3IYL,2CSE


Conserved Protein Domain Family
Reovirus_M2

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pfam05993: Reovirus_M2 (this model, PSSM-Id:283614 is obsolete and has been replaced by 461798)
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Reovirus major virion structural protein Mu-1/Mu-1C (M2)
This family consists of several Reovirus major virion structural protein Mu-1/Mu-1C (M2) sequences. This family is family is thought to play a role in host cell membrane penetration.
Statistics
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PSSM-Id: 283614
Aligned: 5 rows
Threshold Bit Score: 880.138
Created: 20-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3IYL_A   2 GNVQTSVNTYNITGDGNSFTPTSDMTSTAAPAIDLKPGVLNPTGKLWRPVG--TSVATIDSL------------------ 61  Grass carp reovirus
P11077   2 GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAIGdeTSVTSPGALrrmtskdipetaiintdn 81  Mammalian orthoreovir...
Q8JU57   2 GNVQTSVNTYNITGDGNSFTPTSDMTSTAAPAIDLKPGVLNPTGKLWRPVG--TSVATIDSL------------------ 61  Golden shiner reovirus
B2BNE4   2 GNVQTSTNVYNIDGNGNTFAPSSQMASTASPAIDLKPGVLNPTGKLWQTMG--TGAPSADSL------------------ 61  American grass carp r...
2CSE_A   2 GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAIGdeTSVTSPGALrrmtskdipetaiintdn 81  Mammalian orthoreovir...
3IYL_A  62 ---------AIVSDRFGQYSFVNEGMRETFSKALFDINMWQPLFQATKTGCGPIVLSSFTTTTSGYVGATAGDALDN-PV 131 Grass carp reovirus
P11077  82 ssgavpsesALVPYNDEPLVVVTEHAIANFTKAEMALEFNREFLDKLRVLSVSPKYSDLLTYVDCYVGVSARQALNNfQK 161 Mammalian orthoreovir...
Q8JU57  62 ---------AIVSDRFGQYSFVNEGMRETFSKALFDINMWQPLFQATKTGCGPIVLSSFTTTTSGYVGATAGDALDN-PV 131 Golden shiner reovirus
B2BNE4  62 ---------VLVVDNKGEYTYLSENMRETLNKAVTDVNMWQPLFQATKSGCGPVVLANFTTISTGYVGATADDAFSNgLV 132 American grass carp r...
2CSE_A  82 ssgavpsesALVPYNDEPLVVVTEHAIANFTKAEMALEFNREFLDKLRVLSVSPKYSDLLTYVDCYVGVSARQALNNfQK 161 Mammalian orthoreovir...
3IYL_A 132 TNGVFISTVQIMNLQrTIAARMRDVALWQKHLDTAMTMLTPDISAGSASCNWKSLLAFAKDILPLDNLCLTYPNEFYNVA 211 Grass carp reovirus
P11077 162 QVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVAL 240 Mammalian orthoreovir...
Q8JU57 132 TNGVFISTVQVMNLQrTIAARMRDVALWQQHLDTAMTMLTPDISAGSASCNWKSLLAFAKDILPLDNLCLTYPNEFYNVA 211 Golden shiner reovirus
B2BNE4 133 SNGPFLATMHIMELQkTIAARMRDVAIWQKHLDTAMTLMTPDVSAGDVTCKWRSLLEFAQDILPLDNLCRSYPNEFYTVA 212 American grass carp r...
2CSE_A 162 QVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVAL 240 Mammalian orthoreovir...
3IYL_A 212 IHRYPALKpgNPDTKLPDAQAHPLGEVAGAFNAATSEVGSLVGSSSTLSQAISTMAGKDLDLIEADTPLPVSVFTPSLAP 291 Grass carp reovirus
P11077 241 AKRNGGIQ--WMDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKP 318 Mammalian orthoreovir...
Q8JU57 212 IHRYPALKpgNPDTKLPDAQAHPLGEVAGAFNAATSEVGSLVGSSSTLSQAISTMAGKDLDLIEADTPLPVSVFTPSLAP 291 Golden shiner reovirus
B2BNE4 213 AQRYPAIRpgQPDTQVALPQPHPLGEVAGSFNAPTSEVGSLVGAGAALSDAISTLASKDLDLVEADTPLPVSVFTPSLAP 292 American grass carp r...
2CSE_A 241 AKRNGGIQ--WMDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKP 318 Mammalian orthoreovir...
3IYL_A 292 RSYRPAFIKPEDAKWiaefnnsslIRKTLTYSGATYTVQLGP-----------GPTRVIDMNAMIDSVLTLDVSGTilPY 360 Grass carp reovirus
P11077 319 ADYNVRTLKIDEATW---------LRMIPKTMGTPFQIQVTDntgtnwhlnlrGGTRVVNLDQIAPMRFVLDLGGK--SY 387 Mammalian orthoreovir...
Q8JU57 292 RSYRPAFIKPEDAKWiaefnnsslIRKTLTYSGATYAVQLGP-----------GPTRVIDMNAMIDSVLTLDVSGTilPY 360 Golden shiner reovirus
B2BNE4 293 RTYRPAFIDPQDAAWiaqwngdanIRIITTYQSTDYTVQLGP-----------GPTRVIDMNAMIDAKLTLDVSGTilPF 361 American grass carp r...
2CSE_A 319 ADYNVRTLKIDEATW---------LRMIPKTMGTLFQIQVTDntgtnwhfnlrGGTRVVNLDQIAPMRFVLDLGGK--SY 387 Mammalian orthoreovir...
3IYL_A 361 DTNP-DLSTSVPAFVLIQTSVPIQQVTTAANITAITVV---------SAAGASAI----NLAINV------RGQPRFNMl 420 Grass carp reovirus
P11077 388 KETSwDPNGKKVGFIVFQSKIPFELWTAASQIGQATVVnyvqlyaedSSFTAQSIiattSLAYNYepeqlnKTDPEMNY- 466 Mammalian orthoreovir...
Q8JU57 361 DTNP-DLSTSVPAFVLIQTSVPIQQVTTAANITAITVV---------SAAGASAI----NLAINV------RGQPRFNMl 420 Golden shiner reovirus
B2BNE4 362 QENN-DLSSAIPAFVLIQTKVPLHSVTQASDVEGITVV---------SAAESSAI----NLSVNV------RGDPRFDMl 421 American grass carp r...
2CSE_A 388 KETSwDPNGKKVGFIVFQSKIPFELWTAASQIGQATVVnyvqlyaedSSFTAQSIiattSLAYNYepeqlnKTDPEMNY- 466 Mammalian orthoreovir...
3IYL_A 421 hlqatferetitgipyiYGLGTFLIPSPTSSSNFSNPTLMDGLLTVTPVLLRETTYKGEVVDAIVPATVMANQTSEEVAS 500 Grass carp reovirus
P11077 467 -----------------YLLATFIDSAAITPTNMTQPDVWDALLTMSPLSAGEVTVKGAVVSEVVPAELIGSYTPESLNA 529 Mammalian orthoreovir...
Q8JU57 421 hlqatferetitgipyiYGLGTFLIPSPTSSSNFSNPTLMDGLLTVTPVLLRETTYKGEVVDAIVPATVMANQTSEEVAS 500 Golden shiner reovirus
B2BNE4 422 hlhamferetiagipyiYGIGTFLIPSITSSSSFCNPTLMDGELTVTPLLLRETTYKGAVVDTVTPSEVMANQTSEEVAS 501 American grass carp r...
2CSE_A 467 -----------------YLLATFIDSAAITPTNMTQPDVWDALLTMSPLSAGEVTVKGAVVSEVVPAELIGSYTPESLNA 529 Mammalian orthoreovir...
3IYL_A 501 ALANDAIVLVSNHLNKLANVVgdaipvasRTDDSA--------TSAIVSRLAVQHk-lSQVGQASPTPPDYPLLWRRAKR 571 Grass carp reovirus
P11077 530 SLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ---LETGYGVRIFNPKGILSKIASR 598 Mammalian orthoreovir...
Q8JU57 501 ALANDAIVLVSNHLNKLANVVgdaipvasKTDDSA--------TSAIVSRLAVQHk-lSQVGQTSPTPPDYPLLWRRAKR 571 Golden shiner reovirus
B2BNE4 502 ALANDAVLLVSGQLERLATVVgdvipiasGEDDAA--------TSAIVGRLAIEAtmrARHGGDTRALPNFGQLWKRAKR 573 American grass carp r...
2CSE_A 530 SLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ---LETGYGVRIFNPKGILSKIASR 598 Mammalian orthoreovir...
3IYL_A 572 AASMFVSNPSLALQVGIPVLTQSGMLSALTSGVGTALRTGSLGKGVTDASEKLRARQSLTVAKQAFFDQIGSLWPG 647 Grass carp reovirus
P11077 599 AMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSTHFPA 674 Mammalian orthoreovirus 1...
Q8JU57 572 AASMFVSNPSLALQVGIPVLTQSGMLSALTSGVGTALRTGSLGKGVTDASEKLRARQSLTVAKQAFFDQIGSLWPG 647 Golden shiner reovirus
B2BNE4 574 AASMFASNPALALQVGVPVLADSGILSALTSGVSTAIRTGSLGKGVSDASSKLNARQSLTLARKTFFKKVEELWPS 649 American grass carp reovi...
2CSE_A 599 AMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSTHFPA 674 Mammalian orthoreovirus 1...
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