Conserved Protein Domain Family
PKS

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cd00833: PKS 
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.
Statistics
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PSSM-Id: 238429
Aligned: 230 rows
Threshold Bit Score: 167.35
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
AAC38075       10 EPIAIIGSGCRFAKGAstPEAFWELLR----AGTDFVgpvpaerwdtaaiyd---------esaaetgttyskvgAFLEH 76    Pseudomonas ...
BAC76470       10 DTPVVVGMACRFAGSDg-LGEYWERLR----LGRSALgttgrwtee---------------------edagsftgGFLDG 63    Streptomyces...
ZP_00109664    12 HKIAIVGMDCYLGGGCkgLDTFERSIY----EGTQHFisrppqrwqaieaqqq-------llknyslpdgvaplgAYIKD 80    Nostoc punct...
NP_489395      10 AKIAIVGMDAFFGECNg-LDAFERSIY----DGKQHFitlppkrwygideqkd-------llqeygltdakapvgAYIKD 77    Nostoc sp. P...
NP_821274      10 TGIAIVGLGCRFPGAGd-IQAYWKLLLsg-qRQFSAVpanrwnhdtfhepg-----------rrrgghaaytdqvAFLDG 76    Streptomyces...
BAA92854        4 QPIAIVGMGCRFPGANn-PSEFWEILQ----NGVHKItkdpidrp-----------------------tqmtgwaGFLDG 55    Microcystis ...
EAA53526     1263 NLYAIVGISCRFPGANt-AEQLWNVLM----EQRDAIttfcpaenlgfa---------------leensvfvpryGMIDA 1322  Magnaporthe ...
CAG05481        6 DEIAVVGVGCHFPGGEg-LDSFWRVLL----EGKNCTveipterfesaswcs---------adgskpgrtqttraALVDE 71    Tetraodon ni...
AAM78457       15 TPIAICGIGIRLPGGIhnADQLWEFIA----TGCDSPspp---------------------------------rlGGDCQ 57    Hypocrea virens
EAA61668      129 MYKHIYNVLALVKRAA--NGEFVSALRevkvDFIKCSvlevppagiitepsrkfyldryeneymgwqpgqfagweGHSID 206   Aspergillus ...
Feature 1                                                                                         
AAC38075       77 IDrfdah---------yfgisASEAKEm----------dPQQRLLLEVACESVARAGLTreq-lkgSRTAVYVGMLGM-- 134   Pseudomonas ...
BAC76470       64 HQefdar---------ffrisPNEAQCm----------dPQQRILLQTVQHAVDDGYLTaad-lrdLDCGVFAAGLPG-- 121   Streptomyces...
ZP_00109664    81 FEidtfs----------leipPEEVDNf----------nPQELLMLQVADNALKDAALRk-----sTRIAIIIAITKD-- 133   Nostoc punct...
NP_489395      78 FDldtla----------ykipPNEVEKl----------nPQQLLLLTVADRALKDAKIPe-----gGNVAVIIAAEAEls 132   Nostoc sp. P...
NP_821274      77 VErfagl---------hyglpPARVRAm----------dPQHRLMLDVTREALDDAGWGrgg-fdrENTGVFVGISVSdy 136   Streptomyces...
BAA92854       56 IDkfdaa---------ffgiySEEAIKm----------dPQHRLLLETSWEALEDAKLVpan-lagTDTGVFIGLSGS-- 113   Microcystis ...
EAA53526     1323 LKdfeps---------aysmsDAEAQTi----------dPQKRVFLDVAADALADAGTSaspgnplDPVGVFVGAATNtf 1383  Magnaporthe ...
CAG05481       72 FNmfdhr---------ffgitETEADLm----------dPQQKLLLHCTYRTLEDAGISmes-isgSRTGVYIGDCQMal 131   Tetraodon ni...
AAM78457       58 KDq-----------------gPVGASFffttseqaegctLQQAQLLEVTRECLEDACEInyq-gedACVGCYVGMLEDv- 118   Hypocrea virens
EAA61668      207 AEhdrwsrisvkirvrsstcsGNEAEAm----------dPQQRLLLEVVYEALEDGIPLikv--agSQTSVLCGTFTN-- 272   Aspergillus ...
Feature 1                                                                                         
AAC38075      135 --------DYLALHSReagi--------eqiNPYYAAGKEf----------SFAAGRIAYHLGv----------hGPAMT 178   Pseudomonas ...
BAC76470      122 --------DYRTLVARrad---------lvyGTHSFLGNAp----------STLSGRISYFYDv----------nGPSLT 164   Streptomyces...
ZP_00109664   134 --------LTLHQQKEq-------------vEDNEYTDYIe----------NSPANYISKLWNf----------aGPTFT 172   Nostoc punct...
NP_489395     133 vhklqqrwDSSWQVKDglnaaeitlpspqvsQLESIVKDSvhhqveigeylSYITNIMASRISslw------nftGPSFT 206   Nostoc sp. P...
NP_821274     137 kdl-mtarIRAVSLADgsiggatdprileafRERAEELSTihsftlpgsllNMAPATVSRQFGl----------gGPSFA 205   Streptomyces...
BAA92854      114 --------EYPNLLIEd-------------sTFNTTIGTLd----------CMLANRISSYFDf----------qGLSIT 152   Microcystis ...
EAA53526     1384 lss-rdnpGSKPPGDE---------------EPQSFANHYqql------ldCPIGTFASFKLNl----------tGPVVT 1431  Magnaporthe ...
CAG05481      132 cggvscilEPGMFVALs-------------kAKMISPGGTs---------kPFSSKADGYGRGegcgvvllkplkDRLCA 189   Tetraodon ni...
AAM78457      119 --------DASMISSKnd-----------lkGPWFVYHLTv----------DLLLQPCVPFADpf---------vSSSMV 160   Hypocrea virens
EAA61668      273 --------DYNSTITK---------------DLEYYPKYSi----------TDTGNSILSNRI------------SYFYN 307   Aspergillus ...
Feature 1             #                                                                           
AAC38075      179 VTTACSSSLVAMHLACRALQAGe----------aDMALAGGVNLmla--------pdLTIYMSQI-----RAISps---- 231   Pseudomonas ...
BAC76470      165 LDSACSSSLAALHEAALNIRAGq----------cRAAIVGAVSVf------------STPEVLRFaq-rsRMSSpe---- 217   Streptomyces...
ZP_00109664   173 LIAEQNSVFKALELAQKLLAIRe----------vDAVLVGAIDL-------------AGDGASVLq---rNEITkvnt-- 224   Nostoc punct...
NP_489395     207 LTAVESSAFKAVEVAQMLLMTQe----------vDAVVVGAVDLag---------gvENVLLRSQaapinTGIN------ 261   Nostoc sp. P...
NP_821274     206 VDAACSSSLIALETAVAHLRQGt----------cRIAVVGGAYLslt--------pdGLVGFSQL-----GALSat---- 258   Streptomyces...
BAA92854      153 INTACSSVLVAIDSACQSLWNEd----------iCLALVGGTHLt-----------fSPVIASRAs---lNAMRpkiqa- 207   Microcystis ...
EAA53526     1432 LNTACSSALAALHLACASLSHGd----------cNAAVVGGVSMayp-------qegGYVTARPGgd-ssAVFSps---- 1489  Magnaporthe ...
CAG05481      190 AETVDFQALSYTSACRRSHSRHkyrksfsasslsDLKRQLTSSLktktestrsdvqlGFVFCGNGva-ykGMCKqlirvp 268   Tetraodon ni...
AAM78457      161 AKSSPSPSLVALHEACCAVQSGd----------aRSAVVVGSSLvldie----dgakPVEAVSAVy---iKMLPdaird- 222   Hypocrea virens
EAA61668      308 LHGASATTLQAGEASMSIVLGS------------ALHFDPNIFI-------------TMTDLGML-----STDGr----- 352   Aspergillus ...
Feature 1                                                                                         
AAC38075      232 ------grCRVFDAAADGIVRGEGCGVTVLKRLADAlrd--------gdpIQAVIRGSAINQDGASAGQTvp--nANAQA 295   Pseudomonas ...
BAC76470      218 ------gaSLPFTDAADGFVPAEGAAALVVMRHDEArar--------glrVYGAVQATGTNHNGTTNGLMap--sSKAQS 281   Streptomyces...
ZP_00109664   225 -----gvnTLSYDQKANGWIVGEGAAAVVLKLHETAkre--------nnrIYATIDALSLVENSKSKIHSltvpnSEMIA 291   Nostoc punct...
NP_489395     262 --------TLSYDQKANGWTVGEGAGAVVLKRHQQAien--------gdrIYAVIDAISIGQSHTKVDGEs---vNQACQ 322   Nostoc sp. P...
NP_821274     259 ------gvCRPFDKDADGFVLGEGAGSVVLRPLPDAlad--------gdrVYAVIKGIGSANDGASPEPLap--tPEGQL 322   Streptomyces...
BAA92854      208 ---ivddlLDRFAPRGEMEIIADFATPLPAFAITKIlglp-------iedYQQLIRWSAKTVFIFDQPVSleeykEQNQI 277   Microcystis ...
EAA53526     1490 ------gvCHPLDSRADGCVPADGAAALVIKRLADArad--------gcrVYAVIEGVAVSADGSDDKAGlgvpsSSGQS 1555  Magnaporthe ...
CAG05481      269 afrdkikqVESILQHHNSICISQWFTGEDENDDATTpsavqpllfaiqvgLVAALKHWGVTPDFVIGHSV-----GEVAA 343   Tetraodon ni...
AAM78457      223 ----gnpiRAVVRASSAGNIAGDQSSGSDVPGEAAPglt---------slIKAVVTLENRATPLNASSGKf----WASFK 285   Hypocrea virens
EAA61668      353 --------CRAFDADRSGYVRGEGICAIIHKRKSQAefd--------gdvIRAIVRGTGVNHDGTKQGITlp--sSESQE 414   Aspergillus ...
Feature 1                                    #                                              #     
AAC38075      296 AVISQALKvagl-----svdDIDYVEAHGTGTPLGDPIELSSLDSAFqgre----------rplWVGSVKANMGHLDAAA 360   Pseudomonas ...
BAC76470      282 RLIAELYDreki-----dasQIAYLETHGTGTPLGDPIELEGLRSAFrrag---------adgcHLGAVKPLIGHTLVAS 347   Streptomyces...
ZP_00109664   292 QACQQAFHladi-----kprDINYLEVVGSGIPQQDESEIQGLLAAYrtfep--------nltcAIGSIKANIGHTYAAS 358   Nostoc punct...
NP_489395     323 QALKMAGVpp---------eQVKYVEVCASGIPQEDEAEIAGLVQAYpsvgd--------glhcAIGSVKANIGHTFVAS 385   Nostoc sp. P...
NP_821274     323 RAMRRAYAdarv-----tpsSVGFIEAHGTGTRAGDRAEAQALRRLRteypdd------dpalcYLGSAKALIGHSLSAA 391   Streptomyces...
BAA92854      278 LIEHRAYFaqkvaeykrqpnDGLISQLANYNDNINALTEDEIISTSI-----------------LLIATSQESMKGLLSN 340   Microcystis ...
EAA53526     1556 RTVEAALRragp----qalsRLRYVEMHGSGTPWGDALEVQGLKMAFdrlsktgaaeqsgtgraQPEADRIYLGSNKGNC 1631  Magnaporthe ...
CAG05481      344 AHCSGLLSledavk-vlhlrSTFQNKVTGGKMLLVSNVSVEEVLETLpefsgr-----vcvaafNSPQSCTLSGDADAVD 417   Tetraodon ni...
AAM78457      286 IIFTECTDvstgs---snvdSSDHTEGISINSSGADGCGIQVIIGYYpq-------------saPIRFEARPELVLFSAH 349   Hypocrea virens
EAA61668      415 ALIRQVTR------------ADSTEHCRGLISAQEGPAASMGHQKPYlgfselq----aksvrsLVPRMFYEQIHSLGLQ 478   Aspergillus ...
Feature 1                                                                                         
AAC38075      361 GMASVIKTMMVLKh-------AEVPAQLHLaqlnplvdw-krsrlavpTAIESLPdr------------pRLAGISGFGL 420   Pseudomonas ...
BAC76470      348 GLASVVKALLAFHh-------ATIPPVAAAgeavsyld---vapfkvnREPLPWPed------------kPLCAISAFGF 405   Streptomyces...
ZP_00109664   359 GIVSLIKTALCLYh-------RYIPAVPQWsgpkmpeiw-rdspfyvaSESKPWFlekg--------atrRIAAINGMEI 422   Nostoc punct...
NP_489395     386 GIASLIKTALCLYy-------RYIPATPNWsgvktpqvf-egspfyvvTESRPWFlskn--------asrRIAAINGMGC 449   Nostoc sp. P...
NP_821274     392 GIAGLIKTALVVHh-------RTIVPQPDTtphpdlgi--eaaglrfaPAARPWPssg----------gpLRAAVSSFGF 452   Streptomyces...
BAA92854      341 GLLALLKHPQSLEy------vRQNPGNIENi----------------vEELLRYDspi---------qyvSRRAIEDVEV 389   Microcystis ...
EAA53526     1632 GNTEAASGLLSLIkasmalnlGVVPPLPNLaepnpk-------cefeeTKFEPLGkqlalapgdrvmnkrQRIVRSPNWI 1704  Magnaporthe ...
CAG05481      418 SLREKLRVVFSERslf--lheLDVPAAYHShmmdpilddieksidllrAENKQCElyst--------vtgRSYSDGDFST 487   Tetraodon ni...
AAM78457      350 NVSSLAKQIELHRly-----aQSHPRQAADiaft----------ralrRETLEYKafsi-------lsnsSFTNTSNYAK 407   Hypocrea virens
EAA61668      479 YGVSFALMSGGIKs-------GSVFATAPL------------------RWTSHWFnsa----------apSHATLIHPSL 523   Aspergillus ...
Feature 1                  
AAC38075      421 SGTNVHMIL 429   Pseudomonas fluorescens
BAC76470      406 TGSNGHVVL 414   Streptomyces rochei
ZP_00109664   423 DGSYAHLIL 431   Nostoc punctiforme PCC 73102
NP_489395     450 DGSYAHVIL 458   Nostoc sp. PCC 7120
NP_821274     453 GGTNVHVVL 461   Streptomyces avermitilis MA-4680
BAA92854      390 SGKIIHRGE 398   Microcystis aeruginosa
EAA53526     1705 SDATWFVIS 1713  Magnaporthe grisea 70-15
CAG05481      488 GRYWARNIR 496   Tetraodon nigroviridis
AAM78457      408 SSAQTSAIT 416   Hypocrea virens
EAA61668      524 LDAALHAIF 532   Aspergillus nidulans FGSC A4

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