Conserved Protein Domain Family
IHO1
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pfam15771: IHO1 (this model, PSSM-Id:406255 is obsolete and has been replaced by 464859)
Interactor of HORMAD1 protein 1
Interactor of HORMAD1 protein 1 (IHO1, previously known as coiled-coil domain-containing protein 36 or DUF4700) is required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. It is thought to function, in collaboration with SPO11-auxiliary proteins MEI4 and REC114, through the formation of DSB-promoting recombinosomes on chromatin at the onset of meiosis.
Links
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Statistics
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PSSM-Id: 406255
Aligned: 16 rows
Threshold Bit Score: 788.218
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003409712  20 AIKSSNWNNNQTDYSSLSDSQFLFGSQFCPENSETLSAPLDIGTHLRHPKQSQQNSLDSEPSIFTKYQTKPQLFGGDRTD 99  African savanna...
EGW08946      49 ITKPSNWNSNQTDCSSPSDSQFLFGSQFCPENSESLSASLDIGAYSRHPKQTQQNSVDNEPSIFTKYQTKPQLFGGDTKD 128 Chinese hamster
Q6PDM4        20 ITKPSNWNNNQTDCS-LSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDTKD 98  house mouse
EDL77175      20 LTKPSNWNSNQTDCSSLSDSQFLFGSQFCPENSETLLPPLDAGTYLRYPKQTQQNSVDNEPSIFTKYQAKPQLFGGDTKG 99  Norway rat
XP_005326966  20 TTKSSNWNNNQTDYTALSDSQFLFGSQFCPENSETLSAPLDFSAHLRHSKQSQQNSLDSEPSIFTKYQTKPQLFAGDTKD 99  thirteen-lined ...
EHB14801      20 TTKSSHWNNNQTDYSALSDSQFLFGSQFCPENSETLSAPLDLGAHLRHSKQLQQNSVDSEPSIFTKYQTKPQLFGGETKD 99  naked mole-rat
XP_016279869  20 TNKSSSWNNNLNDYSSLTDSQFLFGSQFCPENSQSLSASLDFSTHLRHAKTSQSEDV----SCFHKVSLLPQLFGGDTKD 95  gray short-tail...
XP_017199304  20 NTKASVSNNNQTDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRQQKQSQQNSLDSEPSIFTKYQTKPQLFGGNAKD 99  rabbit
XP_006107035  20 TTKSSNWANNPGDYSSLSDSQFLFGSQFCPESSETLSAPLDVGVHLRDPKPLQKGSLDNEPSIFTKYQTKPQLFEEDIND 99  little brown bat
XP_003800629  20 ttKSSNWINNQTDYSSLSDSQFLFGSQFCPENSETMLAPLDFGTHLRYPKQSQQNSLESEPTIFTKYQAKPQLFGGDTKD 99  small-eared galago

XP_003409712 100 GGLFPPPLSVGKSKGLLEQFEEKKKLAKDKCDSETLCSFISRVRESIHRLQTSVEKSEEHLSSRSQTILDSLETVAKTLQ 179 African savanna...
EGW08946     129 EGLFSLPLPVGKSKGLLKQFEEKKRRATDKCDSEMLYNFVSHFQEVIHKLQTSVEKSEENLSSRSQSILDSLETVAKTFQ 208 Chinese hamster
Q6PDM4        99 ESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKTFQ 178 house mouse
EDL77175     100 EGLFSLPLPVGKPKGLSKQFEEKKRRATDQSDSETLHNFVSHFPEVIHKLQTAVEKSEEHLSSRSQSILDSVETIAKTFQ 179 Norway rat
XP_005326966 100 IGLFSLPLPVGKSKGLLTQFEEKNKRTKDQCDSETLYNFVSQVRESIHRLQMSVEKSEEHLSSRSQSILDSLENMAKTLQ 179 thirteen-lined ...
EHB14801     100 RGLFSLPLPVGKSKCLLKQFEEKNKTAKDKCDSESLYNFLSQVRENIQRLQTSVDKSEEHLTSRSQSILDSLETVAKTLQ 179 naked mole-rat
XP_016279869  96 EKLLLPHLPMGKSKSILEQFEENKKRAQDKQDSEALNSFISYVRESMHKLQTSVEKLEEELSSRNQTVLDSLEAVAKTLQ 175 gray short-tail...
XP_017199304 100 GDLFPLPLPVGKSKGLLEQFEEKKKTAKDKCDSETLYNFVSNVRESIHKLQTSVEKSEEHLTIRSQSILDSLETVAKTLQ 179 rabbit
XP_006107035 100 GGLFPLPLPVGKSKGLLEQFEEKKKIAKDKCDSETLYSFISHVRESIHKLQTSVEKSEEHLSSRSQSILDSLETVAKTLQ 179 little brown bat
XP_003800629 100 GGLFPLPSSVGKSKGLMEQFEEKKKRTKDKCDSETLYNFVSHVTESIHRLQTSVEKSEEHLSLRSQSILDSLETVAKTLQ 179 small-eared galago

XP_003409712 180 ETSKAQSDLVLEAVQDKGSTEQTILEMQKRFEARQAEFIEMKSNLKHLEVLVAQQNKEFQKLCEHLVQLNVPSVLADLKK 259 African savanna...
EGW08946     209 ESAQVQRDLIFDAMRDKGNMEQAILELQRSSETRQAEFMEMKSNLKNLEVLVTQQSKDFQQLCEKLGQLNVPGVLEELKK 288 Chinese hamster
Q6PDM4       179 ETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEELKK 258 house mouse
EDL77175     180 ETARVQHDLMVEAVKDKGSVEQAVLEIQRACAARQAEFMEMKSTLKNLEVLVVQQSKDFQQFCDNLGQLIVPSVLGELKK 259 Norway rat
XP_005326966 180 DTTRSQSDLIFEAVQEKINVEQAILEIQKKFETSQAEFIEMKSNLENLEVLVAQQSKDFQQLCEQLDQLKVPSVLAELKR 259 thirteen-lined ...
EHB14801     180 ETARVQSDLRFEAIQEKGNAEQAILEMQKKFEARQTEFIEMKSSLKHLEVLVAQQNKDFQQLCEHLGQLHMPDVLEELKR 259 naked mole-rat
XP_016279869 176 ESAQAHCDLMLDALRDRSRIEQRALELERLLETREAEFLDMKSSLKNLEVLAAEQSKQHQRLCDQLDQLNFP----KMQS 251 gray short-tail...
XP_017199304 180 ETARTQSDLVFEAVQEKGNTEQAILELQKKFEAKQAEILEMKSNLKHLEVLVAQQSKDFQQLCEQLGQLNVPSVLAELKR 259 rabbit
XP_006107035 180 ETARAQRDLVLETAQDKGRVEQAVLELRREFQARQAEIVEMKSGLKHLEAVATQQSNYVQQLCEQLARLDVPGTLAELKS 259 little brown bat
XP_003800629 180 ETARAQNDLVFEAVQDKGNMEQAILEMQKRFEARQAEFIEMKSNLKHLETLVAQQNKDFQQLCDKIGQLNVPSVLAELKS 259 small-eared galago

XP_003409712 260 FiSAPRVHEHVKDSASQTSPAPAQSLNFTRQEKSASEgpvmwqAQLLPaawnpSVGSLWPRESGVWGKGGKSDILQEeAT 339 African savanna...
EGW08946     289 L-SAPRLVGHLKDSTSQTSPALAQSLHFTGQEKCTSE------AQVSP-----TGSSQRPREFGVWDEGAESGVFQK-AA 355 Chinese hamster
Q6PDM4       259 FtSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEepatwqAQEAPag-npSTSSQRPGECGVWDEGAESGVFQK-AA 336 house mouse
EDL77175     260 FtSVPQVVGHLKDSASQTSPSLTQSHHYPRQEPYPSEepatwqGQEPPag-nsSRGSQRPTEFGVWDEGAESDVFQK-AT 337 Norway rat
XP_005326966 260 LiLVPQIPEHVKDNTSQTSPSLTQSLNFTRQEKYASEelvmwqAQAHTaagnpSTGSLVTREFGIMGEGTKGDALQKeVA 339 thirteen-lined ...
EHB14801     260 LiSAPQVPRHVKDSASQTSPSLAQSLSFIKQSKLTCEepvawqIQAAPaagncSAGFLRPGEFGVWGKQAKSDSLQEkAA 339 naked mole-rat
XP_016279869 252 LdLEAQLSCHVNDRSPQTVSALLQASNLSRKGTSISKssdiseTIMLPphlnpLASSHQSEKCSAEKQEAKDETHRP--- 328 gray short-tail...
XP_017199304 260 WiSVPQVPRHVRDSTSQTSPLLARNLSFTGQEQYALEdpvpwqAQGLPgagnpSRGSSQPGKFDVWGEGAKNGAPQEeAA 339 rabbit
XP_006107035 260 FlAGPRAPTHVRDSTSQTSPPRAQSLSPAPQAq----------AQALPar-dlRMGALRPGESDVWGEGAKRAALPEe-- 326 little brown bat
XP_003800629 260 LiSVSRVPGHVKDNTSQTSPPLAQSLNLTRQEKYISKervlwqAQPLP-----SIGSLQPGESSVWG-----DALQEeAT 329 small-eared galago

XP_003409712 340 LPAAGLSKGNKHVQDKEVQTNSEHCVLTKIERKNHGLSILGHKVPGNRDLVSQGASRLvslDLNNFAASTENSC--QEYH 417 African savanna...
EGW08946     356 LLTDEPHRGNEHVKNNAMQTYYKNWVITTRSLTNHCASLPSQKADHDEDLVADEASQL---DLNKFESRVKNAC--PQIE 430 Chinese hamster
Q6PDM4       337 LPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNHFSNLPSQRAGNGQGLMAQGASQR---DVSKFEARVKNAC--PEYG 411 house mouse
EDL77175     338 LPTDRPHRGSEHVKGKAVQTYCKNWVMTSRSLSNHFS-VPDQKAGSEQDLTAPGASQL---DCES-EARVEGIC--PTYE 410 Norway rat
XP_005326966 340 LPALWPCKGNEHVKDKSVQTNCQNWAITKADSKNHGSRIPGHKVLGDSDLLYQGNSQLislDLHNFAMSIKNLC--PEYQ 417 thirteen-lined ...
EHB14801     340 LPAVEPCKGNEQVKDKEMQTNCQDLAVTKTSPKNHGSSIPDHKACADRDLVSQGGSQLislDLNDVTNSIQNVC--PEYQ 417 naked mole-rat
XP_016279869 329 -----LDKKNQNGKDEAVQTDLEPQDPAKKWSESWDSSSKIYGDHCKRDIVVQETSQFpsmAVKDLGTKAKPTCilQECQ 403 gray short-tail...
XP_017199304 340 LPGAQPREGNGCAKDQAMQPHSNNQGVSKSHPENPGSHIPGYRIPGDRDQVSQGASQLislDLNTFATSIENAY--PKHQ 417 rabbit
XP_006107035 327 --AVGEGKRSRGVRDKAVQTSLKSQLLPKTSSENC----------GGRKLVAQGALRLlslDVNNFVTS-------PKCQ 387 little brown bat
XP_003800629 330 SLAAWPHKGNGHVTDKAVQTNCKNWAITKMDPKNHGSSIPCHKVSDDKDPVSQGTPPFksrNFNNFTTSIKNAC--QKCQ 407 small-eared galago

XP_003409712 418 AKDVFSCDPRGQsLITEPK-GRTVERGKKGKQWQPRKAHKGRLLARKREQTPSKTCAVLSKNQSPQPPVSVPKRPSLEqq 496 African savanna...
EGW08946     431 AQNMCSSDLFEQ-SATEQK-DRTRGKERKGKKQHPRKSQRGRLLARKQEQTPRKACAFVSRHCRTQTSVSSPQGSIIC-- 506 Chinese hamster
Q6PDM4       412 PQSMCSFDSLEQ-SATEQK-GRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPLIC-- 487 house mouse
EDL77175     411 AQSKCALDSFEQ-SAAEQKrGRTCRKRRRGKKPQPRRAKRGRLLARVQKQTSGEACAITAERPCPQSSVCSSQGPLIC-- 487 Norway rat
XP_005326966 418 AKSIFSCAPSEQ-LETEQK-GRTVERGRKCKRQPTRKTQRGRF-ARKREQTPSKTCIFNYKYQNPQSPVSDERIPPTEqq 494 thirteen-lined ...
EHB14801     418 AQSIFFCDPCQQ-LVTEQK-GKTVERGRKSKKQQPRKAHRGRVPARKREQTPSKTRAFNPKYQSTLSPVSGPGRPPTGqq 495 naked mole-rat
XP_016279869 404 PTALFCSNTHDQnKVQEQK-GMSVDVRKRGKRKKPRKSQRGSFIKRKSSGLLRNTFTFNSRIGGPQAAAPKQRNVFLGqv 482 gray short-tail...
XP_017199304 418 TKSMSSSDPCEQ-VVTEQK-GRAIESRGKGMRQQTRRACRGRPIARKQEQAPSETHALKSKYQSPQPPVSVPQSGPLGqq 495 rabbit
XP_006107035 388 TKGVFSRDPCEQrLVTGEH-RR--------RGRPPRSTHRGRPPTRRQEQPRSTACAFSSRC--PQPPGPGSQGSPPEqq 456 little brown bat
XP_003800629 408 AKSMFLCDPCEQ-LAIKQK-GRTVERGRKGKKQQPRKAHRGRLLAKKREQTPSKTCAFSSKYQSLQSSVSGSQRPPMGqq 485 small-eared galago

XP_003409712 497 epl--qqplrLLRSRSPAKPAGPTLGGAVMPGKTAKA-----VQGRLLQLRRLPSQDNGLL--SSSSQGDHQMSWFSNLN 567 African savanna...
EGW08946     507 ----------WRAPRIAMKSARPILGRIVRTNKTARA-----TPGSIQQSTQCSSPVCESL--SSSSQEDQQINWFSDLS 569 Chinese hamster
Q6PDM4       488 ----------WLTPRSSTKSTCHILGGTGETSQTARA-----AQGNLVQHSQRSST-------DSSSQGDQQINWFSDLS 545 house mouse
EDL77175     488 ----------WPPLRSSTKSACHILGGRGETSMTAGA-----VQGSLLKSSQHSST-------DSSSQEDQQINWFSDIS 545 Norway rat
XP_005326966 495 epl--aqplhLRGPRSSTKSVCHVLGGTVKSSKIAPA-----VQESLSKFPECSSQNKDLH--SSSSQGDHQMRWFSDLN 565 thirteen-lined ...
EHB14801     496 ell--aqalcLQGPRSSPKSVCPALGRRVKPSKTARA-----VRGGALQFTTCSSKGNRLLpkESSFQRDHQMSWFSDLN 568 naked mole-rat
XP_016279869 483 enp--rqpvpLLCPH---KTVQPVVKVRRKAEKAERAdsphkAANNFFLNDYSSQETSSPF--PNSTEGDKYMSWFSNIN 555 gray short-tail...
XP_017199304 496 epl--thvlpLQGVRSPSKPVHPVLRGTVMPTKTARA-----ARGNCLQFNRSSSQDNSLL--SGSSQGDHQMSWFSDLS 566 rabbit
XP_006107035 457 epraqplcrgFQG-RNPTQ---PARGGALRP-RMAQA-----APRALPQLSGHSPQDSSQR--SDSSQGDPQMSWFSDLN 524 little brown bat
XP_003800629 486 epv--aqplhLQGPRSLTKSVCPILGGTVMPNKTSKT-----VQGSFLQLSHSSSQDNSLL--SSSSQRDHQMSWFSDLN 556 small-eared galago

XP_003409712 568 ----LRSSESPLCKEPGKNLLYDLAFDSSDD 594 African savanna elephant
EGW08946     570 ----LENPEPPLCKKGGKNLLCDPDFDSSDD 596 Chinese hamster
Q6PDM4       546 ----LENLEPPQCKKGGTNLLCDPDFDSSDD 572 house mouse
EDL77175     546 ----LENLEPPLCKKGGKNLLSDPDFDSSDD 572 Norway rat
XP_005326966 566 ----LGNSESPPCKETGKNLLYDLGFDSSDD 592 thirteen-lined ground squirrel
EHB14801     569 ----LENSEPAQCKEAGKNLLYHLGFDSSDD 595 naked mole-rat
XP_016279869 556 ----SDNSESSNAMEAEENTFYAIVFDSSDD 582 gray short-tailed opossum
XP_017199304 567 ----LGRSEPPLRKEPGKHFLYDLGFDSSDD 593 rabbit
XP_006107035 525 ----PESPQAPQPRQPGKAVFYHLGFDSSDE 551 little brown bat
XP_003800629 557 sdlsLGSSEPSLCKEPGKNLLYDLGFDSSDD 587 small-eared galago
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