Conserved Protein Domain Family
Shisa

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pfam13908: Shisa (this model, PSSM-Id:404745 is obsolete and has been replaced by 464036)
Wnt and FGF inhibitory regulator
Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.
Statistics
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PSSM-Id: 404745
Aligned: 40 rows
Threshold Bit Score: 80.9879
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009018344  16 YEQCPGYTDHHGVWNNGFKCPkwgYLNDNYCCGGDKNRYCCPPPPSNKTTHVVTSSSGsssggsssgSSGSSSGGNDFLA 95  Helobdella robusta
1_pfamImport   1 -DTCRGYYDVMGQWDEPFVCK---TGIYLYCCGTCGFRFCCSYKHSRLDQNTCTNYATplwmktgqtPYKKINNMRDSTK 76 
NP_001013527  54 EDKCRGYYDVMGQWDPPFVCQ---TGNYLYCCGTCGFRFCCAYKNSRLDQSTCKNYDTpvwl-tgqtPYKKTLDP----R 125 zebrafish
NP_001167557  71 pDSCRGYFDVMGQWDPPFNCS---SGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTplwlntgkpPARK-DDP----L 142 house mouse
XP_006637248  53 EEECLGYFDVMGQWDPPFVCN---TDDYLYCCGTCGFRFCCTVKSSRLDQSTCKNYDTplwmmtgrpPYKK-NDP----A 124 spotted gar
2_pfamImport   1 -DRCRGYYDVMGQWDPPFLCR---TADYVYCCGSCGFRFCCSLRSSRLNQTNCKNNDTppsmmtgrpP------PKADVA 70 
XP_003442114  54 eDKCRGYYDVMGQWDPPFVCR---TGSYLYCCGTCGFRFCCAFKSSRLDQTTCKNYDTppwmmtgrpP------PKVDVA 124 Nile tilapia
B3DHW5        54 EDRCRGYYDVMGQWDPPFVCR---TGSYLYCCGTCGFRFCCEFKNSRLDQTTCKNYDTppwsmtgrpP------PKMMDQ 124 zebrafish
XP_023197085  55 EEQCRGYYDVMGQWDPPFVCK---TGDYLYCCGTCGFRFCCSLKHSRLDQSTCKNYDTpvwmktgqtPYKKMNKMHDSTK 131 southern platyfish
XP_003964892  54 eDKCRGYYDVMGQWDPPFVCT---TGSYLYCCGTCGFRFCCAFKSSRLDQTTCKNYDTppwlmtgrpPPKVEVS--LDAA 128 torafugu
XP_009018344  96 gtivgedvileqstvtvpvvvivtgAGLFIALTIVVATICLCCyfCSC----------------CNSWKYNVfnG--PIK 157 Helobdella robusta
1_pfamImport  77 d------------------------KTNLIVYIICGVVAIMVL--VGIftklglekahrpqrenMSRPSLGN--M--SSM 126
NP_001013527 126 hdp-------------------tkdKTNLIVYIICGVVAIMAL--VGIftklglekahrphresMSRAVASVmqG----- 179 zebrafish
NP_001167557 143 hdp-------------------tkdKTNLIVYIICGVVAVMVL--VGIftklglekahrpqrehMSRALADVmrPqgHCN 201 house mouse
XP_006637248 125 hdp-------------------trdKTNLIVYIICGVVAIMAL--VGIftklglekahrpqrenMSRVLASVmrQqgPCP 183 spotted gar
2_pfamImport  71 lda-------------------akdKTNLVAYVICGVVAIVAL--VGIftklvlekthlphrgnMSRALAHVirH----- 124
XP_003442114 125 les-------------------akdKTNLIVYVICGVVAIMAL--IGIftklglektqrphrenMSRALAHVirH----- 178 Nile tilapia
B3DHW5       125 hdp-------------------tkdKTNLIVYIICGVVAIMAL--VGIftklglekahrphrenMSRALAQVmrQ--TAP 181 zebrafish
XP_023197085 132 d------------------------KTNLIVYIICGVVAIMAL--VGIftklglekahrpqrenMSRAVASVlqG--RGP 183 southern platyfish
XP_003964892 129 k-----------------------dKTNMIVYVICGVVAIMAL--IGIftklglekthrpqrenTSRALAHV--I--RHP 179 torafugu
XP_009018344 158 DDhmnkDATKISSAIESQAMTSSSTSrp--rTPAsv----------------hqMtPRILdLtSAV 205 Helobdella robusta
1_pfamImport 127 TPp--mTTNPMASNPM-----ISNTMnp--nIAQmnsvap---------mpsmmPmTSMTpMtSLA 174
NP_001013527 180 ARqgqhEEAIGMHTQHYDTVQAR--Ann--mQAGqinnmm---------qthpyPaLSQ--LsHVY 230 zebrafish
NP_001167557 202 TDhmerDLNIVVHVQHYENMDSRTPInn--lHTTqmnna-----------vptsPlLQQMgHpHSY 254 house mouse
XP_006637248 184 GEhlerEDNLGVHVQHYENIQARAAVnn--lQGPqmnnvgpgspllpttsqphyPtLGQ--MsHAY 245 spotted gar
2_pfamImport 125 -PasehTDDIGL-GQHYENMQTRVSAns--lHSNqmnnmaqa----stlmtqlyPaVGR--IpSPY 180
XP_003442114 179 -PasehTDDAGL-SQHYENIQTRLTAns--fQSNqmnnaaqv----ptlvsqpyPgVGpiispyed 236 Nile tilapia
B3DHW5       182 GEhverEESLAVHGQPYENLQARATGnn--lQSAqmnsvgpss--smmqamtpyPaLGQVpVaHPY 243 zebrafish
XP_023197085 184 GEpfrgEEALGIHSQHFVSRPPALQGgq--lNNNvaasssv-------gpqhpyPaLSQ--LaQAY 238 southern platyfish
XP_003964892 180 ASd--hMDDIGL-GQHYENIHTRVTVkslhmDHMnnmaqas------alvtqpyPdVGQL----TS 232 torafugu
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