Conserved Protein Domain Family
TMEM70

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pfam06979: TMEM70 
TMEM70/TMEM186/TMEM223 protein family
This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.
Statistics
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PSSM-Id: 462058
Aligned: 50 rows
Threshold Bit Score: 110.384
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003385675   8 KQVLLYQNtvTKPLFFLFITVASGIQYTFWSYLALEAFKDYqqkppekhsdkqkeeaesgstqgtakralfesikEKASS 87 
XP_001748139  98 GDVLVFSC--ERTGFIRLMKAAAFSQVTLWISAATLAPQMReegald-----------------------------gkas 146
EPB90960      56 KDVVFYQApaGVGRTFMWMYISAGVQLMFWGNLASLAYVAYtvkdgeqed-----------------------apvvlap 112
EGF79722      68 SDILIYRS--NNNKLLRFAYLAAGIQMFMWLNIAELAWTYMtdtetdeq----------------------gvetherSS 123
XP_002433820  54 KNTELYRY--DNFRVFGALRIFSVSQVFLWTYLAHASKTLFddpnlvskvrsd-----------gekrtfaqtiaEKLTV 120
XP_001869108  71 KDVMLFKY--DNPKFFRMLNIFAISQFLFWGYLTHFAYTTLkdapvpeteh---------------peelawyqkINLGE 133
EDO64090      60 KDVMLFKY--ENPRFFKVLNIFAVSQFLFWGYLCHFSYTTLkdapvqedg----------------kedlpwykrVNLGE 121
XP_022169955  58 KDVILYKS--SSDKTYKMISVFSIVQFGFWLTVAD-SYNVLlnkepdnnvn---------------hqpiswvdkIKSRG 119
EDV27092      14 RDIVIYTN--KKESFFATISVVSICQLFFWTYLGEFAFSELrdpyssikpn---------------kdkkkeelaLDDSD 76 
XP_001639265   3 SDATLFHH--DRRKFFRTVGLASTSQFFFWVYLAHFQYTTRpqleamkekg---------------kidftryiyIGDSN 65 
XP_003385675  88 GKWRLGVTL-LA-LTFGSLFAFTSVIYPRRTINKVMYSHSKQALEITTYTPLG-----------GLTSKEVPC--LSVWR 152
XP_001748139 147 sSTRFGWTF-AS-LMMAVMFLGLGIYVPRRYVSRLYTT-GQGQLRIQTYNYWG------------RRSFEMPVseLLMTT 211
EPB90960     113 qGKRMAVAG-GL-VTVGVAIASLMCLYPWRYVDKLILLKGANTVKLVTHARVLk----------SHKYREYPIeqLYCKQ 180
EGF79722     124 TLKRVAASG-IC-GLSSLVFPGLVHYFATRKAKTVTILKGGKLVAIQNAARIGnkinvfkrldlSSSARIVPI--LNAMQ 199
XP_002433820 121 DKYRYGLVA-FC-LLFANGVVAAASLYMLRSVRSVVLLKGGQSVYIQTYAPFR-----------NLRGFQVPLdhLSCLH 187
XP_001869108 134 NKYRNGIAI-MS-FFIGYGILFASWMFTLRSVRFLILRKGGAQVSVVTYGPFG-----------RNRIMDVPVrcISAQE 200
EDO64090     122 NKYRNGIAI-MC-FFIGYGVLFASWMFTLRSVRYLVLRKGGDKVSVVTYAPFG-----------TNRIMDVPLkyVSAQE 188
XP_022169955 120 KIATLGIPI-AC-LCMGTMLIAICSVYTMKSVKMLVLCKGGDRLSITSFGFFN-----------RNITTTIPLetVSCAV 186
EDV27092      77 SISRVGLAT-VS-IVAGLSFCVIGFFYCYRSVKSLALTRGGIDVKITTYGPFG-----------MHRQLTVPLsnMSAMA 143
XP_001639265  66 NKYKNPVFLpVVgVSVGVFLSFTGWFYCLRNINRIALLKGGGSLRLVTHTPLG-----------GTREIVTPIhqVSSLG 134
XP_003385675 153 Kgs--------------aqSSHVSLKVKGDIfYYLLGEKngKFHNPKMFDMIIGT 193
XP_001748139 212 Rqtt------------avaNSVVTFRIPGHRfFYMLDGTngTLHNQSAYNLIVRQ 254
EPB90960     181 KvftgvgkngtdavgtkanSSHIFLGAKGEKmAYMLDRKg-SFMDSKLFD---GL 231
EGF79722     200 Ntha------------sglANQIYLKPHSKRsGYILEKDg-EFVDPYLYDYLFSK 241
XP_002433820 188 Srg--------------qkSAYISLKVKGRWfYFMLDQKg-LFPHPSLFDQTVGL 227
XP_001869108 201 Sre--------------aaRVTIPIKIKDRSfFYVLDKRg-EFFNNRLYDYTVGM 240
EDO64090     189 Sre--------------aaRVTVPVKIKNRAlFYMLDMRg-EFTNTKLYDYTVGL 228
XP_022169955 187 Grn--------------ssGQSIPLKVKGKWfHYTLDKNg-KIYNPKLFDYTAGL 226
EDV27092     144 Krn--------------etDSPIPIRIRNYSfYFLVDHQg-KFLEPRLYDRTISI 183
XP_001639265 135 Srm--------------dnKSQIAIKVKGYRfFFILDKEg-SFVQPSLFDRIVGV 174
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