pfam04061: ORMDL (this model, PSSM-Id:397947 is obsolete and has been replaced by 461151)
ORMDL family
Evidence form suggests that ORMDLs are involved in protein folding in the ER. Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).
Jiyao W et al.(2023). "The conserved domain database in 2023.",