Conserved Protein Domain Family
bHLH_TS_FERD3L_NATO3
?
cd11415: bHLH_TS_FERD3L_NATO3 
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins
FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is a bHLH transcription factor expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription.
Links
?
Statistics
?
PSSM-Id: 381421
Aligned: 16 rows
Threshold Bit Score: 114.447
Created: 9-Jun-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #   # ### #    #                 ####                  
Q96RJ6        94 RKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELL 157 human
NP_001158470 156 RRRVITTAQRKAANIRERRRMYNINEAFDMLRKRVPTFAYERRLSRIETLRLAIVYIGFMMDML 219 Saccoglossus kowalevskii
EFX85409      36 RKRVATVAQRRAANIRERRRMFNLNEAFDKLRRKVPTFAYEKRLSRIETLRLAITYISFMDQVI 99  common water flea
XP_780135    229 RRRVVTAGQRTAANVRERRRMFGLNDAFDNLRKEVPKFKHEKRLSRIETLRLAILYIEFLADIV 292 purple urchin
XP_002609171 197 RRRIPTLAQRKAANIRERRRMFNLNDAFDKLRKRVPTFSYEKRLSRIETLRLAIIYIHFMKDVL 260 Florida lancelet
PRD23018     169 RRRVATIAQRRAANIRERRRMFNLNSAFDKLRKKVPTFAYEKRLSRIETLRLAIMYIAFMTEVV 232 Nephila clavipes
KOF70821     388 RRRIPTVAQRRAANIRERRRMFNLNEAFDTLRKRVPTFAYEKRLSRIETLRLAITYISFMTDVV 451 Octopus bimaculoides
CDQ80826     113 RRRVINVGQRQAANVRERKRMFSLNEAFDELRRKVPTFAYEKRLSRIETLRLAIVYISFMTDLL 176 rainbow trout
PAA66693     122 RKRVASQAQRKAANVRERRRMFNLNEAFDTLRTKVPTFAFEKRLSRIETLRLAITYIRFMGQVI 185 Macrostomum lignano
Q9VGJ5        79 RRRVASMAQRRAANIRERRRMFNLNEAFDKLRRKVPTFAYEKRLSRIETLRLAITYIGFMAELL 142 fruit fly

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap