Conserved Protein Domain Family
RAB3GAP2_N

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pfam14655: RAB3GAP2_N 
Rab3 GTPase-activating protein regulatory subunit N-terminus
This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily.
Statistics
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PSSM-Id: 464240
Aligned: 35 rows
Threshold Bit Score: 355.078
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFA84188      113 WL-DQLSVA--ITADGSMMVVGGGGTggvgtglAIVLVk----------RAHD-QSQWRTSITLDhqSGQid-------- 170 
XP_002984023   27 WL-DDAALV--AAMGRDLVAIARQRS---------LVVtpwsgahssapRASGfSIDSIPAATGAdpSYR---------- 84  
Q69LW2         34 WL-DDPAVLpsLAPRARALAVASAAR-------SVLAVvpv--------agVGgGVTVRPALGPDdgR------------ 85   Japanese rice
NP_001334864   28 WLvNNPNLL--TALDTHSIALAN--R-------SLVLIlhws----egsDPVGnRVKIVPDLSPIeaEY----------- 81  
KRH26184       28 WLvETPQLL--CAIDTHSLILAN--R-------STILLlsws----sdsSAAPpPLKIRPDLSPIdaES----------- 81  
EEF37847       29 WLvDNPNLK--CALDTHSIAISN--R-------YLILItgw---------ddGpRLKIRPDLSPIesES----------- 77  
XP_006370146   29 WLvENPNLL--CALDTHSLALAN--R-------SLILItgw---------ddGpRSKIRPELSPIesEI----------- 77  
Q9LKB3         28 WLvNNPNLL--SALDSHSLALAN--R-------FLILIvnw-------gdPDApRVKIRPDLSPIeaES----------- 78   thale cress
CBI20190       28 WLvENPSLI--CALDTDSLALAN--R-------SFVLVlgws----engDPYNsPVKIRPTLSQIetER----------- 81  
EDQ92492       61 L--STCLIT--LNADGGLMAIARQQR-------IVLLSgpeh----dwnICARySIAAPAPIRDNplDRIaerrprqklq 125 
EFA84188      171 --rITAISILTLSN------PQLEQAIAIGYTSGHLRIFSLHGNLLLSQLFHKAPIQKIKvkmtpiltSSQERYVMQEVS 242 
XP_002984023   85 ---ITALEWLFWEG---------WSVLAVGTSLGILCFYSEIGDLLIKQSFNVGSICNLHvr-----cNQNKRDTAEELS 147 
Q69LW2         86 ---ISAVEWVPLVGedaeeaGGEGVAVAVGTDAGWLLFYSLAGDLLHKQSIYPSKILKLNfre--rkeNAWEDSGSDELS 160  Japanese rice
NP_001334864   82 ---ISAIEWLVFDD---------IKVLALGTSRGYLLIYSLRGDLIHKQIVSPGKILRLRvrdt-krdLT-QDASSEEVC 147 
KRH26184       82 ---ISALEWLAFRD---------HRVIVAGTSSGNVLFYSLRGELIHRQMIYPSRVLKLRvrgt-kkdLI-QDTSSEEFC 147 
EEF37847       78 ---ITALEWLVFDE---------IRVVAVGTSCGYFLVYSLDGHLIHKQMVYPGRILKIRvrgt-kkdLTQQTSSSEEIS 144 
XP_006370146   78 ---ISALEWLVFDE---------IKVIAVGTSRGYFMVYSLDGLLIHRQLVYPGRILKLRvrgtkkdmMSSHEGSSEEVS 145 
Q9LKB3         79 ---ITAIEWLVFDD---------VRVVVAGTSCGYLLVYSVTGDLIHKQIVHQSRILKIRvrgt-kkdLM-QETSSEEIC 144  thale cress
CBI20190       82 ---ITAVEWLVFDE---------IRVLAVGTSSGYLMIYSLGADLIHKQMINPGRILKFRvrgt-krdLT-QGSSSEEVC 147 
EDQ92492      126 qpsIVALSSISISLna---tGQPEQLILAGTNRGYLHVLRHNGERILCQMLHDAPVVRIT--------QQPGKGPLNDLA 194 
EFA84188      243 ILYPGNIVAsMAGGSLSGVLAVCYQQVQRg-----------DTASAAQTKLDFRKWSLGS--IDVANDFSFAGPFLGSPF 309 
XP_002984023  148 VAFQSSIAR-IDALDLQSQLRRRLLEVArnst------lerQLIAAESTKLSYQVWSVKSsgSSICVDAAITGVLPPALF 220 
Q69LW2        161 VVFPGVIAR-FDGADLQNMLQKSLHEVKShlwkdkseqedaEE-DSSFGRIPFQIWNVSK--FSSCADAAIVGLMPPPLL 236  Japanese rice
NP_001334864  148 VVMSGVIAR-FDGSDIQNMLQRWFRERHSqfwd----etesENSADTFGRLPYQLWNVNK--YGSCVDAAITGLMPPPLL 220 
KRH26184      148 LIMSGVIAH-FDGSDIQNMLQKWFEESHSrfwdqnpkshdsEDFGNTDVKIPYQLWNIGK--YGTCAEAAITGIMPPPLM 224 
EEF37847      145 IVMPGVIAR-FDGSDLQNMLQEWIQEKHSqfwdek-pnrdaDGLGITYKRLPYQLWNVNK--YGSCADAAITGVMPPPLM 220 
XP_006370146  146 VVIPGVIAR-FDGADIRNILQEWFQETNShfwdekskrrdyEELGNGFKRLPHQLWSVDK--FGLCADAAITGIMPPPLM 222 
Q9LKB3        145 IVLPGVIAR-FDGSNIQSMVQKWVQEKNSnfwdqknrkgdaEDTGSLYQRLPYQIWNVNK--NGVCVDATVTGVMPPPLL 221  thale cress
CBI20190      148 VVMPGVIAR-FDGADLQSMLQRWFQDTHSqfwdekpkrrdqEDSEKSYGRLPYQLWNVSK--YGPCADAAITGTMPPPLM 224 
EDQ92492      195 LLYPDAVVI-IDGLSLARTVLGRIHQ-----------------DSESEATLEVKKYGLED--QDNCRDIACCGPSLASDY 254 
EFA84188      310 RALp----yGTSEHAMTRLIVAGSDPMLAYYYPSDdsGSSFTVA--VALVSSVAAKLTNAVysfaknwWGGSQQ------ 377 
XP_002984023  221 EQQs--------RERYFCAVTIGSDSTLAAFRLSE--DRRKSLT--ELLFNKVVPATVSRItsfak------------af 276 
Q69LW2        237 E-Lq-------sSQRHYCAITVGEDAVVSAYRLSE--DRSRSIV--GAILSRGVAATFSTIssls-------------ki 291  Japanese rice
NP_001334864  221 E-Lq-------sSQRYYCAITVGADAVISAYRLSV--DRSRSIV--GAILSKVVPATFSTItsis-------------km 275 
KRH26184      225 EQQq-------sSQRYYCAVAVGEDAVISAYRLSE--NKGRSLV--GAILSKVVPATFSTIssfs-------------kl 280 
EEF37847      221 E-Vq-------sSQRYYCAVTIGDDAVISAYRLSE--DRSKSLV--GAILSKVVPATFSTIasls-------------km 275 
XP_006370146  223 E-Iq-------sSQRYYRAVTIGEDAVISAYRLSE--DRSRSLV--GAILSKVMPAAFSTIssvs-------------km 277 
Q9LKB3        222 E-Lq-------sSQRYYCAVTIGEDSVISAYRLSE--DRGRSLV--GAILSKVVPAAASTIasfs-------------kl 276  thale cress
CBI20190      225 E-Lq-------sSQRYYCAVTIGDDAVISAFRLSE--DRNRSLV--GAILSKVVPATFSTIasfs-------------km 279 
EDQ92492      255 DHLmlyaarHAEHQEMCAYIVAGASPMLAKYTTL---GVDRPFStvAALATSMATQFSKAMfsmvnsfWGGSSTaaksqs 331 
EFA84188      378 --SQQQQQQqqQEANAKQqeskieNPSPLQVRWSLIDEKRELKSLLMDPSGRYAVATDNLGRVLLVDIVNSLIVRMWKGY 455 
XP_002984023  277 rrNSEPVQEarPAEVKAQ------EFSRASLITALKDSPRKGESLALSPTCSLAAVTDSLGRVLLVDVHALVVVRLWKGY 350 
Q69LW2        292 iwRSEPSPTk-KSRPKPQ------SFAKTSPLTCLKDSPRKGERLTLSPSGTLAAITDSLGRILLLDTHALVAVRLWKGY 364  Japanese rice
NP_001334864  276 lwRSDPSPTk-RPEPKPQ------PFARASPLTCFKDHPRKGEKLTLSPSGTLAAITDSLGRILLLDTQALVVVRLWKGY 348 
KRH26184      281 iwRSEQSSPk-KSDQKPQ------PFARASPLTCLKDHPRKGEKLTLSPSGTLAAITDSLGRILLLDTQALVVVRLWKGY 353 
EEF37847      276 iwRSEKASPk-KSEAKPQ------SFAKASPLTCLKDHPRKGEKLTLSPGGTLAAITDSLGRILLLDTQALIVVRLWKGY 348 
XP_006370146  278 iwRSERTPTk-KPEVKPQ------SFAKASPLTCLKDHPRKGEKLTLSPSGTLAAITDSLGRILLLDTQALVVVRLWKGY 350 
Q9LKB3        277 iwRSNDQSPkrKPEAKTQ------SFARASSLTCIKDYPRKGEKLTLSPSGTLAAITDSLGRILLLDTQALVVVRLWKGY 350  thale cress
CBI20190      280 iwRSEQKSPk-RSEPKPQ------PFARASPLTCLKDHPRKGEKLTLSPSGTLAAITDSLGRILLLDTQALVVVRLWKGY 352 
EDQ92492      332 kaPAESSDPseVPPSARE------PATPLPMASSLSDAKREFLRLSLSPDQRLLAAADNLGRVFLLDVATLSAVRMWKGY 405 
EFA84188      456 RDCQCGWINQLSNEDDDDEEEEedsndnnvdkdnnssnsnnndsfmtledfipakmmkkkvgvnHYRTYLAIYIGRRGYL 535 
XP_002984023  351 RDAHCKFLEAPLNGSSGLQHRSscv-------------------------------------keDFSLCLAIHAPRRAVV 393 
Q69LW2        365 RDASCLFVEMLLNKD-KASSSLhtey-----------------------------------tksDYCLCLAIHAPRKGII 408  Japanese rice
NP_001334864  349 RDASCLFVEMLAKKDVETSRSAyhdh-----------------------------------vksDYCLCLAIHAPRKGIV 393 
KRH26184      354 RDASCLFMEMLVNKDIASSSSSysep-----------------------------------lksDYCLCLAIHAPRKGII 398 
EEF37847      349 RDASCFFMEMQVKRDNAGASSSyyep-----------------------------------sksDYCLCLAIHAPRKGII 393 
XP_006370146  351 RDANCLFMEMLVSMNSAGASSShhep-----------------------------------sksDYCLCLAIHAPRKGII 395 
Q9LKB3        351 RDASCVFMEMLAKKD-KGKSVIhtep-----------------------------------vksDYCLCLAIHAPRKGII 394  thale cress
CBI20190      353 RDASCLFTEMLVSKDTAASSSSyyep-----------------------------------vksDYCLCLAIHAPRKGIV 397 
EDQ92492      406 RDAEVAWHVSEPMKERAGPMA-------------------------------------------LRAMFLIIYAPRRGQV 442 
EFA84188      536 EVWGMKHKSRVVFEKVGMGCRLI 558 
XP_002984023  394 EVWQLRNGPRLSVIHCSESCRLL 416 
Q69LW2        409 EIWQMRTGARLLTIPCPKGSRIL 431  Japanese rice
NP_001334864  394 EIWQMRTGPRLLTIPCAKGSKIL 416 
KRH26184      399 EIWQMRTGPRLRTISCAKGSKML 421 
EEF37847      394 EVWQMRTGPRLLTIQCARGTKLL 416 
XP_006370146  396 EVWQMRTGPRLLTIQCAKGSKLL 418 
Q9LKB3        395 EVWQMRTGPRLLTIQCAKGSKLL 417  thale cress
CBI20190      398 EVWQMRTGPRLLTVQCSKGSKIL 420 
EDQ92492      443 ELWNVPFGDRAAAFNIGvgqipp 465 
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