Conserved Protein Domain Family
vWA_collagen_alpha_1-VI-type
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cd01480: vWA_collagen_alpha_1-VI-type 
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 238757
Aligned: 14 rows
Threshold Bit Score: 203.771
Created: 10-Jan-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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integrin-coll..metal
Feature 1:integrin-collagen binding site
Evidence:
  • Comment:three loops on the upper surface of integrin that coordinate the metal through MIDAS residues also engage collagen
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ### #                                                                
P12109     612 GPIDLLFVLDSSESIGl------QNFEIAKDFVVKVIDRLsrd-------elvKFEPGQSYAGVVQYS--HSQMQEHVSL 676  human
Q04857     611 GPIDILFVLDSSESIGl------QNFEIAKDFIIKVIDRLskd-------elvKFEPGQSHAGVVQYS--HNQMQEHVDM 675  house mouse
AAH47255   635 GPLDLLFVLDSSESIGl------SNFQISKDFILKVIDRLsrd-------ehvKFDADNSHVGVVQYS--HGQTQEVVAM 699  African clawed frog
Q02788     622 GALDVVFVIDSSESIGy------TNFTLEKNFVINVVNRLgai-------akdPKSETGTRVGVVQYS--HEGTFEAIRL 686  house mouse
P12110     612 GALDVVFVIDSSESIGy------TNFTLEKNFVINVVNRLgai-------akdPKSETGTRVGVVQYS--HEGTFEAIQL 676  human
P12109      34 CPVDLFFVLDTSESVAlrlkpygALVDKVKSFTKRFIDNLrdr-------yyrCDRNLVWNAGALHYS--DEVEIIQGLT 104  human
AAH47255    62 CPVDIFFVLDTSESVA-------LRVKPFKTLVTQVKEFTkkfidkltsryyrCDRNLVWNAGALHYS--DEVILINSLT 132  African clawed frog
Q04857      33 CPVDLFFVLDTSESVA-------LRLKPYGALVDKVKSFTkrfidnlrdryyrCDRNLVWNAGALHYS--DEVEIIRGLT 103  house mouse
AAH47255   846 GPADITMLVDSSTRVGn------QHFQTSKSFVKLLAERFlk---------akPPPSGSARVSVVQYSgqNQQIVEAQFL 910  African clawed frog
Q02788      53 CPVNVYFVLDTSESVAm-----qSPTDSLLYHMQQFVPQFisqlq---nefylDQVALSWRYGGLHFS--DQVEVFSPPG 122  house mouse

Feature 1                              #                                                       
P12109     677 rspsiRNVQELKEAIKSLQWMAGGTFTGEALQYTRDQLL---PPSPNNRIALVITDGrs---dTQRDTTPLNVLCSPgiq 750  human
Q04857     676 rspnvRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLL---PPTQNNRIALVITDGrs---dTQRDTTPLSVLCGAdiq 749  house mouse
AAH47255   700 gdssiQSIGQLKEAVKNLKWIAGGTWTGEALAFTKDNLLk--RFTLEKKIALVLTDGhs---dILRDKTPLNTLCEVtpv 774  African clawed frog
Q02788     687 ddervNSLSSFKEAVKNLEWIAGGTWTPSALKFAYNQLIkesRRQKTRVFAVVITDGrh---dPRDDDLNLRALCDRdvt 763  house mouse
P12110     677 ddehiDSLSSFKEAVKNLEWIAGGTWTPSALKFAYDRLIkesRRQKTRVFAVVITDGrh---dPRDDDLNLRALCDRdvt 753  human
P12109     105 rm--pGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLvggSHLKENKYLIVVTDGhplegyKEPCGGLEDAVNEAk-- 180  human
AAH47255   133 -----RDMKTLRDNVETVEYIGKGTHTDCAIKRGIEEVLiggSHQKENKYLIVVTDGhplegyKEPCGGLEDAANEAk-- 205  African clawed frog
Q04857     104 rm--pSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLiggSHLKENKYLIVVTDGhplegyKEPCGGLEDAVNEAk-- 179  house mouse
AAH47255   911 -----TNYTVLEVPVDNMQFINGATNVVSALRAVTELYRe-dSLAGVNKKLLVFSDGn-----TQEEKGLLKVVQDAq-- 977  African clawed frog
Q02788     123 -----SDRASFTKSLQGIRSFRRGTFTDCALANMTQQIRq-hVGKGVVNFAVVITDGhv---tGSPCGGIKMQAERAr-- 191  house mouse

Feature 1                                                                   
P12109     751 vvsVGIKDVFDFIP---GSDQLNVISCQGLapsqgrpglslVKENYAELLe-DAFLKNVTA 807  human
Q04857     750 vvsVGIKDVFGFVA---GSDQLNVISCQGLsqgrp--gislVKENYAELLd-DGFLKNITA 804  house mouse
AAH47255   775 -vsVGVGDIFQNAP---NSDQLVQISCGGKpysk---glslQRTSFAELLd-DGFLHNVTS 827  African clawed frog
Q02788     764 vtaIGIGDMFHETH---ESENLYSIACDKPqq-------vrNMTLFSDLVa-EKFIDDMED 813  house mouse
P12110     754 vtaIGIGDMFHEKH---ESENLYSIACDKPqq-------vrNMTLFSDLVa-EKFIDDMED 803  human
P12109     181 --hLGVKVFSVAITpdhLEPRLSIIATDHT-----------YRRNFTAADw-GQSRDAEEA 227  human
AAH47255   206 --hLGIKVFSVAISpnhLEPRLSVIASDAS-----------HRRNFTATSa-VGLTDDEID 252  African clawed frog
Q04857     180 --hLGIKVFSVAITpdhLEPRLSIIATDHT-----------YRRNFTAADw-GHSRDAEEV 226  house mouse
AAH47255   978 --sAGIEIYVLAVGs-rLNYPNLQVMLTGSaa--------dIAGPFPEER--LFRVPDYTS 1025 African clawed frog
Q02788     192 --eEGIRLFALAPNrnlNEQGLRDIANSPHe---------lYRNNYATMRpdSTEIDQDTI 241  house mouse

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