6W1S,5U0S


Conserved Protein Domain Family
Med18

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pfam09637: Med18 
Med18 protein
Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators.
Statistics
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PSSM-Id: 462845
Aligned: 21 rows
Threshold Bit Score: 156.793
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W1S_M     3 MEYLLQGSVLDHSLESLIHRLRGLCDNmE--PETFLDHEMVFL-------------------LKGQ--QASPFVLRARRS 59  house mouse
Q0USA0     2 YELLLYGQVPVGRHEQVLKILAGVAAM-Q--PLRILERCIIYKpqrep----------eepgLNVRrgGTQNIALKQGNK 68  Parastagonospora no...
Q5B128     2 HELLLFASVPSHQHHELLQQLTGLTAM-Q--PRHCLERRLIFKatrk------------pdlANMRsgTGQ---GPDIVR 63  Aspergillus nidulan...
Q1E065     2 HEHSLFAPVPAAQHHDLLQQLAGVTAM-Q--PNRIYERRLVFKpyrk------------pgyLKPRpgGSQDVQAPEVQR 66  Coccidioides immiti...
EDO01479   2 HELFLSASVDSEDVSRALRILQGYCGMi---PQPFIRRRLVFEgprsrtnl----kgldpsfLKKQppNKQFWWKNLNDQ 74 
EAA34144   3 VEVFLITVVPAADTTKARSVLHGYTET-RpvTHRFTRVRHVRRldqsirgipilrslqssnpKPDSlaQWQDLHSTLSRQ 81 
Q966M5    26 QECVLYGSIFAKNVPDLERRLAGLCDPg---CEEFFEHEMSFS-------------------LRSSgiMDIKTDIKLRRR 83  Caenorhabditis elegans
Q61D43    26 QECVLYGSIFVKNVPDLERRLAGL-------WIRAAKNSMSTK-------------------CRSA--LEPPVHQILRRR 77  Caenorhabditis brig...
Q9XZT1    23 LEYLLQGSILDSAVEHLMHRLKGLCDNvDtsPEPFHDLEVCMS-------------------LRQPn-ANQPLLLRVRRA 82  fruit fly
EDO41427  13 MEYLLQGSVAKENVETLLHRLRGLCDNtAhdATKFADHEMVYT-------------------LRNS---TNTVTFRARHS 70 
6W1S_M    60 MDRA-----------------------------------------------GAPWHLRYLGQPEMGDknRHALVRNCVDI 92  house mouse
Q0USA0    69 PATAaaalyytkliqklsedd-------------fgvehgkplsadvkdgeEAKWSMRWEDQPDTGD--RGVSIRFTNTT 133 Parastagonospora no...
Q5B128    64 LNKMlngqmfytqvvgplseadfdgkpsssdsqdvsmsgtheaagssydydSQPWRLEFRDTPEAGFr-STITARLAASA 142 Aspergillus nidulan...
Q1E065    67 LNKMlngglyhvqvvgevkltdfgthp-stvdatmggtdfgnqhqneydisNQSWRIEFKDIPDAGTg-SAVTSRLISTS 144 Coccidioides immiti...
EDO01479  75 LIRQsyvltliydvdrsqfgqp------------akelgsgedksgllpcdEVPGTLRWNDLPDPANa-AIVNSRMFIAI 141
EAA34144  82 qymltervditqdvda--------------------avaagqpvpmseqtqKGERILRFNDFPDPPNprVPQTVMQRKQI 141
Q966M5    84 FRTEhr--------------------------------------------iQNYWQLKYIGVPEPDQk-CPTIVRKEISS 118 Caenorhabditis elegans
Q61D43    78 FRTEhq--------------------------------------------iQNYWQLKYIGVPEPDQk-CPTIVRKEISS 112 Caenorhabditis brig...
Q9XZT1    83 LGR------------------------------------------------DAPFQMRYLGNPEVDLr-RPTLVRSCMDC 113 fruit fly
EDO41427  71 LADP-----------------------------------------------SAPWQLRYLGQAEMGDksRATLLRSCVEV 103
6W1S_M    93 A---TSENLTDFLMEMG-FRMDHEFVAKGHLFRK-GIMKVVVYKIFR-ILVPGNT------------------DSTEALS 148 house mouse
Q0USA0   134 Dl--LSGDPHAHMIATGpNRFVTEYYVEGHRFVH-GNVIIFLHRVLH-EPGVRSLevapktq-----lpdfaaLQLLDMS 204 Parastagonospora no...
Q5B128   143 Al--PKGDVVPSMNAWG-YSFVTEYVVEGDMFIY-NDIVIFLHRVLQ-YPATGQEpheprrq-----lpsfrdLAPLEKT 212 Aspergillus nidulan...
Q1E065   145 Rv--PYGDIVPVMKAWG-YDYVSEYVLEGDMFIL-DDTVILLHRILN-FPAKHHLqglpafy-----lpplqeMVPLDST 214 Coccidioides immiti...
EDO01479 142 D---NEKSLCKLLQDSN-HRFTREIIQECHRTVH-NNIVFTLSRYFE-VPSEFQEvdgnsrpkvnsrlppfelLEPFDAE 215
EAA34144 142 DirePGPLLEQHMADSG-FSVANEYIEETYHWWDnNNLEFVLWRQYNdLPNPTPAplvqvagqanwmvpdmskMEPVAPF 220
Q966M5   119 Lv--HSQDMMTYAKSLG-LRMDYEYMTQGKLWTK-GNIKILHSILTS-TSRAGTYd----------------sNSIKSVS 177 Caenorhabditis elegans
Q61D43   113 Lv--HSQDMMTYAKSLG-LRMDYEYITQGKLWTK-GNIKILHSTLTR-TLRAGTYd----------------sSSLKSMS 171 Caenorhabditis brig...
Q9XZT1   114 A---CTNGILEFLTEMG-FRLEFEYIAKGYMFRK-GRMKITVSKLIK-IVPGKQQd-----------------MANEPIS 170 fruit fly
EDO41427 104 S---TSENLTAFLEELG-FRFDYEVVLKGFVFYK-GHMRITVSQVFR-VRVT---------------------------- 149
6W1S_M   149 LSYLVELSVVAPAGQDM-VSDDMRN-----FAEQLKPLVHLEKID 187 house mouse
Q0USA0   205 GAYILEVKLRVQDFKDA-ATLESGVnelkgFQKQMAGCVELSLPD 248 Parastagonospora nodorum SN15
Q5B128   213 GSYILQAAITVQDGSNQ-ELMRTASqhlfgLREQLKSAVRLEHAD 256 Aspergillus nidulans FGSC A4
Q1E065   215 GGYLLQASITVQDSGNP-DLMKATTqrllgLKEHLKSAVRLESAD 258 Coccidioides immitis RS
EDO01479 216 DKWILTASVEVQNGSDP-DHMKSAMaelsgVQEEFRGCFALKAAD 259
EAA34144 221 WMLYVRALVDANPVDRMaERMAEAHgrlgkVEKELEGVFSFMVFD 265
Q966M5   178 DSALVEISISLPESAEY-MPAAKSLr---dFADQLMPLVNMEKVD 218 Caenorhabditis elegans
Q61D43   172 DSALVEISISLPESAEY-MPAAKSLr---dFADQLMPLVNMEKID 212 Caenorhabditis briggsae
Q9XZT1   171 QSYIVELSVVAPTGQEN-VGEEMRV-----FAEQLKPLVQLEKID 209 fruit fly
EDO41427 150 ------------------------------FHGKTHAIVsrka-- 162
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