4NSD,4NSC


Conserved Protein Domain Family
EFh_MICU1

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cd16173: EFh_MICU1 
Click on image for an interactive view with Cn3D
EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins
MICU1, also termed atopy-related autoantigen CALC (ara CALC), or calcium-binding atopy-related autoantigen 1 (CBARA1), or Hom s 4, or EFHA3, localizes to the inner mitochondrial membrane (IMM). It functions as a gatekeeper of the mitochondrial calcium uniporter (MCU) and regulates MCU-mediated mitochondrial Ca2+ uptake, which is essential for maintaining mitochondrial homoeostasis. MICU1 and its paralog, MICU2, are physically associated within the uniporter complex and are co-expressed across all tissues. They may operate together with MCU to regulate the channel. The mutations in MICU1 are associated with neuromuscular abnormalities in children. MICU1 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.
Statistics
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PSSM-Id: 320081
Aligned: 5 rows
Threshold Bit Score: 241.466
Created: 19-Nov-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca binding site [ion binding site]
Evidence:
  • Structure:4NSD; Homo sapiens MICU1 binds two Ca2+ ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # # #      #                                                           
4NSD_A       129 NFEIAFKMFDLNGDGEVDMEEFEQVQSIIRsqtsmgmrhrdrp-ttgntlksglcsALTTYFFGADLKGKLTIKNFLEFQ 207 human
4NSC_A       147 NFEIAFKMFDLNGDGEVDMEEFEQVQSIIRsqtsmgmrhrdrp-ttgntlksglcsALTTYFFGADLKGKLTIKNFLEFQ 225 human
B1H2N3       219 NFEIAFKMFDLNGDGEVDMEEFEQVQSIIRsqtsmgmrhrdrs-ttgntlktgfssALTTYFFGADLKGKLTIKNFLEFQ 297 western clawed ...
XP_008104875 231 NFEIAFKMFDLNGDGEVDMEEFEQVQSIIRsqtsmgmrhrdrs-ttgntlktgfnsALTTYFFGADLKGKLTISHFLEFQ 309 green anole
A4IG32       233 NFEIAFKMFDLNGDGEVDLEEFEQVQSIIRsqtsmgmrhrdrsttgntlktggcssALTTYFFGADLKGKLTISSFLEFQ 312 zebrafish
Feature 1                                                                                        
4NSD_A       208 RKLQHDVlkleferhdpvdgriterqfggmllaysgvqskkltamqrqlkkhfkegkgltfqevenfftflkniNDVDTA 287 human
4NSC_A       226 RKLQHDVlkleferhdpvdgriterqfggmllaysgvqskkltamqrqlkkhfkegkgltfqevenfftflkniNDVDTA 305 human
B1H2N3       298 RKLQHDVlkleferhdpvdghiterqfgsmllaysgvqskklthmlkqlkkrfkdaegltfeevenfftflkniNDVDTA 377 western clawed ...
XP_008104875 310 RKLQHDIlkleferhdpvngriterqfgsmllaysgvqskklclmlkqlkkhfqdgegltfeevenfftflkniNDVDTA 389 green anole
A4IG32       313 RKLQHDVlkleferndpvdgritekqfggmllaysgvqsrklkqmqknlkrmfkdaqgitfeevenfftflknvNDVDTA 392 zebrafish
Feature 1                                                # # #      #         
4NSD_A       288 LSFYHMAGASLDKVTMQQVARTVAkvelsdhVCDVVFALFDCDGNGELSNKEFVSIMKQRL 348 human
4NSC_A       306 LSFYHMAGASLDKVTMQQVARTVAkvelsdhVCDVVFALFDCDGNGELSNKEFVSIMKQRL 366 human
B1H2N3       378 LSFYHMAGASLDKVTMQQVARTVAkvelsdhVCDVVFALFDCDGNGELSNKEFIAIMKQRL 438 western clawed frog
XP_008104875 390 LSFYHMAGASLDKDTMQQVAKTVAkvelsdhVCDVVFALFDCDGNGELSNKEFVAIMKQRL 450 green anole
A4IG32       393 LSFYHMAGASIDKATMKQVARTVAkvelsdhVCDVVFALFDCDGNGELSNKEFIAIMKQRL 453 zebrafish

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