Conserved Protein Domain Family
hsFATP2a_ACSVL_like

?
cd05938: hsFATP2a_ACSVL_like 
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins.
Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Statistics
?
PSSM-Id: 341261
Aligned: 14 rows
Threshold Bit Score: 972.535
Created: 14-Nov-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
O35488        74 FRDETLTYAQVDRRSNQVARALhd---qlGLRQGDCVALFMGNEPAYVWIWLGLLKLGCPMACLNYNIRAKSLLHCFQCC 150 house mouse
NP_001008639  74 FEGETFSYEEVEKRSNKVADALrs---vvGLREGDTVALFLGNEPRFVWTWLGLAKLGCPAALLNFNIRSKSLLHCFSCC 150 zebrafish
AAI42579     110 YREQNVTYRNVWDQSQRLARALl------GLAPGDTVALLLGNEPRFLAAWFGLAQLGVVSAFLNTNVRKGALMHCLGAS 183 African clawed ...
Q5K4L6       188 AAGSGAEFAGGDGAARGGGAAA-------PLSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSC 260 human
Q9Y2P4        75 YEGDIYTYQDVDKRSSRVAHVFln---hsSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRAC 151 human
XP_001336957  70 FLDQTYSYEQSDKESNKIARTLlk---haDLHEGDTVALLLGNEPMFLWIWLGLAKIGCSVALLNHNIRSKSLLHCFTCC 146 zebrafish
NP_001020470  72 FGDERYTYRDADRISNRLANAL-------RDRSGQIVALFHGNAPMYVFTWLALAKLGCTVALLNTNIRSRSLVHCCECS 144 zebrafish
XP_003199367  95 FEDQTLTYRDVDVRSNKLANVLks---hrGLKHGDIVALLMNNEADFICVWLGLCKLGCEVAFLNFNIKSQSLQHCLDRC 171 zebrafish
NP_001076488  74 FEGQTLTYRDADRESNRIANALlr---ecGMRAGDTAALFITNQPAFILCWIALAKLGCACALLNTSIRDDSLIRSFRCC 150 zebrafish
O88561       118 RGSGRGSTEEGARVAPPAGDAAargttapPLAPGATVALLLPAGPDFLWIWFGLAKAGLRTAFVPTALRRGPLLHCLRSC 197 house mouse
Feature 1                                                                                   #    
O35488       151 GAKVLLAspd-lqEAVEEVLPTLKkdavsvfyvsrtsntngvdTILDKVDGVSAEPTPeswrsevtfTTPAVYIYTSGTT 229 house mouse
NP_001008639 151 GANVLIAdae-llDAVEEILPALKqkgirvyllssecttegvqCIGAAIAGASDKAISpslrsnvhiRSTALYIYTSGTT 229 zebrafish
AAI42579     184 GSRGLITspe-lfEAVQEILPELRemgvkvwvmgggdfpddiiNLQQLMDETTGDLPPqap---irpMDTAIYIFTSGTT 259 African clawed ...
Q5K4L6       261 GARALVLape-flESLEPDLPALRamglhlwaagpgthpagisDLLAEVSAEVDGPVPgylsspqsiTDTCLYIFTSGTT 339 human
Q9Y2P4       152 GPRALVVgad-llGTVEEILPSLSenisvwgmk--dsvpqgviSLKEKLSTSPDEPVPrshhvvsllKSTCLYIFTSGTT 228 human
XP_001336957 147 GANVLIAgad-lqDAVEEVLPALReqgisiyiltehvssegmtSLTDKIKQASDQPIPtdlranvafNTPAAYIYTSGTT 225 zebrafish
NP_001020470 145 GAKTLITaae-lvPAVLEVLPSLRqqqvsvlmlsgeaethgiiNLTNQVSCASEEAPPislrqhitmKSPALYIYTSGTT 223 zebrafish
XP_003199367 172 GAKTLVIgsd-lvKSLDEVLLMLTdggieiwvasessshqnvkTLLDKLDSASPEKPVvdap-qpnlMSNFLFIFTSGTT 249 zebrafish
NP_001076488 151 RGAKVLIasadlqAAVQQVCVPLQqdgvcvlmm--gmecsgmrSLSRAAQESSDTAVPaavrahltnNTPAVYIYTSGTT 228 zebrafish
O88561       198 GASALVLate-flESLEPDLPALRamglhlwatgpetnvagisNLLSEAADQVDEPVPgylsapqniMDTCLYIFTSGTT 276 house mouse
Feature 1                                          ##                                            
O35488       230 GLPKAATINHHRLWYGTGLAMSSGItaQDVIYTTMPLYHSAALMIGLHGCIVVGATLALRsKFSASQFWDDCRKYNVTVI 309 house mouse
NP_001008639 230 GLPKAAYVTHERVWASSFIQGVCGVtsEDIFYINLPLYHSAGFLIGLVGCIERGSTFVLRrKFSASQFWDDCRKYNITVM 309 zebrafish
AAI42579     260 GLPKAARISNLKTLMCCNFYHLRGAgaDDIIYMSLPLYHMSGALLGIGGCIGVGASLVLKeKFSASQFWSDCHKHNVTIF 339 African clawed ...
Q5K4L6       340 GLPKAARISHLKILQCQGFYQLCGVhqEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKsKFSAGQFWEDCQQHRVTVF 419 human
Q9Y2P4       229 GLPKAAVISQLQVLRGSAVLWAFGCtaHDIVYITLPLYHSSAAILGISGCVELGATCVLKkKFSASQFWSDCKKYDVTVF 308 human
XP_001336957 226 GLPKAAVITHRRLWAMAFFQSICGVksDDVIYVCLPLYHSSGFGLGFGGSVERGATIVLRsKFSSSQFWDDCRKYNVTVI 305 zebrafish
NP_001020470 224 GLPKAAVVTHEKVWMMSFLQRLSGVcsSDIIYICLPLYHSAGFLAGLSGAIERGITVVLKsKFSASRFWDDCREHNVTVI 303 zebrafish
XP_003199367 250 GLPKAARISHIKAVMCMAFLRLCGAcaDDKIYLTLPLYHMSASLLGIGGCIELGATCVLKrKFSASQFWKDCLKYDITVF 329 zebrafish
NP_001076488 229 GLPKAAVITQTRLLASLAVLPSIGVthTDVLYVTLPLYHTAGFLIGFMGCVETGSSMVLRrKFSASRFWDECRAHEVTVV 308 zebrafish
O88561       277 GLPKAARISHLKVLQCQGFYHLCGVhqEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKpKFSASQFWDDCQKHRVTVF 356 house mouse
Feature 1                   # ##  #           ##                   ######                        
O35488       310 QYIGELLRYLCNTPQKPNDRDHKVKKALGNGLRGDVWREFIKRFGDiHVYEFYASTEGNIGFVNYPRKIGAVGRANYLqr 389 house mouse
NP_001008639 310 QYIGETLRYLCNTPQKDNDRDHKVKIAIGNGVRADIWKEFLKRFGRiHVRELYAATEGNVGFINYTDKVGVVGRINIIsk 389 zebrafish
AAI42579     340 QYIGELCRYLTNLPPSDNETGHRVHLAAGSGLRPDVWRDFSRRFGNiRIFETYGMTEFSISFFNYTGTPGAVGRGSFLyk 419 African clawed ...
Q5K4L6       420 QYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPlQVLETYGLTEGNVATINYTGQRGAVGRASWLyk 499 human
Q9Y2P4       309 QYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNiKVCELYAATESSISFMNYTGRIGAIGRTNLFyk 388 human
XP_001336957 306 QYIGETMRYLCNMPKCVSDQVHNVRMAIGNGIRPDIWRTFINRFGHvEIKEFYGSTEGTLGFLNYAGKIGAVGTVNSFhk 385 zebrafish
NP_001020470 304 QYIGEVMRYLCNTPERENDRQHSVRLALGNGIRAETWREFLRRFGDvRVCECYGATEGNIGFFNYTGKIGSIGRVSAIhk 383 zebrafish
XP_003199367 330 QYIGELCRYLVNQPKTLEEVAHNVRLAAGSGLRADVWKEFIRRFGKiQIREAYGLTEASIGFVNYTDEIGPIGRASYFnk 409 zebrafish
NP_001076488 309 QYIGEILRYLCNTPQRAVDQHHAVRLAIGNGLRADVWREFLQRFGQmEVREFYASTEGNIGFLNYTGRLGAVGRVSFLhr 388 zebrafish
O88561       357 QYIGELCRYLVNQPPSKAECDHKVRLAVGSGLRPDTWERFLRRFGPlQILETYGMTEGNVATFNYTGRQGAVGRASWLyk 436 house mouse
Feature 1                                                                                   #    
O35488       390 kvARYELIKYDVEKDEPVRDANGYCIKVPKGEVGLLVCKItqLTPFIGYAGGKTQTEKKkLRDVFKKGDIYFNSGDLLMI 469 house mouse
NP_001008639 390 lfFPFALIKFDIEKEEPVRNAEGFCIPVERDEVGLLVGKItkHTPFVGYAGNKQQTDKKrLADVFEKGDLYFHSGDLLRI 469 zebrafish
AAI42579     420 cfCPFELIRFDTDKNEAVRDATGRGLRVATGEPGLLISPItpTSPFLGYVGSRELSEKKlLRDVLKPGDCYFNTGDLMVQ 499 African clawed ...
Q5K4L6       500 hiFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVsqQSPFLGYAGGPELAQGKlLKDVFRPGDVFFNTGDLLVC 579 human
Q9Y2P4       389 llSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVnaKNPFFGYAGPYKHTKDKlLCDVFKKGDVYLNTGDLIVQ 468 human
XP_001336957 386 klYPYVFIKFDHEKEEPVRNADGFCIEVAKGETGLLVTRLtqKIEFSGYARDPKQTEKKkLHDVFEKGDVYFNTGDLFRT 465 zebrafish
NP_001020470 384 llFPYAFLKFDPEKEEPVRGSDGLCVEAAPGETGLLVAKIhkLAPFEGYAKNSTQTEKKrLRDVFQRGDMYFNTGDLILA 463 zebrafish
XP_003199367 410 lnLPFEFLKCDPQTFEPLRTDTGHCIKVSKGEAGLLVAPVvfTNPFLGYAGDKAMSEKKlLRDVFKTGDVYFNTGDLMLQ 489 zebrafish
NP_001076488 389 maVHYALIQFDTEREEPVRDSSGRCVEVPKGQTGLLVSQIthMAPFVGYAHDEQQTERKrLRDVFRRGDVYFNSGDLMRM 468 zebrafish
O88561       437 hiFPFSLIRYDVMTGEPIRNAQGHCMTTSPGEPGLLVAPVsqQSPFLGYAGAPELAKDKlLKDVFWSGDVFFNTGDLLVC 516 house mouse
Feature 1               #  #       ####                                                          
O35488       470 DRENFVYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGhEGRIGMASLKIKENYEFNGKKLFQHIAEY 549 house mouse
NP_001008639 470 DHQNFVYFQDRVGDTFRWKGENVATTEVADILTMVDCIEEANVYGVKVEGhEGRIGMAAVKLKEGREFDCVSTCSVLANY 549 zebrafish
AAI42579     500 DSLQCVYFRDRTGDTFRWKGENVATTEVSEILTGLDFFQEVNVYGVTIPGhEGRAGMAAVTLRPGTDLDLGRIYKYIMEF 579 African clawed ...
Q5K4L6       580 DDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGhEGRAGMAALVLRPPHALDLMQLYTHVSEN 659 human
Q9Y2P4       469 DQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGyEGRAGMASIILKPNTSLDLEKVYEQVVTF 548 human
XP_001336957 466 DRENFIYFQDRVGDTFRWKGENVSTNEVSDIMTLVPCIEEANVYGVTVPGfEGRIGMAAIILKKDHQFECDDVFNHVTSY 545 zebrafish
NP_001020470 464 DRQGFLFFQDRIGDTFRWKGENVATTEVSEILLMLDFIEAANVYGVTVPGhEGRVGMAALQLTDGMEFDGSAAYEHMKNL 543 zebrafish
XP_003199367 490 DHRDFVYFKDRIGDTFRWKGENVSTTEVSEVLGSLDFLLDVNVYGVTVPGyEGRAGMAAVVLKDGHELDGKRVYSHLLHT 569 zebrafish
NP_001076488 469 DQDNFLYFIDRVGDTFRWKGENVATTEVSDVLSLLECVAEASVYGVCVPGhEGRIGMAAVKLKDGAEFEQKQVFEHVSRL 548 zebrafish
O88561       517 DEQGFLHFHDRTGDTIRWKGENVATTEVAEVLETLDFLQEVNIYGVTVPGhEGRAGMAALALRPPQALNLVQLYSHVSEN 596 house mouse
Feature 1           #                                                         
O35488       550 LPsYARPRFLRIqdTIEITGTFKHRKVTLMEEGFNPtvikDTLYFMDDAEKTFVPMTENIY 610 house mouse
NP_001008639 550 LPvYARPRFIRIqnSLEVTGTFKMMKVKLVEEGFNPalieDSLFFLDLTQKKYIPLSQDIY 610 zebrafish
AAI42579     580 LPsYARPRFLRImdSMEATGTFKQQKTKLVQEGFSPsliaDPLYVLDETSRSYLPLSQDLY 640 African clawed frog
Q5K4L6       660 LPpYARPRFLRLqeSLATTETFKQQKVRMANEGFDPstlsDPLYVLDQAVGAYLPLTTARY 720 human
Q9Y2P4       549 LPaYACPRFLRIqeKMEATGTFKLLKHQLVEDGFNPlkisEPLYFMDNLKKSYVLLTRELY 609 human
XP_001336957 546 LPvYARPRFIRIqsSLAVTCTFKQLKGRLVEEGFNPalitDPLFILDETVKSYRPLTHDTY 606 zebrafish
NP_001020470 544 LPaYARPRFIRIqeELRLTGTFKQVKVQLVQEGFDPnstrDRLFIMEENQQTFVPLTEEIF 604 zebrafish
XP_003199367 570 LPpYAWPWFLRLqtSLDMTDTFKQQKGLLVKQGFSPdtvqKPVYLLDTSQKTYTPLTAQLY 630 zebrafish
NP_001076488 549 LPaYARPRFLRLqsSMELTSTFKQLKLKLVEAGFNPsmtsDPIYFLCEREQTYVTLTPNIY 609 zebrafish
O88561       597 LPpYARPRFLRLqeSLATTETFKQQKVRMANEGFDPsvlsDPLYVLDQDIGAYLPLTPARY 657 house mouse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap