6WCZ


Conserved Protein Domain Family
Flavi_NS5
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pfam00972: Flavi_NS5 (this model, PSSM-Id:366396 is obsolete and has been replaced by 460013)
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Flavivirus RNA-directed RNA polymerase
Flaviviruses produce a polyprotein from the ssRNA genome. This protein is also known as NS5. This RNA-directed RNA polymerase possesses a number of short regions and motifs homologous to other RNA-directed RNA polymerases.
Links
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Statistics
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PSSM-Id: 366396
Aligned: 3 rows
Threshold Bit Score: 1319.57
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6WCZ_B  252 KYEEDVNLGSGTRAVASCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTWAYHGSYEAPTQGSASSLVNGVVRLLSK 331  Zika virus
P17763 2743 TYERDVDLGAGTRHVAVEPEVANLDIIGQRIENIKNGHKSTWHYDEDNPYKTWAYHGSYEVKPSGSASSMVNGVVRLLTK 2822 Dengue virus 1 Naur...
P03314 2758 TLEADVILPIGTRSVETDKGPLDKEAIEERVERIKSEYMTSWFYDNDNPYRTWHYCGSYVTKTSGSAASMVNGVIKILTY 2837 Yellow fever virus 17D

6WCZ_B  332 PWDVVTGVTGIAMTDTTPYGQQRVFKEKVDTRVPDPQEGTRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKVRSNAALG 411  Zika virus
P17763 2823 PWDVIPMVTQIAMTDTTPFGQQRVFKEKVDTRTPKAKRGTAQIMEVTARWLWGFLSRNKKPRICTREEFTRKVRSNAAIG 2902 Dengue virus 1 Naur...
P03314 2838 PWDRIEEVTRMAMTDTTPFGQQRVFKEKVDTRAKDPPAGTRKIMKVVNRWLFRHLAREKNPRLCTKEEFIAKVRSHAAIG 2917 Yellow fever virus 17D

6WCZ_B  412 AIFEEEKEWKTAVEAVNDPRFWALVDREREHHLRGECHSCVYNMMGKREKKQGEFGKAKGSRAIWYMWLGARFLEFEALG 491  Zika virus
P17763 2903 AVFVDENQWNSAKEAVEDERFWDLVHRERELHKQGKCATCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALG 2982 Dengue virus 1 Naur...
P03314 2918 AYLEEQEQWKTANEAVQDPKFWELVDEERKLHQQGRCRTCVYNMMGKREKKLSEFGKAKGSRAIWYMWLGARYLEFEALG 2997 Yellow fever virus 17D

6WCZ_B  492 FLNEDHWMGRENSGGGVEGLGLQRLGYILEEMNRAPGGKMYADDTAGWDTRISKFDLENEALITNQMEEGHRTLALAVIK 571  Zika virus
P17763 2983 FMNEDHWFSRENSLSGVEGEGLHKLGYILRDISKIPGGNMYADDTAGWDTRITEDDLQNEAKITDIMEPEHALLATSIFK 3062 Dengue virus 1 Naur...
P03314 2998 FLNEDHWASRENSGGGVEGIGLQYLGYVIRDLAAMDGGGFYADDTAGWDTRITEADLDDEQEILNYMSPHHKKLAQAVME 3077 Yellow fever virus 17D

6WCZ_B  572 YTYQNKVVKVLRPAEGGkTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKP--EKVTRWL 649  Zika virus
P17763 3063 LTYQNKVVRVQRPAKNG-TVMDVISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMESEGIFSPSELETPNLA--ERVLDWL 3139 Dengue virus 1 Naur...
P03314 3078 MTYKNKVVKVLRPAPGGkAYMDVISRRDQRGSGQVVTYALNTITNLKVQLIRMAEAEMVIHHQHVQDCDESvlTRLEAWL 3157 Yellow fever virus 17D

6WCZ_B  650 QSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSNWEEVPFCSHHFNKLYLKDGRSIVVP 729  Zika virus
P17763 3140 KKHGTERLKRMAISGDDCVVKPIDDRFATALTALNDMGKVRKDIPQWEPSKGWNDWQQVPFCSHHFHQLIMKDGREIVVP 3219 Dengue virus 1 Naur...
P03314 3158 TEHGCDRLKRMAVSGDDCVVRPIDDRFGLALSHLNAMSKVRKDISEWQPSKGWNDWENVPFCSHHFHELQLKDGRRIVVP 3237 Yellow fever virus 17D

6WCZ_B  730 CRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGEWMTTE 809  Zika virus
P17763 3220 CRNQDELVGRARVSQGAGWSLRETACLGKSYAQMWQLMYFHRRDLRLAANAICSAVPVDWVPTSRTTWSIHAHHQWMTTE 3299 Dengue virus 1 Naur...
P03314 3238 CREQDELIGRGRVSPGNGWMIKETACLSKAYANMWSLMYFHKRDMRLLSLAVSSAVPTSWVPQGRTTWSIHGKGEWMTTE 3317 Yellow fever virus 17D

6WCZ_B  810 DMLMVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWAENIKDTVNMVRRIIGdEEKYMDYLSTQ 889  Zika virus
P17763 3300 DMLSVWNRVWIEENPWMEDKTHVSSWEDVPYLGKREDRWCGSLIGLTARATWATNIQVAINQVRRLIG-NENYLDFMTSM 3378 Dengue virus 1 Naur...
P03314 3318 DMLEVWNRVWITNNPHMQDKTMVKKWRDVPYLTKRQDKLCGSLIGMTNRATWASHIHLVIHRIRTLIG-QEKYTDYLTVM 3396 Yellow fever virus 17D

6WCZ_B  890 VRYLGEE 896  Zika virus
P17763 3379 KRFKNES 3385 Dengue virus 1 Nauru/West Pac/1974
P03314 3397 DRYSVDA 3403 Yellow fever virus 17D
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