1DKR,2H06,1U9Y


Conserved Protein Domain Family
ribP_PPkin

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TIGR01251: ribP_PPkin 
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ribose-phosphate pyrophosphokinase
Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 273523
Aligned: 21 rows
Threshold Bit Score: 297.268
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1DKR_A        10 LKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDGEVQINIEESIRGCDCYII---------------QSTSDPVNEHIM 74  Bacillus subtilis
Q9RUD2         8 LLVFSGQSNRPLAQAICDNLGVPLGRSRTEKFTNDNLIVHYEESLREGDVFIV---------------QTFSTPVSDAIM 72  Deinococcus rad...
O26877         1 -MIIGCSASQKLAASVADLLDEPLCPVETRKFPDGERYIRVKEEVEG-EVTVVq--------------STGYP-QDENLM 63  Methanothermoba...
O28853         1 MKIIPCPSSPLLARRVAEAAGIEIGGAVFKKFPDGELYVRVMEK----EGVVVg--------------SINS---NEDLI 59  Archaeoglobus f...
O59586         3 kVFVIGSGAKHLEEEISKNA--KILKTEIKKFPDGEKYVRILEHG---EEVIVv--------------QSTYRPQDEHLI 63  Pyrococcus hori...
WP_010874430  66 HVVFSLSKTHDLVSRICQKLKMPMGLITHNEFADGETYIRFEESVRNKDVFIF---------------QSTCAPVNDSLM 130 Mycoplasma pneu...
O29666         1 MVILVGGTNGLMALKVAKISGLPLCYSHVDRYPDGEKYFRFASNIDG-EDVVIf--------------NSMHPNPDEIIF 65  Archaeoglobus f...
WP_010903634   1 -MLLSGSSSQSLAAALAAATGERLGDVTYDSFPDGEQLVTVPPAVDG-ERAVIv--------------ASTP--TSDAHI 62  Halobacterium s...
1U9Y_A         1 MIVVSGSQSQNLAFKVAKLLNTKLTRVEYKRFPDNEIYVRIVDEIND-DEAVIi--------------NTQKN-QNDAIV 64  Methanocaldococ...
WP_010881743  61 YRDLFSTELCAHDDVRRFNPPHFKVDAQFICFLNGELKTQINECIRGKDVFIFqdvenhqpvlvnngkSKKIFSVNDHVM 140 Treponema
1DKR_A        75 ELLIMVDALKRASAKTINIVIPYYGYARQDRKaRSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFD-IPIDHLMG 153 Bacillus subtilis
Q9RUD2        73 ELMLMIDAAKSASAGRVTAVIPYYSYARSDKKdSPRISIAGRLVADLLQEAGADRVLTMTLHSPQVHGFFK-VPVDHLSA 151 Deinococcus rad...
O26877        64 ELLFMIENLKDLGADYVRAAIPYFGYGRQERRfKSGEAVSAKIVAHLLEAAGADEIVTVNLHENCLSEFFR-VPVRELSA 142 Methanothermoba...
O28853        60 ALIFALDVLEN-----AKAVVPYMGYARQDKVfQEGEAVSIKIVAEMLESR-ADEVVTVNIHSSDAASHFS-K-LKNLDA 131 Archaeoglobus f...
O59586        64 ETIIIGDALKEAGFEKLKLVVPYLAYSRQDRVtKEGEPISVRAIMKMLGLY-YDELYVFDIHNPKTLDFFP-GKAVNIYP 141 Pyrococcus hori...
WP_010874430 131 ELLIAIDALKRGSAKSITAILPYYGYARQDRKtMGREPITSKLVADLLTTAGVSRVALTDIHSDQTQGFFN-IPVDTLRT 209 Mycoplasma pneu...
O29666        66 ETLLIAETAYSNGARSVTCVFPYFAYARSLDTvK-GEALPIKTVVKVLKAAGVKKIITVDFHLQEN--VFG-VEHVDLTG 141 Archaeoglobus f...
WP_010903634  63 EVLQLQDAARDAGASEIITVLPYMGYARQDDAfDPGQPVSARAVARAISTG-TDRVLTVNPHEDGVLECFD-VPAAGVDA 140 Halobacterium s...
1U9Y_A        65 ETILLCDALRDEGVKKITLVAPYLAYARQDKKfNPGEAISIRALAKIYSNI-VDKLITINPHETHIKDFFT-IPFIYGDA 142 Methanocaldococ...
WP_010881743 141 MLIVTIDAVRHAGAGRVTLVLPTYPYSRQHKK-CGREGLTAGLLGSVYEYLGVSHIVTLDLHSREIENAFHrTRLENLHA 219 Treponema
1DKR_A       154 VPILGEYFEGKN-----LEDIVIVSPDHGGVTRARKLADRLK-APIAIIDKRRP--------RPNVAEVMNIVGNIEGKT 219 Bacillus subtilis
Q9RUD2       152 DVVLSQHFKKCVp---dAHNGVVLAPDAGSIKRASQIARRLD-SGLAMIDKERL--------SDTEVRPRALIGDVDGKT 219 Deinococcus rad...
O26877       143 MPLIAEHISF-------LDDPVIIAPDKGALGHAREVSDILG-CECDYMEKVRIs-------PE-VVETRVSDLDVEGKD 206 Methanothermoba...
O28853       132 MPLVGEYFA--------GKDVVMISPDKGSMERVKTAAKHAG-CEWDYMEKRRId-------AT-TVEITPKTIDVEGRD 194 Archaeoglobus f...
O59586       142 -AKVIAEYFRDK-----LENGLVLAPDRGALERAKEVANILG-LEYSHFEKERIs-------PT-EVKMTPVDVNVKGRN 206 Pyrococcus hori...
WP_010874430 210 YHVFLTRTVELLg----KKDLVVVSPDYGGVKRARLIATSLE-LPLAIIDKRRP--------AHNVAESINVLGEVANKN 276 Mycoplasma pneu...
O29666       142 MEKLAEYCLEEF-----SDSFTVLAPDEKAAFWAEKFAAKAN-CDVVALRKIRId-------AE-NVIIDDLRTGVEG-D 206 Archaeoglobus f...
WP_010903634 141 APQLAAPLPAD------LTDPVFLSPDHGATDLATSVRDAYGtGVTDHFQKVRHs-------GS-DVTVEPSEIQTAGRD 206 Halobacterium s...
1U9Y_A       143 VPKLAEYVKDK------LNDPIVLAPDKGALEFAKTASKILN-AEYDYLEKTRLs-------PT-EIQIAPKTLDAKDRD 207 Methanocaldococ...
WP_010881743 220 SYQIIRELAKIEnlsdpDIPFVVVAPDSGAVERNKFYSSGLK-KPLAMIYKVRDysvvaqnaKQSNIVEINLLGDVEGKT 298 Treponema
1DKR_A       220 AILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNST----IKELVVTNSIklPE--E---K--KIE 288 Bacillus subtilis
Q9RUD2       220 VFIVDDEISTAGSLVETVSIARSMGAKDVYVAVTHGVYSGPAIERIAALD----VTQVASCNTV--LVpqDkldR--AGG 291 Deinococcus rad...
O26877       207 AVVVDDIISTGGTIVNAAGILGKCGASSITVCCVHPVLVEDALLKIFSAG----VERVIATDTL--KS------------ 268 Methanothermoba...
O28853       195 VVIVDDIISTGGTVAEAARILYGLGAKSVSAACVHAVLAENAAIKLFNAG----IKDIIATDTV--EC------------ 256 Archaeoglobus f...
O59586       207 VLIVDDIISTGGTMIRAAEILKDLGAEKVFVVATHGVFAEGAIERVSKA-----VDELAVTNTI--PT------------ 267 Pyrococcus hori...
WP_010874430 277 CLIVDDMIDTGGTVIAAAKLLREHHAKKVCVMATHGLFNGEAPQRFQKAFneglVDYLFVSNSI--PQ--T---KfdQCP 349 Mycoplasma pneu...
O29666       207 VVIVDDIVSTGGTVCQAARIAKRAGARRVFVACTHAILARDAMMRILESG----IEDIVSTDTI--LS------------ 268 Archaeoglobus f...
WP_010903634 207 VVVTDDIVATGTTMSEAITALDDP--ARVFVATVHPLLAGSARLKLARAG----VEAVYGTDTI--EC------------ 266 Halobacterium s...
1U9Y_A       208 VFIVDDIISTGGTMATAVKLLKEQGAKKIIAACVHPVLIGDALNKLYSAG----VEEVVGTDTY--LS------------ 269 Methanocaldococ...
WP_010881743 299 AFIADDMLGSGGTMLKAMEFLKSRGAKQVIAAVSLPFFTGNALELFDEAYekryFSRIIGTNAV--FHt-Ql--S--HKQ 371 Treponema
1DKR_A       289 RFKQLSVGPLLAEAIIRVHEQQSVSYLFS 317 Bacillus subtilis
Q9RUD2       292 KLAVLDVAPLFASAIANIHTGASVSTLFT 320 Deinococcus radiodurans R1
O26877       269 DVSEISVAPLIADVMKD------------ 285 Methanothermobacter thermautotrophicus str. Delta H
O28853       257 AFSRISVAELIAENI-------------- 271 Archaeoglobus fulgidus DSM 4304
O59586       268 KVSKISIVPEIMRSILEVKS--------- 287 Pyrococcus horikoshii OT3
WP_010874430 350 QFQVIDLAPLFEEVLLCYANNSSISAIYT 378 Mycoplasma pneumoniae
O29666       269 PVSHVSVADVIASALS------------- 284 Archaeoglobus fulgidus DSM 4304
WP_010903634 267 AVSEVSAAPAIADAL-------------- 281 Halobacterium salinarum
1U9Y_A       270 EVSKVSVAEVIVDLL-------------- 284 Methanocaldococcus jannaschii
WP_010881743 372 WYTETDVSGLFARVIARIHHNQSLSSLLD 400 Treponema
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