Conserved Protein Domain Family
SpoT

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COG0317: SpoT 
(p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
Statistics
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PSSM-Id: 440086
Aligned: 678 rows
Threshold Bit Score: 503.919
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_129892214   1 MAMLNsfveqp----------fvpretPDA-LSR---------------------------LhAL----ALRY-MT-SEE 36 
WP_104937374   1 MQHGTf------------------------------------------------------dI-EDyrqsMAAiiGL-GpE 24 
WP_049766292   1 MAREEtvqa--------------pksaNASrIRMmlpstt---------------dvhgfdL-EHyrarMSKFlDPaESD 50 
WP_011189146   1 MRHILf------------------------------------------------------dL-EIyraqMQRilGV-KeE 24 
WP_003662724   1 MPDSQdlttptnl----------shplvdeaRDS---------------------------LmRA----V-AY-LK-PDE 36 
WP_119724785   1 MEDKYsk-------------------iDKR-VEV---------------------------IvKK----VSiY-MP-NLN 27 
AKH32902       1 MGKVRyaygleamedflsydeedssndDVKiMEQ---------------------------IiHT----ASKY-LP-EED 47 
WP_011280986   1 MIQNLpklshp---------------lvddaQYN---------------------------LlRS----V-GY-LT-GAE 31 
WP_095043014  83 LE-------------------------IAD-AEQ---------------------------LfAL----TNSY-LP-TAE 103
WP_013164774   1 MTKPAi---------------------AKTgSDSpngrhpdpavrggnlcpigfkgagsfdI-AAycrrMEEllGDq--E 56 
WP_129892214  37 ----INLIIQAFHLAREAFQKSENSaaAPLLFRALDVASILAdLMHV-DAVGVAAGLVFEAVDAD-A-LSLNQVEEVLGA 109
WP_104937374  25 ----TRVFWSALDFACDAHKNQRRRsgDPYIMHPCLAAQILAaELDIrSPEMLAAALLHDTIEDV-KgVDSALLTEKFGP 99 
WP_049766292  51 ----NRVFYDALQYSYDLHKGQTRKsgAPYISHPCSVAEILArELHFrDPHLLAAALLHDVVEDIpG-ITLEDILRRFGS 125
WP_011189146  25 ----NDVFWRALDFAVDAHDDQWRKsgDAYILHPCYVAKILAgEMDItHPEILAAALLHDTIEDVeE-VTAEVVGELFGS 99 
WP_003662724  37 ----RADVLRACHFGDVAHIKDKRKsgEPYITHPIAVAEILA-GFRL-DRDTIVAAILHDTIEDT-E-VTDEMVTQEFGQ 108
WP_119724785  28 ikyiREEIFKAYEYARDAHEGQYRLsgEPYISHPVEATMILL-ELKP-DIFTIQSCLLHDVIEDT-P-KTKEDIEKEFGK 103
AKH32902      48 ----IRKIQKAYIYAAQAHLGQKRLsgEDYIVHPLRATQILL-TLKP-DAVTIQTCILHDVIEDT-D-ITYEDVKSEFGQ 119
WP_011280986  32 ----RRDIVDACEFGDVAHIKDKRKsgEPYITHPIAVAEILA-GFRL-DRDTIIAAILHDTVEDT-E-VSDEQIETRYGK 103
WP_095043014 104 ----RAQIEKAYEFARREHGTERRNtgELFFTHPLAVATYLA-EYRL-DAPAISAALLHDIAEDT-P-ILLSQIEDEFSA 175
WP_013164774  57 g--pARLFWQALSFAVTAHQDQRRKsgEAYISHPLQVAQILTeELDVrDPKILAAAVLHDTIEDVpE-ITTVTIGEMFGS 133
WP_129892214 110 STARVVGSMLRLNILERRKqevsaagsrrsleedagssssaesKkprirEal----rRQQAETVRKMFVAMAEDPRVVLL 185
WP_104937374 100 DVAAIVEGCTKVTNFT-GG------------------------R-----Q-------TFKKlVHRKIFSGAAARLEVMLV 142
WP_049766292 126 RIAELVDGCTKLTRHQL-D------------------------R-----Aa------LKDL-THSKIFLSASRRLGVLII 168
WP_011189146 100 YVQAIVEGCTKVTHVS-DN------------------------K-----Q-------LNSKRTHRKIFSGAALRPEVMLV 142
WP_003662724 109 MVAQLVDGVTKLKSSGM-S------------------------K-----Q-------QSQAATFHKILTATLSDPRVLII 151
WP_119724785 104 EVAFLCEGLSKLSKVRYKG------------------------------E-------DRSIGSLRKMFVAMAEDLRVIFV 146
AKH32902     120 EVADLCEGLVKVSKVRYHG------------------------------E-------DRQIETLKKTFLAMASDLRVIFV 162
WP_011280986 104 VVSRLVDGVTKLKSSTH-N------------------------K-----Q-------ENKAATFHKILTATLADPRVLII 146
WP_095043014 176 EVAQLVDGVTKLKEVTRRVa-----------------------K-----EstrmsplDLKQATLRKLMLAMTVDVRTVII 227
WP_013164774 134 DVEETVEACTKIASFA-GD------------------------R-----Q-------NFYKlVHRKLFSGAAARLEVMLI 176
WP_129892214 186 KLAYRLQAMRQMCQPTfKgdpQEMITMAQETREIYAPLAGRLGMSRIESELEDQAFQILEPDKFVWVRDLVELESKQWRS 265
WP_104937374 143 KLADRLHNMRTLKSMP-R---DKRQKIADETLDIYAPLATILGLFDIKRELYNLALTHKFPRQCKPIRAHIRELLKn--P 216
WP_049766292 169 KLVDRLHNLRTLHYLP-Q---AKRQRIAQETVEVYAPIAARFNIYPLKRELYHLALSYLYPRKSKKILQHVRELRNs--A 242
WP_011189146 143 KLADRLHNLRTLQAMP-K---RKRQRIADETLDIYAPLATVFGLFCMKREMYNLALLYKFPKQGVKLKGYVRNIGNe--P 216
WP_003662724 152 KLSDRLHNMSTLDAVS-E---EKQKRTAKETLDFYIPFARLMGLNSIADYIELLCYRNLNPDMYNKFTDKLLQHGLGRNF 227
WP_119724785 147 KLSDRLHNMRTLKSHPkP---EKRQRIALETLNIYAPIADRLGLFGFKNNLEEECFKILDPESYKELKRQFREIEPQRRT 223
AKH32902     163 KIADRIHNIQTLHFHPkE---DKKIRIAQETLKIYVPICKRLGLYQFQLYLENGVFKILHPEEYQQVITFLKKKYPYADR 239
WP_011280986 147 KLADRLHNMSTLDAVR-P---EKQRATAQETLDFYVPFARLMGLNDIADYIEVLCYRNLDSEMYNKISDKLLQHGLGRNF 222
WP_095043014 228 KLFDRLHNMRTIHGMS-A---QSQKAKAEETLAVYAPLAYRLGMWQVKGELEGRSLEVLQPHAFETIQAELERLFRVQEP 303
WP_013164774 177 KIADRLHNLRTLDSMP-R---HKRQKIAEETLDIYAPLAKVMGLYAIKRELYNLALSYKFPRQSQKVNAKIKRLAAs--E 250
WP_129892214 266 YVERVCTILRAEMAAIGVK-A-E--V-SGRVKHLYSFYKKLARtagdvddlealkAA--ADIN--Q-IHDLIAFRILVTS 335
WP_104937374 217 DALDIVNRIRAALAEKGLK-A-C--V-ELRTRELWAYYDMHHHml---------mQR----------IETPQTIVILTED 272
WP_049766292 243 EVVDIENRLREILLQAGVA-A-D--I-RPRPKGLGSYYNALKRt---------------LDIGnpEnYFD-FAVVLATGE 301
WP_011189146 217 IVTKIAEALRESASELDLD-C-D--V-NIRIKDLWAYYDTNSHil---------lKQ----------IDTPVEILILVDE 272
WP_003662724 228 QKTEISTYLQSLLSHLNLD-G-HvqVlDNRT----AMYRQFFK------------NR--GQIS--Q-LIRQYDFEVILKD 284
WP_119724785 224 FMKNVESEIDKILKGKVEN-Y-E--I-DYRVKSIYSIHKKLLK------------KGl-THMK--E-LFDVFGVRVMVET 282
AKH32902     240 DIIKSKMKLEKLLSSKGVHhF-S--I-TGRVKSPYRIYEKLIK------------KYntLDFS--K-VFDIMAFRIVVDT 300
WP_011280986 223 QREAIHRYLSIVLNNLDLD-G-MvkVlDNRV----VIFRQFFR------------NR--GEIN--A-LLRHYAFEIVLDN 279
WP_095043014 304 LFDVVRTRIIDYLGANGLP-VrD--V-KMAPESIYTVFRDLEK------------QD--AGYR--E-VDRMLRITVLLDD 362
WP_013164774 251 VMQDVKRTLEELCRQSWVT-A-D--V-RIRPKGLWAYFDPGPKvl---------hKS----------INHPMEVEIIADD 306
WP_129892214 336 TPDCYTALGHVHSLWKPKEGRIKDFIANPKPNGYSALHTTV-FC----LDDHLVEVQIRTHSMHEMAEYGVAMHWHYK-D 409
WP_104937374 273 LDSCYTALGVVNGIYAPSPRSIRDFIASPKPTGYQCLHCRPiIG------GRKYLFKIRTEEMQRRARRGMVRDWTMG-S 345
WP_049766292 302 DLKCYLVLGIICKDFVSIPRSLRDFIANPKINGYRSLHVRVhVG------GQNYLIKIRTEEMDLQASYGVLQDWTAQ-T 374
WP_011189146 273 PSSCYHALGVVNQTFPPIPRTIRDFISNPKPTGYQGLHARTiI------EGRKYLVKIRTKEMALQGQRGIFRDWSSK-T 345
WP_003662724 285 IEACDTLATYLIQKYQIGNHQIHDNIRKPLAGGNQSL-TLF-YD----RDYNHIKITLMTRRMQEAARLGIISNDR---A 355
WP_119724785 283 EADCYKVLGIIHNTWTPIPRRFKDYIALPKPNGYKSLHTSI-IGlfqeDTKQPTEIQIKTYEMKEYADIGVAAHFEYK-E 360
AKH32902     301 IPECYNVLGIIHSSYNPLINKIKDYIAVPKFNDYQSLHTTI-LG----LYPFPIEIQIRTKDMNTIAEFGVAAHFLYK-D 374
WP_011280986 280 IEACDKLAYYLIKKYQIADSHIADNIRRPLPGGNQSL-TLI-YE----RDNDFVKVTILTKQMQSAARLGVIGAEH---A 350
WP_095043014 363 PIQCYTALGHIHHLWPAVPNHFDDYISVRRENLYQSLHTTV-QA-----DGQHLKVRLRTVDMDLIAQIGVLARWKYA-K 435
WP_013164774 307 IQNCYRTLGLIDQTYPPIPRTIRDFIANPKSTGYQSIHVRCnV------KGWHVLFKIRTPEMQNSSRAGLLRGWTSRgN 380
WP_129892214 410 VGDNaSAS-ARELL-TWLRQLSEW--Q-H---ELraSDa---sDT-EFVEAVKGDIFQEQIFVFTPKGEVKDLPVGSTPL 477
WP_104937374 346 RAS---T----RFF-KQIQEMFD---I------L--GRd---eSL-SYRDLIAAG-DRKEIYTYTPKGDLICLPVNSIAL 401
WP_049766292 375 PMS--D-----DHW-AEISDLLR---TiG---Ey--GG-----AGpQRKELIRLS-EAEEIFVYSPQGDIYYLPKGSVVL 432
WP_011189146 346 GKQ---G----KFV-QEIQEMFD---I------I--GTd---dSF-SYRDVIAAS-GKKEVYTYTPNGDLICLPVNSTVL 401
WP_003662724 356 Gv--sQ-SvIQASL-RNMQDLAN---AgKa--E---GDd---aHV-VIIEELISYLHERKIVCYSPKGRAYELPRGSTAL 419
WP_119724785 361 KGS----K-IAKDI-DWVKELKDM--V-D---SI--QDs-------DFVGSLKVDLFKDRIYVFTPQGDFINLPFGSTPI 419
AKH32902     375 TDSSnPv-lTQRQS-EWIRDLQDSvkKyQt--E---EK-----KD-AFKDKLAIELLDNTIFVYTPKGDVIELTKGSTVL 441
WP_011280986 351 SDv-sQ-SvIQASL-RNMKDLVD---E-DclsE---GNpdfatAV-STINELMDYLHSSKIICYSPQGRAYELPQGATAL 419
WP_095043014 436 TPLw-SAG-LAERVeAFFASISS-----SigvDP--QD-----PG-SGVRSAMEDVLGEQIRVYSKDGDAVDLAQGGTPI 500
WP_013164774 381 GEA---A----ALT-REVREMFD---L------M--GSd---dSS-SYRDMIAVS-SSKEIYTYTPKGALMVLPKDSIVL 436
WP_129892214 478 DFAYRIHTKIGDSCAGARIiteagsgetarlMTRMVPLDYELKSGEIVDIITSRSA-HPTRDWLS----FARTAAAKSKI 552
WP_104937374 402 DFAFRIHSAIGLSCTGAMI------------GQQKVPASHVLQDGNVVRILRQDEPvVFDQEVQS----LCQTPQARAEL 465
WP_049766292 433 DFAYKIHSELGDHCQGALV------------NGLWEPPTRVLKDAETVEIVTSPDLlDVDPDLEQ----LCKTPRARSFL 496
WP_011189146 402 DFAFRVHTHIGLSCLGALI------------RSEKVGPAHVLRDGDMVRVIHSDEPiRFEQENLA----ACKTPRARSEL 465
WP_003662724 420 DFAYAVGPAIGNIATGADI------------NHKHGKLGLVLADGDIVSIDTDKNA-TPRAEWLG----FVATNKARNEI 482
WP_119724785 420 DFAYAVHSELGDHITVAKV------------NGIVYPLDKELNNGDVVEVITDKNR-KPNPFWIS----FVKTVKAKNKI 482
AKH32902     442 DFAFRVHTDVGLKLKNATV------------NGSIKPISHVLKSGDVVSINTYKNRyTATKYWLD----YLHTPTAKSKL 505
WP_011280986 420 DFAYAVGPMVGNVAVGANI------------DKKPAKLGTVVKNGQLVEIEVNSHS-EPKAEWLG----FVVTNKARVEI 482
WP_095043014 501 DFAYRIHSELGNQCLEAQV------------NDLPFPLNRPLRNGDQVRICKNARA-QPMRAWLDedlgYITTTYARMRA 567
WP_013164774 437 DFAFKVHTDIGKRCVSAMI------------GRQKVGPEKVLHDGDQVSIVTRKEAvRFEPGIQQ----LCQTPKARAEL 500
WP_129892214 553 RRYLKLHERDINIQIGRERLERELKMVTGRvldavsEDLENYLSDEY-H----LESFDDILAAVGADDVRPRAVVQRMIE 627
WP_104937374 466 SKTFRIRREDVSRQIGASVLQQELRRYGIPre--vlDKDMSGVLDHF-G----LPDMPALYLALGENRVRLPELVAEIRD 538
WP_049766292 497 NRHLQHRRQHFAREIGRQVLSQELRRHGFGpda-ldDETVALLLEVI-N----LKDISELYTRLGQDLLSPELVLYYLEA 570
WP_011189146 466 AKGFRARRRKVTTIVGATILRQEMLRYGLPidl-ltSPNIDICLKRF-S----IDCLDDLHALIGEGRLHLHTIISAIKE 539
WP_003662724 483 LKFLKHLPEDQKIHYGKQALDRALSTYGKSitd-ltDDDWTDILKWR-G----ISTPDELFMQLSTGMLLPQLVVSRLFS 556
WP_119724785 483 KSFLRKEDKEIHRERGKEILSKYLEKFGFDk----lDKDL-SILKNIdGktlgIEERWSLLEQVGDFSYPASTLLRKIQK 557
AKH32902     506 TRFIKQQEKDTYVKKGIEFIEVKLLKYSLPll--snD---KDKIKKFyGd-----QFEHTMMQVASKAIAPMTILKEVYN 575
WP_011280986 483 LRWFKDLSVADKQHHGRQALDRALKTYQKSldd-ltDSDWKNLTEWR-G----LTEKSALFEQISSGTLLPQLVVTRLFS 556
WP_095043014 568 RRWFRRLSEDEAIRQGRDILLHELTMLGLp------DQSHEAIAGLF-G----YEDADELYYNLGRAELLPTVLSTRILS 636
WP_013164774 501 AKMFRQRRLKLALEVGRSIVHQELKRYGVPldi-leSAGMGDILAYF-R----EENQEELFQAVGEGRLRLQELVFELIE 574
WP_129892214 628 Yw-QlR-Eg-KEgrenkDeEETvKlpavsSV-KP--T--TEARLKVAGVSGLLTRLANCCCPLPGDPIVGFVSRGKGVIV 699
WP_104937374 539 Rl--yA-Ghp-----------------tlVP-PT--G--ILNQVTFSTVDPVVMKVSACCHPSPLDRGIIGLLSERGLSL 593
WP_049766292 571 Pl--hA-K---------D-----Rhp-hhSPhPP--D--ERNAILVSELDKAFHKFARCCNPYPGQENVLATISERGTTF 628
WP_011189146 540 Dl--fD-Gis-----------------plVD-PT--G--AFNSIEITTLDPVSVKLSSCCKPNPTAKDNFALLTPHGLSV 594
WP_003662724 557 EeiD---Ta--------------Dd----H---Ei----TRSKHLLAGIKGVEVDFARCCNPIYGDTIVGHLSRQ-GLVV 607
WP_119724785 558 Sk-D-P-NfdKkekrltggGEIhKe---nEKv-S--H--GKQTLIIGGEVGLDYKICSCCKRKLGKDIVAHINNKGVITI 626
AKH32902     576 Lt-G-EpN--KSt---kN-SDTsK------NiEGi----HQNTVVIDDSQlFEYELCPQCLPQGRDKIIARSGKD-GFKI 636
WP_011280986 557 Dev---cDi--------------Qs----Q---EriDdmTQPQQLIVNASGVELDFANCCHPIYGDPIVGHLSRH-GLVV 611
WP_095043014 637 Gh--wT-E--G------Dslp------vgSvvAA--A--DGTRYIITNAGSHRLHICATCDPRPRDSIVGYLRLDNILTV 695
WP_013164774 575 Gl--yA-Drp-----------------tlQP-PT--G--TLNRIFLNTLDPACIKFSRCCNPVPTDKGLYALLSERGLSI 629
WP_129892214 700 HRTDCRNIAGFRQR-EHE---RLIHVSWQG-M-------S---P-M-S-YMAPIVIT-GRDRVGLTRDIVSTIADAGISL 760
WP_104937374 594 HRKECPQLARIDF--QRE---DAVEVRWQL-Sr----------T-P-VvKLQKLIVMq-aTKSALLTMLAKAPE--IMAI 652
WP_049766292 629 HDPRCEDLKSRHGL-QPQ---HLLDVCWDf-Dg----------TwR-HvLVFQLHIQ-QQSISDLLPLLARMPS--TVRI 689
WP_011189146 595 HHKRCKTLEKLNF--RRD---DAVNITWRT-Rq----------T-N-VrKPQIISIPr-aSSAEVMSALSNAPI--FMKI 653
WP_003662724 608 HRHKCYSLQAIRTD-TPY---QIIHLDWKSdQs-----lQnqpD-AlR-FPAMLRIY-ASLNEEQISQVIYEMRVLNIGV 675
WP_119724785 627 HKRNCKILNEVNK----D---RLLTAYIDG-E-------K---E-E-S-IIYEISFI-IKNETGVLNELTSIIYSMKIDV 684
AKH32902     637 HSLQCKALQTVAL----D---KLIKAHRSE-Q-------T---P-S-L-YHFTIELY-LNTRHVNLITLLSTLQDLGIAI 694
WP_011280986 612 HRHKCFSLDDIRKD-NPY---QVIQLRWHNdKaikqsdsEdhgN-KiR-FPAYLKLS-IAMSDEQISKVIYNLRQLNIGV 684
WP_095043014 696 HRDTCRTLNAg--RgRPEvshRLLKLGWGEtE-------P---Q-Q-A-RIIPLYVD-VYDRPGLLNEMTRLMREKDVNI 759
WP_013164774 630 HRKECQTMAKLKV--KRE---DVVEVRWSL-Ka----------T-K-LyKAQTLLILaAPSRNRVLMMLSVAPE--EMQI 689
WP_129892214 761 ISI-HSNV-Sg--K--GTVVVTTATLELD---DLEQM--YRLF-----------T-----RL-EKIKG------VMHVAR 806
WP_104937374 653 SEVvHLGS-----S--DRDSAWEISFRIS---TLLDL--KKIM-----------R-----HL-EHSGL------VYEFEL 697
WP_049766292 690 RYI-ESAIgKh--N--E--PTVRLSVALHsfaEAREL--FRILpedrvcideygRqgasaRVhTECPY------VPDRAR 754
WP_011189146 654 HEV-KLVSvRh--Ev--PEPAWQITFKVE---NLFEL--HRVQ-----------R-----YL-QKTSL------IYQSVF 700
WP_003662724 676 EQT-HIKT-DtksDqsSKVGTTTLHIVVR---SRSHL--AEGI-----------E-----KL-RTLLG------YPNIMR 725
WP_119724785 685 DSI-NTEKi----G--NSQRKLIFGLKIF---DYEYMiiDRLL-----------D-----RIrMKLGDrilnyfILGVTK 738
AKH32902     695 ESV-NIQR-P---N--DlSYHIHIQFSHE---NPSKI--AYVI-----------H-----YI-QKNYGn-----NITIKK 740
WP_011280986 685 EKV-DVRG-----------SDTIIHIVVR---SRNHL--AQGI-----------R-----EL-RSLLG------FPNIMR 724
WP_095043014 760 RHI-CTIE-R---Kr-DGELMIEMELELL---SPRHM--VRIL-----------H-----QI-EALVN------VKAVRC 805
WP_013164774 690 TDI-ELLS-Rh-sNa--RTSAWQIHFTLE---NLQGL--KSLL-----------Q-----HL-TKTGL------HYEFVL 736
WP_129892214 807 dLG 809
WP_104937374 698 dm- 699
WP_049766292     ---    
WP_011189146 701 kv- 702
WP_003662724 726 lYQ 728
WP_119724785 739 e-- 739
AKH32902     741 kit 743
WP_011280986 725 lYQ 727
WP_095043014 806 vPE 808
WP_013164774 737 eh- 738
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