?cl40466: ORF8-Ig_SARS-CoV-2-like Superfamily (this model, PSSM-Id:424097 is obsolete and has been replaced by 454761)
SARS-CoV-2 ORF8 immunoglobulin (Ig) domain protein and related proteins This family includes the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins including those classified as type II, such as bat coronavirus Rf1 ORF8, and those classified as type III, such as Bat SARS coronavirus HKU3-1 ORF8. SARS-CoV-2 causes the disease called "coronavirus disease 2019" (COVID-19). SARS-CoV-2 ORF8 is a fast-evolving protein in SARS-related CoVs, and a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts (DOI:10.1101/2020.03.04.977736). |
Jiyao W et al.(2023). "The conserved domain database in 2023.",