Conserved Protein Domain Family
bHLH_TS_scleraxis
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cd18951: bHLH_TS_scleraxis 
basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins
Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons.
Links
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Statistics
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PSSM-Id: 381521
Aligned: 5 rows
Threshold Bit Score: 119.878
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   # ### #    #                 ####                           
Q7RTU7        73 EPRQRHTANARERDRTNSVNTAFTALRTLIPTEPaDRKLSKIETLRLASSYISHLGNVLLAGEACGDG 140 human
ACL00849      63 EPRQRHTANARERDRTNSVNSAFTALRTLIPTEPqDRKLSKIETLRLASSYISHLGNVLLLGDTCGDG 130 African clawed frog
P59101        65 EPRQRHTANARERDRTNSVNTAFTALRTLIPTEPaDRKLSKIETLRLASSYISHLGNVLLVGEACGDG 132 chicken
NP_001076538  82 EIRQRNAANARERDRTNSVNTAFTALRTLIPTEPaDRKLSKIETLRLASSYISHLGNVLLVGEACGDG 149 zebrafish
XP_005996846  64 ESRQRHTANARERDRTNSVNTAFTALRTLIPTEPaDRKLSKIETLRLASSYISHLGNVLLVGEACGDG 131 coelacanth

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