Conserved Protein Domain Family
ADEAMc

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smart00552: ADEAMc 
tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
Statistics
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PSSM-Id: 214718
Aligned: 14 rows
Threshold Bit Score: 332.806
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_036223    2 WTADEIAQLCYEHYGiRLPKKGKPEPNhEWTLLAAVVKIQSPAdkacdtp----------dkpvqvTKEIVSMGTGTKCI 71   human
P55265     839 TFHDQIAMLSHRCFN-TLTNSFQPSLL-GRKILAAIIMKKDSEd----------------------MGVVVSLGTGNRCV 894  human
AAF69672   958 TIHDHIAMLSHQRFN-ALTARIQHSLL-GRKILATIVMRNGTDs----------------------LGKVVSLGTGNRCV 1013 zebrafish
T20331       1 ---------MTEYYQiPPS-----------NLFAAFLLVNAQe-----------------------EKRVLAMGSSIQYI 37   Caenorhabditis e...
AAF69765   319 VLADAVSRLVVDKFS-ELTDHFSSPHA-RRKVLAGVVMTTGTDv---------------------kEAQVICISTGTKCI 375  torafugu
CAA22774   257 IHADTIGRLVLEKFM-EVIK-GQEAYS-RRKVLAGIVMTENMNfceakvspqpakhcetnynakpiLDQVISVSTGTKCV 333  fruit fly
Q22618       1 ------MYPFYYHF--RLCKNNALIYG-FEKVIASVFLKINg------------------------NLQIIALSTGNKGL 47   Caenorhabditis e...
NP_033376  246 VQYAKISQLLKETFG-QLISNHSQYLK-CSSSLAAFIIERa------------------------gHHEVVAIGTGEYNY 299  house mouse
AAF06773     7 PTVKEIAELCLKKFE-SLPKTGKPTAN-QWTILAGIVEFNRNTe----------------------ACQLVSLGCGTKCI 62   fruit fly
AAF78409     4 DWGKTVSEKVISAYM-SLPKKGKPQGR-EVTVLSAFLVSSPSq-----------------------DPKVIALGTGTKCV 58   thale cress
NP_036223   72 GQ--SKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLK--------------EDSIFVPGTQKG----VWKLRRDL 131  human
P55265     895 KG--DSLSLKGETVNDCHAEIISRRGFIRFLYSELMKYNSQTa-------------KDSIFEPAKGGE----KLQIKKTV 955  human
AAF69672  1014 KG--EELSLRGDTVNDCHAEIISRRGFIRFLYSELMKHWESPg-------------DETIFELAGDG-----ELKIKSDI 1073 zebrafish
T20331      38 VEpdTLSGANGTSLLHLDAIILARRAMLKAFIHELSTVDSEC----------------SIFEKKEEG-----KAALKPNL 96   Caenorhabditis e...
AAF69765   376 NG--EYMSDRGLALNDCHAEIIARRSLIRYLYSQLEFFLSNNke----------dhQKSIFVHCEKG-----GYRLKDNV 438  torafugu
CAA22774   334 SG--EHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQat------------aYQSIFVRNTDGQy---PYKLKSGV 396  fruit fly
Q22618      48 RG--DKIVNDGTALIDCHAEILARRGLLRFLYSEVLKFSTEp--------------PNSIFTKGKNA------LVLKPGI 105  Caenorhabditis e...
NP_033376  300 S---QCIKPNGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNpa----------mmEKSIFCTEPASN----LLTLKQNY 362  house mouse
AAF06773    63 GE--SKLCPNGLILNDSHAEVLARRGFLRFLYQELKQ--------------------DRIFHWNSTLS----TYDMDEHV 116  fruit fly
AAF78409    59 SG--SLLSPRGDIVNDSHAEVVARRALIRFFYSEIQRMQLTSgksneakrqridseTSSILESADSSCpgevKYKLKSGC 136  thale cress
NP_036223  132 IFVFFSSHTP-CGDASIIPMLEFEDQPccpvfrnwannssveassnleapgnerkcedpdspvtkkmrlepgtaarevtn 210  human
P55265     956 SFHLYISTAP-CGDGALFDKSCSDRAMes--------------------------------------------------- 983  human
AAF69672  1074 TFHLYISTAP-CGDGALFDKSCSEAAEln--------------------------------------------------- 1101 zebrafish
T20331      97 RLVLYSNYSPpCIHAVDDAATK---------------------------------------------------------- 118  Caenorhabditis e...
AAF69765   439 QFHLYISTSP-CGDARIFSPHEAGVEDq---------------------------------------------------- 465  torafugu
CAA22774   397 HFHLYINTAP-CGDARIFSPHENDTG------------------------------------------------------ 421  fruit fly
Q22618     106 SFHLFINTAP-CGVARIDKKLKPGTS------------------------------------------------------ 130  Caenorhabditis e...
NP_033376  363 NLYLYMNQLP-KGSAQIKSQLRLNPH------------------------------------------------------ 387  house mouse
AAF06773   117 EFHFLSTQTP-CGDACILEEEQPAAR------------------------------------------------------ 141  fruit fly
AAF78409   137 LLHLYISQLP-CGYASTSSPLYALKKIpst-------------------------------------------------- 165  thale cress
NP_036223  211 gaahhqsfgkqksgpispgihscdltveglatvTRIAPGSAKVTDVYRTGAKCVPGEAGDsgkpgAAFHQVGLLRVKPGR 290  human
P55265     984 -------------------------------teSRHYPVFENPKQGKLRTKVENGEGTIP-----VESSDIVPTWDGIRL 1027 human
AAF69672  1102 --------------------------------gsGHMPLFENIKQGKLRTKVENGEGTIP-----VESSDIVPTWDGIQH 1144 zebrafish
T20331     119 ----------------------------------------------KLSYVTPTNLTCVP---------DDVLTYEQIKE 143  Caenorhabditis e...
AAF69765   466 ---------------------------------GDRHPNRKA--RGQLRTKIESGEGTIP-----VRSSNTIQTWDGVLQ 505  torafugu
CAA22774   422 ---------------------------------VDKHPNRKA--RGQLRTKIESGEGTIP-----VKSSDGIQTWDGVLQ 461  fruit fly
Q22618     131 -------------------------------------DDLQN--SSRLRFKIDKGMGTVLg---gASEFEAPQTFDGIMM 168  Caenorhabditis e...
NP_033376  388 ---------------------------------------------SISAFEANEELSLHVav--eGKIYLTVYCSADGV- 419  house mouse
AAF06773   142 ----------------------------------AKRQRLDEDSEMVYTGAKLISDLSDDp-----mLQTPGALRTKPGR 182  fruit fly
AAF78409   166 ------------------------------qvdDSLLVQASDICSSRHSDVPEIGSNSNKgn--gSQVADMVQRKPGRG- 212  thale cress
NP_036223  291 GDRTRSMSCSDKMARWNVLGCQGALLMHLLEePIYLSAVVIGk------CPYSQEAMQRALIGRCQNV--------SALP 356  human
P55265    1028 GERLRTMSCSDKILRWNVLGLQGALLTHFLQ-PIYLKSVTLG-------YLFSQGHLTRAICCRVTRDgsa---feDGLR 1096 human
AAF69672  1145 GERLRTMSCSDKILRWNVLGLQGALLTHFIH-PIYLHSITLG-------YLYSHGHLTRAVCCRLSKDgdt---fkSSLP 1213 zebrafish
T20331     144 TKSLRVHCTADKLFKWNTLGIQGALLSNVLH-PIFIDNIFFGs-----eAPVSDESLSYALQGRLGPNenereiivESMP 217  Caenorhabditis e...
AAF69765   506 GERLLTMSCSDKIARWNVVGIQGSLMSYFTE-PIYFSSIILG-------SLYHADHLSRAMYQRIADi--------EDLP 569  torafugu
CAA22774   462 GQRLLTMSCSDKIARWNIVGIQGSLLSSIIE-PVYLHSIVLG-------SLLHPEHMYRAVCGRIEKSi-------QGLP 526  fruit fly
Q22618     169 GERMRTMSCSDKLLRANVLGVQGAILSHFID-PIYYSSIAVA-------ELNNADRLRKAVYSRAAT---------FKPP 231  Caenorhabditis e...
NP_033376  420 -NRVNSMSSSDKLTRWEVLGVQGALLSHFIQ-PVYISSILVGd-----gNCNDTRGLEIAINQRVDDal------tSKLP 486  house mouse
AAF06773   183 GERTLSMSCSDKIARWNVIGVQGALLDVLISkPIYFSSLNFCc------DDAQLESLERAIFKRFDCR--------TFKH 248  fruit fly
AAF78409   213 -ETTLSVSCSDKIARWNVLGVQGALLYQVLQ-PVYISTITVGqslhspdNFSLADHLRRSLYERILPl-------sDELL 283  thale cress
NP_036223  357 KGFGVQELKI-LQSDLLFeqsrsavQAKRADSPGRlvpcgaAISWSAVPE---QPLDVTANGFPQgttkktiGSLQARSQ 432  human
P55265    1097 HPFIVNHPKVgRVSIYDS-------KRQSGKTKET------SVNWCLADGy-dLEILDGTRGTVD-------GPRNELSR 1155 human
AAF69672  1214 ANFTLNHPEVgRVSVYDS-------TRHTSKTKES------SVNWSQPDQy-sVEVLDGTKGKLD-------SPKMEVSR 1272 zebrafish
T20331     218 VQMRMHMGI--------------------------------SHLWHRGVDs--VETLDYNTGRT---------SKGSPSR 254  Caenorhabditis e...
AAF69765   570 QQFTLNRPLLsGISNAEA--------RQPGKAPNF------SVNWTVGDQg--LEVINATTGKD---------DMGRASR 624  torafugu
CAA22774   527 PPYHLNKPRLaLVTSAEP--------RNQAKAPNF------GINWTIGDTe--LEVVNSLTGRT---------IGGQVSR 581  fruit fly
Q22618     232 APFHVQDVEIgECQVEDTeq----sTSAAARSTIS------SMNWNLADGn--TEVVRTSDGMVHdkd-msgADITTPSR 298  Caenorhabditis e...
NP_033376  487 MFYLVNRPHIsLVPTAYP-------LQINLDHKSL------SLNWAQGDNs--LEIVDGLNGKITess-pfkSGLSMASR 550  house mouse
AAF06773   249 TRFQPQRPQInIDPGIRFef---sqRSDWQPSPN-------GLIWSQVPEe-lRPYEISVNGKRQgvtkkkmKTSQAALA 317  fruit fly
AAF78409   284 TSFRLNKPLFfVAPVPPSef----qHSETAQATLTc-----GLVFNTLPHmtcVSFLCFLKGGVI-------YLLALRYS 347  thale cress
NP_036223  433 ISKVELFRSFQKLLSRIARDKWPHslrv--qklDTYQEYKEAASSYQEAW----STLRKQVFGSWIRNPPDYHQFK 502  human
P55265    1156 VSKKNIFLLFKKLCSFRYRRDLLR---------LSYGEAKKAARDYETAKnyfkKGLKDMGYGNWISKPQEEKNFY 1222 human
AAF69672  1273 VSKSNLFRLFHALCQRAGRADLLAl--------QSYAHAKMAATSFQEAKrlffLALSQHGYGAWIGKPLEEKSFE 1340 zebrafish
T20331     255 VCKAEIFEAYRKLNGVDQAV-------------VNYAKAKEMASEYQYEKkvfyEKLEAAGLGKWQTKPAELVDSF 317  Caenorhabditis elegans
AAF69765   625 LCKNALYSRWVRLHSKLSSILSNKml-----kpSSYHEAKQVASEYHSAKqaliKAFHKAGLGAWVKKPIEQDQFT 695  torafugu
CAA22774   582 ITKQAFFVKYGFLMANLPGILVRKv-------tTDYGQTKANVKDYQIAKlelfSAFKREDLGSWLKKPIEQDEFG 650  fruit fly
Q22618     299 LCKKNMAELMITICTLTKTSVDYP---------ISYEELKAGSQEYAAAKksfiTWLRQKDLGIWQRKPREFQMFT 365  Caenorhabditis elegans
NP_033376  551 LCKAAMLSRFNLLAKEAKTDDLLEa--------RTYHAAKCMSGPYQEAKallkAYLQQHGYGSWIVKSPCIEQFS 618  house mouse
AAF06773   318 ISKYKLFLTFLELVKFNPKLSEMFdqqlsdperIAYASCKDLARDYQFAW----REIKEKYFLQWTKKPHELLDFN 389  fruit fly
AAF78409   348 LCWNYSGLHEVILGTTGRKQG------------TSAKGALYPSTQSSICKqrllELFLKETHGHKRESSKSKKSYR 411  thale cress
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