocaldococcu... 20094401 1 ---------------------------------memerEFEEALRnsktflrSIDRVITDy-pKWRTVVVDLEEFDEp-- 44 Methanopyrus kand... 14520777 -------------------------------------------------------------------------------- Pyrococcus abyssi
1723953 164 ------gALAMAISEQYYRFLAFLQKGLRRVVRKYAPELLNTSdslkrsegdegqadedeqqdddmngsslprdsgssaa 237 baker's yeast 19074471 20 -------ELANSMVLGVSEHPYLSKKVLRKIPCALFTDNACNS------------------------------------- 55 Encephalitozoon c... 19074880 46 -------ETRVYHISAQSLEKLVEKNLLDTNAGNLLLCISCAVsellyd------------------------------- 87 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 88 yytdklkEYFKHKLSTEGPEWDIFDVKEFIMHFPESGDLNDKLiehpyevr----------------------------- 138 Methanocaldococcu... 2497830 51 -------EVNDLIIERPKEIEEIILDIFKEAYVELFGEDKEl-------------------------------------- 85 Methanocaldococcu... 2497831 59 -------EFVEFLINNPQKGIDFIKECYNDAYYTLRNEYPTNVii----------------------------------- 96 Methanocaldococcu... 2497832 43 smkklanLGFGYLVDSTLSSITGYYKVRDWIEELLKEELQKSGe------------------------------------ 86 Methanocaldococcu... 20094401 45 -------DIAFAVSDDVVEAMKVVQRVAMELIKKERPDVDR--------------------------------------- 78 Methanopyrus kand... 14520777 -------------------------------------------------------------------------------- Pyrococcus abyssi
1723953 238 pgngtsamatrsittstspeqteRVFQISFFNLPTVH------------RIRDIRSEKIGSLLSISGTVTRTSEVRPELY 305 baker's yeast 19074471 56 --------------------------------------------------------KNINRIVTVNGTVIRAYETLIRNV 79 Encephalitozoon c... 19074880 88 ------------------sghlsIKISTRVETLRDQg------------GFGDIDRANLGKLVFMTGTVCRVGFRRVVST 137 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 139 ---------------ksitnvyiEAYEELFNETPNVEfihirnpidcriSLSELSSAHKGKLVEFRAMILQATKLKLRYA 203 Methanocaldococcu... 2497830 86 -----------------------EKIQIAFKNPkgc-----------ekLIEEISAEDINKLVKFEGNILQAGKVNALLK 131 Methanocaldococcu... 2497831 97 ---------------------avKNLPKIFKTTRkgk----------ifTIEDIRSKTLGKLVEFEGIIVMASKIRPMLK 145 Methanocaldococcu... 2497832 87 ----------------------nKCCNIVLCDYPEEFe----------iSMREIP-YYVNKVVKFNGVIISASYPCVLSK 133 Methanocaldococcu... 20094401 79 -------------------------VWVEFRGSPIRl------------RARDMSVEFKDRLVTVEGIVRRVDNVAAEVV 121 Methanopyrus kand... 14520777 -------------------------------------------------------------------------------- Pyrococcus abyssi
1723953 306 KASFT-----------------CDMCRAIVDNVEQSFK----------------------YTEPTFCPN----------- 335 baker's yeast 19074471 80 TSELV-----------------CLKC--NVRAYRCSAG----------------------KRKDRMLCEsc--------- 109 Encephalitozoon c... 19074880 138 KMFFE-----------------CSKCGETVCVDVKNNV----------------------YRPPRTCRGsc--------- 169 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 204 KGFYY-----------------CPKCGATKTLDLGFWDkp------------------keVGKSLTCPAdgc-------- 240 Methanocaldococcu... 2497830 132 KAVYYcnkrikdenggflckytYTPCDGRVEIEIDDYFsegefikdmlsprevkkilenkKVWDKLVEKgkiprcvdlke 211 Methanocaldococcu... 2497831 146 KAYYIcp-----------------kCGREVVREIDILNtd------------------seK---AVCECgae-------- 179 Methanocaldococcu... 2497832 134 KHLYI-----------------CPKCGRIKEVYFSELF----------------------WDDKVFCEFcg--------- 165 Methanocaldococcu... 20094401 122 RVEAE-----------------CPQCGNRFEVRRREYR------------------------PDVRCPNc---------- 150 Methanopyrus kand... 14520777 -------------------------------------------------------------------------------- Pyrococcus abyssi
1723953 336 -----PSceNRAFWTLNVTRSRFLDWQKVRIQENANEIPTG--SMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDvt 408 baker's yeast 19074471 110 ---gsS----LLRDRRCFGGAIP--SQKIRIQDIGNRSS-----MSETLEVVLEEDLAGKFLPGDNLLITGTVLIRWRpf 175 Encephalitozoon c... 19074880 170 ---nsR----SFAPVRNHPEVEYRDVQEIKIQELYGGSEGDgnGIPKAVDCILYDEFAGTLAPGDIVEIVG-VLGVELen 241 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 241 ---dcKG------LIFDEDLSGKVDFQEIKVQTPLQESIYA---NKHSTTVFYEFNKPKKAVYSGYVKIVGVPIVKE--- 305 Methanocaldococcu... 2497830 212 ndevfKEnlKEIKFILDEYDSIYVNIQEMEIQQPIDLMKNPe-EPARSIRVFLENT--PGIYAG-RVNVIGRVMKREy-- 285 Methanocaldococcu... 2497831 180 -------------lnLIEHKSIYTDFQEIKVQQPLDLMENPe-EPPKYITVFLENS--PGIYAG-RVKITGIPIKVKk-- 240 Methanocaldococcu... 2497832 166 ---------gK---MEFANVMDYENFQELVVQDLSDESE----YYGIEKNPIVWYCGAKPYYFG-HVKITGIVREVPR-- 226 Methanocaldococcu... 20094401 151 ------------gMRCEPDELFYTDYQLVVLQEAPEHVRGG--EQPATVEVEFRYDHINRVRPGDRVRVTAVPRVRLP-- 214 Methanopyrus kand... 14520777 1 --mplLFkpLLRPEKRVKRFLEEIRSDYVKVRGFLLLRRPPc-EVPWKYVEYLLSPLSPSELEKTKLKAFAVVRITDS-- 75 Pyrococcus abyssi
1723953 409 qlglpgvkpsstlDTRGIsktteglnsgvtGLRSLGVRDLTYKISFLACHVIsigsnigasspdansnnretelqmaanl 488 baker's yeast 19074471 176 -----------------------------kVGEQMASSIYMHALAVHKQDEE---------------------------- 198 Encephalitozoon c... 19074880 242 -----------------------------dNLYKLTVHINNLQIVKNKNFFV---------------------------- 264 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 306 ------------------------------NKNGSVGELYIHAFYIEKDDEDie-------------------------- 329 Methanocaldococcu... 2497830 286 ------------------------------RHNIPIYKIYIKSNYIKISESYnki------------------------- 310 Methanocaldococcu... 2497831 241 ------------------------------SKKLPIYDIHVKALHCEVLDGe---------------------------- 262 Methanocaldococcu... 2497832 227 --------------S----------------SKSRIYELIVQAINVEKLGVEk--------------------------- 249 Methanocaldococcu... 20094401 215 -------------SSSPR--------------PGDTGEIVLEAHGVERSDSPlp-------------------------- 241 Methanopyrus kand... 14520777 76 -------------TEISGg-----------IRSGGFVEVEGSVEPYPCGNMRv--------------------------- 104 Pyrococcus abyssi
1723953 489 qannvyqdnerdqevFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEA-VKKGILLQMLGGVHKSTVEGIKLRG 567 baker's yeast 19074471 199 ---------------SMGDSFGRTFLGRLDGMGWFERRLLLVNSFAEEIQGLEN-VKLGLLLALVSGSHGADQKSG-TRS 261 Encephalitozoon c... 19074880 265 ---------------EDVEYQSRDFAEFRKIAGAGNTLASLVCSLYSAVYGNEL-IKVGLVLSLFGGTKKSAGQHS-IRS 327 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 330 --------------eIAKNLNEKDLELINRIAKDKNVIQKLSDYAFREVTGYDM-IKRAVLLQLVSSGTNIDMRTS---- 390 Methanocaldococcu... 2497830 311 -------------evKDILRNEELIETLNELGRKKNIIDILSNYLISQIKGYEL-VKKAIFLQQIKGAFKFLPDGTpLRR 376 Methanocaldococcu... 2497831 263 --------------vKIKLTN-SDIENIKKIAKRKDVVNILADRLIPEIKGHSA-IKKAVLLQQIKGVKK--P-GK--RA 321 Methanocaldococcu... 2497832 250 ---------------SLINLTEEDVKNIKKVAKRGDIIDILADILIPPLLCDDAiVRKAILIQQIAPYLEDIG------- 307 Methanocaldococcu... 20094401 242 --------------eEDLRFTQDEVERFEELAE-GDPLGEFVEAVAPHIHGHEV-IKKAVSLQLFSCVEEGQIRER---- 301 Methanopyrus kand... 14520777 105 ---------------INARRISSVEYSKYWELKEYELSRREIKSILVSALSAPTeVQDSFLYSLFGSPKVLDNPLGWDEG 169 Pyrococcus abyssi
1723953 568 DINICVVGDPSTSK--SQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEE-GG-D-YTIEAGALMLADNGICCIDEFD 642 baker's yeast 19074471 262 NSHILLVGDSGTGK--SHLLKTCSRLLSPAVLTNGVGTTQAGLTTCAVRQ----GrE-WVLEAGALVLADTGLCCIDEFN 334 Encephalitozoon c... 19074880 328 ETHVLIVGDPGLGK--SRLLLSTCGILPKSSYVSGSFTTTAGLTVSLTHDPV--SgE-YMADAGALVVADNGICCLDEFD 402 Encephalitozoon c... 20093190 1 -------------------MEFGDKPSHYVVVVCPKCRQHVQITETGKKTLR--C-----QHCGALLKARK----LRIFG 50 Methanosarcina ac... 2497829 391 -IHILMISDPGVGK--STLMESLIQKFPFVKKVYAVTSSGPGLVGSVVREKAeFG-DsWVLKAGVLTEADGGVVCIDEFS 466 Methanocaldococcu... 2497830 377 DSHILLITDPGIGK--STMLRRIARLFPQNAYASVTTATGGGLTAIVTREATeIG-DgWVVKPGVFVRANEGTACIDELT 453 Methanocaldococcu... 2497831 322 DIHILLITDPGIGK--TVILRKIA-EIPGNLYGSVTTATGVGLTAAVVREKTeIGeDtWVIKPGLLVKAHKGTACIDELT 398 Methanocaldococcu... 2497832 308 KINILLVTEVGIDK--TAILKRIG-NIPGNNFINIAALKEEELATPYDKRSNiLGk--FYTVCGGVIPRTLGVLCIDDFN 382 Methanocaldococcu... 20094401 302 -VHVLIVGDPATAKs-QILQHVIEHLAPRGVYVSAQHVTGAGLTAAAERTED--G---WTLEAGAVVMADGGVIAIDELD 374 Methanopyrus kand... 14520777 170 YSLSIINGKLKVVKsfAEFYRKFYEMLPRELRLEKETSWEFSDDFLGIDFKVf---D----PNGGLKYYAPSVKMIRRSV 242 Pyrococcus abyssi
1723953 643 KMDISDQVAIHEAMEQQTISIAKAG-IHATLNARTSILAAANPVGG--RYNRKLSLRGNLNMTAP-IMSRFDLFFVILDD 718 baker's yeast 19074471 335 KLKVNEKNGLLEAMEQQTLSIAKAG-IVSSLNTRCSVIAAINTRH---KYSFNKSISENIMVATP-LISRFDLIFGLFDD 409 Encephalitozoon c... 19074880 403 --KIDDHAALFEAMEDQKVSIAKGG-VICSVPTRATVIAATNPRHG--HFDRGKTMAENIRFDPG-LLSRFDLIFLLLDD 476 Encephalitozoon c... 20093190 51 SFEELSEAVNFRTCLQAELSGKGKG----TFFLESSPEEAESPGSG--DQSGKKTVHSGTRASSGkTAARKDPKSILKEI 124 Methanosarcina ac... 2497829 467 R-NKEVYDYLLGVMEQQKIEINKAGvIDAVLPARVAILAACNPRFG--RFNPDLTVWEQINLPKE-LLDRFDLIFVIKDK 542 Methanocaldococcu... 2497830 454 -VDKNVMKYILEAMESQTIHVNKGG-INVKLPARCAVLAACNPKRG--RFDRNLTVIEQIDIPAP-LLSRFDLIFPLMDK 528 Methanocaldococcu... 2497831 399 -VNKELQSYVLEAMESQTIHISKGG-INAKLPAECAILAACNPRWG--RFNPEVSVAEQINIPAP-LLSRFDLIFPIRDV 473 Methanocaldococcu... 2497832 383 E-NNKLSTKLSEAFERNVLTTNKGS--FYCVPAECSFLCACYPKTKfrKFDQKKSIIKQIGISSI-LLKNFDLIFPIRDI 458 Methanocaldococcu... 20094401 375 KASRGDLNALLEAMESGKISVAKAG-ITTTLNARCAVLAAANPEAG--RWQGGHPI-EEINLDPA-LLSRFDVILFTRDE 449 Methanopyrus kand... 14520777 243 PIPRWAFNSFKLKRAVYLVPKFSRPeVTDILPSLSETPFIISEPLG---FELDEIEKHLSNILATvFVKRNDLPVLNPVS 319 Pyrococcus abyssi
1723953 719 CNEKIDTELASHIVDLHMKRDEA-------IEPPfsAEQ----------------LRRYIKYARTF--K----------- 762 baker's yeast 19074471 410 RDGRSDLLIVDKILGRR----PEtgltdkkqg---------------svcwdhniLRNYIGVARK---Rr---------- 457 Encephalitozoon c... 19074880 477 LSEKESYMISGQILKKRRTLSPGegg-fddVVETvrRDMfvedirsggcvypmdiVRKYISYARAN--Vf---------- 543 Encephalitozoon c... 20093190 125 LTAS-DGKIGIEEFREKa-------------------------------------VEKGISHEK----Fd---------- 152 Methanosarcina ac... 2497829 543 IDKKKDEDIADFSIDNYNSKVRErkg--ksSGKKfvINGveln---------delLLKYVLYARQ---Ie---------- 598 Methanocaldococcu... 2497830 529 PNRKSDEEIAEHILNTH---IETatkd-ykiLGAidIDGitvd---------eklLKYYIIYARSCayIeenqdlylgef 595 Methanocaldococcu... 2497831 474 SDKDKDKDIAEYIVDLHRAYLDEkinr-emgLDYleVDGvkid---------kefIIKYIYYAR----Qk---------- 529 Methanocaldococcu... 2497832 459 PDKDRDEEVAKYIFLKYINSDNEei----egYDYvfVDVggekik-----idfefLKKYVVYSRQ---It---------- 516 Methanocaldococcu... 20094401 450 PDPEQDKLVAERMMEAFDGEFDEiegk-------------------------yelLRRYVLYATKE--Fp---------- 492 Methanopyrus kand... 14520777 320 EEVQKLRLKFEAMLWKKRMEYGEdtidallsLDG--VFHvekr--------yflsVNLLGSMGRSTgrVtk--------- 380 Pyrococcus abyssi
1723953 763 -------PILTKEARSYLVEKYKELRKDDAQ---GF-SRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLL 831 baker's yeast 19074471 458 -------AVIPDDLNAVLLSYYHHRRKAEGAn---------EFNTVRMLESLARLTEAHSKLLNSERAEEGDVYSAIILL 521 Encephalitozoon c... 19074880 544 -------PVLSKSASEAIKEYYVGMRSRGGV------------S-TRDLESLVRLTEARAKVELRSIATKADAMFCIELH 603 Encephalitozoon c... 20093190 153 --------TILEKLLETGELYFPEPG-------------------------IVKLV------------------------ 175 Methanosarcina ac... 2497829 599 -------PEISDEARKIIKEYYVSVRKMSe-------AKGTFGISARQLGSIIRLAVAHAKLRLSEVVKAVDAEEAIRLV 664 Methanocaldococcu... 2497830 596 detklimPYLTDKAKKMIKKYYLEMRKLGEG-------DNPIPITARQLEAIIRIAEMHAKARLSDKVEDVDAEVAISII 668 Methanocaldococcu... 2497831 530 ------kPIISEKAKELFVNYYVEMRKK-----------HQ--ITARQLEAAIRIAEAHAKAKLKDVVDEEDAKEAINII 590 Methanocaldococcu... 2497832 517 -------PKITDEVIEKISNWYDEMRKN-------------HYITAKQLNTVIKLSIAVARAKLKECVDEDDVKEAIDII 576 Methanocaldococcu... 20094401 493 ------nVTISEDAREELRDWFVSARQEAADr-iDEgDLRTVPVTRRQMGSVLRLARASARMRLSETVGRGDVSVALSVV 565 Methanopyrus kand... 14520777 381 -----sfIFEVVNIDEELIDMWLNEIGKKALqeyVErYKRLYITEDSKVQRVFQLLLDLQSTSISGVISKEEIFEAGKEI 455 Pyrococcus abyssi
1723953 832 RQSIIR---VDVDDVEMDEEFDNIESQSHAASGNNDDNDDGTGS----------GVITSEPPadieegqseatarpgtse 898 baker's yeast 19074471 522 ETALGTkplVEIDPCRVFVDEAYHNMVVSGLKTKIMGGEIWK-------------------------------------- 563 Encephalitozoon c... 19074880 604 KRTFVSkegVARNKKSKDLTEALREYGRKKKGCLVSGEELCRLIatldssrpasEFVDALNHsgliikkgagmykivv-- 681 Encephalitozoon c... 20093190 -------------------------------------------------------------------------------- Methanosarcina ac... 2497829 665 DTCLKQ---IAYDPESGSIDIDKIAG-TPKSKRDKVEKVLNIIK----------EISNSRDDgl---------------- 714 Methanocaldococcu... 2497830 669 DDCLKQ---VAYDPETGTLDLDKIAG-TPKSRRDKMDAVLNIIR----------EIVSLRDDgl---------------- 718 Methanocaldococcu... 2497831 591 TECLKE---IAYDPETGIFDVDKILG-VSKKERDKLTTVYEIIK----------ELSEKSEl------------------ 638 Methanocaldococcu... 2497832 577 MHYLKQ---VVYNPKKGIIDVILLYKNKT--------------------------------------------------- 602 Methanocaldococcu... 20094401 566 EEFMKE-----VMQEDGVLDADVIETGKPKSVREVREYVLKVVR----------KLAKKHEDg----------------- 613 Methanopyrus kand... 14520777 456 GFSEST---IAMAIEKLKARGDIYEPRIGFYKVIKGEKS----------------------------------------- 491 Pyrococcus abyssi
1723953 899 kkktTVTYDKYVSMmnmivrKIAEVDREGAEELTAVDIVDWYLLQKENDLG 949 baker's yeast 19074471 --------------------------------------------------- Encephalitozoon cuniculi 19074880 --------------------------------------------------- Encephalitozoon cuniculi 20093190 --------------------------------------------------- Methanosarcina acetivorans C2A 2497829 715 ---aPEEEIYERAEr----aGLSEKEVEDAINYLKRVGDIYSPKSGYWQLM 758 Methanocaldococcus jannaschii 2497830 719 ---aPEEEIYEKAMa----iGLSEKDVNDALEYLKKAGDIYNPRYGFWGLL 762 Methanocaldococcus jannaschii 2497831 639 ---vEHEDIAEEAKk----kGIKEDELENIIKKLIKYGDIDEPKPGRYRLL 682 Methanocaldococcus jannaschii 2497832 --------------------------------------------------- Methanocaldococcus jannaschii 20094401 614 ---vPKREIVKAVKh-----RVSRERVEEILDDLVEEGSLLQPRPGVYLPM 656 Methanopyrus kandleri AV19 14520777 --------------------------------------------------- Pyrococcus abyssi
Jiyao W et al.(2023). "The conserved domain database in 2023.",