Conserved Protein Domain Family
fumC

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PRK00485: fumC 
fumarate hydratase; Reviewed
Statistics
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PSSM-Id: 234779
Aligned: 674 rows
Threshold Bit Score: 537.753
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
296121118   1 MTETRIETDSMGEVHVPAKAYYSAQTQRAIENFPVSGWTLHPELIRAMGWVKYACGVANRDLGKLthsgknklTDQQVQF 80 
221218259   1 -MTVRLEEDAFGAVEILEGRLWGAQTQRALAVFGASGPRLPVAVIRAFAAQKAAAARANLALGML--------DAERAGL 71 
15897944    1 ---------------MDYVQLIMKYTDTAPKLFMNTGTKFPRRIIWSMGVLKKSCAKVNADLGLL--------DKKIADS 57 
73539339    6 SSATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGNEKMPPALIEAFAILKLCAARANRELDVL--------PQELAGA 77 
146304227   1 ----------------------MKYTESAPKLFMNTGTKFHRSLIFAMGVVKYSCARANATLGIL--------DQQIGKA 50 
159041501   1 ----------------------MKYTEAATRLFMATGTKFPRQVIWAMGLVKYASAKVNTELGLL--------SGDIGHA 50 
160896884  13 QAHTRIEHDAFGPVHIPADRLWGAQTQRALELFTIGEERFPQGLYRAFGLQKLAAARANRRLGVL--------DDERGAA 84 
188591938   6 TAATRIEKDSLGDVPVPADHLWGAQTERSRQNFRIGTEKMPPALIEAFAILKLCAARANGELGVL--------PPELAHA 77 
302348337   1 ---------------------MSSYAERARPYYLETGTRPPRRLIWAVAMIKAAAARANRELGLL--------DAVKASA 51 
110635947   1 -MTIRSESDANGPIEIPADRYWGAQTARALRLFPQEGPRLPVSFLRAFGLQKAAAARANMALGVL--------DRERGER 71 
296121118  81 MLDAALEVAHGKWDGEFPIDVFQTGSGTSSNMNVNEVISNRAIELAGGDRfEA-KKPIHPNDHVNMGQSTNCTFPTAIHV 159
221218259  72 ILAACERLGQGAFDDHFPLPVWQTGSGTQTNMNVNEVLANAANMAAGQGP-GT-RAPVHPNDHVNRSQSSNDSFPTVMQI 149
15897944   58 IIKASDDLIDGKLDDKIVLDVFQTGSGTGLNMNVNEVIAEVASS-------YS-NLKVHPNDHVNFGQSSNDTVPTAIRI 129
73539339   78 IEQAASEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAIQLLGGQV-GS-KKPVHPNDHVNASQSSNDSFPTAMHI 155
146304227  51 IEQASMELMEGKLDDKIVLDVFQTGSGTGLNMNVNEVLAERSSQ-------IS-GLKVHPNDHVNMSQSSNDTVPTAIRI 122
159041501  51 IMEASKEVMDGRFDDEVTVDVFQTGSGTGLNMNINEVIAERAGE-------IS-GKRIHPNDHVNLGQSSNDTVSTAIRI 122
160896884  85 IEAAAAELRDGLLDAHFPLTIWQTGSGTQTNMNANEVIANRANQMLGQPP-GT-RSPVHPNDHANASQSSNDSFPTVMHL 162
188591938  78 IEQAAAEVIEGRWPDEFPLSVWQTGSGTQTNMNLNEVIANRAIQLLGGEV-GS-KTPVHPNDHVNASQSSNDSFPTAMHI 155
302348337  52 IESSALEVAKGAHDDKVTVDVFQTGSGTGINMNINDVVADLAS--------GLcGCRVHPNDDVNMSQSSNDVMPTALRL 123
110635947  72 ILAAAVELRDGRFDDHFPLSIWQTGSGTQTNMNANEVLANRANELSGQPL-GT-RDPIHPNDHVNLGQSSNDTFPTVMHV 149
296121118 160 AVAHSIKTQLIPALKNLANTLAEKAKAWDKVLKIGRTHLADATPIRLGQEFSGFARQLELSVQRAQQAMAAVMELPVGGT 239
221218259 150 AAVAEARGRLAPELDRMAVALEERAAAFAGIPRLGRTHLNDAVPVPLSQGFAASAAEMRRSARRLSAALDELLALPQGGT 229
15897944  130 AAVAEVTNRLLPALQQIISSLNKKAEEYKDVIKAGRTHLRDALPVTLGQELSAYADAFQHEHEQVMNILEYVKELPIGGT 209
73539339  156 AATRAIQQKLLPALETLQQTFARKVDAFADIVKVGRTHLQDAVPLTLGQEFSGYMTQVADAQSRLQQAMLRAMPVAQGGT 235
146304227 123 GAVKQVQDKLIPALEGIISSLRETGDKYSSVIKSGRTHLRDAMPVTLGQELHAYADALSHDLNMLKTVLEYVKEIPLGGT 202
159041501 123 AAVHSSMLLLIPALNKLITSLGEKSSLFNTVIKAGRTHLRDALPITLGQELSGYLDAFSHDLKIIESTLDYVKELPIGGT 202
160896884 163 ATALELRDHLLPALEQLQQRLQERALAFAGVLKVARTHLMDAVPMTLGQSFETFAHQVGHGIHRLQATQPRLWSLAQGGT 242
188591938 156 AATRAIQQELLPALEQLQQTFARKVEAFADIVKVGRTHLQDAVPLTLGQEFSGYMAQVADAQSRLQQAMLRAMPVAQGGT 235
302348337 124 AAVAAINEDLLPAVRELVSALREAGSRFSDAVRPGRTHLRDALPITLGQQMEAYAHMVERDLSAVTSVLGLLYEVPLGGT 203
110635947 150 AAVLELQDGVLPALDQLETAFARLETDHGAYVRMGRTHLNDAVPVTLGQTLASYRRQVSQAQKRIAATLADLKVLSQGGT 229
296121118 240 AVGTGINTHPEFSSRVCAVLAKELGIPFIEAVNHFEANAQRDGLVECHGHLRAIAVTLFNVANNIRWLGSGPRCGFYEVI 319
221218259 230 AAGSGLNAPEGFDRAFCAALSEATGEAFRPAAVKVEGMAGHDALLGLSAVCEALAVALTRLCNDVRHLAAGPHAGTGELS 309
15897944  210 ATGTGLNSHPEFQERVINEINRITGLGFKPA-NRFRAMRLLTDLLLLSGALRNIAVDLYRLGQDIRLMFSGPLTGLNEID 288
73539339  236 AVGTGLNAPPGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDFMLLGSGPRAGFAELQ 315
146304227 203 AVGTGVNSHPKFRETVITVINQVTGLGFTLA-NPFRGLRFLTDLLTLSGIMRTIAVELYRMAQDFRLMFSGPMTAIGEID 281
159041501 203 AVGTGLNTHPEFQGRVIKEINEITSLDFKPA-NKFRGLKLLTDILNLSGALRATAIDLYRLGQDIRLMFSGPMTGLNEID 281
160896884 243 AAGTGLNAPSGFDRVFCEEIQALTGLAVTPNPCKFEGMAAHDALIEVSGALNVVAGSLAKMANDIRLLGSGPRCGLGELV 322
188591938 236 AVGTGLNAPHGFAAAFARALADYTGLPFEPAPNRYALQAAHDALADLSGALNTTASSFLKIARDFMLLGSGPRAGFAELV 315
302348337 204 AVGTGANTDPRFAEVALKELSSLSGVSLRPSPSKSALMRSLSDVVALSGALRSLALDMLRISNDLRLLNSGPNTGLNEVE 283
110635947 230 AAGSGLNAAEGFDQAFCAALSDATGIDFAPNPVKVEGMAAHDALVAASAALEGLATALIHILNDIRLLAAGPRAGLAELT 309
296121118 320 LADLQ--PGSSIMPGKVNPVMCESLMQVAALVMGNDQTVAISGATgGNFQLNIMMPVMGQTTVGSVVVMAGGVKAFDDLC 397
221218259 310 LPDDG--LTSSIMPGKRNATLAEALVQVCQHVAGCHETVSRAAAS-GVWDLNVSKPVLIHALLGAMEALAQGMEGFRLHC 386
15897944  289 LPTQEeiAGSSIMPGKTNPVTVEATLLISAQVVGLDHANQFASML-GEFELSMGIPLVGYNIVTQVNFISEALEKMSRLV 367
73539339  316 LPANE--PGSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANAL-GTLELNAYKPVIVYSLLQSVTLLADAASSFAEHM 392
146304227 282 LPTQEeiAGSSIMPGKTNPVTAEASMLIAAQVVGLDQANQFASNL-GEFELAMGVPLIGQNVVTQVDLLSEGLNKFSSLL 360
159041501 282 LPTQGevAGSSIMPGKTNPVTVEATLLAVAQVVGLDHANQFASML-GEFELAMGVPLMGYNIVLQVHLLSEALSKFTNLV 360
160896884 323 FPDDG--LSSSIMPGKRNPTVAEVVVQAAYQAMGHHLTVTLAGSA-GHFELNVAKPVLIHHLLRAMLALGDASRVFAEKL 399
188591938 316 LPANE--PGSSIMPGKVNPTQAEALAMVCCRVIGNHTTVTLANGL-GTLELNAYKPVIIYSLLQSVSLLAGAAASFAEHM 392
302348337 284 VPVDV--PGSSMMPGKKNPVTLEAVNQGAAQVLGYDQAIAWGASL-GELELNMGIPVVAYNVLKEVELLAEMARKLA-RT 359
110635947 310 LPDDG--LSSSIMPGKRNATLAEALLQVCFRVIGNHTTVVWAAGS-GLFELNVAKPVLIHAFLESATALKVAIASFVAGT 386
296121118 398 AKLMEANPEACEASIEKSLAMVTSLNPYIGYEKAAQLAKEAFKTGKTIRQLCLEQKI---LSEEQLTEALDPYSMTEP-- 472
221218259 387 LAGIEPRRARLADNLARSMMAATALTPRLGYDRVAGLIRRAEAQGLTLRAACLAEGI---LGPEAFDRLVDPERMARG-- 461
15897944  368 IDGMVANVEKMKRYAESSPSLITIVSPVIGYDKATEIGKKLNK-GMSIREALRELGY----SDNEINKILDLSKLVKP-- 440
73539339  393 VEGVEADRERIAELLERSLMPVTALNPHIGYDKAAEIAKLAVKRNLSLREAAIASGH---VTEEQFAQWIDLKGMTKE-- 467
146304227 361 VKGMVPNQEKMKRYAESSPALVTVISPIVGYDKASQIGKMLNR-GMSIREALKELGF----SDKQIDDILDLSKLIKP-- 433
159041501 361 IDGMVPNTDRMRRYAESSPSLITVISPVIGYDKAAEIGRR-LTHGLSIREALRELGY----TDEQINEILNLEKLTKPgf 435
160896884 400 VAGLQAHTERLEQQVSHSLLQATALNPVLGYDAVARITREAMARGIAPRQAAVALGL---ITAAEYDRLVDLRAMAGL-- 474
188591938 393 VEGVEADRERIAELLERSLMPVTALNPHIGYDRAAEIAKLAVKRNLSLREAAIASGH---VTEAQFAEWIDLKGMTRE-- 467
302348337 360 VSQVIPHRERMLQLAASSQALVTFLSPLVGYDVAAAISE-AISRGASLEDAVRSAVKdeeKARKVVELLSDVRKLTGPvr 438
110635947 387 LNGLEVNGERMAHYVNSSLMLATALTPRLGYDRVAEVIRLADLENLTLREACARFGV---ISMQDYDALIDPARMANG-- 461
296121118 473 ---H 473
221218259 462 ---G 462
15897944  441 ---G 441
73539339  468 ---V 468
146304227 434 ---G 434
159041501 436 plsH 439
160896884 475 ---P 475
188591938 468 ---V 468
302348337 439 lr-- 440
110635947 462 ---G 462
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