Conserved Protein Domain Family
DCAF17
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pfam15802: DCAF17 (this model, PSSM-Id:406283 is obsolete and has been replaced by 464881)
DDB1- and CUL4-associated factor 17
DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes. It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.
Links
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Statistics
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PSSM-Id: 406283
Aligned: 13 rows
Threshold Bit Score: 561.596
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005799456  32 FCLKILRSITLHEN---RSFIKVWSKTSKTAIMYDSGRIY---FDNYQNCY--SCVHDQPQNLYKFPKKSKQQKIEDALL 103 southern platyfish
2_pfamImport   1 KNLKILKHLVCQDT---TSLRNVWMKQSKSPVVYERGRIY---FDNYQCCF--SCANSSPKLLYKMPKCSKMEKIEDALL 72 
XP_011488071  32 HCLNVLRGVLLQEN---RNFQKIWSKISKSTITYESGKVY---FENYQNCY--SCIQAEPHSLYKMPKRSKHEKIQDALL 103 Japanese medaka
XP_005452992  46 HNLKILRGILLQEN---RTFTKVWSKTSKSTVMYENCKLY---FENYQHCY--SCVHAEPQILYKLPTRSKQEKIEDTLM 117 Nile tilapia
XP_007253568  51 gNLRILRNLILQDG---TEFTKVWTKSSKSLISYESGRIY---FENYRNCY--SSLTAEPQVLYELPRRSKAEKIEDSLL 122 Mexican tetra
A8WHR0        44 SNLKILRNIILKDD---TEFVKVWSKTSKSLISYESGRIY---FDNYRCCY--SSLLPEPELLYELPRTPKTEKIEDALL 115 zebrafish
XP_006636656  54 KNMRMLRHILLQDT---TNFTNVWRKHSKGPIDYEHGKIY---FENYRSCY--SSIPPKPQCLYELPNCSKSQKIEDALI 125 spotted gar
XP_001640777  24 KDLKLLRLLVEKRS---TKFKNVWSKKSKDPIGFDCGHLF---LDKFRTSF--ST-NGKPKELYRMQPLRSSEKVESAVV 94  starlet sea ane...
XP_009031969  24 QNMKLLKFLLSKHDiheEVFSSECTIESKYKLFYDNLIVFnnkLQKYSNIFskTCMKGI-KIKFKSISSSKYGKIEDCLF 102 Helobdella robusta
XP_515899     31 TNLGILRALVCQES---TKFKNVWTTHSRSPIAYERGRIY---FDNYRRCV--SSVASEPRKLYEMPKCSKSEKIEDALL 102 chimpanzee
XP_008117078  47 KNMGILRKLICQES---TTFRNVWTKHSTSPITYQSGKIY---LENYRYCL--SSITPEPRIIYQMPACPKSEKIEDVLL 118 green anole
XP_011608106  32 HNMKVFRNLLFQDN---RSFIKVWSRSSKSTIMYESGKIY---FENYLNCY--SCVHSVPQVLYKLPQRSKLEKFEDALL 103 torafugu
XP_012826782  54 TNLDIIRKLVCQKN---TVFRRVWTKHSKLAINYAKGRIY---FDNFRCCF--NSATPVPQQMYEMPRCSKLEKIEDALL 125 tropical clawed...

XP_005799456 104 CQSPLDK----TLSSPSEHKPCLLALTADNWLCRISAETGKELQRIYLSPKYKY-RYLAWNVPQETFYIKSVQNKETPLA 178 southern platyfish
2_pfamImport  73 SECPVGE----LLPSLLDYKSSLITVTANNWLFRVSVNTGEVLEKVFLSSLYRF-RYVTWDVPQESLVVKSAQNRQRAMV 147
XP_011488071 104 CQSPLDT----TLPSASDHTPSLLALTANNWLYRISSNTGKELQRVYLSPRFQF-RYLGWDVSQETFYIKSLQKKETPLE 178 Japanese medaka
XP_005452992 118 CHSPVEK----SLSSPSDHKPSLLALTANNWLIRLSAETGEELQRVYLSPNYKF-RYLGWDVSQETFYVKSVQNKETPLA 192 Nile tilapia
XP_007253568 123 CQCPLEK----VLSQASQQKPFLLALTANNWLYCLSADTGETLQKVYLSSHFKF-RSLDWDISQETFYVKSVHRKQTAIA 197 Mexican tetra
A8WHR0       116 CQCPLEN----VLPNASEQKSCLLTLTANNWLYLLSADTGETLQRVYLSSRFKFsRSLGWDSSQETFYVKSVQCKQTALE 191 zebrafish
XP_006636656 126 CQCPLDR----TLPSPSDRNPCLLALNASNWLYCYSAMTGEQLEKVYLSPRYKF-RYLCWDVPQETLCIKSVQNKQTSIA 200 spotted gar
XP_001640777  95 FESPLDQqsfvSTVETKGFKSCVIGVTANGFLFRQDVDTGKRLQTVFLSRTIKF-KNIFWESDLTRLVIKSVHSK--PLP 171 starlet sea ane...
XP_009031969 103 SQCPVED----VSYLESLEQPHFYVISQNNWFLRINCHTCTVDKELYMTDLCKF-KLIMWDVQEERLYLSATISEG---- 173 Helobdella robusta
XP_515899    103 WECPVGD----ILPNSSDYKSSLIALTAHNWLLRISATTGKILEKIYLAAYCKF-RYLSWDTPQEVIAVKSAQNRGSAVA 177 chimpanzee
XP_008117078 119 LECPVGE----VLPNPSDYKPSLVVLTAHNWLLRLSATTGEILEKVYLAAHCKF-RYLSWDTPQDVMVVKSIQQKHPGAA 193 green anole
XP_011608106 104 CQSPLGD----VLSNPSDHKPSLLALTANGWLYRLSAETGEELQKVYLSPNIKF-RYLGWDVSQETVYIKSVQNKETSLE 178 torafugu
XP_012826782 126 CECPLGE----SLPHPSDYTPSLLAVTGQNWLLRISADTGEILEKIYLGSYRKF-RYINWDVPQETLVLKSIQTKSATVS 200 tropical clawed...

XP_005799456 179 RQ-AGIS---QNVVMHMAIFHVF----PLQIVGILEINKKGFGSGVTDVVLSQGVLAVSYSNKSVKLYSFEHVVQRCLIE 250 southern platyfish
2_pfamImport 148 AQeVNIK---QTISVYYLILNYLlknnPYALIGYIETNEKVFGNHVIDATISHGILIVMYRMGLVRLYNFQWITETYTSK 224
XP_011488071 179 RQ-AGIS---QSTVMHLAVFHVF----PLQIVGILEINKKVFGSGVTDVVLSQGVLAVSHSNKSVRLYSFVHIIQKYLTE 250 Japanese medaka
XP_005452992 193 RQ-AGIT---QNTVMHIAIFHVF----PLDVIGIMEINKKVFGNGVIGADLVQGVLALYYSNKSVKMYSFEHIVQRYLTE 264 Nile tilapia
XP_007253568 198 RQ-AGTD----NVLMHLAIFTVF----PLQVVGLLEISKKVFGKSVVDVLLSQGVLAVSHSSKCVKLYSLEYIVKKFRTT 268 Mexican tetra
A8WHR0       192 RQ-AGVD---NNILMRVAAFQVF----PLQLVGMLEINKKVFGKTAVDVLLSQGVLAVSHSSKLVRLYSFEYIVNKFRTE 263 zebrafish
XP_006636656 201 RQ-TGPG---QDTLMCLAVFRVL----PLELLGMLEISRRVFGNNVVDVMLSQGILAISHSTGMVKLYSFENIVEKFMIK 272 spotted gar
XP_001640777 172 RViSGNNphvNNVLLHLALFDVA----PLKFVALIPIERSLFGSTITDATSSMGILFVMHRSGLIQLYSTQEIIDKY-SQ 246 starlet sea ane...
XP_009031969 174 ----------GKKTFVFALFSVW----PLRFQGVFSLSSKSFGFDMKEALLSENMLLVTSSDAMVRIF------------ 227 Helobdella robusta
XP_515899    178 RQ-AGIQ---QHVLLYLAVFRVL----PFSLVGILEINKKIFGN-VTDATLSHGILIVMYSSGLVRLYSFQTIAEQFMQQ 248 chimpanzee
XP_008117078 194 RQ-AGVQ---QSVLFVLAVFRVL----PLSFIGMLELDKKFFGNSMTDASMSDSMLIVTHSTGLVRLYSFQTISEQFMLQ 265 green anole
XP_011608106 179 RQ-AGIT---QNTVMHLAIFHVF----PLQIVGILEINKRVFGNGVTDVVVSQGAIVVSYSNKSVKLYSFEHILQRHLTE 250 torafugu
XP_012826782 201 QEdEGNT---RAVLFYLAVFSVF----PLSLVGILEITKHIFGSTVTDAMISHGMLIVMHSVGLVRLYSFERITEQFMKQ 273 tropical clawed...

XP_005799456 251 ELTLGQQSPLL----------------GHR-TVGDVPF-GIPVNIQITEPPPLLFEAF-SHNGIQIGGFPWHYIYTPPHK 311 southern platyfish
2_pfamImport 225 KVMLGQKCQWN----------------GTTgIVGDTPF-GIPCNITVTDTPPLLFEVPcLENAFQIGGYPWHYIITPNKK 287
XP_011488071 251 KLTLGQQSALL----------------EGK-TVGDAPF-GIPVNIQIPDCPPVLFEVScSNNGVQIGGFPWHYIYTPPHK 312 Japanese medaka
XP_005452992 265 KVTLGKQSPLL----------------GGK-TVGDAPF-GIPLNIQITDCPPVLFKVScAENSVQIGGNPWHYIYTPPRK 326 Nile tilapia
XP_007253568 269 ELVLGQQCDLY----------------GAKgTVGEVPY-GIPVNIQIKECPPVLFEMSyLDNGIQIGGHPWHYIYTPNHK 331 Mexican tetra
A8WHR0       264 ELILGQQCELN----------------NARgIVGDAPY-GVPVNICIHECPPVLFEMTyFENGVQIGGHPWHYIYTPNHK 326 zebrafish
XP_006636656 273 KLTLGEKCEWN----------------GIQgSVGESPL-GIPFNIQITDSPTLMFEVScLESGFQIGGHPWHYIYTPRSK 335 spotted gar
XP_001640777 247 ITDLGKPYTINtsacsnptseyhanniDGTgIVGSHPF-GIPVNVHMVSKPTLLLEVSsHQHSLSFGGFPWHFVVSPP-- 323 starlet sea ane...
XP_009031969 228 ----GLDCEFY------------------SkPVNNLKFeSLPVIPSIENYCRLLFEVPaPWDFFTVGGMPWHYIVFSS-- 283 Helobdella robusta
XP_515899    249 KLDLGCACRWG----------------GTTgTVGEAPF-GIPCNIKITDMPPLLFEVSsLENAFQIGGHPWHYIITPNKK 311 chimpanzee
XP_008117078 266 RVDLGQEYNWN----------------GKIgIVGKYPF-GIPYNIKITGAPDLLFEVSsLESTFQIGGFPWHYIITPNKK 328 green anole
XP_011608106 251 RLILGKQSSLL----------------EGK-TVGDFPF-GIPRNIHITDCPPLLFEVLcSNNSVQIGGYPWHFIYTPPQK 312 torafugu
XP_012826782 274 KHVVGQVCSWK----------------GETgTIGDFPF-GIPCNIKPTESLPFLFEVScLENAFQVGGHPWHYIITPNKK 336 tropical clawed...

XP_005799456 312 KHRGTHYISALKDSTLAKNGIQNMNCCSLESDVIFFHPADSGRVIHIGPNTINVLKVISELNSPLPSEVLED-------- 383 southern platyfish
2_pfamImport 288 KQKGTYHICSLENNTLAENGIQDMKCCSLECDWIYFHPDDSGRVVHVGPNQINVLRLKETPETDHQHQVTED-------- 359
XP_011488071 313 THRGTHHICSLQDHSMAINGIQNMNCCALESDGIFFHPDDSGRIIHVGPTTIKVLKILGEINSSLPSEVVED-------- 384 Japanese medaka
XP_005452992 327 KDEGTYHICSLKDGTMATNGVQEMDSYSLENDGIFFHPDDSGRIIHVGPVTINVLKILGELNSALPSKVVED-------- 398 Nile tilapia
XP_007253568 332 KHKGTHHICSIRDGTLAKNGVQDMKCDSLEADWIFFHPDDSGRIIHAGPSTINVLKIIEGKEVDTNYEVIHD-------- 403 Mexican tetra
A8WHR0       327 RHRGTHHVCSITDGALAKNGVQDMKCDSLEVDWIFFHPDDSGRIIHAGPSTINILKIMAETGCDWKYEIITD-------- 398 zebrafish
XP_006636656 336 KHKGTYHICSLKDGQLAKNGIQDMNCCSLESDWIYFHPGDSGRIIHVGPSKVNVLKIAETQENLLQFEVIQE-------- 407 spotted gar
XP_001640777 324 RQSSVFHVYSIKEKELVGNGIIKSDVLSVEPDQAYFHADHSGRLLHICPHSIRFLKLKTLGDLGVGQLVLDTc------- 396 starlet sea ane...
XP_009031969 284 FSQSQFSVQCLRTRTVAKDGKLNIKNALLDPDKCFFYPDSSGKIVKVSNDSVELYNLKSD-----GYDKFNNptcsvell 358 Helobdella robusta
XP_515899    312 KQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIYFHPDASGRIIHVGPNQVKVLKLTEIENNSSQHQISED-------- 383 chimpanzee
XP_008117078 329 SQKGIFHVCSLKDHTLAKNGVQEMKCCSLEPDWITFHPDSSGRILHVGPNLIKVLKLKEVEGNTELQKVTED-------- 400 green anole
XP_011608106 313 NHRGTHHVCSLKDCSLAINGVQSMSCNSLESDAMSFHPDDSGRMIHVGPTIINVLKLVSDLNNDMQSRVVKD-------- 384 torafugu
XP_012826782 337 KEKGTYHIRSLDDHSLAKNGIRDMSCCSLEPDWIHFHPDASERIIHVGPDQIRVLRLKELQNDSYRHQVCED-------- 408 tropical clawed...

XP_005799456 384 YSLTT--HR-SHPS-PRVTVTSSGRTVRSRFQQLD---DDPMQETFRLLEYEDELDLLAIA-VTnGEGEEGRAHVQLHDN 455 southern platyfish
2_pfamImport 360 FVILA--KReAKLL-HSVTVTASGRVVKKRFEQLD---DEPEQETFKIVDYEDELDLLAVVaVT-QTESEGRAHIDLYNN 432
XP_011488071 385 FSMAT--HR-NAPT-PEVTVTSSGRTVKRRFHQLD---DDPGQEAFRMVEYEDELDLLAVV-MTdGVEEEGRAHVLLHDN 456 Japanese medaka
XP_005452992 399 FSLKT--HR-NNPI-SQVTVTSSGRTVKRRFQQLD---DDPSQKTFRMVEYEDELDLLAIV-VTnGEEGEGRACIQLHDN 470 Nile tilapia
XP_007253568 404 FSIIT--SRdRSAT-SKVTVTSSGRTVKRRFQQLD---DDPEQETFKMAKYEDELDLLAIVdVSpTAEDVGQASVRLYDN 477 Mexican tetra
A8WHR0       399 FSITA--ARdSNA--SQVIVTSSGRTVKRRFQMLD---DDPAQETFRMVKYEDELDLLAVVdIT-HAEDEGQARLRLHDN 470 zebrafish
XP_006636656 408 YSIEA--HReNKAD-SLVTVTASGRTVRRRLHQLD---DDPEQETFQCVEYEDELDLLAVVsVT-QTESEGKAHVGIYDN 480 spotted gar
XP_001640777 397 FSISTrdNQsNRSTkGQTSYTSSGRLVKCVSSDGY---HDPEYDSIQDLDYEDELDLVAVL----SSRDCSSGYIGLYDN 469 starlet sea ane...
XP_009031969 359 YMLDY--SEeKRPV---VTHTSSGRAIKKR--TFPgaiSENFHSKVQLVICEIDMDIIGV--VTlSRCSSNVAAITFYEI 429 Helobdella robusta
XP_515899    384 FVILA--NReNNKNeNVLTVTASGRVVKKSFNLLD---DDPEQETFKIVDYEDELDLLSVVaVT-QIDAEGKAHLDFHCN 457 chimpanzee
XP_008117078 401 FIIQA--SReNNIE-NSITVTSSGRIVKNRFNSLD---DDPEKETFQIVDYEDELNLLSIAaVT-QIGSDGSARLDLRCN 473 green anole
XP_011608106 385 FSMAT--HRsSNPT-QQVTVTSSGRTVKRRFHQLD---DDPDQETFRMVEYEDELDLLAAV-VTdGNEGEGRAHIQLYDN 457 torafugu
XP_012826782 409 FAILA--TRdKEVN-KPVTVTASGRLVKKRFAQLD---DDPEQETFKIVVYEDELDLLTVVaVT-QTEAEGKAHVALHCN 481 tropical clawed...

XP_005799456 456 QTGRLQRKIDLDEPWDETYPHELFFDRDTIVHIEQ-KGSQFCCYVYKL 502 southern platyfish
2_pfamImport 433 QTGTLVKTVPLVEYWDVTYSHRIFFDRETVVHIEQkPNRIFCCYVYKM 480
XP_011488071 457 QTGRLLRKIDLVESWDETYQHQLFFDKDTIVHIEQ-KNSNFCCHVYKL 503 Japanese medaka
XP_005452992 471 QTGQLLRTIDLIETWDETNKNEVFFDKDTIVHIEQ-KNAKFCCHVYKL 517 Nile tilapia
XP_007253568 478 KSGGLMKRITLNEPWDVTYSHEVYLDRDTVIHIEQeRNNSFCCHVYKM 525 Mexican tetra
A8WHR0       471 KTGALMKRVPLEEPWDVTYSHEVYFDRDTIIHTVQeKNNSFCCHVYKM 518 zebrafish
XP_006636656 481 WSGVLMKSVPLVESWDVTYGHQFFFDCDTIIHIEQeKNHKFCCHVYKM 528 spotted gar
XP_001640777 470 QTGVLVKEITL-DNWDDESEHSIMMERDLIVHICRtPFKKFSCTLYRL 516 starlet sea anemone
XP_009031969 430 DTGNYITKLEFAEAWDVNAEHDVKLDLDILYHYIK-TNSKHVLIVYRL 476 Helobdella robusta
XP_515899    458 EYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQkPNRVFSCYVYQM 505 chimpanzee
XP_008117078 474 ERGTRLKSIPFVESWDVTYSHEVYFDRNVVLHIEQkPNRTFSCYVYHM 521 green anole
XP_011608106 458 QSGQLLRNVALSESWDETFPHELFLDKDTIVHIEQ-KNSTFWCHVYKL 504 torafugu
XP_012826782 482 DTGKLLKNIVLLESWDVTHSHAVFFDRDTLIHIEErPNRNFSCYVYKM 529 tropical clawed frog
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