6VOY,6QBW


Conserved Protein Domain Family
rve
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pfam00665: rve 
Integrase core domain
Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.
Links
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Statistics
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PSSM-Id: 459897
Aligned: 69 rows
Threshold Bit Score: 41.1455
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6VOY_A            151 PNHIWQGDIT--HFKyKNTL--------------------------------YRLHVWVDTFSGAISATQKRKE-TSSEA 195 Saccharolo...
Q5LF59            169 yGEYAQADFG--EKWiPVKNggs---------------------------tkVYFFAIVLTRSRYKFIHFSRRPfDTELA 219 Bacteroide...
Q7ARN5            120 PGRQMQVDWG--TMR--NGRs------------------------------pLHVFVAVLGYSRMLYIEFTDNM-RYDTL 164 Yersinia p...
Q9RI04             33 PGYQLQHDWGevELEvAGQRc------------------------------kVNFAVNTLGFSRRFHVFAAPKQ-DAEHT 81  Yersinia p...
WP_012576119      117 pgEQMQVDWKe-VGEvVIEGkk----------------------------vkLSLFVAVLGYSRMKYAVFTTSQdQEHLM 167 Anoxybacillus
O69924            158 VDWGDEGKILa-HVGiPk----------------------------------VYSFHMTLSYSRDPFCCFTTSQ-DLATF 201 Streptomyc...
Q50700             57 RLGMWFDPAT--ARRvA-----------------------------------VWAFVMVLAFSRHLFVRPVIRM-DQTAW 98  Mycobacter...
mgcchina:PST_0673 131 VGEKLFVDYAgqTVPvIDRHsge--------------------------irrAQVFVAVLGASSYTFAEATWSQ-QLPDW 183
O86758            134 PGELVHIDVKk-LGRiPDGGghktlgraeg------------hrsrtngagwAYLHTALDDHSRIAYTEDLPDE-TAPTC 199 Streptomyc...
Q4JUC9            134 PGSLIHVDVTk-FGNiPDGGghryvgrqqgarnklatpglprgkdhkprtgtAFVHTVIDDHSRVAYAEIWSDE-QASTA 211 Corynebact...

6VOY_A            196 ISSLLQAIAYLGK----PSYINTDNGPAYISQ-------------DFLNMCTSLAIRHTTHVPYNP 244 Saccharolobus solfataric...
Q5LF59            220 IYAHELAFQYFGGr---PEKIIYDQDRVLIARenlgd---liltgKFQSFIKEQHFQPVFCRRSDP 279 Bacteroides fragilis NCT...
Q7ARN5            165 ETCHRNAFRFFGGv---PREVLYDNMKTVVLQrdayqtgqhrfhpSLWQFGKEMGFSPRLCRPFRA 227 Yersinia pestis
Q9RI04             82 YESLVRAFRYFGGs---VKTVLVDNQKAAVLKnnngk---vvfnsGFLLLAEHYDFLPRACRPRRA 141 Yersinia pestis
WP_012576119      168 ECLIQ-SFKYFGGv---PKKVLFDNMKTVTDGreqgv---vkwnqRFSEFASYYGFIPKVCRPYRA 226 Anoxybacillus
O69924            202 FDCHRKAFAHFGGv---PMSVVYDRTKTVVrrhvapg-eavplhpEAVAFAGHYDFDIDVLAAYRP 263 Streptomyces coelicolor
Q50700             99 CACHVAAFEFFDGv---PARLVCDNLRTGVDKpdlyd---pqinrSYAELASHYATLVDPARARKP 158 Mycobacterium tuberculos...
mgcchina:PST_0673 184 LGSHTRCFAFLGGv---PEIVVPDNLRSAVSKahrye---pdinpSYRDLAEHYGVAVVPARARKP 243
O86758            200 AAFLVRATAYFASlgirIERVLTDNAWAYSk-------------nTWRNTCRDLDISPRWTRPWRP 252 Streptomyces coelicolor
Q4JUC9            212 VGVLERAVAWFAErgvtVERVLSDNGSAYRSH-------------AWRDFCARLGIRHKRTRPYRP 264 Corynebacterium jeikeium...
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