Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins
UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.
Feature 1:putative UBX-p97 interaction site [polypeptide binding site]
Evidence:
Comment:based on the structural evidence that Rattus norvegicus UBX domain of p47/UBXN2C (1S3S) in complex with p97, contacts at 4A
Comment:Hexameric p97 N terminal domains are complexed with UBX domain of p47 through a loop that is highly conserved in UBX domains but is absent in Ubiquitin.
Jiyao W et al.(2023). "The conserved domain database in 2023.",